{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T05:30:18Z","timestamp":1772602218271,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.diagmicrobio.2023.116031","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T02:31:57Z","timestamp":1689733917000},"page":"116031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Are cerebrospinal fluid biochemical parameters valid to predict positive results in microbiological molecular diagnostic platforms? A 4-year experience with the FilmArray\u00ae Panel Meningitis\/Encephalitis for detection of community-acquired bacterial meningitis"],"prefix":"10.1016","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-0789","authenticated-orcid":false,"given":"Consuelo","family":"Garc\u00eda-S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iv\u00e1n","family":"Bloise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Garc\u00eda-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Cendejas-Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0001","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.nrl.2016.05.009","article-title":"Usefulness of blood and cerebrospinal fluid laboratory testing to predict bacterial meningitis in the emergency department","volume":"34","author":"Juli\u00e1n-Jim\u00e9nez","year":"2019","journal-title":"Neurologia"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0002","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/bmb\/ldz023","article-title":"Community-acquired acute bacterial meningitis in adults: a clinical update","volume":"131","author":"Ellis","year":"2019","journal-title":"Br Med Bull"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/QCO.0000000000000335","article-title":"Community-acquired bacterial meningitis","volume":"30","author":"Costerus","year":"2017","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0004","series-title":"Resultados de la Vigilancia Epidemiol\u00f3gica de las enfermedades transmisibles","author":"Transmisibles","year":"2021"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0005","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1016\/S0140-6736(16)30654-7","article-title":"Acute bacterial meningitis in adults","volume":"388","author":"McGill","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0006","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ncl.2008.03.013","article-title":"Update in the diagnosis and management of central nervous system infections","volume":"26","author":"Ziai","year":"2008","journal-title":"Neurol Clin"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0007","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1128\/JCM.00730-16","article-title":"Multicenter evaluation of biofire filmarray meningitis\/encephalitis panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens","volume":"54","author":"Leber","year":"2016","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0008","first-page":"2014","article-title":"Role of clinical presentations and routine CSF analysis in the rapid diagnosis of acute bacterial meningitis in cases of negative gram stained smears","author":"Fouad","year":"2014","journal-title":"J Trop Med"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0265187","article-title":"Outcomes of implementation of the FilmArray meningoencephalitis panel in a tertiary hospital between 2017 and 2020","volume":"17","author":"Teoh","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0010","article-title":"Assessment of the FilmArray\u00ae multiplex PCR system and associated meningitis\/encephalitis panel in the diagnostic service of a tertiary hospital","volume":"2","author":"Mostyn","year":"2020","journal-title":"Infect Prev Pract"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0011","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/idr14030045","article-title":"Etiology and outcomes of healthcare-associated meningitis and ventriculitis\u2014a single center cohort study","volume":"14","author":"Panic","year":"2022","journal-title":"Infect Dis Rep"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0012","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/S0140-6736(12)61185-4","article-title":"Dilemmas in the diagnosis of acute community-acquired bacterial meningitis","volume":"380","author":"Brouwer","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0013","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jemermed.2013.08.056","article-title":"Pediatric lumbar puncture and cerebrospinal fluid analysis","volume":"46","author":"Bonadio","year":"2014","journal-title":"J Emerg Med"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0014","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00705-020-04891-1","article-title":"Viral meningitis: an overview","volume":"166","author":"Kohil","year":"2021","journal-title":"Arch Virol"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/NXI.0000000000000425","article-title":"Pleocytosis is not fully responsible for low CSF glucose in meningitis","volume":"5","author":"Baud","year":"2018","journal-title":"Neurol Neuroimmunol NeuroInflammation"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0016","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/jnnp.2007.139725","article-title":"Community-acquired bacterial meningitis in adults","volume":"8","author":"Schut","year":"2008","journal-title":"Pract Neurol"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0017","doi-asserted-by":"crossref","first-page":"R136","DOI":"10.1186\/cc10254","article-title":"Meningitis in adult patients with a negative direct cerebrospinal fluid examination: value of cytochemical markers for differential diagnosis","volume":"15","author":"Viallon","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0018","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40635-021-00385-9","article-title":"Point-of-care detection of lactate in cerebrospinal fluid","volume":"9","author":"Stephani","year":"2021","journal-title":"Intensive Care Med Exp"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0019","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s10096-015-2450-6","article-title":"CSF lactate for accurate diagnosis of community-acquired bacterial meningitis","volume":"34","author":"Giulieri","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0020","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1086\/425368","article-title":"Practice guidelines for the management of bacterial meningitis","volume":"39","author":"Tunkel","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2023.116031_bib0021","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.cmi.2017.05.013","article-title":"Management of post-neurosurgical meningitis: narrative review","volume":"23","author":"Hussein","year":"2017","journal-title":"Clin Microbiol Infect"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889323001414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889323001414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:59:10Z","timestamp":1760003950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889323001414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0732889323001414"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2023.116031","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are cerebrospinal fluid biochemical parameters valid to predict positive results in microbiological molecular diagnostic platforms? A 4-year experience with the FilmArray\u00ae Panel Meningitis\/Encephalitis for detection of community-acquired bacterial meningitis","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2023.116031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116031"}}