{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:25:34Z","timestamp":1791912334988,"version":"4.3.4"},"reference-count":101,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014386","name":"Abbott Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.diagmicrobio.2024.116530","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T16:33:08Z","timestamp":1726245188000},"page":"116530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transforming respiratory tract infection diagnosis in the kingdom of saudi arabia through point-of-care testing: A white paper for policy makers"],"prefix":"10.1016","volume":"110","author":[{"given":"Abdullah M.","family":"Assiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal M","family":"Alshahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussam","family":"Sakkijha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"AlGeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Zeitouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"AlGohary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Dhaini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashi","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmandeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0001","unstructured":"W. H. O. (WHO), \u201cInfluenza monthly update, April 2019.\u201d https:\/\/www.emro.who.int\/pandemic-epidemic-diseases\/influenza\/influenza-monthly-update-april-2019.html."},{"issue":"11","key":"10.1016\/j.diagmicrobio.2024.116530_bib0002","article-title":"The Scope of Respiratory Syncytial Virus Infection in a Tertiary Hospital in the Eastern Province of Saudi Arabia and the Change in Seasonal Pattern during and after the COVID-19 Pandemic","volume":"58","author":"Alkharsah","year":"2022","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0003","unstructured":"K O. L. Saudi Ministry of Health, \u201cStakeholder Feedback - In-depth discussions and round table discussions (MOH and KOLs).,\u201d 2023."},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116530_bib0004","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/jmv.24435","article-title":"Epidemiology of 11 respiratory RNA viruses in a cohort of hospitalized children in Riyadh, Saudi Arabia","volume":"88","author":"Amer","year":"2016","journal-title":"J. Med. Virol."},{"issue":"11","key":"10.1016\/j.diagmicrobio.2024.116530_bib0005","first-page":"1348","article-title":"Viral etiology of respiratory infections in children in southwestern Saudi Arabia using multiplex reverse-transcriptase polymerase chain reaction","volume":"35","author":"Al-Ayed","year":"2014","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0006","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1928795","article-title":"Respiratory tract viral infections and coinfections identified by AnyplexTM II RV16 detection kit in pediatric patients at a riyadh tertiary care hospital","volume":"2017","author":"Eifan","year":"2017","journal-title":"Biomed Res. Int."},{"issue":"5","key":"10.1016\/j.diagmicrobio.2024.116530_bib0007","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2217\/fvl-2020-0071","article-title":"Viral etiology of acute respiratory infections during 2014\u20132016 in Riyadh, Saudi Arabia","volume":"17","author":"Ahmed","year":"2022","journal-title":"Future Virol"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0008","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3390\/vaccines11020353","article-title":"Prevalence and Predictors of Seasonal Influenza Vaccine Uptake in Saudi Arabia Post COVID-19: a Web-Based Online Cross-Sectional Study","volume":"11","author":"Alshahrani","year":"2023","journal-title":"Vaccines"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2024.116530_bib0009","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00705-019-04300-2","article-title":"Epidemiology of respiratory viruses in Saudi Arabia: toward a complete picture","volume":"164","author":"Farrag","year":"2019","journal-title":"Arch. Virol."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0010","first-page":"49","article-title":"Invasive Group A streptococcal bacteraemia: A comparative study at a Teaching Hospital in Riyadh, Saudi Arabia","volume":"12","author":"Al Majid","year":"2008","journal-title":"Curr Pediatr Res"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2024.116530_bib0011","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3201\/eid1508.090264","article-title":"Predictors of death after severe Streptococcus pyogenes infection","volume":"15","author":"Lamagni","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0012","unstructured":"\u201cRisk of severe pressure on healthcare systems due to RSV, flu and COVID-19 co-circulation\u201d."},{"issue":"9","key":"10.1016\/j.diagmicrobio.2024.116530_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics11091192","article-title":"Point-of-Care and Rapid Tests for the Etiological Diagnosis of Respiratory Tract Infections in Children: A Systematic Review and Meta-Analysis","volume":"11","author":"Brigadoi","year":"2022","journal-title":"Antibiotics"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2024.116530_bib0014","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/2047-783X-16-7-315","article-title":"Guideline-adherent initial intravenous antibiotic therapy for hospital-acquired\/ventilator-associated pneumonia is clinically superior, saves lives and is cheaper than non guideline adherent therapy","volume":"16","author":"Wilke","year":"2011","journal-title":"Eur. J. Med. Res."},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/MCP.0b013e32835f8265","article-title":"Current trends and newer concepts on diagnosis, management and prevention of respiratory tract infections","volume":"19","author":"Zumla","year":"2013","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0016","unstructured":"WHO, \u201cGlobal influenza strategy 2019-2030.,\u201d World Health Organization, 2019. https:\/\/www.who.int\/publications\/i\/item\/9789241515320."},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116530_bib0017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40121-021-00534-3","article-title":"A Systematic Review of Influenza Epidemiology and Surveillance in the Eastern Mediterranean and North African Region","volume":"11","author":"Soudani","year":"2022","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0018","unstructured":"W. H. O. (WHO), \u201cInfluenza Update N\u00b0 437.\u201d chrome-extension:\/\/efaidnbmnnnibpcajpcglclefindmkaj\/https:\/\/cdn.who.int\/media\/docs\/default-source\/influenza\/influenza-updates\/2023\/2023_01_23_surveillance_update_437_.pdf?sfvrsn=d6e41cf_1&download=true."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0019","unstructured":"W. H. Organization, \u201cInfluenza (Seasonal),\u201d 2023. https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/influenza-(seasonal)."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0020","unstructured":"\u201cCLINICAL UTILITY OF MULTIPLEX PCR ASSAYS FOR THE DIAGNOSIS OF ACUTE RESPIRATORY INFECTIONS DURING THE SARS-COV-2 PANDEMIC.\u201d https:\/\/kce.fgov.be\/sites\/default\/files\/2021-11\/MutliplexPCR_04_11.pdf%0A."},{"issue":"4","key":"10.1016\/j.diagmicrobio.2024.116530_bib0021","doi-asserted-by":"crossref","first-page":"355","DOI":"10.15537\/smj.2021.42.4.20200769","article-title":"Saudi experts\u2019 recommendation for RSV prophylaxis in the era of COVID-19: Consensus from the Saudi Pediatric Pulmonology Association","volume":"42","author":"Alharbi","year":"2021","journal-title":"Saudi Med. J."},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0022","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/tropej\/44.2.100","article-title":"Viral aetiology and epidemiology of acute respiratory infections in hospitalized Saudi children","volume":"44","author":"Bakir","year":"1998","journal-title":"J. Trop. Pediatr."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0023","first-page":"7","article-title":"Bronchiolitis in Hospitalized Infants at Tawam Hospital, Al Ain","volume":"15","author":"Al Shibli","year":"2021","journal-title":"United Arab Emirates"},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0024","unstructured":"\u201cRSV in Older Adults and Adults with Chronic Medical Conditions | CDC\u201d."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0025","doi-asserted-by":"crossref","unstructured":"A.P. Ralph and J.R. Carapetis, \u201cGroup A Streptococcal Diseases and Their Global Burden,\u201d 2012, pp. 1\u201327. doi: 10.1007\/82_2012_280.","DOI":"10.1007\/82_2012_280"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2024.116530_bib0026","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1056\/NEJMcp1009126","article-title":"Clinical practice. Streptococcal pharyngitis","volume":"364","author":"Wessels","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0027","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2009-2648","article-title":"Prevalence of streptococcal pharyngitis and streptococcal carriage in children: a meta-analysis","volume":"126","author":"Shaikh","year":"2010","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0028","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1086\/341409","article-title":"Epidemiology of invasive group a streptococcus disease in the United States, 1995-1999","volume":"35","author":"O'Brien","year":"2002","journal-title":"Clin. Infect. Dis."},{"issue":"10","key":"10.1016\/j.diagmicrobio.2024.116530_bib0029","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.15537\/smj.2017.10.20966","article-title":"Group A Streptococcal bacteraemia","volume":"38","author":"Al-Khadidi","year":"2017","journal-title":"Saudi Med. J."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0030","article-title":"Global Disease Burden of Streptococcus pyogenes","author":"Craik","year":"2022","journal-title":"Streptococcus pyogenes Basic Biol. to Clin. Manifestations"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0031","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4103\/2230-8229.97929","article-title":"A study of group a streptococcal bacteria isolation from children <12 years with acute tonsillitis, pharyngitis and healthy primary school children","volume":"9","author":"Telmesani","year":"2002","journal-title":"J. Family Community Med."},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0032","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1542\/peds.2007-0484","article-title":"Burden and economic cost of group A streptococcal pharyngitis","volume":"121","author":"Pfoh","year":"2008","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116530_bib0033","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12879-019-3835-4","article-title":"Diagnosis and Management of Group a Streptococcal Pharyngitis in the United States, 2011-2015","volume":"19","author":"Luo","year":"2019","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0034","unstructured":"WHO, \u201cSaudi Arabia Situation,\u201d 2022. https:\/\/covid19.who.int\/region\/emro\/country\/sa (accessed Aug. 23, 2023)."},{"issue":"4","key":"10.1016\/j.diagmicrobio.2024.116530_bib0035","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jiph.2021.01.003","article-title":"Epidemiological and clinical features of COVID-19 patients in Saudi Arabia","volume":"14","author":"Alahmari","year":"2021","journal-title":"J. Infect. Public Health"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2024.116530_bib0036","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/jmv.25674","article-title":"Recent advances in the detection of respiratory virus infection in humans","volume":"92","author":"Zhang","year":"2020","journal-title":"J. Med. Virol."},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116530_bib0037","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.mcna.2020.08.020","article-title":"A Symptom-Directed Paradigm for the Evaluation and Management of Upper Respiratory Tract Infections","volume":"105","author":"Pelzman","year":"2021","journal-title":"Med. Clin. North Am."},{"issue":"9","key":"10.1016\/j.diagmicrobio.2024.116530_bib0038","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.20495","article-title":"Comparison of Clinical Features of COVID-19 vs Seasonal Influenza A and B in US Children","volume":"3","author":"Song","year":"2020","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2023.113491","article-title":"Respiratory Syncytial Virus, Influenza, and Coronavirus Disease 2019 Hospitalizations in Children in Colorado During the 2021-2022 Respiratory Virus Season","volume":"260","author":"Rao","year":"2023","journal-title":"J. Pediatr."},{"issue":"11","key":"10.1016\/j.diagmicrobio.2024.116530_bib0040","doi-asserted-by":"crossref","DOI":"10.1097\/INF.0b013e318157da82","article-title":"Variation in timing of respiratory syncytial virus outbreaks: Lessons from national surveillance","volume":"26","author":"Panozzo","year":"2007","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0041","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10091856","article-title":"Respiratory Tract Infections and Laboratory Diagnostic Methods: A Review with A Focus on Syndromic Panel-Based Assays","author":"Calderaro","year":"2022","journal-title":"Microorg"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0042","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1136\/emermed-2021-211572","article-title":"Association between delays to patient admission from the emergency department and all-cause 30-day mortality","volume":"39","author":"Jones","year":"2022","journal-title":"Emerg. Med. J."},{"issue":"Suppl 3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0043","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/cit578","article-title":"Better tests, better care: improved diagnostics for infectious diseases","volume":"57","author":"Caliendo","year":"2013","journal-title":"Clin. Infect. Dis."},{"issue":"4","key":"10.1016\/j.diagmicrobio.2024.116530_bib0044","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041221","article-title":"Challenges in the Diagnosis and Management of Bacterial Lung Infections in Solid Organ Recipients: A Narrative Review","volume":"21","author":"Carugati","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0045","unstructured":"C. Center for disease control and prevention, \u201cRespiratory Syncytial Virus Infection (RSV), For healthcare providers.\u201d https:\/\/www.cdc.gov\/rsv\/clinical\/index.html."},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0046","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofaa066","article-title":"Influenza and Bacterial Coinfection in Adults With Community-Acquired Pneumonia Admitted to Conventional Wards: Risk Factors, Clinical Features, and Outcomes","volume":"7","author":"Abelenda-Alonso","year":"2020","journal-title":"Open forum Infect. Dis."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0047","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ijid.2020.04.013","article-title":"Clinical manifestations and risk factors for mortality of patients with severe influenza during the 2016-2018 season","volume":"95","author":"Liu","year":"2020","journal-title":"Int. J. Infect. Dis."},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0048","doi-asserted-by":"crossref","DOI":"10.1007\/s00431-022-04787-z","article-title":"Group A streptococcal disease in paediatric inpatients: a European perspective","volume":"182","author":"Boeddha","year":"2023","journal-title":"Eur. J. Pediatr."},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0049","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jinf.2021.01.022","article-title":"COVID-19 in immunocompromised patients: A systematic review of cancer, hematopoietic cell and solid organ transplant patients","volume":"82","author":"Belsky","year":"2021","journal-title":"J. Infect."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0050","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1067\/S0022-3476(03)00508-0","article-title":"Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection","volume":"143","author":"Welliver","year":"2003","journal-title":"J. Pediatr."},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0051","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04368-22","article-title":"Risk Factors Associated with Severe RSV Infection in Infants: What Is the Role of Viral Co-Infections?","volume":"11","author":"Stobbelaar","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0052","article-title":"Focusing on severe infections with the respiratory syncytial virus (RSV) in adults: Risk factors, symptomatology and clinical course compared to influenza A \/B and the original SARS-CoV-2 strain","volume":"161","author":"Andreas","year":"2023","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0053","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ejogrb.2020.07.006","article-title":"COVID-19 in pregnant women: A systematic review and meta-analysis","volume":"252","author":"Capobianco","year":"2020","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0054","article-title":"Economic burden of influenza in Thailand: a systematic review","volume":"57","author":"Kiertiburanakul","year":"2020","journal-title":"Inq. J. Heal. Care Organ. Provision, Financ."},{"issue":"Supplement_7","key":"10.1016\/j.diagmicrobio.2024.116530_bib0055","doi-asserted-by":"crossref","first-page":"S680","DOI":"10.1093\/infdis\/jiz683","article-title":"Cost of respiratory syncytial virus-associated acute lower respiratory infection management in young children at the regional and global level: a systematic review and meta-analysis","volume":"222","author":"Zhang","year":"2020","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0056","article-title":"Public expenditure on hospitalizations for COVID-19 treatment in 2020, in Brazil","volume":"55","author":"dos Santos","year":"2021","journal-title":"Rev. Saude Publica"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0057","doi-asserted-by":"crossref","first-page":"S169","DOI":"10.1093\/infdis\/jis044","article-title":"Opportunities and Challenges for Cost-Efficient Implementation of New Point-of-Care Diagnostics for HIV and Tuberculosis","volume":"205","author":"Schito","year":"2012","journal-title":"J. Infect. Dis."},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116530_bib0058","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3390\/bios13060667","article-title":"Development and In-House Validation of an Enzyme-Linked Immunosorbent Assay and a Lateral Flow Immunoassay for the Dosage of Tenofovir in Human Saliva","volume":"13","author":"Cavalera","year":"2023","journal-title":"Biosensors"},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0059","doi-asserted-by":"crossref","DOI":"10.3389\/fsens.2021.752600","article-title":"Isothermal Amplification of Nucleic Acids: The Race for the Next \u2018Gold Standard","volume":"2","author":"Oliveira","year":"2021","journal-title":"Front. Sensors"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/bios13020160","article-title":"Enzyme-Assisted Nucleic Acid Amplification in Molecular Diagnosis: A Review","volume":"13","author":"Wang","year":"2023","journal-title":"Biosensors"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2024.116530_bib0061","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23094620","article-title":"Types and Applications of Nicking Enzyme-Combined Isothermal Amplification","volume":"23","author":"Cao","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.diagmicrobio.2024.116530_bib0062","doi-asserted-by":"crossref","DOI":"10.3390\/bios11050141","article-title":"Point-of-Care PCR Assays for COVID-19 Detection","volume":"11","author":"Gupta","year":"2021","journal-title":"Biosensors"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0063","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264130","article-title":"Sample-to-answer, extraction-free, real-time RT-LAMP test for SARS-CoV-2 in nasopharyngeal, nasal, and saliva samples: Implications and use for surveillance testing","volume":"17","author":"Kundrod","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0064","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.trac.2017.10.015","article-title":"Recombinase polymerase amplification: Basics, applications and recent advances","volume":"98","author":"Lobato","year":"2018","journal-title":"Trends Analyt. Chem."},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0065","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1750-2659.2009.00079.x","article-title":"Effect of rapid influenza testing on the clinical management of paediatric influenza","volume":"3","author":"Jennings","year":"2009","journal-title":"Influenza Other Respi. Viruses"},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0066","unstructured":"Solve Long COVID Initiative, \u201cLong COVID impact on Adult Americans: Early Indicators EStimating Prelalence and Costs,\u201d 2022. chrome-extension:\/\/efaidnbmnnnibpcajpcglclefindmkaj\/https:\/\/solvecfs.org\/wp-content\/uploads\/2022\/04\/Long_Covid_Impact_Paper.pdf."},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0067","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01611-19","article-title":"Comparison of the ID Now Influenza A & B 2, Cobas Influenza A\/B, and Xpert Xpress Flu Point-of-Care Nucleic Acid Amplification Tests for Influenza A\/B Virus Detection in Children","volume":"58","author":"Kanwar","year":"2020","journal-title":"J. Clin. Microbiol."},{"issue":"8","key":"10.1016\/j.diagmicrobio.2024.116530_bib0068","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1039\/C6AN00145A","article-title":"Real-time quantitative nicking endonuclease-mediated isothermal amplification with small molecular beacons","volume":"141","author":"Xu","year":"2016","journal-title":"Analyst"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116530_bib0069","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s10877-018-00243-2","article-title":"Economic and operational impact of an improved pathway using rapid molecular diagnostic testing for patients with influenza-like illness in a German emergency department","volume":"33","author":"Brachmann","year":"2019","journal-title":"J. Clin. Monit. Comput."},{"issue":"8","key":"10.1016\/j.diagmicrobio.2024.116530_bib0070","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01136-20","article-title":"Performance of Abbott ID Now COVID-19 Rapid Nucleic Acid Amplification Test Using Nasopharyngeal Swabs Transported in Viral Transport Media and Dry Nasal Swabs in a New York City Academic Institution","volume":"58","author":"Basu","year":"2020","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0071","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2018.10.054","article-title":"Nicking enzyme-assisted amplification (NEAA) technology and its applications: A review","volume":"1050","author":"Qian","year":"2019","journal-title":"Anal. Chim. Acta"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116530_bib0072","article-title":"COVID-19 Infection Diagnosis: Potential Impact of Isothermal Amplification Technology to Reduce Community Transmission of SARS-CoV-2","volume":"10","author":"James","year":"2020","journal-title":"Diagnostics (Basel, Switzerland)"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116530_bib0073","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1186\/s12875-022-01919-0","article-title":"What improves access to primary healthcare services in rural communities? A systematic review","volume":"23","author":"Gizaw","year":"2022","journal-title":"BMC Prim. care"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0074","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1542\/peds.112.2.363","article-title":"Impact of the rapid diagnosis of influenza on physician decision-making and patient management in the pediatric emergency department: results of a randomized, prospective, controlled trial","volume":"112","author":"Bonner","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jhin.2021.01.004","article-title":"Outcomes of point-of-care testing for influenza in the emergency department of a tertiary referral hospital in Ireland","volume":"110","author":"Teoh","year":"2021","journal-title":"J. Hosp. Infect."},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116530_bib0076","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1186\/s13054-014-0692-9","article-title":"Point-of-care testing in the overcrowded emergency department\u2013can it make a difference?","volume":"18","author":"Rooney","year":"2014","journal-title":"Crit. Care"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2024.116530_bib0077","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0274222","article-title":"Clinical impact of the rapid molecular detection of RSV and influenza A and B viruses in the emergency department","volume":"17","author":"Yin","year":"2022","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2024.116530_bib0078","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1556\/030.2022.01895","article-title":"Respiratory pathogens among ill pilgrims and the potential benefit of using point-of-care rapid molecular diagnostic tools during the Hajj","volume":"69","author":"Hoang","year":"2022","journal-title":"Acta Microbiol. Immunol. Hung."},{"issue":"4","key":"10.1016\/j.diagmicrobio.2024.116530_bib0079","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.01727-18","article-title":"Impact of rapid molecular diagnostic testing of respiratory viruses on outcomes of adults hospitalized with respiratory illness: A multicenter quasi-experimental study","volume":"57","author":"Wabe","year":"2018","journal-title":"J. Clin. Microbiol."},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0080","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1111\/bcp.15000","article-title":"Changes in antibiotic prescribing following COVID-19 restrictions: Lessons for post-pandemic antibiotic stewardship","volume":"88","author":"Gillies","year":"2022","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116530_bib0081","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/infdis\/jiz236","article-title":"Delayed Diagnosis of Respiratory Syncytial Virus Infections in Hospitalized Adults: Individual Patient Data, Record Review Analysis and Physician Survey in the United States","volume":"220","author":"Lee","year":"2019","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116530_bib0082","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41533-022-00325-4","article-title":"Cost-of-illness comparison between clinical judgment and molecular point-of-care testing for influenza-like illness patients in Germany","volume":"33","author":"Brachmann","year":"2023","journal-title":"npj Prim. Care Respir. Med."},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0083","article-title":"Use of clinical algorithms and rapid influenza testing to manage influenza-like illness: a cost-effectiveness analysis in Sri Lanka","volume":"4","author":"Tillekeratne","year":"2019","journal-title":"BMJ Glob. Heal."},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116530_bib0084","doi-asserted-by":"crossref","DOI":"10.1186\/s12887-019-1393-y","article-title":"Diagnosis and antibiotic treatment of group a streptococcal pharyngitis in children in a primary care setting: impact of point-of-care polymerase chain reaction","volume":"19","author":"Rao","year":"2019","journal-title":"BMC Pediatr"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2024.116530_bib0085","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.japh.2018.03.003","article-title":"Community pharmacist-directed point-of-care group A Streptococcus testing: Evaluation of a Canadian program","volume":"58","author":"Papastergiou","year":"2003","journal-title":"J. Am. Pharm. Assoc."},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116530_bib0086","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.diagmicrobio.2018.11.013","article-title":"Near point-of-care adoption of Cepheid Xpert\u00ae Flu\/RSV XC testing within an integrated healthcare delivery network","volume":"94","author":"Hernandez","year":"2019","journal-title":"Diagn. Microbiol. Infect. Dis."},{"issue":"5","key":"10.1016\/j.diagmicrobio.2024.116530_bib0087","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.37765\/ajmc.2021.88638","article-title":"US cost-effectiveness and budget impact of point-of-care NAAT for streptococcus","volume":"27","author":"Bilir","year":"2021","journal-title":"Am. J. Manag. Care"},{"issue":"10185","key":"10.1016\/j.diagmicrobio.2024.116530_bib0088","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0140-6736(19)30501-X","article-title":"Mass gatherings medicine: public health issues arising from mass gathering religious and sporting events","volume":"393","author":"Memish","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116530_bib0089","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1469-0691.2008.01987.x","article-title":"Viral respiratory infections at the Hajj: comparison between UK and Saudi pilgrims","volume":"14","author":"Rashid","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116530_bib0090","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciy381","article-title":"A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology","volume":"67","author":"Miller","year":"2018","journal-title":"Clin. Infect. Dis."},{"issue":"8","key":"10.1016\/j.diagmicrobio.2024.116530_bib0091","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1002\/jmv.25464","article-title":"Incidence and seasonality of respiratory viruses causing acute respiratory infections in the Northern United Arab Emirates","volume":"91","author":"Jeon","year":"2019","journal-title":"J. Med. Virol."},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116530_bib0092","first-page":"145","article-title":"POCT: An Inherently Ideal Tool in Pediatric Laboratory Medicine","volume":"32","author":"Wilson","year":"2021","journal-title":"EJIFCC"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2024.116530_bib0093","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1093\/cid\/ciz056","article-title":"Rapid Molecular Tests for Influenza, Respiratory Syncytial Virus, and Other Respiratory Viruses: A Systematic Review of Diagnostic Accuracy and Clinical Impact Studies","volume":"69","author":"Vos","year":"2019","journal-title":"Clin. Infect. Dis. An Off. Publ. Infect. Dis. Soc. Am."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0094","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.807253","article-title":"Advances in the Rapid Diagnostic of Viral Respiratory Tract Infections","volume":"12","author":"Gradisteanu Pircalabioru","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.diagmicrobio.2024.116530_bib0095","article-title":"High Number and Specific Comorbidities Could Impact the Immune Response in COVID-19 Patients","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.diagmicrobio.2024.116530_bib0096","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0273837","article-title":"Hospital admissions with influenza and impact of age and comorbidities on severe clinical outcomes in Brazil and Mexico","volume":"17","author":"El Guerche-S\u00e9blain","year":"2022","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116530_bib0097","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1093\/cid\/ciy837","article-title":"The Clinical Utility of Point-of-Care Tests for Influenza in Ambulatory Care: A Systematic Review and Meta-analysis","volume":"69","author":"Lee","year":"2019","journal-title":"Clin. Infect. Dis."},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116530_bib0098","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.xkme.2020.07.006","article-title":"Caring for Dialysis Patients in a Time of COVID-19","volume":"2","author":"Verma","year":"2020","journal-title":"Kidney Med"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116530_bib0099","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0272-2712(18)30371-8","article-title":"Decentralized testing in the 1990s: a survey of United States hospitals","volume":"14","author":"Bickford","year":"1994","journal-title":"Clin. Lab. Med."},{"issue":"12","key":"10.1016\/j.diagmicrobio.2024.116530_bib0100","article-title":"Diagnostic Modalities in Critical Care: Point-of-Care Approach","volume":"11","author":"Rajsic","year":"2021","journal-title":"Diagnostics (Basel, Switzerland)"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2024.116530_bib0101","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.1995","article-title":"Systematic review of the impact of point-of-care testing for influenza on the outcomes of patients with acute respiratory tract infection","volume":"28","author":"Egilmezer","year":"2018","journal-title":"Rev. Med. Virol."}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889324003559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889324003559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T04:45:51Z","timestamp":1740285951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889324003559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":101,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0732889324003559"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2024.116530","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transforming respiratory tract infection diagnosis in the kingdom of saudi arabia through point-of-care testing: A white paper for policy makers","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2024.116530","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116530"}}