{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:42:03Z","timestamp":1791895323736,"version":"4.3.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.diagmicrobio.2024.116568","type":"journal-article","created":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T05:36:22Z","timestamp":1729402582000},"page":"116568","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Systematic review and meta-analysis of antigen rapid diagnostic tests to detect Zaire ebolavirus"],"prefix":"10.1016","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8228-1824","authenticated-orcid":false,"given":"Devy M.","family":"Emperador","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Kelly-Cirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Bausch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Eckerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0001","series-title":"Ebola Disease Basics","year":"2024"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0002","series-title":"Ebola virus disease","year":"2023"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0003","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2019-001955","article-title":"Forty-two years of responding to Ebola virus outbreaks in Sub-Saharan Africa: a review","volume":"5","author":"Rugarabamu","year":"2020","journal-title":"BMJ Glob Health"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0004","series-title":"Ebola virus disease","year":"2022"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0005","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2018-001112","article-title":"Diagnostics for filovirus detection: impact of recent outbreaks on the diagnostic landscape","volume":"4","author":"Emperador","year":"2019","journal-title":"BMJ Glob Health"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0006","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/1040841X.2017.1313814","article-title":"Strategies in Ebola virus disease (EVD) diagnostics at the point of care","volume":"43","author":"Coarsey","year":"2017","journal-title":"Crit Rev Microbiol"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0007","series-title":"Interim guidance on the use of rapid Ebola antigen detection tests","year":"2015"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0008","series-title":"Target Product Profile for Za\u00efre ebolavirus rapid, simple test to be used in the control of the Ebola outbreak in West Africa","year":"2024"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0009","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1038\/nature16041","article-title":"The role of rapid diagnostics in managing Ebola epidemics","volume":"528","author":"Nouvellet","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0010","series-title":"Emergency Use Authorization","year":"2022"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0011","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1093\/infdis\/jiw261","article-title":"Field Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection","volume":"214","author":"Boisen","year":"2016","journal-title":"J Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0012","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0140-6736(15)61042-X","article-title":"ReEBOV Antigen Rapid Test kit for point-of-care and laboratory-based testing for Ebola virus disease: a field validation study","volume":"386","author":"Broadhurst","year":"2015","journal-title":"The Lancet"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/v11070589","article-title":"Clinical Evaluation of QuickNavi(TM)-Ebola in the 2018 Outbreak of Ebola Virus Disease in the Democratic Republic of the Congo","volume":"11","author":"Makiala","year":"2019","journal-title":"VIRUSES-BASEL"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0014","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S1473-3099(21)00675-7","article-title":"Field performance of three Ebola rapid diagnostic tests used during the 2018-20 outbreak in the eastern Democratic Republic of the Congo: a retrospective, multicentre observational study","volume":"22","author":"Mukadi-Bamuleka","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0015","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3201\/eid2802.210981","article-title":"Postmortem Surveillance for Ebola Virus Using OraQuick Ebola Rapid Diagnostic Tests, Eastern Democratic Republic of the Congo","volume":"28","author":"Mukadi-Bamuleka","year":"2022","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0016","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0017","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: A Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0018","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jclinepi.2005.02.022","article-title":"Bivariate analysis of sensitivity and specificity produces informative summary measures in diagnostic reviews","volume":"58","author":"Reitsma","year":"2005","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0019","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12874-023-01910-y","article-title":"MetaBayesDTA: codeless Bayesian meta-analysis of test accuracy, with or without a gold standard","volume":"23","author":"Cerullo","year":"2023","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0020","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jrsm.1439","article-title":"Graphical enhancements to summary receiver operating characteristic plots to facilitate the analysis and reporting of meta-analysis of diagnostic test accuracy data","volume":"12","author":"Patel","year":"2021","journal-title":"Res Synth Methods"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0021","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12874-019-0724-x","article-title":"Development of an interactive web-based tool to conduct and interrogate meta-analysis of diagnostic test accuracy studies: MetaDTA","volume":"19","author":"Freeman","year":"2019","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0022","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","author":"Balduzzi","year":"2019","journal-title":"Evid Based Ment Health"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0023","series-title":"Instruction for use: DPP\u00ae Ebola Antigen System","year":"2019"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0024","first-page":"653","article-title":"EBOLA Ag K-SeT rapid test: field evaluation in Sierra Leone","volume":"24","author":"Colavita","year":"2018","journal-title":"Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis"},{"issue":"110","key":"10.1016\/j.diagmicrobio.2024.116568_bib0025","first-page":"38","article-title":"[Field assessment of the new rapid diagnostic test Ebola eZYSCREEN\u00ae]","volume":"2017","author":"Gallais","year":"1990","journal-title":"Bull Soc Pathol Exot"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0026","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-020-05339-2","article-title":"Comparative performance study of three Ebola rapid diagnostic tests in Guinea","volume":"20","author":"Moran","year":"2020","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104568","article-title":"Head-to-head comparison of diagnostic accuracy of four Ebola virus disease rapid diagnostic tests versus GeneXpert\u00ae in eastern Democratic Republic of the Congo outbreaks: a prospective observational study","volume":"91","author":"Mukadi-Bamuleka","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0028","doi-asserted-by":"crossref","first-page":"S222","DOI":"10.1093\/infdis\/jiw251","article-title":"Lateral Flow Immunoassays for Ebola Virus Disease Detection in Liberia","volume":"214","author":"Phan","year":"2016","journal-title":"J Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0029","article-title":"Device Classification Under Section 513(f)(2)(De Novo)","year":"2019","journal-title":"Device Classif Sect"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188047","article-title":"Operational evaluation of rapid diagnostic testing for Ebola Virus Disease in Guinean laboratories","volume":"12","author":"VanSteelandt","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0031","first-page":"21073","article-title":"Evaluation of a point-of-care blood test for identification of Ebola virus disease at Ebola holding units, Western Area, Sierra Leone","volume":"20","author":"Walker","year":"2015","journal-title":"Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212113","article-title":"Comparative performance of four rapid Ebola antigen-detection lateral flow immunoassays during the 2014-2016 Ebola epidemic in West Africa","volume":"14","author":"Wonderly","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0033","series-title":"WHO Emergency Use Assessment and Listing for Ebola Virus Disease IVDs PUBLIC REPORT Product: OraQuick\u00ae Ebola Rapid Antigen Test Kit","year":"2020"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0034","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2471\/BLT.21.287496","article-title":"Rapid diagnostic tests versus RT\u2013PCR for Ebola virus infections: a systematic review and meta-analysis","volume":"100","author":"Muzembo","year":"2022","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0035","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cmi.2022.09.014","article-title":"The diagnostic accuracy of rapid diagnostic tests for Ebola virus disease: a systematic review","volume":"29","author":"Dagens","year":"2023","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0036","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1172\/JCI83111","article-title":"Blood kinetics of Ebola virus in survivors and nonsurvivors","volume":"125","author":"Lanini","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0037","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1093\/infdis\/jiw269","article-title":"Analysis of Diagnostic Findings from the European Mobile Laboratory in Gu\u00e9ck\u00e9dou, Guinea, March 2014 Through March 2015","volume":"214","author":"Kerber","year":"2016","journal-title":"J Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0038","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-pathol-052016-100506","article-title":"The Pathogenesis of Ebola Virus Disease","volume":"12","author":"Baseler","year":"2017","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0039","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1086\/503836","article-title":"Detection of Ebola Virus in Oral Fluid Specimens during Outbreaks of Ebola Virus Hemorrhagic Fever in the Republic of Congo","volume":"42","author":"Formenty","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0040","series-title":"FDA allows marketing of first rapid diagnostic test for detecting Ebola virus antigens","year":"2020"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0041","year":"2016","journal-title":"FDA Completes Transfer Of Emergency Use Authorization For Reebov Ebola Antigen Rapid Test To Zalgen Labs"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0042","article-title":"Authorizations of Emergency Use of In Vitro Diagnostic Devices for Detection of Ebola Virus; Availability","year":"2015","journal-title":"Fed Regist"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0043","article-title":"Revocation of Authorization of Emergency Use of an In Vitro Diagnostic Device for Detection of Ebola Virus","year":"2018","journal-title":"Fed Regist"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0044","unstructured":"World Health Organization. Ebola virus disease | WHO - Prequalification of Medical Products (IVDs, Medicines, Vaccines and Immunization Devices, Vector Control) n.d. https:\/\/extranet.who.int\/prequal\/vitro-diagnostics\/ebola-virus-disease (accessed June 28, 2024)."},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0045","series-title":"Emergency Use Authorization","year":"2024"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0046","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5527505","article-title":"Pooled Analysis of the Accuracy of Xpert Ebola Assay for Diagnosing Ebola Virus Infection","volume":"2021","author":"Pan","year":"2021","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0047","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1074\/jbc.M112.443960","article-title":"The Ebola Virus Matrix Protein Penetrates into the Plasma Membrane","volume":"288","author":"Adu-Gyamfi","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0048","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/srep01206","article-title":"The spatio-temporal distribution dynamics of Ebola virus proteins and RNA in infected cells","volume":"3","author":"Nanbo","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0049","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1086\/514282","article-title":"Detection and Molecular Characterization of Ebola Viruses Causing Disease in Human and Nonhuman Primates","volume":"179","author":"Sanchez","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0050","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1128\/JVI.72.8.6442-6447.1998","article-title":"Biochemical Analysis of the Secreted and Virion Glycoproteins of Ebola Virus","volume":"72","author":"Sanchez","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0051","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008817","article-title":"Development of an antigen detection assay for early point-of-care diagnosis of Zaire ebolavirus","volume":"14","author":"DeMers","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0052","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd9696","article-title":"Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR","volume":"13","author":"Fontes","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0053","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/clinchem\/46.2.306","article-title":"Hemolyzed specimens: a reason for rejection or a clinical challenge?","volume":"46","author":"Carraro","year":"2000","journal-title":"Clin Chem"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0054","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12936-018-2268-7","article-title":"Performance of an ultra-sensitive Plasmodium falciparum HRP2-based rapid diagnostic test with recombinant HRP2, culture parasites, and archived whole blood samples","volume":"17","author":"Das","year":"2018","journal-title":"Malar J"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0055","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1172\/JCI83162","article-title":"Ebola viral load at diagnosis associates with patient outcome and outbreak evolution","volume":"125","author":"de","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0056","doi-asserted-by":"crossref","unstructured":"Dinnes J, Sharma P, Berhane S, Wyk SS van, Nyaaba N, Domen J, et al. Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection - Dinnes, J - 2022 | Cochrane Library n.d.","DOI":"10.1002\/14651858.CD013705.pub3"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0057","doi-asserted-by":"crossref","unstructured":"Fox T, Geppert J, Dinnes J, Scandrett K, Bigio J, Sulis G, et al. Antibody tests for identification of current and past infection with SARS-CoV-2 - Fox, T - 2022 | Cochrane Library n.d.","DOI":"10.1002\/14651858.CD013652.pub2"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0058","series-title":"Ebola disease caused by Sudan ebolavirus \u2013 Uganda","year":"2023"},{"key":"10.1016\/j.diagmicrobio.2024.116568_bib0059","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s12916-023-02847-1","article-title":"Sudan Ebola virus (SUDV) outbreak in Uganda, 2022: lessons learnt and future priorities for sub-Saharan Africa","volume":"21","author":"Bwire","year":"2023","journal-title":"BMC Med"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889324003936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889324003936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T22:37:30Z","timestamp":1742769450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889324003936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0732889324003936"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2024.116568","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systematic review and meta-analysis of antigen rapid diagnostic tests to detect Zaire ebolavirus","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2024.116568","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116568"}}