{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:16:26Z","timestamp":1778051786283,"version":"3.51.4"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Differentiation"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.diff.2017.09.002","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T11:15:26Z","timestamp":1506078926000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Renal Subcapsular xenografing of human fetal external genital tissue \u2013 A new model for investigating urethral development"],"prefix":"10.1016","volume":"98","author":[{"given":"Dylan","family":"Isaacson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriane","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Baskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.diff.2017.09.002_bib1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1001\/archpedi.1958.02060050414010","article-title":"Female pseudohermaphroditism with penile urethra; report of an unusual case of congenital adrenal hyperplasia","volume":"95","author":"Ainger","year":"1958","journal-title":"AMA J. Dis. Child"},{"issue":"3","key":"10.1016\/j.diff.2017.09.002_bib2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0022-5347(05)67861-5","article-title":"Hypospadias and urethral development","volume":"163","author":"Baskin","year":"2000","journal-title":"J. Urol."},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1210\/endo-101-2-365","article-title":"Heterotransplantation of human fetal pituitaries in nude mice","volume":"101","author":"Bastert","year":"1977","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.diff.2017.09.002_bib4","first-page":"1","article-title":"Follow-up study of male and female offspring of DES-exposed mothers","volume":"49","author":"Bibbo","year":"1977","journal-title":"Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.diff.2017.09.002_bib5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/ar.22708","article-title":"Analysis of the effect of estrogen\/androgen perturbation on penile development in transgenic and diethylstilbestrol-treated mice","volume":"296","author":"Blaschko","year":"2013","journal-title":"Anat. Rec. (Hoboken)"},{"issue":"5","key":"10.1016\/j.diff.2017.09.002_bib6","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.juro.2014.11.087","article-title":"Genetic polymorphisms in ESR1 and ESR2 genes, and risk of hypospadias in a multiethnic study population","volume":"193","author":"Choudhry","year":"2015","journal-title":"J. Urol."},{"issue":"4\u20135","key":"10.1016\/j.diff.2017.09.002_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.diff.2015.10.005","article-title":"Methods for studying human organogenesis","volume":"91","author":"Cunha","year":"2016","journal-title":"Differentiation"},{"issue":"7","key":"10.1016\/j.diff.2017.09.002_bib8","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0046-8177(88)80260-0","article-title":"Absence of teratogenic effects of progesterone on the developing genital tract of the human female fetus","volume":"19","author":"Cunha","year":"1988","journal-title":"Hum. Pathol."},{"issue":"5","key":"10.1016\/j.diff.2017.09.002_bib9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrurol.2015.57","article-title":"Current understanding of hypospadias: relevance of animal models","volume":"12","author":"Cunha","year":"2015","journal-title":"Nat. Rev. Urol."},{"issue":"4\u20135","key":"10.1016\/j.diff.2017.09.002_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.diff.2015.10.007","article-title":"Use of sub-renal capsule transplantation in developmental biology","volume":"91","author":"Cunha","year":"2016","journal-title":"Differentiation"},{"issue":"1","key":"10.1016\/j.diff.2017.09.002_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/10520298409113823","article-title":"Identification in histological sections of species origin of cells from mouse, rat and human","volume":"59","author":"Cunha","year":"1984","journal-title":"Stain Technol."},{"issue":"4","key":"10.1016\/j.diff.2017.09.002_bib12","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1097\/01.AOG.0000154159.75022.11","article-title":"Improving the accuracy of fetal foot length to confirm gestational duration","volume":"105","author":"Drey","year":"2005","journal-title":"Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.diff.2017.09.002_bib13","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0090-4295(00)01105-5","article-title":"Hypospadias: a contemporary epidemiologic assessment","volume":"57","author":"Gallentine","year":"2001","journal-title":"Urology"},{"issue":"1","key":"10.1016\/j.diff.2017.09.002_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/taap.1994.1227","article-title":"Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat","volume":"129","author":"Gray","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF00305483","article-title":"Cytodifferentiation of human fetal lung tissue following transplantation into \"nude\" mice","volume":"165","author":"Groscurth","year":"1982","journal-title":"Anat. Embryol. (Berl.)"},{"key":"10.1016\/j.diff.2017.09.002_bib16","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1542\/peds.58.4.505","article-title":"Urogenital tract abnormalities in sons of women treated with diethylstilbestrol","volume":"58","author":"Henderson","year":"1976","journal-title":"Pediatrics"},{"key":"10.1016\/j.diff.2017.09.002_bib17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1741-7015-11-152","article-title":"The differential role of androgens in early human sex development","volume":"11","author":"Hiort","year":"2013","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib18","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11934-008-0025-0","article-title":"Associations among hypospadias, cryptorchidism, anogenital distance, and endocrine disruption","volume":"9","author":"Hsieh","year":"2008","journal-title":"Curr. Urol. Rep."},{"issue":"7","key":"10.1016\/j.diff.2017.09.002_bib19","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s12094-010-0540-6","article-title":"Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review","volume":"12","author":"Jin","year":"2010","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.diff.2017.09.002_bib20","doi-asserted-by":"crossref","first-page":"13006","DOI":"10.1038\/srep13006","article-title":"Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo","volume":"5","author":"Jorfi","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2011.01.006","article-title":"Hypospadias: interactions between environment and genetics","volume":"335","author":"Kalfa","year":"2011","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.diff.2017.09.002_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.eururo.2015.05.008","article-title":"Is hypospadias associated with prenatal exposure to endocrine disruptors? A french collaborative controlled study of a cohort of 300 Consecutive children without genetic defect","author":"Kalfa","year":"2015","journal-title":"Eur. Urol."},{"issue":"3","key":"10.1016\/j.diff.2017.09.002_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0013-9351(03)00085-9","article-title":"Induction of hypospadias in a murine model by maternal exposure to synthetic estrogens","volume":"94","author":"Kim","year":"2004","journal-title":"Environ. Res."},{"issue":"9312","key":"10.1016\/j.diff.2017.09.002_bib24","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0140-6736(02)08152-7","article-title":"Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study","volume":"359","author":"Klip","year":"2002","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.diff.2017.09.002_bib25","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/S0022-5347(05)65358-X","article-title":"Spermatogenesis, fertility and sexual behavior in a hypospadiac mouse model","volume":"167","author":"Kojima","year":"2002","journal-title":"J. Urol."},{"issue":"6","key":"10.1016\/j.diff.2017.09.002_bib26","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/1523-1747.ep12284423","article-title":"Development of human fetal skin transplanted to the nude mouse","volume":"93","author":"Lane","year":"1989","journal-title":"J. Investig. Dermatol."},{"issue":"4","key":"10.1016\/j.diff.2017.09.002_bib27","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.juro.2014.09.108","article-title":"Canalization of the urethral plate precedes fusion of the urethral folds during male penile urethral development: the double zipper hypothesis","volume":"193","author":"Li","year":"2015","journal-title":"J. Urol."},{"key":"10.1016\/j.diff.2017.09.002_bib28","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0022-5347(17)64439-2","article-title":"Familial female pseudohermaphroditism with hypertension and penile urethra","volume":"90","author":"Madsen","year":"1963","journal-title":"J. Urol."},{"issue":"2\u20133","key":"10.1016\/j.diff.2017.09.002_bib29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.diff.2014.09.004","article-title":"Comparative effects of neonatal diethylstilbestrol on external genitalia development in adult males of two mouse strains with differential estrogen sensitivity","volume":"88","author":"Mahawong","year":"2014","journal-title":"Differentiation"},{"issue":"2\u20133","key":"10.1016\/j.diff.2017.09.002_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.diff.2014.09.005","article-title":"Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse strains","volume":"88","author":"Mahawong","year":"2014","journal-title":"Differentiation"},{"issue":"1","key":"10.1016\/j.diff.2017.09.002_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF00880061","article-title":"Importance of orthotopic implantation for human tumors as model systems: relevance to metastasis and invasion","volume":"11","author":"Manzotti","year":"1993","journal-title":"Clin. Exp. Metastas-."},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib32","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/j.1939-4640.2005.tb01078.x","article-title":"Hypospadias: psychosocial, sexual, and reproductive consequences in adult life","volume":"26","author":"Mieusset","year":"2005","journal-title":"J. Androl."},{"issue":"10","key":"10.1016\/j.diff.2017.09.002_bib33","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/humrep\/deq183","article-title":"Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation","volume":"25","author":"Mitchell","year":"2010","journal-title":"Hum. Reprod."},{"issue":"6","key":"10.1016\/j.diff.2017.09.002_bib34","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00418-008-0435-6","article-title":"The human keratins: biology and pathology","volume":"129","author":"Moll","year":"2008","journal-title":"Histochem Cell Biol."},{"issue":"4 Pt 2","key":"10.1016\/j.diff.2017.09.002_bib35","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.juro.2015.07.117","article-title":"Canalization of the vestibular plate in the absence of urethral fusion characterizes development of the human clitoris: the single zipper hypothesis","volume":"195","author":"Overland","year":"2016","journal-title":"J. Urol."},{"issue":"5","key":"10.1016\/j.diff.2017.09.002_bib36","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1542\/peds.100.5.831","article-title":"Hypospadias trends in two US surveillance systems","volume":"100","author":"Paulozzi","year":"1997","journal-title":"Pediatrics"},{"issue":"4","key":"10.1016\/j.diff.2017.09.002_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1289\/ehp.99107297","article-title":"International trends in rates of hypospadias and cryptorchidism","volume":"107","author":"Paulozzi","year":"1999","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.diff.2017.09.002_bib38","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0891-6632(89)90007-X","article-title":"Human fetal pancreas transplants","volume":"3","author":"Peterson","year":"1989","journal-title":"J. Diabet. Complicat."},{"issue":"3","key":"10.1016\/j.diff.2017.09.002_bib39","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000431010","article-title":"A comprehensive atlas of the adult mouse penis","volume":"9","author":"Phillips","year":"2015","journal-title":"Sex. Dev."},{"issue":"5","key":"10.1016\/j.diff.2017.09.002_bib40","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.juro.2007.01.058","article-title":"Cryptorchidism and hypospadias","volume":"177","author":"Pohl","year":"2007","journal-title":"J. Urol."},{"issue":"10","key":"10.1016\/j.diff.2017.09.002_bib41","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1093\/molehr\/gau058","article-title":"Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies","volume":"20","author":"Poulain","year":"2014","journal-title":"Mol. Hum. Reprod."},{"issue":"445","key":"10.1016\/j.diff.2017.09.002_bib42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/248247a0","article-title":"Heterotransplantation of human foetal organs to the mouse mutant nude","volume":"248","author":"Povlsen","year":"1974","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.diff.2017.09.002_bib43","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0046-8177(82)80177-9","article-title":"Normal development of the human female reproductive tract and alterations resulting from experimental exposure to diethylstilbestrol","volume":"13","author":"Robboy","year":"1982","journal-title":"Hum. Pathol."},{"issue":"6","key":"10.1016\/j.diff.2017.09.002_bib44","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1095\/biolreprod.111.091504","article-title":"New insights on the morphology of adult mouse penis","volume":"85","author":"Rodriguez","year":"2011","journal-title":"Biol. Reprod."},{"issue":"3","key":"10.1016\/j.diff.2017.09.002_bib45","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.diff.2012.07.003","article-title":"Specific morphogenetic events in mouse external genitalia sex differentiation are responsive\/dependent upon androgens and\/or estrogens","volume":"84","author":"Rodriguez","year":"2012","journal-title":"Differentiation"},{"issue":"3","key":"10.1016\/j.diff.2017.09.002_bib46","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.diff.2017.09.002_bib47","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.ymthe.2004.08.013","article-title":"Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer","volume":"10","author":"Shaw","year":"2004","journal-title":"Mol. Ther."},{"issue":"4","key":"10.1016\/j.diff.2017.09.002_bib48","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.diff.2016.06.003","article-title":"Complex epithelial remodeling underlie the fusion event in early fetal development of the human penile urethra","volume":"92","author":"Shen","year":"2016","journal-title":"Differentiation"},{"issue":"5","key":"10.1016\/j.diff.2017.09.002_bib49","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.diff.2016.03.004","article-title":"Mouse hypospadias: a critical examination and definition","volume":"92","author":"Sinclair","year":"2016","journal-title":"Differentiation"},{"key":"10.1016\/j.diff.2017.09.002_bib50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.diff.2016.12.001","article-title":"Flutamide-induced hypospadias in rats: a critical assessment","volume":"94","author":"Sinclair","year":"2016","journal-title":"Differentiation"},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib51","first-page":"657","article-title":"Cytokeratin expression patterns in normal and malignant urothelium: a review of the biological and diagnostic implications","volume":"14","author":"Southgate","year":"1999","journal-title":"Histol. Histopathol."},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib52","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0046-8177(88)80340-X","article-title":"Temporal and spatial factors in diethylstilbestrol-induced squamous metaplasia of the developing human prostate","volume":"19","author":"Sugimura","year":"1988","journal-title":"Hum. Pathol."},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib53","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0012-1606(84)90238-0","article-title":"Timing and irreversibility of Mullerian duct inhibition in the embryonic reproductive tract of the human male","volume":"106","author":"Taguchi","year":"1984","journal-title":"Dev. Biol."},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib54","first-page":"56","article-title":"Experimental study of the effect of diethylstilbestrol on the development of the human female reproductive tract","volume":"4","author":"Taguchi","year":"1983","journal-title":"Biol. Res. Pregnancy Perinatol."},{"issue":"12","key":"10.1016\/j.diff.2017.09.002_bib55","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.2337\/diab.33.12.1180","article-title":"Histologic differentiation of human fetal pancreatic explants transplanted into nude mice","volume":"33","author":"Tuch","year":"1984","journal-title":"Diabetes"},{"issue":"Suppl 1","key":"10.1016\/j.diff.2017.09.002_bib56","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2337\/diab.29.1.S74","article-title":"Transplantation of human fetal pancreas: experience in thymusaplastic mice and rats and in a diabetic patient","volume":"29","author":"Usadel","year":"1980","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.diff.2017.09.002_bib57","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/ng.721","article-title":"Common variants in DGKK are strongly associated with risk of hypospadias","volume":"43","author":"van der Zanden","year":"2011","journal-title":"Nat. Genet."},{"issue":"12","key":"10.1016\/j.diff.2017.09.002_bib58","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0024-3205(92)90204-3","article-title":"Adrenal glands of mouse and rat do not synthesize androgens","volume":"50","author":"van Weerden","year":"1992","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.diff.2017.09.002_bib59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/pros.20225","article-title":"Development and characterization of efficient xenograft models for benign and malignant human prostate tissue","volume":"64","author":"Wang","year":"2005","journal-title":"Prostate"},{"issue":"11","key":"10.1016\/j.diff.2017.09.002_bib60","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/labinvest.3700335","article-title":"An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line","volume":"85","author":"Wang","year":"2005","journal-title":"Lab Investig."},{"issue":"10","key":"10.1016\/j.diff.2017.09.002_bib61","first-page":"2662","article-title":"Intraperitoneal xenografts of human epithelial ovarian cancer in nude mice","volume":"47","author":"Ward","year":"1987","journal-title":"Cancer Res."},{"issue":"1\u20132","key":"10.1016\/j.diff.2017.09.002_bib62","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.mce.2011.08.009","article-title":"Morphology of the external genitalia of the adult male and female mice as an endpoint of sex differentiation","volume":"354","author":"Weiss","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.diff.2017.09.002_bib63","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0016-5085(91)90587-B","article-title":"Human intestine matures as nude mouse xenograft","volume":"100","author":"Winter","year":"1991","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.diff.2017.09.002_bib64","first-page":"2664","article-title":"Complete androgen insensitivity syndrome: long-term medical, surgical, and psychosexual outcome","volume":"85","author":"Wisniewski","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.diff.2017.09.002_bib65","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/ki.2009.73","article-title":"Uroplakins in urothelial biology, function, and disease","volume":"75","author":"Wu","year":"2009","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.diff.2017.09.002_bib66","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.juro.2010.03.051","article-title":"Environmental factors in genitourinary development","volume":"184","author":"Yiee","year":"2010","journal-title":"J. Urol."},{"issue":"1","key":"10.1016\/j.diff.2017.09.002_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000147709","article-title":"Temporal and spatial factors in diethylstilbestrol-induced squamous metaplasia in the developing human prostate. II. persistent changes after removal of diethylstilbestrol","volume":"153","author":"Yonemura","year":"1995","journal-title":"Acta Anat. (Basel)"},{"issue":"52","key":"10.1016\/j.diff.2017.09.002_bib68","doi-asserted-by":"crossref","first-page":"E7194","DOI":"10.1073\/pnas.1515981112","article-title":"Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies","volume":"112","author":"Zheng","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468117300713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468117300713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T06:06:03Z","timestamp":1659506763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301468117300713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":68,"alternative-id":["S0301468117300713"],"URL":"https:\/\/doi.org\/10.1016\/j.diff.2017.09.002","relation":{},"ISSN":["0301-4681"],"issn-type":[{"value":"0301-4681","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renal Subcapsular xenografing of human fetal external genital tissue \u2013 A new model for investigating urethral development","name":"articletitle","label":"Article Title"},{"value":"Differentiation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diff.2017.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}