{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:27:21Z","timestamp":1785803241810,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.diagmicrobio.2025.116719","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T21:36:37Z","timestamp":1738186597000},"page":"116719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and genetic insights of linezolid resistance in tuberculosis: A study of sensitive and resistant clinical isolates"],"prefix":"10.1016","volume":"111","author":[{"given":"Mina","family":"Hajizadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niloofar","family":"Hekmatpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahman","family":"Rahimlou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Eskandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Saber","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kianoosh","family":"Ferdosnejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Sakhaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Masoumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Marjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira","family":"Tarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Davar","family":"Siadat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0001","series-title":"Tuberculosis: integrated studies for a complex disease","first-page":"977","article-title":"The correlation of microbiota and host epigenome in tuberculosis","author":"Tarashi","year":"2023"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0002","series-title":"Fourth WHO consultation on the translation of tuberculosis research into global policy guidelines: meeting report, 15 February 2024","year":"2024"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0003","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.tube.2017.03.005","article-title":"Prevalence of Beijing and Haarlem genotypes among multidrug-resistant Mycobacterium tuberculosis in Iran: systematic review and meta-analysis","volume":"107","author":"Tarashi","year":"2017","journal-title":"Tuberculosis"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2025.116719_bib0004","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.resinv.2024.01.010","article-title":"The occurrence rate of Haarlem and Beijing genotypes among Middle Eastern isolates of multi drug resistant Mycobacterium tuberculosis: a systematic review and meta-analysis","volume":"62","author":"Ferdosnejad","year":"2024","journal-title":"Respir Investig"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0005","series-title":"WHO global lists of high burden countries for tuberculosis (TB), TB\/HIV and multidrug\/rifampicin-resistant TB (MDR\/RR-TB), 2021\u20132025: Background Document","year":"2021"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2025.116719_bib0006","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1093\/jac\/dkz206","article-title":"Linezolid resistance in patients with drug-resistant TB and treatment failure in South Africa","volume":"74","author":"Wasserman","year":"2019","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2025.116719_bib0007","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3343\/alm.2018.38.6.563","article-title":"Delamanid, bedaquiline, and linezolid minimum inhibitory concentration distributions and resistance-related gene mutations in multidrug-resistant and extensively drug-resistant tuberculosis in Korea","volume":"38","author":"Yang","year":"2018","journal-title":"Ann Lab Med"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2025.116719_bib0008","doi-asserted-by":"crossref","first-page":"89","DOI":"10.31674\/ijbb.2024.v01i01.005","article-title":"Current review of the use of linezolid in the treatment of multidrug-resistant tuberculosis: effectiveness and management of side effects","volume":"1","author":"Rahman","year":"2024","journal-title":"Int J Biotechnol Biomed"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0009","article-title":"The economic cost and cost-effectiveness of treatment strategies and care models to reduce the burden of multi-drug resistant tuberculosis","author":"Rosu","year":"2023","journal-title":"Liverpool School of Tropical Medicine"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0010","article-title":"Linezolid use for the treatment of multidrug-resistant tuberculosis, TB centers of excellence, United States, 2013\u20132018","volume":"22","author":"McDowell","year":"2021","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2025.116719_bib0011","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3390\/ph16060784","article-title":"Ngeow YF. Mechanisms of linezolid resistance in mycobacteria","volume":"16","author":"Gan","year":"2023","journal-title":"Pharmaceuticals"},{"issue":"12","key":"10.1016\/j.diagmicrobio.2025.116719_bib0012","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.5588\/ijtld.18.0822","article-title":"Linezolid for the treatment of extensively drug-resistant tuberculosis: a systematic review and meta-analysis","volume":"23","author":"Lifan","year":"2019","journal-title":"Int J Tubercul Lung Dis"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2025.116719_bib0013","first-page":"203","article-title":"Linezolid resistance among multidrug-resistant Mycobacterium tuberculosis clinical isolates in Iran","volume":"68","author":"Khosravi","year":"2021","journal-title":"Acta Microbiol Immunol Hung"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2025.116719_bib0014","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.ijantimicag.2015.02.004","article-title":"Antimycobacterial activity of linezolid against multidrug-resistant and extensively drug-resistant strains of Mycobacterium tuberculosis in Iran","volume":"45","author":"Kazemian","year":"2015","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0015","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2147\/DDDT.S164515","article-title":"Linezolid: a review of its properties, function, and use in critical care","author":"Hashemian","year":"2018","journal-title":"Drug Des Devel Ther"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2025.116719_bib0016","doi-asserted-by":"crossref","first-page":"331","DOI":"10.4103\/ijmy.ijmy_139_24","article-title":"Agreement between phenotypically detected linezolid resistance and mutations in rrl and rplc genes of mycobacterium tuberculosis isolates using nanopore sequencing","volume":"13","author":"Sengupta","year":"2024","journal-title":"Int J Mycobacteriol"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0017","series-title":"Policy quidance on drug-susceptibility (DST) of second line antituberculosis drugs","year":"2018"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2025.116719_bib0018","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1093\/jac\/dkaa136","article-title":"Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid","volume":"75","author":"Kadura","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0019","doi-asserted-by":"crossref","first-page":"7587","DOI":"10.2147\/IDR.S440711","article-title":"Bedaquiline, delamanid, linezolid, clofazimine, and capreomycin MIC distributions for drug resistance mycobacterium tuberculosis in Shanghai, China","author":"Guo","year":"2023","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0020","article-title":"Gut-lung axis: tuberculosis and drug resistance","author":"Tarashi","year":"2024","journal-title":"Front Media SA"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0021","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.tube.2017.09.004","article-title":"Mixed infections in tuberculosis: the missing part in a puzzle","volume":"107","author":"Tarashi","year":"2017","journal-title":"Tuberculosis"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2025.116719_bib0022","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ijantimicag.2013.12.007","article-title":"Beijing genotype of Mycobacterium tuberculosis is significantly associated with linezolid resistance in multidrug-resistant and extensively drug-resistant tuberculosis in China","volume":"43","author":"Zhang","year":"2014","journal-title":"Int J Antimicrob Agents"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2025.116719_bib0023","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1128\/AAC.02941-15","article-title":"Mycobacterium tuberculosis mutations associated with reduced susceptibility to linezolid","volume":"60","author":"Zhang","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2025.116719_bib0024","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02752-16","article-title":"Activity of LCB01-0371, a novel oxazolidinone, against Mycobacterium abscessus","volume":"61","author":"Kim","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2025.116719_bib0025","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1128\/AAC.06227-11","article-title":"rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains","volume":"56","author":"Beckert","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2025.116719_bib0026","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1128\/AAC.01113-06","article-title":"First linezolid-resistant clinical isolates of Mycobacterium tuberculosis","volume":"51","author":"Richter","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"10.1016\/j.diagmicrobio.2025.116719_bib0027","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1046\/j.1365-2958.2002.03242.x","article-title":"Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations","volume":"46","author":"Sander","year":"2002","journal-title":"Mol Microbiol"},{"issue":"6","key":"10.1016\/j.diagmicrobio.2025.116719_bib0028","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000109769","article-title":"Importance of the efflux pump systems in the resistance of Mycobacterium tuberculosis to fluoroquinolones and linezolid","volume":"53","author":"Escribano","year":"2007","journal-title":"Chemotherapy"},{"key":"10.1016\/j.diagmicrobio.2025.116719_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcsw.2020.100044","article-title":"Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall","volume":"6","author":"Batt","year":"2020","journal-title":"Cell Surface"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889325000422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889325000422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:04:36Z","timestamp":1740560676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889325000422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0732889325000422"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2025.116719","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence and genetic insights of linezolid resistance in tuberculosis: A study of sensitive and resistant clinical isolates","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2025.116719","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116719"}}