{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:59:15Z","timestamp":1784159955069,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.diagmicrobio.2024.116624","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T15:59:01Z","timestamp":1732291141000},"page":"116624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The first case of Aspergillus fumigatus with high-level resistance to voriconazole due to the TR46\/Y121F\/T289A mutation in the Russian Federation"],"prefix":"10.1016","volume":"111","author":[{"given":"Galina","family":"Klyasova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Malchikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Khrulnova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0001","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1093\/jac\/dkz258","article-title":"group on behalf of the D-BM study, Lestrade PPA, group on behalf of the D-BM study, et al. Prevalence of voriconazole-resistant invasive aspergillosis and its impact on mortality in haematology patients","volume":"74","author":"Resendiz-Sharpe","year":"2019","journal-title":"J Antimicrobial Chemother"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.01024","article-title":"Azole resistance in Aspergillus fumigatus: a consequence of antifungal use in agriculture?","volume":"8","author":"Berger","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0003","doi-asserted-by":"crossref","first-page":"S436","DOI":"10.1093\/infdis\/jix210","article-title":"Azole-resistant Aspergillosis: epidemiology, molecular mechanisms, and treatment","volume":"216","author":"Chowdhary","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0004","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","article-title":"Revision and update of the consensus definitions of invasive fungal disease from the European Organization for research and treatment of cancer and the mycoses study group education and research consortium","volume":"71","author":"Peter Donnelly","year":"2020","journal-title":"Clin Infectious Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0005","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/mmy\/myx115","article-title":"Identification of clinical isolates of Aspergillus, including cryptic species, by matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS)","volume":"56","author":"Vidal-Acu\u00f1a","year":"2018","journal-title":"Med Mycol"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0006","series-title":"CLSI document M38","article-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi","year":"2017"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0007","series-title":"CLSI document M59","article-title":"Epidemiological Cutoff Values for Antifungal Susceptibility Testing","year":"2020"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0008","article-title":"Universal method for isolating high molecular weight DNA from microorganisms, based on the pre-treatment of biomass with a solution of ammonium acetate","volume":"100","author":"Sidoruk","year":"2008","journal-title":"Aktual'nye Voprosy Genetiki, Radiobiologii i Radioekologii"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0009","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/jac\/dkh507","article-title":"Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma","volume":"55","author":"Chen","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0010","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1093\/jac\/dkaa357","article-title":"Deciphering Aspergillus fumigatus cyp51A-mediated triazole resistance by pyrosequencing of respiratory specimens","volume":"75","author":"Novak-Frazer","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0011","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2015.0460","article-title":"Clinical implications of globally emerging azole resistance in Aspergillus fumigatus","volume":"371","author":"Meis","year":"2016","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0012","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3201\/eid2607.200088","article-title":"Paradoxal trends in azole-resistant aspergillus fumigatus in a national multicenter surveillance program, the Netherlands, 2013-2018","volume":"26","author":"Lestrade","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0013","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3389\/fmicb.2018.01395","article-title":"Determination of the prevalence of triazole resistance in environmental aspergillus fumigatus strains isolated in South Wales","volume":"9","author":"Tsitsopoulou","year":"2018","journal-title":"UK. Front Microbiol"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0014","doi-asserted-by":"crossref","first-page":"e02023","DOI":"10.1128\/JCM.02023-18","article-title":"Epidemiology and antifungal susceptibility profile of aspergillus species: comparison between environmental and clinical isolates from patients with hematologic malignancies","volume":"57","author":"Cho","year":"2019","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0015","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1128\/AAC.00127-15","article-title":"First description of azole-resistant Aspergillus fumigatus due to TR46\/Y121F\/T289A mutation in France","volume":"59","author":"Lavergne","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0016","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1093\/jac\/dku289","article-title":"New case of azole-resistant Aspergillus fumigatus due to TR46\/Y121F\/T289A mutation in Belgium","volume":"69","author":"Montesinos","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0017","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/jac\/dku566","article-title":"Emergence of azole-resistant invasive aspergillosis in HSCT recipients in Germany","volume":"70","author":"Steinmann","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0018","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1128\/AAC.02855-14","article-title":"First Detection of TR46\/Y121F\/T289A and TR34\/L98H alterations in aspergillus fumigatus isolates from azole-naive patients in denmark despite negative findings in the environment","volume":"58","author":"Astvad","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0019","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1093\/jac\/dku259","article-title":"Multi-azole-resistant Aspergillus fumigatus in the environment in Tanzania","volume":"69","author":"Chowdhary","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2024.116624_bib0020","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/jac\/dkt397","article-title":"Azole-resistant Aspergillus fumigatus with the environmental TR46\/Y121F\/T289A mutation in India","volume":"69","author":"Chowdhary","year":"2014","journal-title":"J Antimicrob Chemother"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889324004486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889324004486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:01:02Z","timestamp":1740560462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889324004486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0732889324004486"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2024.116624","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The first case of Aspergillus fumigatus with high-level resistance to voriconazole due to the TR46\/Y121F\/T289A mutation in the Russian Federation","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2024.116624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"116624"}}