{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:59:36Z","timestamp":1792202376935,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005278","name":"Universidad de Antioquia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Microbiology and Infectious Disease"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.diagmicrobio.2025.117013","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T05:11:22Z","timestamp":1752642682000},"page":"117013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Polymorphisms of the CYP2D6 gene and its relationship with Plasmodium vivax relapses after chloroquine-primaquine treatment in Turbo, Colombia"],"prefix":"10.1016","volume":"113","author":[{"given":"Veronica","family":"Sierra-Cifuentes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zuluaga-Id\u00e1rraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Aguirre-Acevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina","family":"Silva de Barros Pu\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tais","family":"Nobrega de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9401-2779","authenticated-orcid":false,"given":"Tatiana M.","family":"Lopera-Mesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0001","unstructured":"World malaria report 2023, https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2023; 2023 [Accessed april 2024]."},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0002","first-page":"22","volume":"52","author":"Epidemiol\u00f3gico","year":"2023","journal-title":"Semana"},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0003","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/B978-0-12-397900-1.00002-5","volume":"80","author":"White","year":"2012","journal-title":"Adv Parasitol"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2025.117013_bib0004","doi-asserted-by":"crossref","first-page":"e00011","DOI":"10.1128\/CMR.00011-19","article-title":"8-Aminoquinoline therapy for latent Malaria","volume":"32","author":"Baird","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0005","unstructured":"Gu\u00eda de Pr\u00e1ctica Cl\u00ednica Diagn\u00f3stico y tratamiento de la malaria. Gu\u00eda Cl\u00ednica 2022, 2022. https:\/\/www.minsalud.gov.co\/sites\/rid\/Lists\/BibliotecaDigital\/RIDE\/VS\/PP\/ET\/Guia-atencion-clinica-malaria.pdf; 2022 [Accessed august 2022]."},{"issue":"1","key":"10.1016\/j.diagmicrobio.2025.117013_bib0006","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4269\/ajtmh.18-0655","article-title":"Chloroquine-Primaquine therapeutic efficacy, safety, and plasma levels in patients with uncomplicated plasmodium vivax malaria in a Colombian Pacific region","volume":"100","author":"Mesa-Echeverry","year":"2019","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2025.117013_bib0007","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s12936-024-05170-z","article-title":"Chloroquine-primaquine therapeutic response and safety in patients with uncomplicated Plasmodium vivax malaria in the Colombian Amazon region","volume":"23","author":"Calder\u00f3n-Ruiz","year":"2024","journal-title":"Malar J."},{"issue":"8","key":"10.1016\/j.diagmicrobio.2025.117013_bib0008","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1128\/AAC.00186-16","article-title":"Prospective study of plasmodium vivax malaria recurrence after radical treatment with a chloroquine-primaquine standard regimen in Turbo, Colombia","volume":"60","author":"Zuluaga-Id\u00e1rraga","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"10.1016\/j.diagmicrobio.2025.117013_bib0009","first-page":"429","article-title":"Ten years of chloroquine efficacy for uncomplicated Plasmodium vivax malaria treatment, Turbo, Antioquia, 2002 and 2011","volume":"33","author":"R\u00edos","year":"2013","journal-title":"Biomed Rev Inst Nac Salud"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2025.117013_bib0010","doi-asserted-by":"crossref","first-page":"364","DOI":"10.7705\/biomedica.5988","article-title":"Eficacia de la tafenoquina en la profilaxis y tratamiento de la malaria por Plasmodium vivax, revisi\u00f3n sistem\u00e1tica y metaan\u00e1lisis","volume":"42","author":"Cubillos","year":"2022","journal-title":"Biom\u00e9dica"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2025.117013_bib0011","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/jbt.20174","article-title":"Mechanisms of cytochrome P450 substrate oxidation: miniReview","volume":"21","author":"Guengerich","year":"2007","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2016.03.011","article-title":"Primaquine pharmacology in the context of CYP 2D6 pharmacogenomics: current state of the art","volume":"161","author":"Marcsisin","year":"2016","journal-title":"Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2025.117013_bib0013","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/cts.12692","article-title":"Standardizing CYP2D6 genotype to phenotype translation: consensus recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group","volume":"13","author":"Caudle","year":"2020","journal-title":"Clin Transl Sci"},{"issue":"14","key":"10.1016\/j.diagmicrobio.2025.117013_bib0014","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1056\/NEJMc1301936","article-title":"Primaquine failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria","volume":"369","author":"Bennett","year":"2013","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.diagmicrobio.2025.117013_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160172","article-title":"Variation in human cytochrome P-450 drug-metabolism genes: a gateway to the understanding of plasmodium vivax relapses","volume":"11","author":"Silvino","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0016","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02056-19","article-title":"Novel insights into plasmodium vivax therapeutic failure: CYP2D6 activity and time of exposure to malaria modulate the risk of recurrence","volume":"64","author":"Silvino","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2025.117013_bib0017","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12936-017-2139-7","article-title":"CYP2D6 activity and the risk of recurrence of plasmodium vivax malaria in the Brazilian Amazon: a prospective cohort study","volume":"17","author":"Brasil","year":"2018","journal-title":"Malar J"},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0018","series-title":"Farmacogen\u00e9tica del CYP2D6 en la poblacion colombiana en relacion con las americas","author":"Sanchez","year":"2015"},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0019","doi-asserted-by":"crossref","unstructured":"Isaza C.A., Henao J., L\u00f3pez A.M., Cacabelos R. Isolation, sequence and genotyping of the drug metabolizer CYP2D6 gene in the Colombian population. Methods Findings Experiment Clin Pharmacol 22(9):695-705. doi: 10.1358\/mf.2000.22.9.802286.","DOI":"10.1358\/mf.2000.22.9.802286"},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0020","unstructured":"Plan territorial de salud. Distrito de turbo.2020-2023. https:\/\/turboantioquia.micolombiadigital.gov.co\/sites\/turboantioquia\/content\/files\/000316\/15789_15784_planterritorialdesalud202020233.pdf; 2023 [Accessed april 2024]."},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0021","unstructured":"Portal Sivigila 2019 datos. http:\/\/portalsivigila.ins.gov.co\/Paginas\/datos.aspx?cod=93; 2022 [Accessed april 2022]."},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0022","unstructured":"PHASE software for haplotype estimation. Matthew Stephens, https:\/\/stephenslab.uchicago.edu\/phase\/download.html; 2023 [Accessed January 2023]."},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0023","unstructured":"PharmGKB. Gene-specific information tables for CYP2D6. https:\/\/www.pharmgkb.org\/page\/cyp2d6RefMaterials; 2021 [Accessed april 2021]."},{"issue":"4","key":"10.1016\/j.diagmicrobio.2025.117013_bib0024","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/clpt.2013.254","article-title":"Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy","volume":"95","author":"Crews","year":"2014","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2025.117013_bib0025","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/sj.clpt.6100406","article-title":"The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype","volume":"83","author":"Gaedigk","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0026","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jpba.2014.03.006","article-title":"Validation of a method for the simultaneous quantification of chloroquine, desethylchloroquine and primaquine in plasma by HPLC-DAD","volume":"95","author":"Zuluaga-Id\u00e1rraga","year":"2014","journal-title":"J Pharm Biomed Anal"},{"issue":"2","key":"10.1016\/j.diagmicrobio.2025.117013_bib0027","first-page":"156","article-title":"Evaluating effect size in psychological research: sense and nonsense. Advances in methods and practices in psychological","volume":"2","author":"Funder","year":"2019","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.diagmicrobio.2025.117013_bib0028","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1089\/omi.2018.0114","article-title":"Interethnic variability in CYP2D6, CYP2C9, and CYP2C19 genes and predicted drug metabolism phenotypes among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomics","volume":"22","author":"Naranjo","year":"2018","journal-title":"OMICS"},{"issue":"4","key":"10.1016\/j.diagmicrobio.2025.117013_bib0029","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2018.1449","article-title":"Association of impaired cytochrome P450 2D6 activity genotype and phenotype with therapeutic efficacy of Primaquine treatment for latent plasmodium vivax Malaria","volume":"1","author":"Baird","year":"2018","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.diagmicrobio.2025.117013_bib0030","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01204-23","article-title":"Delayed gametocyte clearance in Plasmodium vivax malaria is associated with polymorphisms in the cytochrome P450 reductase (CPR)","volume":"68","author":"Salazar","year":"2024","journal-title":"Antimicrob Agents Chemother"},{"issue":"8","key":"10.1016\/j.diagmicrobio.2025.117013_bib0031","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/jac\/dkae196","article-title":"Monoamine oxidase-A (MAO-A) low-expression variants and increased risk of Plasmodium vivax malaria relapses","volume":"79","author":"Pu\u00e7a","year":"2024","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2025.117013_bib0032","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/17425255.2022.2049235","article-title":"An update on pharmacogenetic factors influencing the metabolism and toxicity of artemisinin-based combination therapy in the treatment of malaria","volume":"18","author":"Pernaute-Lau","year":"2022","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2025.117013_bib0033","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011020","article-title":"Individual variation in plasmodium vivax malaria risk: are repeatedly infected people just unlucky?","volume":"17","author":"Corder","year":"2023","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"10.1016\/j.diagmicrobio.2025.117013_bib0034","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12936-019-2774-2","article-title":"Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor","volume":"18","author":"Chen","year":"2019","journal-title":"Malar J"}],"container-title":["Diagnostic Microbiology and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889325003360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0732889325003360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T02:17:08Z","timestamp":1762309028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0732889325003360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0732889325003360"],"URL":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2025.117013","relation":{},"ISSN":["0732-8893"],"issn-type":[{"value":"0732-8893","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymorphisms of the CYP2D6 gene and its relationship with Plasmodium vivax relapses after chloroquine-primaquine treatment in Turbo, Colombia","name":"articletitle","label":"Article Title"},{"value":"Diagnostic Microbiology and Infectious Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diagmicrobio.2025.117013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"117013"}}