{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:08:20Z","timestamp":1785888500593,"version":"3.56.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.diagmicrobio.2021.115571","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T03:22:02Z","timestamp":1634008922000},"page":"115571","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of the selection of cerebrospinal fluid testing in suspected meningitis and encephalitis"],"prefix":"10.1016","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-9605","authenticated-orcid":false,"given":"Austin R.","family":"Morrison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7334-3723","authenticated-orcid":false,"given":"Mathew C.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T.","family":"Makowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linoj P.","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9717-1054","authenticated-orcid":false,"given":"Ahmad R.","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-776X","authenticated-orcid":false,"given":"George J.","family":"Alangaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7521-9486","authenticated-orcid":false,"given":"Susan L.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Kenney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.diagmicrobio.2021.115571_bib0001","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.diagmicrobio.2013.07.017","article-title":"Interpretation of positive molecular tests of common viruses in the cerebrospinal fluid","volume":"77","author":"Bhaskaran","year":"2013","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2021.115571_bib0002","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1086\/513754","article-title":"Varicella-zoster virus (VZV) DNA in cerebrospinal fluid of patients infected with human immunodeficiency virus: VZV disease of the central nervous system or subclinical reactivation of VZV infection?","volume":"25","author":"Cinque","year":"1997","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2021.115571_bib0003","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1136\/jnnp.2004.045336","article-title":"Factors influencing PCR detection of viruses in cerebrospinal fluid of patients with suspected CNS infections","volume":"76","author":"Davies","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2021.115571_bib0004","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1128\/JCM.01950-06","article-title":"Validation of laboratory screening criteria for herpes simplex virus testing of cerebrospinal fluid","volume":"45","author":"Hanson","year":"2007","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2021.115571_bib0005","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1128\/JCM.02850-15","article-title":"Preclinical Assessment of a Fully Automated Multiplex PCR Panel for Detection of Central Nervous System Pathogens","volume":"54","author":"Hanson","year":"2016","journal-title":"J Clin Microbiol"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2021.115571_bib0006","article-title":"Criteria to screen molecular tests for the diagnosis of herpes simplex virus in the central nervous system have no propensity to harm","volume":"8","author":"Hauser","year":"2017","journal-title":"J Pathol Inform"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2021.115571_bib0007","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1128\/JCM.00119-17","article-title":"Cost-effectiveness study of criteria for screening cerebrospinal fluid to determine the need for herpes simplex virus PCR testing","volume":"55","author":"Hauser","year":"2017","journal-title":"J Clin Microbiol"},{"issue":"11","key":"10.1016\/j.diagmicrobio.2021.115571_bib0008","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11908-016-0545-6","article-title":"Laboratory diagnosis of central nervous system infection","volume":"18","author":"He","year":"2016","journal-title":"Curr Infect Dis Rep"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2021.115571_bib0009","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1471-2431-12-145","article-title":"Northwest Neurological Infections Networks. Suboptimal management of central nervous system infections in children: a multi-centre retrospective study","volume":"12","author":"Kelly","year":"2012","journal-title":"BMC Pediatrics"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2021.115571_bib0010","doi-asserted-by":"crossref","first-page":"554","DOI":"10.7861\/clinmedicine.11-6-554","article-title":"How appropriate are cerebrospinal fluid polymerase chain reaction requests for suspected central nervous system infections?","volume":"11","author":"Mamoojee","year":"2011","journal-title":"Clinical Medicine"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2021.115571_bib0011","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1093\/ofid\/ofz359.084","article-title":"1821. Evaluation of Cerebrospinal Fluid White Blood Cell Count Criteria for Use of the BioFire\u00ae FilmArray\u00ae Meningitis\/Encephalitis Panel in Immunocompetent Patients","volume":"6","author":"McCreery","year":"2019","journal-title":"Open Forum Infect Dis"},{"issue":"23","key":"10.1016\/j.diagmicrobio.2021.115571_bib0012","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1001\/jama.2015.13453","article-title":"Measurement is essential for improving diagnosis and reducing diagnostic error: a report from the Institute of Medicine","volume":"314","author":"McGlynn","year":"2015","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2021.115571_bib0013","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1017\/ice.2016.61","article-title":"Choosing wisely in healthcare epidemiology and antimicrobial stewardship","volume":"37","author":"Morgan","year":"2016","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2021.115571_bib0014","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/jama.2017.8531","article-title":"Diagnostic stewardship\u2014leveraging the laboratory to improve antimicrobial use","volume":"318","author":"Morgan","year":"2017","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2021.115571_bib0015","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/cid\/ciy077","article-title":"Diagnostic stewardship: opportunity for a laboratory\u2013infectious diseases partnership","volume":"67","author":"Patel","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2021.115571_bib0016","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1128\/JCM.00950-13","article-title":"PCR for detection of herpes simplex virus in cerebrospinal fluid: alternative acceptance criteria for diagnostic workup","volume":"51","author":"Roa","year":"2013","journal-title":"J Clin Microbiol"},{"issue":"10","key":"10.1016\/j.diagmicrobio.2021.115571_bib0017","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1468-1331.2012.03808.x","article-title":"EFNS-ENS guidelines for the use of PCR technology for the diagnosis of infections of the nervous system","volume":"19","author":"Steiner","year":"2012","journal-title":"Eur J Neurol"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2021.115571_bib0018","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/cid\/cit458","article-title":"on behalf of the International Encephalitis Consortium. Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium","volume":"57","author":"Venkatesan","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2021.115571_bib0019","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1128\/JCM.03161-14","article-title":"Criteria for reducing unnecessary testing for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and enterovirus in cerebrospinal fluid samples from adults","volume":"53","author":"Wilen","year":"2015","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2021.115571_bib0020","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fcimb.2021.639658","article-title":"Unexpectedly High False-Positive Rates for Haemophilus influenzae Using a Meningoencephalitis Syndromic PCR Panel in Two Tertiary Centers","volume":"11","author":"Zanella","year":"2021","journal-title":"Front Cell Infect Microbiol"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889321002637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889321002637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:56:44Z","timestamp":1760003804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889321002637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0732889321002637"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2021.115571","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the selection of cerebrospinal fluid testing in suspected meningitis and encephalitis","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2021.115571","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115571"}}