{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:49:34Z","timestamp":1787701774443,"version":"build-2784847793"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T00:00:00Z","timestamp":1667692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.diagmicrobio.2022.115854","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T02:09:12Z","timestamp":1667786952000},"page":"115854","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Emerging multidrug resistance contributes to treatment failure in Mycoplasma genitalium infected patients in China"],"prefix":"10.1016","volume":"105","author":[{"given":"Lei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8233","key":"10.1016\/j.diagmicrobio.2022.115854_bib0001","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0140-6736(81)92461-2","article-title":"A newly discovered Mycoplasma in the human urogenital tract","volume":"1","author":"Tully","year":"1981","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115854_bib0002","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1128\/CMR.00006-11","article-title":"Mycoplasma genitalium: from Chrysalis to multicolored butterfly","volume":"24","author":"Taylor-Robinson","year":"2011","journal-title":"Clin Microbiol Rev"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115854_bib0003","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/infdis\/jis356","article-title":"Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis infections in men with nongonococcal urethritis: predictors and persistence after therapy","volume":"206","author":"Sena","year":"2012","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2022.115854_bib0004","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/jdv.17972","article-title":"2021 European guideline on the management of Mycoplasma genitalium infections","volume":"36","author":"Jensen","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115854_bib0005","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/cid\/civ312","article-title":"Mycoplasma genitalium infection and female reproductive tract disease: a meta-analysis","volume":"61","author":"Lis","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"10","key":"10.1016\/j.diagmicrobio.2022.115854_bib0006","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/OLQ.0b013e3181b01948","article-title":"Mycoplasma genitalium as a contributor to the multiple etiologies of cervicitis in women attending sexually transmitted disease clinics","volume":"36","author":"Gaydos","year":"2009","journal-title":"Sex Transm Dis"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2022.115854_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"issue":"10","key":"10.1016\/j.diagmicrobio.2022.115854_bib0008","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1177\/0956462419825948","article-title":"British Association for Sexual Health and HIV national guideline for the management of infection with Mycoplasma genitalium (2018)","volume":"30","author":"Soni","year":"2019","journal-title":"Int J STD AIDS"},{"issue":"11","key":"10.1016\/j.diagmicrobio.2022.115854_bib0009","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S1473-3099(20)30154-7","article-title":"Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis","volume":"20","author":"Machalek","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2022.115854_bib0010","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/cid\/ciz294","article-title":"Mycoplasma genitalium in symptomatic male urethritis: macrolide use is associated with increased resistance","volume":"70","author":"Li","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115854_bib0011","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/andr.12646","article-title":"Mycoplasma genitalium incidence, treatment failure, and resistance: a retrospective survey of men of infertile couples from a hospital in China","volume":"8","author":"Li","year":"2020","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115854_bib0012","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1186\/s12879-020-05659-3","article-title":"Macrolide and fluoroquinolone associated mutations in Mycoplasma genitalium in a retrospective study of male and female patients seeking care at a STI Clinic in Guangzhou, China, 2016-2018","volume":"20","author":"Ke","year":"2020","journal-title":"BMC Infect Dis"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2022.115854_bib0013","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198355","article-title":"Mutations in ParC and GyrA of moxifloxacin-resistant and susceptible Mycoplasma genitalium strains","volume":"13","author":"Hamasuna","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2022.115854_bib0014","first-page":"1017","article-title":"Moxifloxacin and sitafloxacin treatment failure in Mycoplasma genitalium infection: association with parC mutation G248T (S83I) and concurrent gyrA mutations","volume":"221","author":"Murray","year":"2020","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115854_bib0015","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jiac.2021.11.011","article-title":"Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains","volume":"28","author":"Hamasuna","year":"2022","journal-title":"J Infect Chemother"},{"issue":"12","key":"10.1016\/j.diagmicrobio.2022.115854_bib0016","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/OLQ.0000000000001035","article-title":"Lack of association between the S83I ParC mutation in Mycoplasma genitalium and treatment outcomes among men who have sex with men with nongonococcal urethritis","volume":"46","author":"Chambers","year":"2019","journal-title":"Sex Transm Dis"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115854_bib0017","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12879-019-3797-6","article-title":"Macrolide and fluoroquinolone resistance-associated mutations in Mycoplasma genitalium in Johannesburg, South Africa, 2007-2014","volume":"19","author":"Muller","year":"2019","journal-title":"BMC Infect Dis"},{"issue":"12","key":"10.1016\/j.diagmicrobio.2022.115854_bib0018","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1086\/599033","article-title":"A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men","volume":"48","author":"Mena","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2022.115854_bib0019","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/cid\/ciq074","article-title":"Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens\u2013a randomized clinical trial","volume":"52","author":"Schwebke","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2022.115854_bib0020","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1093\/cid\/cis1022","article-title":"Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial","volume":"56","author":"Manhart","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2022.115854_bib0021","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1128\/JB.184.8.2131-2140.2002","article-title":"Mutations in the 16S rRNA genes of Helicobacter pylori mediate resistance to tetracycline","volume":"184","author":"Trieber","year":"2002","journal-title":"J Bacteriol"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2022.115854_bib0022","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/jac\/dkn118","article-title":"Reduced susceptibility to tetracyclines is associated in vitro with the presence of 16S rRNA mutations in Mycoplasma hominis and Mycoplasma pneumoniae","volume":"61","author":"Degrange","year":"2008","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2022.115854_bib0023","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1089\/mdr.2016.0268","article-title":"Monitoring the decrease in susceptibility to ribosomal RNAs targeting antimicrobials and its molecular basis in clinical Mycoplasma bovis isolates over time","volume":"23","author":"Khalil","year":"2017","journal-title":"Microb Drug Resist"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2022.115854_bib0024","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1093\/jac\/dkab016","article-title":"Identification of 16S rRNA mutations in Mycoplasma genitalium potentially associated with tetracycline resistance in vivo but not selected in vitro in M. genitalium and Chlamydia trachomatis","volume":"76","author":"Le Roy","year":"2021","journal-title":"J Antimicrob Chemother"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2022.115854_bib0025","doi-asserted-by":"crossref","first-page":"e2127","DOI":"10.1093\/cid\/ciaa1832","article-title":"High prevalence and high rate of antibiotic resistance of Mycoplasma genitalium infections in men who have sex with men: a substudy of the ANRS IPERGAY pre-exposure prophylaxis trial","volume":"73","author":"Bercot","year":"2021","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2022.115854_bib0026","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1136\/sti.2006.022970","article-title":"Mycoplasma genitalium: prevalence and behavioural risk factors in the general population","volume":"83","author":"Andersen","year":"2007","journal-title":"Sex Transm Infect"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2022.115854_bib0027","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.2105\/AJPH.2005.074062","article-title":"Mycoplasma genitalium among young adults in the United States: an emerging sexually transmitted infection","volume":"97","author":"Manhart","year":"2007","journal-title":"Am J Public Health"},{"issue":"10","key":"10.1016\/j.diagmicrobio.2022.115854_bib0028","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1086\/656739","article-title":"Is Mycoplasma genitalium in women the \u201cNew Chlamydia?\u201d A community-based prospective cohort study","volume":"51","author":"Oakeshott","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2022.115854_bib0029","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/0956462413515196","article-title":"Mycoplasma genitalium: a review","volume":"25","author":"Daley","year":"2014","journal-title":"Int J STD AIDS"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2022.115854_bib0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1099\/mic.0.000830","article-title":"Mycoplasma genitalium: a review","volume":"166","author":"Gnanadurai","year":"2020","journal-title":"Microbiology (Reading)"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889322002188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889322002188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:57:45Z","timestamp":1760003865000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889322002188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S0732889322002188"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2022.115854","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging multidrug resistance contributes to treatment failure in Mycoplasma genitalium infected patients in China","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2022.115854","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115854"}}