{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:13:53Z","timestamp":1780496033326,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Achaogen Inc."}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.diagmicrobio.2020.115092","type":"journal-article","created":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T19:17:53Z","timestamp":1590261473000},"page":"115092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparative in vitro activity of plazomicin and older aminoglyosides against Enterobacterales isolates; prevalence of aminoglycoside modifying enzymes and 16S rRNA methyltransferases"],"prefix":"10.1016","volume":"97","author":[{"given":"Deniz","family":"G\u00fcr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Hasdemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"\u00c7akar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130ffet","family":"\u00c7avu\u015fo\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011f\u00e7e","family":"\u00c7elik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.diagmicrobio.2020.115092_bb0005","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/jac\/dkq003","article-title":"Low prevalence of 16S methylases among extended-spectrum-\u03b2-lactamase producing Enterobacteraceae from a Turkish hospital","volume":"65","author":"Ber\u00e7ot","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0010","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1469-0691.2008.02037.x","article-title":"Antimicrobial resistance in invasive strains of Escherichia coli from southern and eastern Mediterranean laboratories","volume":"14","author":"Borg","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5578\/mb.10695","article-title":"Investigation of carbapenemases in carbapenem-resistant Escherichia coli and Klebsiella pneumoniae strains isolated in 2014 in Turkey","volume":"50","author":"\u00c7akar","year":"2016","journal-title":"Mikrobiyol Bul"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0020","first-page":"199","article-title":"Molecular epidemiology of carbapenem-resistant Klebsiella pneumoniae at a Turkish centre: Is the increase of resistance a threat for Europe?","volume":"94","author":"Candevir Ulu","year":"2019","journal-title":"Diagnostic Microbiology and Infectious Disease"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2020.115092_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.00313-18","article-title":"In vitro activity of plazomicin against gram-negative and gram-positive isolates collected from United States hospitals and comparative activity of aminoglycosides againts carbapenem resistant Enterobacteraceae and isolates carrying carbapenemase genes","volume":"62","author":"Castanheira","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0030","doi-asserted-by":"crossref","first-page":"e02418","DOI":"10.1128\/AAC.02418-19","article-title":"Activity of plazomicin tested against Enterobacterales isolates collected from U.S. hospitals in 2016\u20132017: effect of different breakpoint criteria on susceptibility rates among aminoglycosides","volume":"64","author":"Castanheira","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0035","author":"Central Asian and European Surveillance of Antimicrobial Resistance (CAESAR)"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/phar.2203","article-title":"Plazomicin: a next-generation aminoglycoside","volume":"39","author":"Shaeer","year":"2019","journal-title":"Phatmacotherapy"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0045","first-page":"1","article-title":"Aminoglycoside resistance determinants in multiresistant Escherichia coli and Klebsiella pneumoniae clinical \u00f5isolates from Turkish and Syrian patients","volume":"26","author":"Cirit","year":"2019","journal-title":"Acta Microbiol Immunol Hung."},{"issue":"5","key":"10.1016\/j.diagmicrobio.2020.115092_bb0050","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.ijantimicag.2014.02.003","article-title":"Revised and updated multiplex PCR targeting acquired 16S RMTases","volume":"43","author":"Corr\u00eaa","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0055","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jgar.2018.10.020","article-title":"Aminoglycoside-modifying enzymes and 16S ribosomal RNA methyltransferase genes among a global collection of Gram-negative isolates","volume":"16","author":"Costello","year":"2019","journal-title":"Journal of Global Antimicrobial resistance"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0060","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1021\/acsinfecdis.8b00001","article-title":"Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes","volume":"4","author":"Cox","year":"2018","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0065","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.idc.2016.02.011","article-title":"Aminoglycoside resistance, The emergence of acquired 16S ribosomal RNA methyltransferases","volume":"30","author":"Doi","year":"2016","journal-title":"Infect Dis Clin N Am"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0070","author":"EUCAST"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0075","author":"European Antimicrobial Resistance Surveillance Network"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2020.115092_bb0080","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/AAC.01477-07","article-title":"Detection of methyltransferases conferring high-level resistance to aminoglycosides in Enterobacteraceae from Europe, North America, and Latin America","volume":"52","author":"Fritsche","year":"2008","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0085","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1473-3099(16)30257-2","volume":"17","author":"Grundmann","year":"2017","journal-title":"Lancet Infect Dis"},{"issue":"Suppl. 1","key":"10.1016\/j.diagmicrobio.2020.115092_bb0090","first-page":"19","article-title":"The In vitro activity of isepamicin against gram-negative hospital isolates","volume":"5","author":"G\u00fcr","year":"2001","journal-title":"Turkish Journal of Hospital Infections"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0095","doi-asserted-by":"crossref","unstructured":"Guven Gokmen T, Nagiyev T, Meral M, Onlen C, Heydari F, Koksal F. NDM-1 and rmtC-producing Klebsiella pneumoniae Isolates in Turkey. Jundishapur J Microbiol 2016, 18;9(10):e33990).","DOI":"10.5812\/jjm.33990"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0100","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1093\/jac\/dkt078","article-title":"Association of the novel aminoglycoside resistance eterminant RmtF with NDM carbapenemase in Enterobacteraceae isolated in India and the UK","volume":"68","author":"Hidalgo","year":"2013","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2020.115092_bb0105","first-page":"e01037","article-title":"Occurrence of acquired 16S RMTase-mediated aminoglycoside resistance in clinical isolates of Enterobacteraceae within a tertiary referral hospital of Northeast India","volume":"61","author":"Jayalaxmi","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"33","key":"10.1016\/j.diagmicrobio.2020.115092_bb0110","first-page":"1","article-title":"ArmA and RmtB were the predominant 16S RMTase genes responsible for aminoglycoside-resistant isolates in Korea","volume":"10","author":"Lee","year":"2018","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0115","unstructured":"Miller GH, Sabatelli FJ, Naples L, Hare RS, Shaw KJ and the Aminoglycoside Resistance Study Groups. The most frequently occuring aminoglycoside resistance mechanisms\u2014combined results of surveys in eight regions of the world. J Chemother 1995; 7(suppl,2): 17-30."},{"issue":"Suppl. 1","key":"10.1016\/j.diagmicrobio.2020.115092_bb0120","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/clinids\/24.Supplement_1.S46","article-title":"the Aminoglycoside Resistance Study Groups. The most frequent aminoglycoside resistance mechanisms\u2014changes with time and geographic area: a reflection of aminoglycoside usage patterns?","volume":"24","author":"Miller","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0125","series-title":"Bacterial resistance to antibiotics: from molecules to man","isbn-type":"print","first-page":"81","article-title":"Resistance and tolerance to aminoglycosides","author":"Mok","year":"2020","ISBN":"https:\/\/id.crossref.org\/isbn\/9781119940777"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0130","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1046\/j.1198-743x.2001.00284.x","article-title":"Aminoglycoside Resistance Study Group. The changing nature of aminoglycoside resistance mechanisms and prevalence of newly recognized resistance mechanisms in Turkey","volume":"7","author":"\u00d6ver","year":"2001","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2020.115092_bb0135","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00284-012-0126-3","article-title":"Rapid and sensitive detection of major uropathogens in a single-pot multiplex PCR assay","volume":"65","author":"Padmavathy","year":"2012","journal-title":"Curr Microbiol."},{"issue":"10","key":"10.1016\/j.diagmicrobio.2020.115092_bb0140","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1093\/jac\/dkr299","article-title":"Prevalence of faecal carriage of Enterobacteraceae with NDM-1 carbapenemase at military hospitals in Pakistan, and evaluation of two chromogenic media","volume":"66","author":"Perry","year":"2011","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2020.115092_bb0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1128\/AAC.48.1.15-22.2004","article-title":"Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae","volume":"48","author":"Poirel","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","article-title":"Aminoglycoside modifying enzymes","volume":"13","author":"Ramirez","year":"2010","journal-title":"Drug resistance Updates"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0155","first-page":"20","article-title":"Plazomicin: a new aminoglycoside","author":"Saravolatz","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2020.115092_bb0160","doi-asserted-by":"crossref","first-page":"ofz123","DOI":"10.1093\/ofid\/ofz123","article-title":"Active against metallo-\u03b2-lactamase-producing Enterobacteraceae","volume":"6","author":"Serio","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0165","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1128\/mr.57.1.138-163.1993","article-title":"Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes","volume":"57","author":"Shaw","year":"1993","journal-title":"Microbiol Rev"},{"issue":"11","key":"10.1016\/j.diagmicrobio.2020.115092_bb0170","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/1471-2105-11-143","article-title":"MPprimer: a program for reliable multiplex PCR primer design","volume":"18","author":"Shen","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0175","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ijantimicag.2018.03.016","article-title":"High prevalence of 16S RMTasesamong carbapenemase-producing Enterobacteraceae in the UK and Ireland","volume":"52","author":"Taylor","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0180","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.diagmicrobio.2018.12.005","article-title":"Frequency of 16S ribosomal RNA methyltransferase detection among Escherichia coli and Klebsiella pneumoniae clinical isolates obtained from patients in Canadian hospitals (CANWARD, 2013\u20132017)","volume":"94","author":"Walkty","year":"2019","journal-title":"Diagnostic microbiology and Infectious Diseases"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0185","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3201\/eid1106.040924","article-title":"Global spread of multiple aminoglycoside resistance genes","volume":"11","author":"Yamane","year":"2005","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/j.diagmicrobio.2020.115092_bb0190","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1093\/jac\/dkx261","article-title":"In vitro activity of plazomicin against \u00df-lactamase-producing carbapenem-resistant Enterobacteraceae (CRE)","volume":"72","author":"Zhang","year":"2017","journal-title":"J Antimicrob Chemother"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889320304697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889320304697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:54:23Z","timestamp":1760003663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889320304697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0732889320304697"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2020.115092","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative in vitro activity of plazomicin and older aminoglyosides against Enterobacterales isolates; prevalence of aminoglycoside modifying enzymes and 16S rRNA methyltransferases","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2020.115092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115092"}}