{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:17:18Z","timestamp":1789647438464,"version":"4.0.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.diagmicrobio.2022.115764","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T17:58:08Z","timestamp":1657475888000},"page":"115764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cepheid Xpert Xpress Flu\/RSV evaluation performed by minimally trained non-laboratory operators in a CLIA-waived environment"],"prefix":"10.1016","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-5680","authenticated-orcid":false,"given":"Bashar S.","family":"Shihabuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Faron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan F.","family":"Relich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Van Heukelom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Mayne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Allen","family":"Staat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangaraj","family":"Selvarangan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Hueschen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"House","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn","family":"Harnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"McGann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Steele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Arms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Lander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Loeffelholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Strouts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.diagmicrobio.2022.115764_bib0001","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s12276-021-00603-0","article-title":"The evolution and future of influenza pandemic preparedness","volume":"53","author":"Harrington","year":"2021","journal-title":"Exp Mol Med"},{"issue":"10098","key":"10.1016\/j.diagmicrobio.2022.115764_bib0002","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/S0140-6736(17)30938-8","article-title":"Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study","volume":"390","author":"Shi","year":"2017","journal-title":"Lancet (London, England)"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115764_bib0003","doi-asserted-by":"crossref","first-page":"e497","DOI":"10.1016\/S2214-109X(19)30545-5","article-title":"Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study","volume":"8","author":"Wang","year":"2020","journal-title":"The Lancet Glob Health"},{"key":"10.1016\/j.diagmicrobio.2022.115764_bib0004","doi-asserted-by":"crossref","DOI":"10.1017\/S0950268820000400","article-title":"The burden of respiratory syncytial virus in adults: a systematic review and meta-analysis","volume":"148","author":"Tin Tin Htar","year":"2020","journal-title":"Epidemiol Infect"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115764_bib0005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.idh.2019.05.001","article-title":"Rapid testing for respiratory viruses: impact on antibiotic use and time to patient discharge","volume":"24","author":"O'Callaghan","year":"2019","journal-title":"Infect Dis Health"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115764_bib0006","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.diagmicrobio.2018.11.013","article-title":"Near point-of-care adoption of Cepheid Xpert Flu\/RSV XC testing within an integrated health care delivery network","volume":"94","author":"Hernandez","year":"2019","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2022.115764_bib0007","unstructured":"Core elements of antibiotic stewardship [cited 2021 April 20]. Available at: https:\/\/www.cdc.gov\/antibiotic-use\/core-elements\/index.html."},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115764_bib0008","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jmoldx.2017.01.009","article-title":"Impact of rapid molecular respiratory virus testing on real-time decision making in a pediatric emergency department","volume":"19","author":"Rogan","year":"2017","journal-title":"J Mol Diagn"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115764_bib0009","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.diagmicrobio.2015.01.008","article-title":"Prospective and retrospective evaluation of the Cepheid Xpert Flu\/RSV XC assay for rapid detection of influenza A, influenza B, and respiratory syncytial virus","volume":"81","author":"Salez","year":"2015","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2022.115764_bib0010","unstructured":"Statistical guidance on reporting results from studies evaluating diagnostic tests - guidance for industry and FDA staff, (2007)."},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115764_bib0011","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1086\/600383","article-title":"Viral loads and duration of viral shedding in adult patients hospitalized with influenza","volume":"200","author":"Lee","year":"2009","journal-title":"J Infect Dis"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2022.115764_bib0012","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.eimc.2017.04.008","article-title":"Usefulness of Ct value in acute respiratory infections caused by respiratory syncytial virus A and B and influenza virus A (H1N1)pdm09, A (H3N2) and B","volume":"36","author":"Reina","year":"2018","journal-title":"Enferm Infec Microbiol Clin"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2022.115764_bib0013","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/infdis\/jiaa076","article-title":"Association of viral load with disease severity in outpatient children with respiratory syncytial virus infection","volume":"222","author":"Uusitupa","year":"2020","journal-title":"J Infect Dis"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115764_bib0014","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/jmv.24373","article-title":"Factors associated with real-time RT-PCR cycle threshold values among medically attended influenza episodes","volume":"88","author":"Spencer","year":"2016","journal-title":"J Med Virol"},{"key":"10.1016\/j.diagmicrobio.2022.115764_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2019.05.002","article-title":"CLIA-waived molecular influenza testing in the emergency department and outpatient settings","volume":"116","author":"Babady","year":"2019","journal-title":"J Clin Virol"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2022.115764_bib0016","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00367-18","article-title":"Detection of influenza A and B viruses and respiratory syncytial virus by use of clinical laboratory improvement amendments of 1988 (CLIA)-waived point-of-care assays: a paradigm shift to molecular tests","volume":"56","author":"Azar","year":"2018","journal-title":"J Clin Microbiol"},{"issue":"12","key":"10.1016\/j.diagmicrobio.2022.115764_bib0017","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1128\/JCM.01816-15","article-title":"Diagnostic accuracy of rapid antigen detection tests for respiratory syncytial virus infection: systematic review and meta-analysis","volume":"53","author":"Chartrand","year":"2015","journal-title":"J Clin Microbiol"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2022.115764_bib0018","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01237-17","article-title":"Accurate PCR detection of Influenza A\/B and respiratory syncytial viruses by use of Cepheid Xpert Flu+RSV xpress assay in point-of-care settings: comparison to prodesse ProFlu","volume":"56","author":"Cohen","year":"2018","journal-title":"J Clin Microbiol"},{"issue":"11","key":"10.1016\/j.diagmicrobio.2022.115764_bib0019","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1128\/JCM.40.11.4337-4339.2002","article-title":"Nasal swab versus nasopharyngeal aspirate for isolation of respiratory viruses","volume":"40","author":"Heikkinen","year":"2002","journal-title":"J Clin Microbiol"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2022.115764_bib0020","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1128\/JCM.00476-17","article-title":"Point-of-care testing for infectious diseases: past, present, and future","volume":"55","author":"Kozel","year":"2017","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2022.115764_bib0021","series-title":"The National Academies Collection: Reports funded by National Institutes of Health. Genome-Based Diagnostics: Clarifying Pathways to Clinical Use: Workshop Summary","year":"2012"},{"key":"10.1016\/j.diagmicrobio.2022.115764_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2020.10.009","article-title":"A critical review of point-of-care diagnostic technologies to combat viral pandemics","volume":"1146","author":"Everitt","year":"2021","journal-title":"Anal Chim Acta"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115764_bib0023","doi-asserted-by":"crossref","first-page":"e00716","DOI":"10.1128\/JCM.00716-18","article-title":"PCR detection of respiratory pathogens in asymptomatic and symptomatic adults","volume":"57","author":"Sundell","year":"2019","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115764_bib0024","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01691-17","article-title":"Parallel validation of three molecular devices for simultaneous detection and identification of influenza A and B and respiratory syncytial viruses","volume":"56","author":"Ling","year":"2018","journal-title":"J Clin Microbiol"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889322001304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889322001304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:57:40Z","timestamp":1760003860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889322001304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0732889322001304"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2022.115764","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cepheid Xpert Xpress Flu\/RSV evaluation performed by minimally trained non-laboratory operators in a CLIA-waived environment","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2022.115764","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115764"}}