{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:37:32Z","timestamp":1791103052597,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Differentiation"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.diff.2010.05.003","type":"journal-article","created":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T06:42:53Z","timestamp":1276238573000},"page":"118-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: Consideration of pancreas differentiation"],"prefix":"10.1016","volume":"80","author":[{"given":"Masayuki","family":"Itoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae","family":"Hanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ichi","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diff.2010.05.003_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1634\/stemcells.2008-0310","article-title":"Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells","volume":"27","author":"Bernardo","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.diff.2010.05.003_bib2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1387\/ijdb.072444cb","article-title":"Genes controlling pancreas ontogeny","volume":"52","author":"Bonal","year":"2008","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.diff.2010.05.003_bib3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/nchembio.154","article-title":"A small molecule that directs differentiation of human ESCs into the pancreatic lineage","volume":"5","author":"Chen","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.diff.2010.05.003_bib4","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1101\/gad.269003","article-title":"Opposing actions of Arx and Pax4 in endocrine pancreas development","volume":"17","author":"Collombat","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.diff.2010.05.003_bib5","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1242\/dev.01870","article-title":"The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas","volume":"132","author":"Collombat","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.diff.2010.05.003_bib6","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1172\/JCI29115","article-title":"Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression","volume":"117","author":"Collombat","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.diff.2010.05.003_bib7","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.bjp.0702594","article-title":"NPY receptor subtype in the rabbit isolated ileum","volume":"127","author":"F\u00e9l\u00e9tou","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.diff.2010.05.003_bib8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.gde.2006.04.003","article-title":"ARX: a gene for all seasons","volume":"16","author":"G\u00e9cz","year":"2006","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.diff.2010.05.003_bib9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1210\/en.2004-1576","article-title":"Minireview: transcriptional regulation in pancreatic development","volume":"146","author":"Habener","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.diff.2010.05.003_bib10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3181\/00379727-202-43511G","article-title":"The pancreatic polypeptide (PP-fold) family: gastrointestinal, vascular, and feeding behavioral implications","volume":"202","author":"Hazelwood","year":"1993","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.diff.2010.05.003_bib11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ydbio.2005.06.041","article-title":"Genetic determinants of pancreatic \u03b5-cell development","volume":"286","author":"Heller","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2010.05.003_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ydbio.2003.12.008","article-title":"The role of Brn4\/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity","volume":"268","author":"Heller","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2010.05.003_bib13","doi-asserted-by":"crossref","first-page":"7186","DOI":"10.1128\/MCB.17.12.7186","article-title":"POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element","volume":"17","author":"Hussain","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.diff.2010.05.003_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/humu.10310","article-title":"Mutations of ARX are associated with striking pleiotropy and consistent genotype\u2013phenotype correlation","volume":"23","author":"Kato","year":"2004","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.diff.2010.05.003_bib15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/ng1009","article-title":"Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans","volume":"32","author":"Kitamura","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.diff.2010.05.003_bib16","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s00125-008-1006-z","article-title":"Transcription factor expression in the developing human fetal endocrine pancreas","volume":"51","author":"Lyttle","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.diff.2010.05.003_bib17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1507\/endocrj.46.755","article-title":"Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells","volume":"46","author":"Miyagawa","year":"1999","journal-title":"Endocr. J."},{"key":"10.1016\/j.diff.2010.05.003_bib18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.braindev.2008.08.008","article-title":"Analysis of the hypothalamus in a case of X-linked lissencephaly with abnormal genitalia (XLAG)","volume":"31","author":"Miyata","year":"2008","journal-title":"Brain Dev."},{"key":"10.1016\/j.diff.2010.05.003_bib19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0925-4773(97)00062-2","article-title":"Expression of a novel aristaless related homeobox gene \u2018Arx\u2019 in the vertebrate telencephalon, diencephalon and floor plate","volume":"65","author":"Miura","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2010.05.003_bib20","first-page":"379","article-title":"Severe diarrhea associated with X-linked lissencephaly with absent corpus callosum and abnormal genitalia: a case report of successful treatment with the somatostatin analogue octreotide","volume":"39","author":"Nanba","year":"2007","journal-title":"No to Hattatsu"},{"key":"10.1016\/j.diff.2010.05.003_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1096-7192(02)00126-9","article-title":"Human ARX gene: genomic characterization and expression","volume":"77","author":"Ohira","year":"2002","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.diff.2010.05.003_bib22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00401-008-0382-2","article-title":"Aristaless-related homeobox gene disruption leads to abnormal distribution of GABAergic interneurons in human neocortex: evidence based on a case of X-linked lissencephaly with abnormal genitalia (XLAG)","volume":"116","author":"Okazaki","year":"2008","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.diff.2010.05.003_bib23","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1006\/bbrc.1993.1173","article-title":"Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family","volume":"190","author":"Sasada","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.diff.2010.05.003_bib24","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1242\/dev.125.12.2213","article-title":"Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells","volume":"125","author":"Sussel","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.diff.2010.05.003_bib25","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1007\/s00125-007-0724-y","article-title":"Betacellulin inhibits amylase and glucagon production and promotes beta cell differentiation in mouse embryonic pancreas","volume":"50","author":"Thowfeegu","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.diff.2010.05.003_bib26","first-page":"247","article-title":"Development of pancreatic islets","volume":"3","author":"Yamaoka","year":"1999","journal-title":"Int. J. Mol. Med."}],"container-title":["Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468110000502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468110000502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:03:30Z","timestamp":1759565010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301468110000502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":26,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0301468110000502"],"URL":"https:\/\/doi.org\/10.1016\/j.diff.2010.05.003","relation":{},"ISSN":["0301-4681"],"issn-type":[{"value":"0301-4681","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: Consideration of pancreas differentiation","name":"articletitle","label":"Article Title"},{"value":"Differentiation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diff.2010.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 International Society of Differentiation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}