{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:59:32Z","timestamp":1792004372785,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.diagmicrobio.2022.115674","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T02:26:03Z","timestamp":1646879163000},"page":"115674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Aztreonam in combination with imipenem-relebactam against clinical and isogenic strains of serine and metallo-\u03b2-lactamase-producing enterobacterales"],"prefix":"10.1016","volume":"103","author":[{"given":"Mark","family":"Biagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-339X","authenticated-orcid":false,"given":"Michelle","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Shajee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shitalben","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitagauri M.","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo E.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3914-8400","authenticated-orcid":false,"given":"Eric","family":"Wenzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.diagmicrobio.2022.115674_bib0001","doi-asserted-by":"crossref","first-page":"e01076","DOI":"10.1128\/AAC.01076-18","article-title":"Past and present perspectives on \u03b2-Lactamases","volume":"62","author":"Bush","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2022.115674_bib0002","doi-asserted-by":"crossref","first-page":"e00047","DOI":"10.1128\/CMR.00047-19","article-title":"Epidemiology of beta-lactamase-producing pathogens","volume":"33","author":"Bush","year":"2020","journal-title":"Clin Microbiol Rev"},{"issue":"12","key":"10.1016\/j.diagmicrobio.2022.115674_bib0003","doi-asserted-by":"crossref","first-page":"e01426","DOI":"10.1128\/AAC.01426-19","article-title":"Searching for the optimal treatment for metallo- and serine-beta-lactamase producing enterobacteriaceae: aztreonam in combination with ceftazidime-avibactam or meropenem-vaborbactam","volume":"63","author":"Biagi","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115674_bib0004","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/phar.2378","article-title":"Imipenem-cilastatin-relebactam: A novel beta-lactam-beta-lactamase inhibitor combination for the treatment of multidrug-resistant gram-negative infections","volume":"40","author":"Smith","year":"2020","journal-title":"Pharmacotherapy"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115674_bib0005","doi-asserted-by":"crossref","first-page":"e03189","DOI":"10.1128\/mBio.03189-19","article-title":"Novel cassette assay to quantify the outer membrane permeability of five \u03b2-lactams simultaneously in carbapenem-resistant Klebsiella pneumoniae and enterobacter cloacae","volume":"11","author":"Kim","year":"2020","journal-title":"mBio"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2022.115674_bib0006","doi-asserted-by":"crossref","first-page":"e00425","DOI":"10.1128\/AAC.00425-19","article-title":"Comparable efficacy and better safety of double \u03b2-lactam combination therapy versus \u03b2\u2011lactam plus aminoglycoside in gram-negative bacteria in randomized, controlled trials","volume":"63","author":"Jiao","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115674_bib0007","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/jac\/35.1.75","article-title":"Biochemical comparison of imipenem, meropenem and biapenem: permeability, binding to penicillin-binding proteins, and stability to hydrolysis by beta-lactamases","volume":"35","author":"Yang","year":"1995","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2022.115674_bib0008","doi-asserted-by":"crossref","first-page":"e00282","DOI":"10.1128\/AAC.00282-18","article-title":"First penicillin-binding protein occupancy patterns of \u03b2-lactams and \u03b2-lactamase inhibitors in Klebsiella pneumoniae","volume":"62","author":"Sutaria","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115674_bib0009","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/AAC.00912-08","article-title":"Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter","volume":"53","author":"Papagiannitsis","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2022.115674_bib0010","series-title":"Performance standards for antimicrobial susceptibility testing","year":"2021"},{"issue":"11","key":"10.1016\/j.diagmicrobio.2022.115674_bib0011","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1093\/jac\/dks261","article-title":"Identification of acquired antimicrobial resistance genes","volume":"67","author":"Zankari","year":"2012","journal-title":"J Antimicrob Chemother"},{"issue":"D1","key":"10.1016\/j.diagmicrobio.2022.115674_bib0012","doi-asserted-by":"crossref","first-page":"D566","DOI":"10.1093\/nar\/gkw1004","article-title":"CARD 2017: expansion and model-centric curation of the comprehensive antibiotic resistance database","volume":"45","author":"Jia","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2022.115674_bib0013","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"Comput Biol"},{"key":"10.1016\/j.diagmicrobio.2022.115674_bib0014","series-title":"Methods for determining bactericidal activity of antimicrobial agents","year":"1999"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115674_bib0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1128\/AAC.24.1.18","article-title":"Pharmacology of aztreonam after intravenous infusion","volume":"24","author":"Scully","year":"1983","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115674_bib0016","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1128\/AAC.24.3.394","article-title":"Metabolism and pharmacokinetics of aztreonam in healthy subjects","volume":"24","author":"Swabb","year":"1983","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2022.115674_bib0017","doi-asserted-by":"crossref","first-page":"e00280","DOI":"10.1128\/AAC.00280-18","article-title":"Pharmacokinetics, safety, and tolerability of single and multiple doses of relebactam, a beta-lactamase inhibitor, in combination with imipenem and cilastatin in healthy participants","volume":"62","author":"Rhee","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2022.115674_bib0018","doi-asserted-by":"crossref","first-page":"e00883","DOI":"10.1128\/AAC.00883-17","article-title":"Ceftazidime-avibactam is superior to other treatment regimens against carbapenem-resistant Klebsiella pneumoniae bacteremia","volume":"61","author":"Shields","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2022.115674_bib0019","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/cid\/cix783","article-title":"Colistin versus ceftazidime-avibactam in the treatment of infections due to carbapenem-resistant enterobacteriaceae","volume":"66","author":"van Duin","year":"2018","journal-title":"Clin Infect Dis"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115674_bib0020","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s40121-018-0214-1","article-title":"Effect and safety of meropenem-vaborbactam versus best-available therapy in patients with carbapenem-resistant enterobacteriaceae infections: The TANGO II Randomized Clinical Trial","volume":"7","author":"Wunderink","year":"2018","journal-title":"Infect Dis Ther"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115674_bib0021","doi-asserted-by":"crossref","first-page":"ofaa054","DOI":"10.1093\/ofid\/ofaa054","article-title":"Evaluation of renal safety between Imipenem\/Relebactam and colistin plus imipenem in patients with imipenem-nonsusceptible bacterial infections in the randomized, Phase 3 RESTORE-IMI 1 Study","volume":"7","author":"Brown","year":"2020","journal-title":"Open Forum Infect Dis"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2022.115674_bib0022","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/cid\/ciz530","article-title":"RESTORE-IMI 1: a multicenter, randomized, double-blind trial comparing efficacy and safety of imipenem\/relebactam vs colistin plus imipenem in patients with imipenem-nonsusceptible bacterial infections","volume":"70","author":"Motsch","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2022.115674_bib0023","doi-asserted-by":"crossref","first-page":"ofaa011","DOI":"10.1093\/ofid\/ofaa011","article-title":"Clinical features and outcomes of bloodstream infections caused by New Delhi metallo-beta-lactamase-producing enterobacterales during a regional outbreak","volume":"7","author":"Falcone","year":"2020","journal-title":"Open Forum Infect Dis"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115674_bib0024","doi-asserted-by":"crossref","first-page":"e02243","DOI":"10.1128\/AAC.02243-16","article-title":"Can ceftazidime-avibactam and aztreonam overcome beta-lactam resistance conferred by metallo-beta-lactamases in enterobacteriaceae?","volume":"61","author":"Marshall","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115674_bib0025","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/jac\/dkx496","article-title":"Clinical outcomes after combination treatment with ceftazidime\/avibactam and aztreonam for NDM-1\/OXA-48\/CTX-M-15-producing Klebsiella pneumoniae infection","volume":"73","author":"Shaw","year":"2018","journal-title":"J Antimicrob Chemother"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115674_bib0026","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/cid\/ciz1155","article-title":"Monitoring Ceftazidime-Avibactam (CAZ-AVI) and Aztreonam (ATM) concentrations in the treatment of a bloodstream infection caused by a multidrug-resistant enterobacter sp. carrying both KPC-4 and NDM-1 carbapenemases","volume":"71","author":"Yasmin","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2022.115674_bib0027","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1093\/jac\/dkab184","article-title":"Zidovudine enhances activity of carbapenems against NDM-1-producing Enterobacteriaceae","volume":"76","author":"Hu","year":"2021","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2022.115674_bib0028","doi-asserted-by":"crossref","first-page":"3281","DOI":"10.1128\/AAC.05100-14","article-title":"Rapid induction of high-level carbapenem resistance in heteroresistant KPC-producing Klebsiella pneumoniae","volume":"59","author":"Adams-Sapper","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"10.1016\/j.diagmicrobio.2022.115674_bib0029","first-page":"2286","article-title":"Activity of MK-7655 combined with imipenem against Enterobacteriaceae and Pseudomonas aeruginosa","volume":"68","author":"Livermore","year":"2013","journal-title":"J Antimicrob Chemother"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889322000426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889322000426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:57:30Z","timestamp":1760003850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889322000426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0732889322000426"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2022.115674","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aztreonam in combination with imipenem-relebactam against clinical and isogenic strains of serine and metallo-\u03b2-lactamase-producing enterobacterales","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2022.115674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115674"}}