{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:38:20Z","timestamp":1778639900076,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Differentiation"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1016\/j.diff.2011.11.003","type":"journal-article","created":{"date-parts":[[2011,12,10]],"date-time":"2011-12-10T06:17:42Z","timestamp":1323497862000},"page":"S105-S113","source":"Crossref","is-referenced-by-count":20,"title":["FltpT2AiCre: A new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues"],"prefix":"10.1016","volume":"83","author":[{"given":"Anika","family":"Lange","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Gegg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingo","family":"Burtscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doris","family":"Bengel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Kremmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"Lickert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.diff.2011.11.003_bib1","doi-asserted-by":"crossref","first-page":"10109","DOI":"10.1073\/pnas.0909900107","article-title":"Primary cilia regulate Gli\/Hedgehog activation in pancreas","volume":"107","author":"Cervantes","year":"2010","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1016\/j.diff.2011.11.003_bib2","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nature04117","article-title":"Vertebrate smoothened functions at the primary cilium","volume":"437","author":"Corbit","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.diff.2011.11.003_bib3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ncb1670","article-title":"Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms","volume":"10","author":"Corbit","year":"2008","journal-title":"Nature Cell Biology"},{"key":"10.1016\/j.diff.2011.11.003_bib4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1099\/0022-1317-82-5-1027","article-title":"The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences","volume":"82","author":"Donnelly","year":"2001","journal-title":"The Journal of General Virology"},{"key":"10.1016\/j.diff.2011.11.003_bib5","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1073\/pnas.93.12.6191","article-title":"Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice","volume":"93","author":"Dymecki","year":"1996","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1016\/j.diff.2011.11.003_bib6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.cellbio.23.090506.123249","article-title":"Cilia and developmental signaling","volume":"23","author":"Eggenschwiler","year":"2007","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"10.1016\/j.diff.2011.11.003_bib7","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1038\/ng.2007.12","article-title":"Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response","volume":"39","author":"Gerdes","year":"2007","journal-title":"Nature Genetics"},{"key":"10.1016\/j.diff.2011.11.003_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-1-60761-157-8_21","article-title":"Tandem affinity purification of protein complexes from mammalian cells by the Strep\/FLAG (SF)-TAP tag","volume":"564","author":"Gloeckner","year":"2009","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.diff.2011.11.003_bib9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.cmet.2009.08.010","article-title":"LKB1 regulates pancreatic beta cell size, polarity, and function","volume":"10","author":"Granot","year":"2009","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.diff.2011.11.003_bib10","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1056\/NEJMra1010172","article-title":"Ciliopathies","volume":"364","author":"Hildebrandt","year":"2011","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.diff.2011.11.003_bib11","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/dev.050120","article-title":"Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II","volume":"137","author":"Hirota","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.diff.2011.11.003_bib12","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1093\/nar\/gkm475","article-title":"Conditional brain-specific knockdown of MAPK using Cre\/loxP regulated RNA interference","volume":"35","author":"Hitz","year":"2007","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.diff.2011.11.003_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"Huangfu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.diff.2011.11.003_bib14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nrm3085","article-title":"Ciliogenesis: building the cell's antenna","volume":"12","author":"Ishikawa","year":"2011","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10.1016\/j.diff.2011.11.003_bib15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1165\/rcmb.2009-0328OC","article-title":"Temporal relationship between primary and motile ciliogenesis in airway epithelial cells","volume":"43","author":"Jain","year":"2010","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"key":"10.1016\/j.diff.2011.11.003_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ng.2007.54","article-title":"Ciliary proteins link basal body polarization to planar cell polarity regulation","volume":"40","author":"Jones","year":"2008","journal-title":"Nature Genetics"},{"key":"10.1016\/j.diff.2011.11.003_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0014-5793(00)01338-7","article-title":"A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre-mediated recombination","volume":"470","author":"Kawamoto","year":"2000","journal-title":"FEBS Letters"},{"key":"10.1016\/j.diff.2011.11.003_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.devcel.2010.06.005","article-title":"Pitchfork regulates primary cilia disassembly and left-right asymmetry","volume":"19","author":"Kinzel","year":"2010","journal-title":"Development Cell"},{"key":"10.1016\/j.diff.2011.11.003_bib19","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/dvg.20520","article-title":"Generation of a mouse line expressing Sox17-driven Cre recombinase with specific activity in arteries","volume":"47","author":"Liao","year":"2009","journal-title":"Genesis"},{"key":"10.1016\/j.diff.2011.11.003_bib20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1101\/gr.749203","article-title":"A highly efficient recombineering-based method for generating conditional knockout mutations","volume":"13","author":"Liu","year":"2003","journal-title":"Genome Research"},{"key":"10.1016\/j.diff.2011.11.003_bib21","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1152\/physiolgenomics.00128.2007","article-title":"Tissue expression patterns identify mouse cilia genes","volume":"32","author":"McClintock","year":"2008","journal-title":"Physiological Genomics"},{"key":"10.1016\/j.diff.2011.11.003_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0092-8674(03)00511-7","article-title":"Two populations of node monocilia initiate left-right asymmetry in the mouse","volume":"114","author":"McGrath","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.diff.2011.11.003_bib23","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1523\/JNEUROSCI.3744-09.2010","article-title":"Cilia organize ependymal planar polarity","volume":"30","author":"Mirzadeh","year":"2010","journal-title":"The Journal of Neuroscience: The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.diff.2011.11.003_bib24","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/ng.104","article-title":"Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells","volume":"40","author":"Park","year":"2008","journal-title":"Nature Genetics"},{"key":"10.1016\/j.diff.2011.11.003_bib25","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.semcdb.2009.02.007","article-title":"Line up and listen: planar cell polarity regulation in the mammalian inner ear","volume":"20","author":"Rida","year":"2009","journal-title":"Seminars in Cell & Developmental Biology"},{"key":"10.1016\/j.diff.2011.11.003_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.devcel.2010.07.001","article-title":"Tilting at nodal windmills: planar cell polarity positions cilia to tell left from right","volume":"19","author":"Santos","year":"2010","journal-title":"Developmental Cell"},{"key":"10.1016\/j.diff.2011.11.003_bib27","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.cub.2005.09.012","article-title":"PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts","volume":"15","author":"Schneider","year":"2005","journal-title":"Current Biology"},{"key":"10.1016\/j.diff.2011.11.003_bib28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/gene.10023","article-title":"Codon-improved Cre recombinase (iCre) expression in the mouse","volume":"32","author":"Shimshek","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.diff.2011.11.003_bib29","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature09129","article-title":"Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning","volume":"466","author":"Song","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.diff.2011.11.003_bib30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nature Genetics"},{"key":"10.1016\/j.diff.2011.11.003_bib31","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/1471-2164-9-511","article-title":"Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives","volume":"9","author":"Tamplin","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.diff.2011.11.003_bib32","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nn.2555","article-title":"Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus","volume":"13","author":"Tissir","year":"2010","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.diff.2011.11.003_bib33","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/ng1622","article-title":"Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway","volume":"37","author":"Wang","year":"2005","journal-title":"Nature Genetics"},{"key":"10.1016\/j.diff.2011.11.003_bib34","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1093\/hmg\/ddq104","article-title":"The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis","volume":"19","author":"Yates","year":"2010","journal-title":"Human Molecular Genetics"}],"container-title":["Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468111001939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468111001939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T19:57:11Z","timestamp":1543348631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301468111001939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["S0301468111001939"],"URL":"https:\/\/doi.org\/10.1016\/j.diff.2011.11.003","relation":{},"ISSN":["0301-4681"],"issn-type":[{"value":"0301-4681","type":"print"}],"subject":[],"published":{"date-parts":[[2012,2]]}}}