{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:33:55Z","timestamp":1787610835477,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.diagmicrobio.2024.116561","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T11:03:50Z","timestamp":1728731030000},"page":"116561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["In vitro activity of zidebactam\/cefepime (WCK 5222), a \u03b2-lactam enhancer\/ \u03b2-lactam combination against carbapenem- and colistin-resistant Klebsiella pneumoniae isolates"],"prefix":"10.1016","volume":"111","author":[{"given":"Yamuna Devi","family":"Bakthavatchalam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaitra","family":"Shankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christo","family":"Jeyaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayyanraj","family":"Neeravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purva","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasant","family":"Nagvekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeetha","family":"Nithiyanandam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamini","family":"Walia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaji","family":"Veeraraghavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2024.116561_bib0001","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3390\/jcm8070934","article-title":"Treatment options for colistin resistant klebsiella pneumoniae: present and future","volume":"8","author":"Petrosillo","year":"2019","journal-title":"J Clin Med"},{"key":"10.1016\/j.diagmicrobio.2024.116561_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.609840","article-title":"Colistin resistance among multiple sequence types of klebsiella pneumoniae is associated with diverse resistance mechanisms: a report from India","volume":"12","author":"Azam","year":"2021","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116561_bib0003","doi-asserted-by":"crossref","first-page":"12711","DOI":"10.1038\/s41598-017-12637-4","article-title":"Emergence and clonal spread of colistin resistance due to multiple mutational mechanisms in carbapenemase-producing Klebsiella pneumoniae in London","volume":"7","author":"Otter","year":"2017","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116561_bib0004","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ijantimicag.2016.06.023","article-title":"Molecular mechanisms of polymyxin resistance: knowns and unknowns","volume":"48","author":"Baron","year":"2016","journal-title":"Int J Antimicrob Agents"},{"issue":"11","key":"10.1016\/j.diagmicrobio.2024.116561_bib0005","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01238-17","article-title":"Potent \u03b2-lactam enhancer activity of zidebactam and WCK 5153 against acinetobacter baumannii, including carbapenemase-producing clinical isolates","volume":"61","author":"Moya","year":"2017","journal-title":"Antimicrob Agent Chemother"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2024.116561_bib0006","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00128-19","article-title":"In vitro and in vivo activities of \u03b2-lactams in combination with the novel \u03b2-lactam enhancers zidebactam and WCK 5153 against multidrug-resistant metallo-\u03b2-lactamase-producing klebsiella pneumoniae","volume":"63","author":"Moya","year":"2019","journal-title":"Antimicrob Agent Chemother"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2024.116561_bib0007","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1021\/acs.jmedchem.8b00091","article-title":"Strategic approaches to overcome resistance against gram-negative pathogens using \u03b2-lactamase inhibitors and \u03b2-lactam enhancers: activity of three novel diazabicyclooctanes WCK 5153, zidebactam (WCK 5107), and WCK 4234","volume":"61","author":"Papp-Wallace","year":"2018","journal-title":"J Med Chem"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116561_bib0008","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/jac\/dkaa036","article-title":"Effective inhibition of PBPs by cefepime and zidebactam in the presence of VIM-1 drives potent bactericidal activity against MBL-expressing Pseudomonas aeruginosa","volume":"75","author":"Moya","year":"2020","journal-title":"J Antimicrob Chemother"},{"issue":"10","key":"10.1016\/j.diagmicrobio.2024.116561_bib0009","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1093\/jac\/dkac233","article-title":"Antimicrobial activity of cefepime\/zidebactam (WCK 5222), a \u03b2-lactam\/\u03b2-lactam enhancer combination, against clinical isolates of Gram-negative bacteria collected worldwide (2018-19)","volume":"77","author":"Sader","year":"2022","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2024.116561_bib0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.diagmicrobio.2010.12.002","article-title":"Multiplex PCR for detection of acquired carbapenemase genes","volume":"70","author":"Poirel","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116561_bib0011","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2024.116561_bib0012","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00543-17","article-title":"Novel plasmid-mediated colistin resistance gene mcr-3 in Escherichia coli","volume":"8","author":"Yin","year":"2017","journal-title":"mBio"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2024.116561_bib0013","doi-asserted-by":"crossref","first-page":"4178","DOI":"10.1128\/JCM.43.8.4178-4182.2005","article-title":"Multilocus sequence typing of klebsiella pneumoniae nosocomial isolates","volume":"43","author":"Diancourt","year":"2005","journal-title":"J Clin Microbiol"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2024.116561_bib0014","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1128\/AAC.05055-14","article-title":"Heteroresistance to colistin in Klebsiella pneumoniae associated with alterations in the PhoPQ regulatory system","volume":"59","author":"Jayol","year":"2015","journal-title":"Antimicrob Agent Chemother"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2024.116561_bib0015","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01854-22","article-title":"In vitro activity of new \u03b2-lactam-\u03b2-lactamase inhibitor combinations and comparators against clinical isolates of gram-negative bacilli: results from the China Antimicrobial Surveillance Network (CHINET) in 2019","volume":"10","author":"Guo","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.diagmicrobio.2024.116561_bib0016","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1128\/AAC.01870-15","article-title":"Correlation of -lactamase production and colistin resistance among Enterobacteriaceae isolates from a global surveillance program","volume":"60","author":"Bradford","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2024.116561_bib0017","first-page":"e04872","volume":"15","year":"2017","journal-title":"EFSA J"},{"issue":"12","key":"10.1016\/j.diagmicrobio.2024.116561_bib0018","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1017\/ice.2019.252","article-title":"Multiple importations and transmission of colistin-resistant Klebsiella pneumoniae in a hospital in northern India","volume":"40","author":"Mathur","year":"2019","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2024.116561_bib0019","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4103\/ijmr.IJMR_2087_17","article-title":"Molecular characterization of colistin-resistant Klebsiella pneumoniae & its clonal relationship among Indian isolates","volume":"149","author":"Shankar","year":"2019","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.diagmicrobio.2024.116561_bib0020","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3389\/fmicb.2014.00643","article-title":"Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria","volume":"5","author":"Olaitan","year":"2014","journal-title":"Front Microbiol"},{"key":"10.1016\/j.diagmicrobio.2024.116561_bib0021","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01432-20","article-title":"In vitro activity of WCK 5222 (cefepime-zidebactam) against worldwide collected Gram-negative bacilli not susceptible to carbapenems","volume":"64","author":"Karlowsky","year":"2020","journal-title":"Antimicrob Agent Chemother"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2024.116561_bib0022","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/jac\/dkaa036","article-title":"Effective inhibition of PBPs by cefepime and zidebactam in the presence of VIM-1 drives potent bactericidal activity against MBL-expressing Pseudomonas aeruginosa","volume":"75","author":"Moya","year":"2020","journal-title":"J Antimicrob Chemother"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889324003869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889324003869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T18:37:01Z","timestamp":1742755021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889324003869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0732889324003869"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2024.116561","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro activity of zidebactam\/cefepime (WCK 5222), a \u03b2-lactam enhancer\/ \u03b2-lactam combination against carbapenem- and colistin-resistant Klebsiella pneumoniae isolates","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2024.116561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116561"}}