{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:56:15Z","timestamp":1776232575545,"version":"3.50.1"},"reference-count":162,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Differentiation"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.diff.2016.05.001","type":"journal-article","created":{"date-parts":[[2016,5,28]],"date-time":"2016-05-28T01:42:20Z","timestamp":1464399740000},"page":"326-335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Retinoic acid signalling in the development of the epidermis, the limbs and the secondary palate"],"prefix":"10.1016","volume":"92","author":[{"given":"Aysel","family":"Mammadova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine E.L.","family":"Carels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes W.","family":"Von den Hoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.diff.2016.05.001_bib1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1101\/gad.855001","article-title":"The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures","volume":"15","author":"Abu-Abed","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib2","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1242\/dev.054668","article-title":"Inhibition of Wnt signaling by wise (Sostdc1) and negative feedback from Shh controls tooth number and patterning","volume":"137","author":"Ahn","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib3","doi-asserted-by":"crossref","first-page":"9526","DOI":"10.1074\/jbc.271.16.9526","article-title":"Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression","volume":"271","author":"Ang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.diff.2016.05.001_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.0022-202x.2001.01649.x","article-title":"Retinoic acid inhibits downregulation of DNp63a expression during terminal differentiation of human primary keratinocytes","volume":"118","author":"Bamberger","year":"2002","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.diff.2016.05.001_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bone.2015.04.035","article-title":"Bone development","volume":"80","author":"Berendsen","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.diff.2016.05.001_bib6","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/ajcn\/81.3.633","article-title":"Concentrations of retinoids in early pregnancy and in newborns and their mothers","volume":"81","author":"Berggren S\u00f6derlund","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.diff.2016.05.001_bib7","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0003-9969(01)00081-4","article-title":"The distribution of retinaldehyde dehydrogenase-2 in rat and human orodental tissues","volume":"46","author":"Berkovitz","year":"2001","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib8","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1096\/fj.13-227967","article-title":"The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development","volume":"27","author":"Billings","year":"2013","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/neu.20242","article-title":"Overview of retinoid metabolism and function","volume":"66","author":"Blomhoff","year":"2006","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.diff.2016.05.001_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/341450","article-title":"Splitting p63","volume":"71","author":"van Bokhoven","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.diff.2016.05.001_bib11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ydbio.2014.04.016","article-title":"A gene expression atlas of early craniofacial development","volume":"391","author":"Brunskill","year":"2014","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib12","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1242\/dev.120.9.2369","article-title":"Programming gene expression in developing epidermis","volume":"120","author":"Byrne","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.cellbio.17.1.87","article-title":"Patterning mechanisms controlling vertebrate limb development","volume":"17","author":"Capdevila","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.devcel.2005.05.016","article-title":"Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system","volume":"9","author":"Carroll","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.diff.2016.05.001_bib16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ydbio.2004.08.046","article-title":"Developmental origins and evolution of jaws: new interpretation of \"maxillary\" and \"mandibular\"","volume":"276","author":"Cerny","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib17","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/dvdy.20833","article-title":"Recent advances in craniofacial morphogenesis","volume":"235","author":"Chai","year":"2006","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.diff.2016.05.001_bib18","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1096\/fasebj.10.9.8801176","article-title":"A decade of molecular biology of retinoic acid receptors","volume":"10","author":"Chambon","year":"1996","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib19","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1093\/emboj\/cdf331","article-title":"Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled","volume":"21","author":"Chapellier","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.diff.2016.05.001_bib20","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1074\/jbc.M411522200","article-title":"Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.diff.2016.05.001_bib22","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1093\/hmg\/ddn121","article-title":"Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate","volume":"17","author":"Chiquet","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.diff.2016.05.001_bib23","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1242\/dev.056051","article-title":"Interactions between Shh, Sostdc1 and Wnt signaling and a new feedback loop for spatial patterning of the teeth","volume":"138","author":"Cho","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib24","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1097\/SCS.0b013e318208ba10","article-title":"Role of apoptosis in retinoic acid-induced cleft palate","volume":"22","author":"Choi","year":"2011","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.diff.2016.05.001_bib25","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.nutr.22.010402.102745E","article-title":"The role of vitamin A in mammalian reproduction and embryonic development","volume":"22","author":"Clagett-Dame","year":"2002","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.diff.2016.05.001_bib26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3390\/nu3040385","article-title":"Vitamin A in reproduction and development","volume":"3","author":"Clagett-Dame","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.diff.2016.05.001_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-9969(02)00208-X","article-title":"Tooth and jaw: molecular mechanisms of patterning in the first branchial arch","volume":"48","author":"Cobourne","year":"2003","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/dbio.2002.0620","article-title":"Programmed cell death is required for palate shelf fusion and is regulated by retinoic acid","volume":"245","author":"Cuervo","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib29","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrm3932","article-title":"Mechanisms of retinoic acid signalling and its roles in organ and limb development","volume":"16","author":"Cunningham","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib30","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/dvdy.22583","article-title":"Rdh10 mutants deficient in limb field retinoic acid signaling exhibit normal limb patterning but display interdigital webbing","volume":"240","author":"Cunningham","year":"2011","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.diff.2016.05.001_bib31","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.celrep.2013.03.036","article-title":"Antagonism between retinoic acid and fibroblast growth factor signaling during limb development","volume":"3","author":"Cunningham","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.diff.2016.05.001_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bmc.2013.11.025","article-title":"Retinoic acid signaling pathways in development and diseases","volume":"22","author":"Das","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.diff.2016.05.001_bib33","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/bdra.20183","article-title":"Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. Birth defects research","volume":"73","author":"Deak","year":"2005","journal-title":"Part A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2016.05.001_bib34","first-page":"88","article-title":"Mesenchymal changes associated with retinoic acid induced cleft palate in CD-1 mice","volume":"18","author":"Degitz","year":"1998","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib35","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/bies.20080","article-title":"Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis","volume":"26","author":"Diez del Corral","year":"2004","journal-title":"BioEssays: News Rev. Mol. Cell Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib36","first-page":"124","article-title":"Genetic deletion of Cyp26b1 negatively impacts limb skeletogenesis by inhibiting chondrogenesis","author":"Dranse","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.diff.2016.05.001_bib37","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1046\/j.1432-1327.2000.01497.x","article-title":"Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid","volume":"267","author":"Duester","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.diff.2016.05.001_bib38","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/bdrc.20092","article-title":"Retinoic acid regulation of the somitogenesis clock","volume":"81","author":"Duester","year":"2007","journal-title":"Birth Defects Res. Part C Embryo Today: Rev."},{"key":"10.1016\/j.diff.2016.05.001_bib39","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.cell.2008.09.002","article-title":"Retinoic acid synthesis and signaling during early organogenesis","volume":"134","author":"Duester","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.diff.2016.05.001_bib40","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1093\/hmg\/ddg090","article-title":"Pathogenesis of split-hand\/split-foot malformation","volume":"12","author":"Duijf","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.diff.2016.05.001_bib41","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1002\/dvdy.22087","article-title":"Retinoic acid receptors exhibit cell-autonomous functions in cranial neural crest cells","volume":"238","author":"Dupe","year":"2009","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.diff.2016.05.001_bib42","doi-asserted-by":"crossref","first-page":"14036","DOI":"10.1073\/pnas.2336223100","article-title":"A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment","volume":"100","author":"Dupe","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.diff.2016.05.001_bib43","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0940-2993(00)80079-2","article-title":"Histological observations of palatal malformations in rat embryos induced by retinoic acid treatment","volume":"52","author":"Emmanouil-Nikoloussi","year":"2000","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.diff.2016.05.001_bib44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0940-2993(00)80080-9","article-title":"Craniofacial abnormalities induced by retinoic acid: a preliminary histological and scanning electron microscopic (SEM) study","volume":"52","author":"Emmanouil-Nikoloussi","year":"2000","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.diff.2016.05.001_bib45","doi-asserted-by":"crossref","first-page":"4637","DOI":"10.1128\/MCB.23.13.4637-4648.2003","article-title":"Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina","volume":"23","author":"Fan","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib46","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1101\/gad.11.1.59","article-title":"Suprabasal expression of a dominant negative RXRalfa mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids","volume":"11","author":"Feng","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib47","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1387\/ijdb.072416mf","article-title":"The Apical Ectodermal Ridge: morphological aspects and signaling pathways","volume":"52","author":"Fernandez-Teran","year":"2008","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib48","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1096\/fasebj.10.9.8801161","article-title":"Molecular mechanisms of retinoid actions in skin","volume":"10","author":"Fisher","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.diff.2016.05.001_bib49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0925-4773(98)00082-3","article-title":"Signalling interactions during facial development","volume":"75","author":"Francis-West","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib50","doi-asserted-by":"crossref","first-page":"e72739","DOI":"10.1371\/journal.pone.0072739","article-title":"Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's disease","volume":"8","author":"Fransen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.diff.2016.05.001_bib52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/415187a","article-title":"Co-regulator recruitment and the mechanism of retinoic acid receptor synergy","volume":"415","author":"Germain","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.diff.2016.05.001_bib54","doi-asserted-by":"crossref","first-page":"16497","DOI":"10.1074\/jbc.M909382199","article-title":"Characterization of retinoic acid receptor-deficient keratinocytes","volume":"275","author":"Goyette","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.diff.2016.05.001_bib55","first-page":"864904","article-title":"A symphony of regulations centered on p63 to control development of ectoderm-derived structures","author":"Guerrini","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.diff.2016.05.001_bib56","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ydbio.2006.11.021","article-title":"Retinoids control anterior and dorsal properties in the developing forebrain","volume":"303","author":"Halilagic","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib57","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities","volume":"118","author":"Harfe","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.diff.2016.05.001_bib58","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1242\/dev.025767","article-title":"Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development","volume":"135","author":"He","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib59","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1242\/dev.120.11.3267","article-title":"Relationship between retinoic acid and sonic hedgehog, two polarizing signals in the chick wing bud","volume":"120","author":"Helms","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib60","doi-asserted-by":"crossref","first-page":"e898","DOI":"10.1038\/cddis.2013.424","article-title":"Retinoic acid alters the proliferation and survival of the epithelium and mesenchyme and suppresses Wnt\/beta-catenin signaling in developing cleft palate","volume":"4","author":"Hu","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.diff.2016.05.001_bib61","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0925-4773(99)00322-6","article-title":"Reiterative signaling and patterning during mammalian tooth morphogenesis","volume":"92","author":"Jernvall","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib62","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1242\/dev.075796","article-title":"Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development","volume":"139","author":"Jin","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib63","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.celrep.2013.05.010","article-title":"Redefining the role of retinoic acid in limb development","volume":"3","author":"Kawakami","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.diff.2016.05.001_bib64","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.4161\/cc.9.11.11844","article-title":"The retinal dehydrogenase\/reductase retSDR1\/DHRS3 gene is activated by p53 and p63 but not by mutants derived from tumors or EEC\/ADULT malformation syndromes","volume":"9","author":"Kirschner","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.diff.2016.05.001_bib65","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1101\/gad.908801","article-title":"Active repression of RAR signaling is required for head formation","volume":"15","author":"Koide","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib66","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1038\/jid.2010.119","article-title":"p63 in skin development and ectodermal dysplasias","volume":"130","author":"Koster","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.diff.2016.05.001_bib67","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1073\/pnas.0611376104","article-title":"p63 induces key target genes required for epidermal morphogenesis","volume":"104","author":"Koster","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.diff.2016.05.001_bib68","first-page":"9010","article-title":"RXRy null mice are apparently normal and compound RXRa+\/\u2212\/RXRb\u2212\/\u2212\/RXRy\u2212\/\u2212 mutant mice are viable","volume":"93","author":"Krezel","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib69","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.semcdb.2013.12.003","article-title":"Molecular patterning of the mammalian dentition","volume":"25\u201326","author":"Lan","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib70","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ajhg.2011.09.015","article-title":"Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid","volume":"89","author":"Laue","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.diff.2016.05.001_bib71","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1242\/dev.02325","article-title":"p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation","volume":"133","author":"Laurikkala","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib72","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jcp.21784","article-title":"Retinoid-responsive transcriptional changes in epidermal keratinocytes","volume":"220","author":"Lee","year":"2009","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.diff.2016.05.001_bib73","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.2174\/1381612043383728","article-title":"Retinoid-induced limb malformations","volume":"10","author":"Lee","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.diff.2016.05.001_bib74","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ydbio.2004.08.045","article-title":"A new origin for the maxillary jaw","volume":"276","author":"Lee","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib75","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1242\/dev.128.5.675","article-title":"RXRa ablation in skin keratinocytes results in alopecia and epidermal alterations","volume":"128","author":"Li","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib76","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/35036595","article-title":"Skin abnormalities generated by temporally controlled RXRa mutations in mouse epidermis","volume":"407","author":"Li","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.diff.2016.05.001_bib77","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/bdrb.21110","article-title":"Excessive retinoic acid impaired proliferation and differentiation of human fetal palatal chondrocytes (hFPCs). Birth defects research","volume":"101","author":"Li","year":"2014","journal-title":"Part B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.diff.2016.05.001_bib78","doi-asserted-by":"crossref","first-page":"e82388","DOI":"10.1371\/journal.pone.0082388","article-title":"Vitamin a is a negative regulator of osteoblast mineralization","volume":"8","author":"Lind","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.diff.2016.05.001_bib79","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.3390\/ijms140610869","article-title":"Epidermal development in mammals: key regulators, signals from beneath, and stem cells","volume":"14","author":"Liu","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.diff.2016.05.001_bib80","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.bbrc.2015.01.148","article-title":"Retinoic acid inhibits histone methyltransferase Whsc1 during palatogenesis","volume":"458","author":"Liu","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.diff.2016.05.001_bib81","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1242\/dev.011759","article-title":"Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects","volume":"135","author":"Lo Iacono","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib82","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1242\/dev.120.10.2723","article-title":"Function of the retinoic acid receptors (RARs) during development (I) Craniofacial and skeletal abnormalities in RAR double mutants","volume":"120","author":"Lohnes","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib83","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/BJ20050874","article-title":"Transcriptional co-operativity between distant retinoic acid response elements in regulation of Cyp26A1 inducibility","volume":"392","author":"Loudig","year":"2005","journal-title":"Biochem. J."},{"key":"10.1016\/j.diff.2016.05.001_bib84","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1242\/dev.124.9.1643","article-title":"Retinoid signaling is required for the establishment of a ZPA and for the expression of Hoxb-8, a mediator of ZPA formation","volume":"124","author":"Lu","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib85","first-page":"555","article-title":"Interdigital soft tissue separation induced by retinoic acid in mouse limbs cultured in vitro","volume":"37","author":"Lussier","year":"1993","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib86","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/bdrc.20055","article-title":"Proliferation and cornification during development of the mammalian epidermis. Birth defects research","volume":"75","author":"Mack","year":"2005","journal-title":"Part C Embryo Today: Rev."},{"key":"10.1016\/j.diff.2016.05.001_bib87","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/dvdy.21878","article-title":"Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning","volume":"238","author":"Maclean","year":"2009","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.diff.2016.05.001_bib88","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0925-4773(01)00463-4","article-title":"Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development","volume":"107","author":"MacLean","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib89","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ejo\/cjt104","article-title":"Effects of retinoic acid on proliferation and gene expression of cleft and non-cleft palatal keratinocytes","volume":"36","author":"Mammadova","year":"2014","journal-title":"Eur. J. Orthod."},{"key":"10.1016\/j.diff.2016.05.001_bib90","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/dvdy.22072","article-title":"Visualizing canonical Wnt signaling during mouse craniofacial development","volume":"239","author":"Mani","year":"2010","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.diff.2016.05.001_bib91","first-page":"67","article-title":"Newborn serum retinoic acid level is associated with variants of genes in the retinol metabolism pathway","author":"Manolescu","year":"2010","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.diff.2016.05.001_bib92","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.pharmtox.46.120604.141156","article-title":"Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis","volume":"46","author":"Mark","year":"2006","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.diff.2016.05.001_bib93","first-page":"77","article-title":"Genetic control of the dvelopment by retinoic acid","volume":"191","author":"Mark","year":"1997","journal-title":"Comptes Rendus S\u00e9ances Soc. Biol. Fil."},{"key":"10.1016\/j.diff.2016.05.001_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2014.12.003","article-title":"Retinoic acid receptors: from molecular mechanisms to cancer therapy","volume":"41C","author":"di Masi","year":"2015","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.diff.2016.05.001_bib95","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2144\/000114300","article-title":"A newly established culture method highlights regulatory roles of retinoic acid on morphogenesis and calcification of mammalian limb cartilage","volume":"58","author":"Masuda","year":"2015","journal-title":"BioTechniques"},{"key":"10.1016\/j.diff.2016.05.001_bib96","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/bdra.20720","article-title":"Studies with Wnt genes and nonsyndromic cleft lip and palate. Birth defects research","volume":"88","author":"Menezes","year":"2010","journal-title":"Part A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2016.05.001_bib97","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1242\/dev.127.18.3961","article-title":"Opposing RA and FGF signals control proximodistal vertebrate limb development through regulation of Meis genes","volume":"127","author":"Mercader","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib98","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1634\/stemcells.2007-0501","article-title":"Retinoic acid and bone morphogenetic protein signaling synergize to efficiently direct epithelial differentiation of human embryonic stem cells","volume":"26","author":"Metallo","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.diff.2016.05.001_bib99","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1242\/dev.129.9.2271","article-title":"Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice","volume":"129","author":"Mic","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib100","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.1073\/pnas.1231422100","article-title":"Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis","volume":"100","author":"Mic","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.diff.2016.05.001_bib101","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0925-4773(00)00434-2","article-title":"RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid, is expressed in the ventral retina, otic vesicle and olfactory pit during mouse development","volume":"97","author":"Mic","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib102","unstructured":"Micronutrients, I.o.M.U.P.o., 2001. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. The National Academies Press, Washington, DC."},{"key":"10.1016\/j.diff.2016.05.001_bib103","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/19531","article-title":"p63 is a p53 homologue required for limb and epidermal morphogenesis","volume":"398","author":"Mills","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.diff.2016.05.001_bib104","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.130.2.407","article-title":"Expression of Notch i, 2, and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate","volume":"130","author":"Mitsiadis","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib105","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.mod.2004.10.008","article-title":"Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation","volume":"122","author":"Molotkova","year":"2005","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib106","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbalip.2011.05.004","article-title":"Physiological insights into all-trans-retinoic acid biosynthesis","volume":"1821","author":"Napoli","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.diff.2016.05.001_bib107","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/7788","article-title":"Embryonic retinoic acid synthesis is essential for early mouse post-implantation development","volume":"21","author":"Niederreither","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.diff.2016.05.001_bib108","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1242\/dev.129.15.3563","article-title":"Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse","volume":"129","author":"Niederreither","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib109","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1086\/382196","article-title":"Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family","volume":"74","author":"Niemann","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.diff.2016.05.001_bib110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/350083a0","article-title":"Retinoic acid induces polarizing activity but is unlikely to be a morphogen in the chick limb bud","volume":"350","author":"Noji","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.diff.2016.05.001_bib111","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.taap.2007.02.019","article-title":"Involvement of apoptotic cell death and cell cycle perturbation in retinoic acid-induced cleft palate in mice","volume":"221","author":"Okano","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.diff.2016.05.001_bib112","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1002\/dvdy.21715","article-title":"Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice","volume":"237","author":"Okano","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.diff.2016.05.001_bib113","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/cga.12049","article-title":"Roles of retinoic acid signaling in normal and abnormal development of the palate and tongue","volume":"54","author":"Okano","year":"2014","journal-title":"Congenit. Anom."},{"key":"10.1016\/j.diff.2016.05.001_bib114","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1002\/dvdy.23862","article-title":"The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves","volume":"241","author":"Okano","year":"2012","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.diff.2016.05.001_bib115","doi-asserted-by":"crossref","first-page":"485","DOI":"10.17219\/acem\/24111","article-title":"Wolf-Hirschhorn syndrome (WHS) \u2013 literature review on the features of the syndrome","volume":"23","author":"Paradowska-Stolarz","year":"2014","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.diff.2016.05.001_bib116","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.1007\/s00018-008-8591-3","article-title":"Medium- and short-chain dehydrogenase\/reductase gene and protein families: Medium-chain and short-chain dehydrogenases\/reductases in retinoid metabolism","volume":"65","author":"Pares","year":"2008","journal-title":"Cell Mol. Life Sci.: CMLS"},{"key":"10.1016\/j.diff.2016.05.001_bib117","doi-asserted-by":"crossref","first-page":"e32447","DOI":"10.1371\/journal.pone.0032447","article-title":"Retinoic acid-dependent signaling pathways and lineage events in the developing mouse spinal cord","volume":"7","author":"Paschaki","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.diff.2016.05.001_bib118","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2350-10-113","article-title":"ALDH1A2 (RALDH2) genetic variation in human congenital heart disease","volume":"10","author":"Pavan","year":"2009","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.diff.2016.05.001_bib119","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00403-009-0937-7","article-title":"Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis","volume":"301","author":"Pavez Lorie","year":"2009","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.diff.2016.05.001_bib120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ydbio.2009.12.024","article-title":"Analysis of Cyp26b1\/Rarg compound-null mice reveals two genetically separable effects of retinoic acid on limb outgrowth","volume":"339","author":"Pennimpede","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib121","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1242\/dev.063966","article-title":"SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling","volume":"138","author":"Probst","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib122","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/bdra.20275","article-title":"Evidence for a functional genetic polymorphism of the human retinoic acid-metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida. Birth defects research","volume":"76","author":"Rat","year":"2006","journal-title":"Part A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2016.05.001_bib123","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1002\/dvdy.20890","article-title":"Anteroposterior patterning in the limb and digit specification: contribution of mouse genetics","volume":"235","author":"Robert","year":"2006","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.diff.2016.05.001_bib124","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1152\/physrev.2000.80.3.1021","article-title":"Retinoids in embryonal development","volume":"80","author":"Ross","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.diff.2016.05.001_bib125","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/374159a0","article-title":"Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor","volume":"374","author":"Saitou","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.diff.2016.05.001_bib126","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1101\/gad.1533407","article-title":"RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development","volume":"21","author":"Sandell","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib127","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ydbio.2007.05.030","article-title":"Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb","volume":"308","author":"Scherz","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib128","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.bbalip.2011.05.001","article-title":"Retinyl ester hydrolases and their roles in vitamin A homeostasis","volume":"1821","author":"Schreiber","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.diff.2016.05.001_bib129","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1242\/dev.037440","article-title":"Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion","volume":"136","author":"Song","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib130","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1053\/j.sodo.2005.07.003","article-title":"Growth factors and signaling proteins in craniofacial development","volume":"11","author":"Spears","year":"2005","journal-title":"Semin. Orthod."},{"key":"10.1016\/j.diff.2016.05.001_bib131","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/S0960-9822(02)70679-9","article-title":"Retinoic acid is required for the initiation of outgrowth in the chick limb bud","volume":"6","author":"Stratford","year":"1996","journal-title":"Curr. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib132","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/dbio.1999.9487","article-title":"Complementary domains of retinoic acid production and degradation in the early chick embryo","volume":"216","author":"Swindell","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib133","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4161\/derm.15026","article-title":"Regulation of keratin expression by retinoids","volume":"3","author":"T\u00f6rm\u00e4","year":"2011","journal-title":"Derm. Endocrinol."},{"key":"10.1016\/j.diff.2016.05.001_bib134","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1101\/gad.1547407","article-title":"Rethinking the proximodistal axis of the vertebrate limb in the molecular era","volume":"21","author":"Tabin","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib135","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1567-133X(03)00066-8","article-title":"Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed in the hindbrain, inner ear, first branchial arch and tooth buds during murine development","volume":"3","author":"Tahayatoa","year":"2003","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.diff.2016.05.001_bib136","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0925-4773(97)00115-9","article-title":"Signalling networks regulating dental development","volume":"67","author":"Thesleff","year":"1997","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib137","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1172\/JCI40266","article-title":"Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice","volume":"120","author":"Thomason","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.diff.2016.05.001_bib138","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1387\/ijdb.072499mt","article-title":"Generation of pattern and form in the developing limb","volume":"53","author":"Towers","year":"2009","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib139","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1242\/dev.024158","article-title":"Growing models of vertebrate limb development","volume":"136","author":"Towers","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.diff.2016.05.001_bib140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0890-6238(98)00069-0","article-title":"Retinoid-induced limb defects 1: inhibition of cell proliferation in distal mesenchyme of limb buds in rats","volume":"13","author":"Tsuiki","year":"1999","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.diff.2016.05.001_bib141","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ydbio.2006.09.045","article-title":"CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse","volume":"302","author":"Uehara","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib142","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1006\/dbio.2000.9634","article-title":"Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid","volume":"220","author":"Ulven","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib143","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/(SICI)1097-0029(19981015)43:2<137::AID-JEMT7>3.0.CO;2-3","article-title":"Retinoids and their receptors in skeletal development","volume":"43","author":"Underhill","year":"1998","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.diff.2016.05.001_bib144","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/350081a0","article-title":"Conversion by retinoic acid of anterior cells into ZPA cells in the chick wing bud","volume":"350","author":"Wanek","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.diff.2016.05.001_bib145","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.etap.2014.07.008","article-title":"All-trans-retinoid acid (ATRA) suppresses chondrogenesis of rat primary hind limb bud mesenchymal cells by downregulating p63 and cartilage-specific molecules","volume":"38","author":"Wang","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.diff.2016.05.001_bib146","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.toxlet.2013.06.220","article-title":"All-trans-retinoid acid (ATRA) may have inhibited chondrogenesis of primary hind limb bud mesenchymal cells by downregulating Pitx1 expression","volume":"224","author":"Wang","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.diff.2016.05.001_bib147","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/bdrc.10010","article-title":"Revisiting the role of retinoid signaling in skeletal development. Birth defects research","volume":"69","author":"Weston","year":"2003","journal-title":"Part C Embryo Today: Rev."},{"key":"10.1016\/j.diff.2016.05.001_bib148","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1083\/jcb.200112029","article-title":"Requirement for RAR-mediated gene repression in skeletal progenitor differentiation","volume":"158","author":"Weston","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.02.027","article-title":"The mechanisms of dorsoventral patterning in the vertebrate neural tube","volume":"282","author":"Wilson","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib150","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ydbio.2004.01.034","article-title":"Retinoic acid and the control of dorsoventral patterning in the avian spinal cord","volume":"269","author":"Wilson","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib151","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1753-4887.2006.tb00186.x","article-title":"Is 9-cis-retinoic acid the endogenous ligand for the retinoic acid-X receptor?","volume":"64","author":"Wolf","year":"2006","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.diff.2016.05.001_bib152","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/emboj\/18.6.1539","article-title":"Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors","volume":"18","author":"Xiao","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.diff.2016.05.001_bib153","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/19539","article-title":"p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development","volume":"398","author":"Yang","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.diff.2016.05.001_bib154","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1534-5807(04)00062-0","article-title":"Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb","volume":"6","author":"Yashiro","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.diff.2016.05.001_bib155","first-page":"45","article-title":"Effect of retinoic acid on in vitro proliferation activity and glycosaminoglycan synthesis of mesenchymal cells from palatal shelves of mouse fetuses","volume":"7","author":"Yoshikawa","year":"1987","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"10.1016\/j.diff.2016.05.001_bib156","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.bbrc.2005.12.100","article-title":"All-trans retinoic acid inhibited chondrogenesis of mouse embryonic palate mesenchymal cells by down-regulation of TGF-beta\/Smad signaling","volume":"340","author":"Yu","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.diff.2016.05.001_bib157","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2006.04.001","article-title":"atRA-induced apoptosis of mouse embryonic palate mesenchymal cells involves activation of MAPK pathway","volume":"215","author":"Yu","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.diff.2016.05.001_bib158","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/toxsci\/kfi030","article-title":"Induction of cell-cycle arrest by all-trans retinoic acid in mouse embryonic palatal mesenchymal (MEPM) cells","volume":"83","author":"Yu","year":"2005","journal-title":"Toxicol. Sci.: Off. J. Soc. Toxicol."},{"key":"10.1016\/j.diff.2016.05.001_bib159","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.gde.2010.04.014","article-title":"The temporal dynamics of vertebrate limb development, teratogenesis and evolution","volume":"20","author":"Zeller","year":"2010","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.diff.2016.05.001_bib160","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/0022034514530397","article-title":"Proteomic analysis of RBP4\/vitamin A in children with cleft lip and\/or palate","volume":"93","author":"Zhang","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.diff.2016.05.001_bib161","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3892\/mmr.2015.3423","article-title":"All-trans-retinoic acid inhibits chondrogenesis of rat embryo hindlimb bud mesenchymal cells by downregulating p53 expression","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.diff.2016.05.001_bib162","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/dvdy.10267","article-title":"Differential expression of decorin and biglycan genes during palatogenesis in normal and retinoic acid-treated mice","volume":"226","author":"Zhang","year":"2003","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.diff.2016.05.001_bib163","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/dvdy.22188","article-title":"Retinoic acid controls expression of tissue remodeling genes Hmgn1 and Fgf18 at the digit-interdigit junction","volume":"239","author":"Zhao","year":"2010","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.diff.2016.05.001_bib164","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.cub.2009.04.059","article-title":"Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning","volume":"19","author":"Zhao","year":"2009","journal-title":"Curr. Biol.: CB"},{"key":"10.1016\/j.diff.2016.05.001_bib165","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.reprotox.2004.06.012","article-title":"Cellular anomalies underlying retinoid-induced phocomelia","volume":"19","author":"Zhou","year":"2004","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.diff.2016.05.001_bib166","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/jn\/131.3.705","article-title":"Function of vitamin A in vertebrate embryonic development","volume":"131","author":"Zile","year":"2001","journal-title":"J. Nutr."}],"container-title":["Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468116300081?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468116300081?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T05:58:23Z","timestamp":1718603903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301468116300081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":162,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S0301468116300081"],"URL":"https:\/\/doi.org\/10.1016\/j.diff.2016.05.001","relation":{},"ISSN":["0301-4681"],"issn-type":[{"value":"0301-4681","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinoic acid signalling in the development of the epidermis, the limbs and the secondary palate","name":"articletitle","label":"Article Title"},{"value":"Differentiation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diff.2016.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}