{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:10:00Z","timestamp":1790867400855,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Differentiation"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.diff.2008.09.016","type":"journal-article","created":{"date-parts":[[2009,8,5]],"date-time":"2009-08-05T11:42:50Z","timestamp":1249472570000},"page":"148-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Role of NEDD8 in HIV-associated lipodystrophy"],"prefix":"10.1016","volume":"77","author":[{"given":"Vincenzo","family":"Esposito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Manente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica","family":"Perna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Gargiulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Viglietti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Sangiovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nectaria","family":"Doula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Liuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Chirianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diff.2008.09.016_bib1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/01.mjt.0000162013.66614.16","article-title":"Highly active antiretroviral therapy-associated metabolic syndrome: pathogenesis and cardiovascular risk","volume":"13","author":"Barbaro","year":"2006","journal-title":"Am. J. Ther."},{"key":"10.1016\/j.diff.2008.09.016_bib2","first-page":"191","article-title":"Switching strategies to improve lipid profile and morphologic changes","volume":"8","author":"Barragan","year":"2006","journal-title":"AIDS Rev."},{"key":"10.1016\/j.diff.2008.09.016_bib3","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0140-6736(02)08094-7","article-title":"Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance","volume":"359","author":"Bastard","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.diff.2008.09.016_bib4","first-page":"26","article-title":"The long-term consequences of antiretroviral therapy: a review","volume":"11","author":"Boyd","year":"2006","journal-title":"J. HIV Ther."},{"key":"10.1016\/j.diff.2008.09.016_bib5","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1158\/1541-7786.MCR-06-0328","article-title":"Ubiquitin hubs in oncogenic networks","volume":"4","author":"Crosetto","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.diff.2008.09.016_bib6","first-page":"3381","article-title":"Prognostic role of the cyclin-dependent kinase inhibitor p27 in non small cell lung cancer","volume":"57","author":"Esposito","year":"1997","journal-title":"Cancer Res."},{"issue":"S5","key":"10.1016\/j.diff.2008.09.016_bib7","first-page":"57","article-title":"Proposal for a clinic classification of morphological and metabolic alterations under ART","volume":"5","author":"Galli","year":"2000","journal-title":"Antiviral Ther."},{"key":"10.1016\/j.diff.2008.09.016_bib8","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/135965350601100610","article-title":"HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV-1\/HAART-associated lipodystrophy","volume":"11","author":"Giralt","year":"2006","journal-title":"Antiviral Ther."},{"key":"10.1016\/j.diff.2008.09.016_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/135965350400900206","article-title":"Adipocytes targets and actors in the pathogenesis of HIV-associated lipodistrophy and metabolic alterations","volume":"9","author":"Gougeon","year":"2004","journal-title":"Antiviral Ther."},{"key":"10.1016\/j.diff.2008.09.016_bib10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1152\/physrev.1998.78.3.783","article-title":"Understanding adipocyte differentiation","volume":"78","author":"Gregoire","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.diff.2008.09.016_bib11","unstructured":"Haubrich, R., Riddler, S., DiRienzo, D., 2007. Metabolic outcomes of ACTG 5142: a prospective, randomized, phase III clinical trial of NRTI-, PI and NNRTI-sparing regimens for initial treatment of HIV-1 infection. In: Program and Abstracts of the 14th Conference on Retroviruses and Opportunistic Infections, February 25\u201328, 2007, Los Angeles, CA (abstract 38)."},{"key":"10.1016\/j.diff.2008.09.016_bib12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1310\/XP75-7VJ5-HML2-YF1W","article-title":"Update on HIV lipodystrophy","volume":"5","author":"Kravcik","year":"2004","journal-title":"HIV Clin. Trials"},{"key":"10.1016\/j.diff.2008.09.016_bib13","first-page":"3","article-title":"Pathogenesis of lipodystrophy and lipid abnormalities in patients taking antiretroviral therapy","volume":"9","author":"Mallon","year":"2007","journal-title":"AIDS Rev."},{"key":"10.1016\/j.diff.2008.09.016_bib14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1086\/313594","article-title":"Lactic acidosis associated with stavudine administration: a report of five cases","volume":"30","author":"Mokrzycki","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.diff.2008.09.016_bib15","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/bj20030426","article-title":"Perixosome-proliferator-activated receptor \u03b3 suppresses Wnt\/\u03b2-catenin signalling during adipogenesis","volume":"376","author":"Moldes","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.diff.2008.09.016_bib16","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1097\/01.aids.0000242815.80462.5a","article-title":"Microarray analysis during adipogenesis identifies new genes altered by antiretroviral drugs","volume":"20","author":"Pacenti","year":"2006","journal-title":"AIDS"},{"key":"10.1016\/j.diff.2008.09.016_bib17","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/sj.onc.1207414","article-title":"Nedd8 on cullin: building an expressway to protein destruction","volume":"23","author":"Pan","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.diff.2008.09.016_bib18","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1073\/pnas.090465597","article-title":"A Nedd8 conjugation pathway is essential for proteolytic targeting of p27 by ubiquitination","volume":"97","author":"Podust","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.diff.2008.09.016_bib19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/sj.onc.1202308","article-title":"Analysis of cell cycle arrest in adipocyte differentiation","volume":"18","author":"Reichert","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.diff.2008.09.016_bib20","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2174\/138161206776055796","article-title":"Understanding and avoiding antiretroviral adverse events","volume":"12","author":"Shibuyama","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.diff.2008.09.016_bib21","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1083\/jcb.200104035","article-title":"The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice","volume":"155","author":"Tateishi","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.diff.2008.09.016_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00001432-200402000-00005","article-title":"What is HIV-associated lipodystrophy? Defining fat distribution changes in HIV infection","volume":"17","author":"Tien","year":"2004","journal-title":"Curr. Opin. Infect. Dis."}],"container-title":["Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468108000170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468108000170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:01:22Z","timestamp":1759564882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301468108000170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0301468108000170"],"URL":"https:\/\/doi.org\/10.1016\/j.diff.2008.09.016","relation":{},"ISSN":["0301-4681"],"issn-type":[{"value":"0301-4681","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of NEDD8 in HIV-associated lipodystrophy","name":"articletitle","label":"Article Title"},{"value":"Differentiation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diff.2008.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 International Society of Differentiation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}