{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:11:59Z","timestamp":1790662319291,"version":"4.1.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007856","name":"Baylor College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE018215"],"award-info":[{"award-number":["DE018215"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD053509"],"award-info":[{"award-number":["HD053509"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20-RR017702"],"award-info":[{"award-number":["P20-RR017702"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Differentiation"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.diff.2020.11.001","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T11:12:30Z","timestamp":1606475550000},"page":"1-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Gestational folate deficiency alters embryonic gene expression and cell function"],"prefix":"10.1016","volume":"117","author":[{"given":"R.S.","family":"Seelan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Philipose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Pisano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.diff.2020.11.001_bib1","doi-asserted-by":"crossref","first-page":"S202","DOI":"10.1016\/j.ydbio.2018.02.020","article-title":"Characterization of Pax3 and Sox10 transgenic Xenopus laevis embryos as tools to study neural crest development","volume":"444","author":"Alkobtawi","year":"2018","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1056\/NEJM200103223441212","article-title":"Folic acid antagonists during pregnancy and risk of birth defects","volume":"344","author":"Amitai","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.diff.2020.11.001_bib3","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.3390\/ijms18081726","article-title":"Super-resolution localization microscopy of \u03b3-H2AX and heterochromatin after folate deficiency","volume":"18","author":"Bach","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.diff.2020.11.001_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/mgme.1998.2772","article-title":"Expression patterns of folate binding proteins one and two in the developing mouse embryo","volume":"66","author":"Barber","year":"1999","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.diff.2020.11.001_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/bdrc.20100","article-title":"Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression","volume":"81","author":"Beaudin","year":"2007","journal-title":"Birth Defects Res. C Embryo Today."},{"key":"10.1016\/j.diff.2020.11.001_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/bdra.20740","article-title":"Folate pathway and nonsyndromic cleft lip and palate","volume":"91","author":"Blanton","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2020.11.001_bib7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/bdra.20488","article-title":"Genome-wide pathway analysis of folate-responsive genes to unravel the pathogenesis of orofacial clefting in man","volume":"82","author":"Bliek","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2020.11.001_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10545-010-9177-4","article-title":"Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects","volume":"34","author":"Blom","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.diff.2020.11.001_bib9","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1073\/pnas.94.7.3290","article-title":"Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage","volume":"94","author":"Blount","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.diff.2020.11.001_bib10","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1002\/bdra.20732","article-title":"Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and\/or palate in the Brazilian population","volume":"88","author":"Bufalino","year":"2010","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2020.11.001_bib11","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.lfs.2006.10.014","article-title":"Folic acid supplementation delays atherosclerotic lesion development in apoE-deficient mice","volume":"80","author":"Carnicer","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.diff.2020.11.001_bib12","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/jcb.24496","article-title":"Long interspersed nucleotide element-1 hypomethylation in folate-deficient mouse embryonic stem cells","volume":"114","author":"Chang","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.diff.2020.11.001_bib13","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1194\/jlr.R075630","article-title":"Cellular cholesterol homeostasis and Alzheimer's disease","volume":"58","author":"Chang","year":"2017","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.diff.2020.11.001_bib14","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1093\/ajcn\/nqz027","article-title":"Defining the plasma folate concentration associated with the red blood cell folate concentration threshold for optimal neural tube defects prevention: a population-based, randomized trial of folic acid supplementation","volume":"109","author":"Chen","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.diff.2020.11.001_bib15","doi-asserted-by":"crossref","first-page":"13921","DOI":"10.1523\/JNEUROSCI.3343-11.2011","article-title":"SRY-box containing gene 17 regulates the Wnt\/\u03b2-catenin signaling pathway in oligodendrocyte progenitor cells","volume":"31","author":"Chew","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.diff.2020.11.001_bib16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/nrm778","article-title":"Megalin and cubilin: multifunctional endocytic receptors","volume":"3","author":"Christensen","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib17","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.yexcr.2005.04.019","article-title":"Co-expression of SOX9 and SOX10 during melanocytic differentiation in vitro","volume":"308","author":"Cook","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.diff.2020.11.001_bib18","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1093\/hmg\/ddv042","article-title":"Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development","volume":"24","author":"Cunningham","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.diff.2020.11.001_bib19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/ajmg.1320460536","article-title":"Periconceptional multivitamin supplementation and nonneural midline defects","volume":"46","author":"Czeizel","year":"1993","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.diff.2020.11.001_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000266446","article-title":"Orofacial clefts in Hungary. Epidemiological and genetic data, primary prevention","volume":"49","author":"Czeizel","year":"1997","journal-title":"Folia Phoniatrica Logop."},{"key":"10.1016\/j.diff.2020.11.001_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159039","article-title":"Neighborhood deprivation and risk of congenital heart defects, neural tube defects and orofacial clefts: a systematic review and meta-analysis","volume":"11","author":"Deguen","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.diff.2020.11.001_bib22","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1093\/jn\/131.11.2819","article-title":"Folate receptor function is regulated in response to different cellular growth rates in cultured mammalian cells","volume":"131","author":"Doucette","year":"2001","journal-title":"J. Nutr."},{"key":"10.1016\/j.diff.2020.11.001_bib23","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S0899-9007(01)00595-0","article-title":"Folic-acid-mediated inhibition of human colon-cancer cell growth","volume":"17","author":"Duthie","year":"2001","journal-title":"Nutrition"},{"key":"10.1016\/j.diff.2020.11.001_bib24","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1124\/mol.109.055392","article-title":"Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter","volume":"76","author":"Eloranta","year":"2009","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.diff.2020.11.001_bib25","series-title":"Folate and Human Development","article-title":"Vascular disease in women. Folate and homocysteine","author":"Eskes","year":"2002"},{"key":"10.1016\/j.diff.2020.11.001_bib26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40364-015-0049-9","article-title":"Therapeutic potential of folic acid supplementation for cardiovascular disease prevention through homocysteine lowering and blockade in rheumatoid arthritis patients","volume":"3","author":"Essouma","year":"2015","journal-title":"Biomark. Res."},{"key":"10.1016\/j.diff.2020.11.001_bib27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mad.2010.02.004","article-title":"Folate, DNA damage and the aging brain","volume":"131","author":"Fenech","year":"2010","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.diff.2020.11.001_bib28","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/odi.12256","article-title":"The role of the folic acid to the prevention of orofacial cleft: an epidemiological study","volume":"21","author":"Figueiredo","year":"2015","journal-title":"Oral Dis."},{"key":"10.1016\/j.diff.2020.11.001_bib29","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1002\/ajmg.a.38472","article-title":"Mutations in folate transporter genes and risk for human myelomeningocele","volume":"173","author":"Findley","year":"2017","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.diff.2020.11.001_bib30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.pharmtox.42.083001.110955","article-title":"Molecular basis of environmentally induced birth defects","volume":"42","author":"Finnell","year":"2002","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.diff.2020.11.001_bib31","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1194\/jlr.M400188-JLR200","article-title":"apoA-IV tagged with the ER retention signal KDEL perturbs the intracellular trafficking and secretion of apoB","volume":"45","author":"Gallagher","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.diff.2020.11.001_bib32","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/bdra.20453","article-title":"Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation","volume":"82","author":"Gelineau-van Waes","year":"2008","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2020.11.001_bib33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1471-2164-9-156","article-title":"Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex","volume":"9","author":"Gelineau-van Waes","year":"2008","journal-title":"BMC Genom."},{"key":"10.1016\/j.diff.2020.11.001_bib34","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1242\/dev.112672","article-title":"Fox transcription factors: from development to disease","volume":"143","author":"Golson","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.diff.2020.11.001_bib35","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00726-005-0197-6","article-title":"S-adenosylmethionine and protein methylation","volume":"28","author":"Grillo","year":"2005","journal-title":"Amino Acids"},{"key":"10.1016\/j.diff.2020.11.001_bib36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.tem.2013.01.010","article-title":"Folate and fetal programming: a play in epigenomics?","volume":"24","author":"Gu\u00e9ant","year":"2013","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.diff.2020.11.001_bib37","first-page":"321","article-title":"Folbp1 promotes embryonic myocardial cell proliferation and apoptosis through the WNT signal transduction pathway","volume":"23","author":"Han","year":"2009","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.diff.2020.11.001_bib38","doi-asserted-by":"crossref","first-page":"5895628","DOI":"10.1155\/2018\/5895628","article-title":"Global, survival, and apoptotic transcriptome during mouse and human early embryonic development","volume":"2018","author":"Haouzi","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.diff.2020.11.001_bib39","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/(SICI)1096-9926(199911)60:5<292::AID-TERA10>3.0.CO;2-6","article-title":"Mini-review: toward understanding mechanisms of genetic neural tube defects in mice","volume":"60","author":"Harris","year":"1999","journal-title":"Teratology"},{"key":"10.1016\/j.diff.2020.11.001_bib40","first-page":"184","article-title":"Maternal-to-fetal transfer of 5-methyltetrahydrofolate by the perfused human placental cotyledon: evidence for a concentrative role by placental folate receptors in fetal folate delivery","volume":"126","author":"Henderson","year":"1995","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.diff.2020.11.001_bib41","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1056\/NEJM200011303432204","article-title":"Folic acid antagonists during pregnancy and the risk of birth defects","volume":"343","author":"Hernandez-D\u00edaz","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.diff.2020.11.001_bib42","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1172\/JCI118269","article-title":"Apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes","volume":"96","author":"Huang","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.diff.2020.11.001_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/bdra.23003","article-title":"Teratogen update: methotrexate","volume":"94","author":"Hyoun","year":"2012","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2020.11.001_bib44","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1242\/jcs.00389","article-title":"Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins\/occludin by Snail","volume":"116","author":"Ikenouchi","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.diff.2020.11.001_bib45","doi-asserted-by":"crossref","first-page":"20156","DOI":"10.1074\/jbc.273.32.20156","article-title":"Apolipoprotein E inhibits platelet-derived growth factor-induced vascular smooth muscle cell migration and proliferation by suppressing signal transduction and preventing cell entry to G1 phase","volume":"273","author":"Ishigami","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.diff.2020.11.001_bib46","doi-asserted-by":"crossref","first-page":"e534","DOI":"10.1097\/SCS.0000000000004488","article-title":"Maternal folic acid supplementation and the risk of oral clefts in offspring","volume":"29","author":"Jahanbin","year":"2018","journal-title":"J. Craniofac. Surg."},{"key":"10.1016\/j.diff.2020.11.001_bib47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/tera.1420150110","article-title":"Embryotoxicity of the folate antagonist methotrexate in rats and rabbits","volume":"15","author":"Jordan","year":"1977","journal-title":"Teratology"},{"key":"10.1016\/j.diff.2020.11.001_bib48","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/jdb6030022","article-title":"Insights into the etiology of mammalian neural tube closure defects from developmental, genetic and evolutionary studies","volume":"6","author":"Juriloff","year":"2018","journal-title":"J. Dev. Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ydbio.2015.12.016","article-title":"BMPs are direct triggers of interdigital programmed cell death","volume":"411","author":"Kaltcheva","year":"2016","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.lfs.2018.05.029","article-title":"Maternal one carbon metabolism through increased oxidative stress and disturbed angiogenesis can influence placental apoptosis in preeclampsia","volume":"206","author":"Kasture","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.diff.2020.11.001_bib51","doi-asserted-by":"crossref","first-page":"4690","DOI":"10.1073\/pnas.1800138115","article-title":"Formate rescues neural tube defects caused by mutations in Slc25a32","volume":"115","author":"Kim","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.diff.2020.11.001_bib52","doi-asserted-by":"crossref","first-page":"3731S","DOI":"10.1093\/jn\/133.11.3731S","article-title":"Role of folate in colon cancer development and progression","volume":"133","author":"Kim","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.diff.2020.11.001_bib53","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0168-9525(03)00111-2","article-title":"Fox's in development and disease","volume":"19","author":"Lehmann","year":"2003","journal-title":"Trends Genet."},{"key":"10.1016\/j.diff.2020.11.001_bib54","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1177\/0091270009339740","article-title":"Clinical pharmacokinetics and exposure-toxicity relationship of a folate-Vinca alkaloid conjugate EC145 in cancer patients","volume":"49","author":"Li","year":"2009","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.diff.2020.11.001_bib55","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003768","article-title":"Folic acid supplementation and the risk of cardiovascular diseases: a meta-analysis of randomized controlled trials","volume":"5","author":"Li","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.diff.2020.11.001_bib56","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.12659\/MSM.914292","article-title":"Low maternal dietary folate alters retrotranspose by methylation regulation in intrauterine growth retardation (IUGR) fetuses in a mouse model","volume":"25","author":"Li","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.diff.2020.11.001_bib57","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1597\/1545-1569_2001_038_0076_ocavs_2.0.co_2","article-title":"Oral clefts and vitamin supplementation","volume":"38","author":"Loffredo","year":"2001","journal-title":"Cleft Palate Craniofac. J."},{"key":"10.1016\/j.diff.2020.11.001_bib58","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41390-018-0267-6","article-title":"Maternal folic acid supplementation reduces the severity of cleft palate in Tgf-\u03b2(3) null mutant mice","volume":"85","author":"L\u00f3pez-Gordillo","year":"2019","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.diff.2020.11.001_bib59","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/mgme.2000.3027","article-title":"Folic acid: nutritional biochemistry, molecular biology, and role in disease processes","volume":"71","author":"Lucock","year":"2000","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.diff.2020.11.001_bib60","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/ATVBAHA.116.307023","article-title":"Central nervous system lipoproteins: ApoE and regulation of cholesterol metabolism","volume":"36","author":"Mahley","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib61","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000323213","article-title":"Occurrence of cleft-palate and alteration of Tgf-\u03b2(3) expression and the mechanisms leading to palatal fusion in mice following dietary folic-acid deficiency","volume":"194","author":"Maldonado","year":"2011","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.diff.2020.11.001_bib62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.aanat.2018.02.010","article-title":"Craniofacial structure alterations of foetuses from folic acid deficient pregnant mice","volume":"218","author":"Maldonado","year":"2018","journal-title":"Ann. Anat."},{"key":"10.1016\/j.diff.2020.11.001_bib63","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1002\/ajmg.a.37874","article-title":"Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate","volume":"170","author":"Marini","year":"2016","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.diff.2020.11.001_bib64","first-page":"609","article-title":"Fetal myelomeningocele after maternal methotrexate administration: a case report","volume":"61","author":"Martino","year":"2016","journal-title":"J. Reprod. Med."},{"key":"10.1016\/j.diff.2020.11.001_bib65","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/j.1365-2125.2009.03544.x","article-title":"Exposure to folic acid antagonists during the first trimester of pregnancy and the risk of major malformations","volume":"68","author":"Matok","year":"2009","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.diff.2020.11.001_bib66","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0166-2236(03)00032-8","article-title":"Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders","volume":"26","author":"Mattson","year":"2003","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.diff.2020.11.001_bib67","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/dvdy.24403","article-title":"Pdgfra and Pdgfrb genetically interact during craniofacial development","volume":"245","author":"McCarthy","year":"2016","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.diff.2020.11.001_bib68","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/01.moh.0000219654.65538.5b","article-title":"New insights into carrier binding and epithelial uptake of the erythropoietic nutrients cobalamin and folate","volume":"13","author":"Moestrup","year":"2006","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.diff.2020.11.001_bib69","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev.nutr.21.1.407","article-title":"Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia","volume":"21","author":"Moestrup","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.diff.2020.11.001_bib70","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1002\/bdra.20095","article-title":"Developmental gene expression profiling of mammalian, fetal orofacial tissue","volume":"70","author":"Mukhopadhyay","year":"2004","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2020.11.001_bib71","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1097\/00006534-199812000-00050","article-title":"Direct effect of vitamins at the time of palatal fusion","volume":"102","author":"Natsume","year":"1998","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.diff.2020.11.001_bib72","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/13861","article-title":"Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development","volume":"23","author":"Piedrahita","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.diff.2020.11.001_bib73","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3389\/fnmol.2017.00054","article-title":"Functional roles of the interaction of APP and lipoprotein receptors","volume":"10","author":"Pohlkamp","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.diff.2020.11.001_bib74","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mod.2018.07.003","article-title":"A catenin-dependent balance between N-cadherin and E-cadherin controls neuroectodermal cell fate choices","volume":"152","author":"Rogers","year":"2018","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2020.11.001_bib75","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/1073858410373835","article-title":"Cholesterol: a novel regulatory role in myelin formation","volume":"17","author":"Saher","year":"2011","journal-title":"Neuroscientist"},{"key":"10.1016\/j.diff.2020.11.001_bib76","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/dvdy.10203","article-title":"Spatial and temporal expression of folate-binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice","volume":"226","author":"Saitsu","year":"2003","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.diff.2020.11.001_bib77","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrm2428","article-title":"A gene regulatory network orchestrates neural crest formation","volume":"9","author":"Sauka-Spengler","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib78","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/B978-0-12-398397-8.00006-X","article-title":"Genetic and epigenetic footprints of folate","volume":"108","author":"Salbaum","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.diff.2020.11.001_bib79","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.ajhg.2012.10.013","article-title":"Recurrent de novo mutations in PACS1 cause defective cranial-neural-crest migration and define a recognizable intellectual-disability syndrome","volume":"91","author":"Schuurs-Hoeijmakers","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.diff.2020.11.001_bib80","doi-asserted-by":"crossref","DOI":"10.1088\/1478-3975\/5\/4\/044002","article-title":"Folate and S-adenosylmethionine modulate synaptic activity in cultured cortical neurons: acute differential impact on normal and apolipoprotein-deficient mice","volume":"5","author":"Serra","year":"2008","journal-title":"Phys. Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib81","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/oxfordjournals.aje.a009555","article-title":"Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida","volume":"148","author":"Shaw","year":"1998","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.diff.2020.11.001_bib82","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00001648-199505000-00005","article-title":"Periconceptional vitamin use, dietary folate, and the occurrence of neural tube defects","volume":"6","author":"Shaw","year":"1995","journal-title":"Epidemiology"},{"key":"10.1016\/j.diff.2020.11.001_bib83","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0925-4773(01)00547-0","article-title":"Development and degeneration of dorsal root ganglia in the absence of the HMG-domain transcription factor Sox10","volume":"109","author":"Sonnenberg-Riethmacher","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2020.11.001_bib84","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S1673-8527(08)60116-2","article-title":"The common MTHFR C677T and A1298C variants are not associated with the risk of non-syndromic cleft lip\/palate in northern Venezuela","volume":"36","author":"S\u00f6zen","year":"2009","journal-title":"J. Genet. Genomics."},{"key":"10.1016\/j.diff.2020.11.001_bib85","doi-asserted-by":"crossref","first-page":"C95","DOI":"10.1152\/ajpcell.00388.2005","article-title":"Apolipoprotein A-IV attenuates oxidant-induced apoptosis in mitotic competent, undifferentiated cells by modulating intracellular glutathione redox balance","volume":"290","author":"Spaulding","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.diff.2020.11.001_bib86","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1023\/B:NERE.0000023597.37698.13","article-title":"Folate-regulated changes in gene expression in the anterior neural tube of folate binding protein-1 (Folbp1)-deficient murine embryos","volume":"29","author":"Spiegelstein","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.diff.2020.11.001_bib87","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-1119(00)00418-2","article-title":"Identification of two putative novel folate receptor genes in humans and mouse","volume":"258","author":"Spiegelstein","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.diff.2020.11.001_bib88","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev-genet-120417-031559","article-title":"Mechanisms of neural crest migration","volume":"52","author":"Szab\u00f3","year":"2018","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.diff.2020.11.001_bib89","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/bdra.10045","article-title":"Neural and orofacial defects in Folp1 knockout mice","volume":"67","author":"Tang","year":"2003","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.diff.2020.11.001_bib90","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajmg.c.30053","article-title":"Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies","volume":"135C","author":"Tang","year":"2005","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.diff.2020.11.001_bib91","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/10284150500502561","article-title":"Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency under oxidative challenge: modulation by apolipoprotein E-deficiency","volume":"9","author":"Tchantchou","year":"2006","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.diff.2020.11.001_bib92","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S0955-0674(00)00273-8","article-title":"Hox genes, neural crest cells and branchial arch patterning","volume":"13","author":"Trainor","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib93","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ydbio.2004.07.041","article-title":"A balance between the anti-apoptotic activity of Slug and the apoptotic activity of msx1 is required for the proper development of the neural crest","volume":"275","author":"Tr\u00edbulo","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib94","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/ajmg.a.37539","article-title":"Evaluation of proton-coupled folate transporter (SLC46A1) polymorphisms as risk factors for neural tube defects and oral clefts","volume":"170A","author":"VanderMeer","year":"2016","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.diff.2020.11.001_bib95","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ydbio.2015.07.001","article-title":"The role of folate metabolism in orofacial development and clefting","volume":"405","author":"Wahl","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.diff.2020.11.001_bib96","doi-asserted-by":"crossref","first-page":"1222002","DOI":"10.1126\/science.1222002","article-title":"The continuing challenge of understanding, preventing, and treating neural tube defects","volume":"339","author":"Wallingford","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.diff.2020.11.001_bib97","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3390\/ijerph10020590","article-title":"High dosage folic acid supplementation, oral cleft recurrence and fetal growth","volume":"10","author":"Wehby","year":"2013","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.diff.2020.11.001_bib98","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3164\/jcbn.08-223","article-title":"Folate deficiency induces neural stem cell apoptosis by increasing homocysteine in vitro","volume":"45","author":"Zhang","year":"2009","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.diff.2020.11.001_bib99","doi-asserted-by":"crossref","first-page":"10224","DOI":"10.1074\/jbc.C000905200","article-title":"Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs","volume":"276","author":"Zhao","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.diff.2020.11.001_bib100","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/bdra.20347","article-title":"Cardiovascular abnormalities in Folr1 knockout mice and folate rescue","volume":"79","author":"Zhu","year":"2007","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."}],"container-title":["Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468120300736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468120300736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:06:47Z","timestamp":1759565207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301468120300736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":100,"alternative-id":["S0301468120300736"],"URL":"https:\/\/doi.org\/10.1016\/j.diff.2020.11.001","relation":{},"ISSN":["0301-4681"],"issn-type":[{"value":"0301-4681","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational folate deficiency alters embryonic gene expression and cell function","name":"articletitle","label":"Article Title"},{"value":"Differentiation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diff.2020.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}