{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T13:25:34Z","timestamp":1789046734141,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"am","delay-in-days":368,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 DE030045"],"award-info":[{"award-number":["R35 DE030045"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Differentiation"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.diff.2022.06.001","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T19:51:18Z","timestamp":1656877878000},"page":"10-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Piezo channels for skeletal development and homeostasis: Insights from mouse genetic models"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-4020","authenticated-orcid":false,"given":"Xuguang","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Kyo","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.diff.2022.06.001_bib1","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1038\/s41467-020-16971-6","article-title":"Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity","volume":"11","author":"Assaraf","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.diff.2022.06.001_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115247","article-title":"Identification of PIEZO1 polymorphisms for human bone mineral density","volume":"133","author":"Bai","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.diff.2022.06.001_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2021.102431","article-title":"Mechanosensitive Piezo1 in endothelial cells promotes angiogenesis to support bone fracture repair","volume":"97","author":"Chen","year":"2021","journal-title":"Cell Calcium"},{"issue":"14","key":"10.1016\/j.diff.2022.06.001_bib4","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJMoa1602812","article-title":"The role of PIEZO2 in human mechanosensation","volume":"375","author":"Chesler","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"6000","key":"10.1016\/j.diff.2022.06.001_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.diff.2022.06.001_bib6","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.33149","article-title":"Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells","volume":"7","author":"Del Marmol","year":"2018","journal-title":"Elife"},{"issue":"6","key":"10.1016\/j.diff.2022.06.001_bib7","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.ajhg.2016.11.009","article-title":"Biallelic loss of proprioception-related PIEZO2 causes muscular atrophy with perinatal respiratory distress, arthrogryposis, and scoliosis","volume":"99","author":"Delle Vedove","year":"2016","journal-title":"Am. J. Hum. Genet."},{"issue":"3","key":"10.1016\/j.diff.2022.06.001_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103343","article-title":"Periosteal CD68(+) F4\/80(+) macrophages are mechanosensitive for cortical bone formation by secretion and activation of TGF-beta 1","volume":"9","author":"Deng","year":"2022","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.diff.2022.06.001_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13578-020-00522-z","article-title":"Structure, kinetic properties and biological function of mechanosensitive Piezo channels","volume":"11","author":"Fang","year":"2021","journal-title":"Cell Biosci."},{"issue":"7","key":"10.1016\/j.diff.2022.06.001_bib10","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.joen.2017.02.022","article-title":"Role of Piezo channels in ultrasound-stimulated dental stem cells","volume":"43","author":"Gao","year":"2017","journal-title":"J. Endod."},{"issue":"2","key":"10.1016\/j.diff.2022.06.001_bib11","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jbmr.4198","article-title":"Piezo1 inactivation in chondrocytes impairs trabecular bone formation","volume":"36","author":"Hendrickx","year":"2021","journal-title":"J. Bone Miner. Res."},{"issue":"47","key":"10.1016\/j.diff.2022.06.001_bib12","doi-asserted-by":"crossref","first-page":"E5114","DOI":"10.1073\/pnas.1414298111","article-title":"Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage","volume":"111","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"13","key":"10.1016\/j.diff.2022.06.001_bib13","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2001611118","article-title":"Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis","volume":"118","author":"Lee","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.diff.2022.06.001_bib14","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49631","article-title":"Stimulation of Piezo1 by mechanical signals promotes bone anabolism","volume":"8","author":"Li","year":"2019","journal-title":"Elife"},{"issue":"11","key":"10.1016\/j.diff.2022.06.001_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn0485","article-title":"Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states","volume":"8","author":"Ma","year":"2022","journal-title":"Sci. Adv."},{"issue":"9","key":"10.1016\/j.diff.2022.06.001_bib16","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031344","article-title":"Neural regulation of bone and bone marrow","volume":"8","author":"Maryanovich","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"1","key":"10.1016\/j.diff.2022.06.001_bib17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.nmd.2018.10.005","article-title":"A novel nonsense PIEZO2 mutation in a family with scoliosis and proprioceptive defect","volume":"29","author":"Masingue","year":"2019","journal-title":"Neuromuscul. Disord."},{"issue":"6","key":"10.1016\/j.diff.2022.06.001_bib18","doi-asserted-by":"crossref","first-page":"e268","DOI":"10.3324\/haematol.2019.231159","article-title":"PIEZO1 gain-of-function mutations delay reticulocyte maturation in hereditary xerocytosis","volume":"105","author":"Moura","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.diff.2022.06.001_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.644929","article-title":"Piezo2 knockdown inhibits noxious mechanical stimulation and NGF-induced sensitization in A-delta bone afferent neurons","volume":"12","author":"Nencini","year":"2021","journal-title":"Front. Physiol."},{"issue":"50","key":"10.1016\/j.diff.2022.06.001_bib20","doi-asserted-by":"crossref","first-page":"12817","DOI":"10.1073\/pnas.1817070115","article-title":"Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation","volume":"115","author":"Nonomura","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7636","key":"10.1016\/j.diff.2022.06.001_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature20793","article-title":"Piezo2 senses airway stretch and mediates lung inflation-induced apnoea","volume":"541","author":"Nonomura","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.diff.2022.06.001_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2017.06.018","article-title":"How cells channel their stress: interplay between Piezo1 and the cytoskeleton","volume":"71","author":"Nourse","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"issue":"8","key":"10.1016\/j.diff.2022.06.001_bib23","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1073\/pnas.1718177115","article-title":"Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses","volume":"115","author":"Pardo-Pastor","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"45","key":"10.1016\/j.diff.2022.06.001_bib24","doi-asserted-by":"crossref","first-page":"16148","DOI":"10.1073\/pnas.1409802111","article-title":"Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells","volume":"111","author":"Pathak","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.diff.2022.06.001_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41413-021-00168-8","article-title":"Roles of mechanosensitive channel Piezo1\/2 proteins in skeleton and other tissues","volume":"9","author":"Qin","year":"2021","journal-title":"Bone Res"},{"issue":"28","key":"10.1016\/j.diff.2022.06.001_bib26","doi-asserted-by":"crossref","first-page":"10347","DOI":"10.1073\/pnas.1409233111","article-title":"Piezo1, a mechanically activated ion channel, is required for vascular development in mice","volume":"111","author":"Ranade","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.diff.2022.06.001_bib27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00424-022-02667-x","article-title":"Nobel somatosensations and pain","volume":"474","author":"Reeh","year":"2022","journal-title":"Pflueg. Arch. Eur. J. Physiol."},{"issue":"1","key":"10.1016\/j.diff.2022.06.001_bib28","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41467-017-00429-3","article-title":"Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance","volume":"8","author":"Rode","year":"2017","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.diff.2022.06.001_bib29","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.3324\/haematol.2018.202697","article-title":"A gain of function variant in PIEZO1 (E756del) and sickle cell disease","volume":"104","author":"Rooks","year":"2019","journal-title":"Haematologica"},{"issue":"7850","key":"10.1016\/j.diff.2022.06.001_bib30","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41586-021-03298-5","article-title":"A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis","volume":"591","author":"Shen","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.diff.2022.06.001_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-18089-0","article-title":"Piezo type mechanosensitive ion channel component 1 functions as a regulator of the cell fate determination of mesenchymal stem cells","volume":"7","author":"Sugimoto","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.diff.2022.06.001_bib32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cell.2020.06.022","article-title":"RNA sensing by gut Piezo1 is essential for systemic serotonin synthesis","volume":"182","author":"Sugisawa","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.diff.2022.06.001_bib33","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47454","article-title":"The mechanosensitive Piezo1 channel is required for bone formation","volume":"8","author":"Sun","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.diff.2022.06.001_bib34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev-neuro-093020-120939","article-title":"Physiology and pathophysiology of mechanically activated PIEZO channels","volume":"44","author":"Syeda","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.diff.2022.06.001_bib35","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1016\/j.celrep.2017.11.035","article-title":"Cell-type-specific splicing of Piezo2 regulates mechanotransduction","volume":"21","author":"Szczot","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.diff.2022.06.001_bib36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fnmol.2019.00178","article-title":"PIEZO1 is selectively expressed in small diameter mouse DRG neurons distinct from neurons strongly expressing TRPV1","volume":"12","author":"Wang","year":"2019","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.diff.2022.06.001_bib37","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41467-019-14146-6","article-title":"Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.diff.2022.06.001_bib38","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1172\/JCI87343","article-title":"Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release","volume":"126","author":"Wang","year":"2016","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.diff.2022.06.001_bib39","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/nn.4162","article-title":"Piezo2 is the principal mechanotransduction channel for proprioception","volume":"18","author":"Woo","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"12","key":"10.1016\/j.diff.2022.06.001_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126429","article-title":"Piezo channels: awesome mechanosensitive structures in cellular mechanotransduction and their role in bone","volume":"22","author":"Xu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.diff.2022.06.001_bib41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52779","article-title":"Piezo1\/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin","volume":"9","author":"Zhou","year":"2020","journal-title":"Elife"}],"container-title":["Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468122000512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468122000512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:07:30Z","timestamp":1759565250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301468122000512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":41,"alternative-id":["S0301468122000512"],"URL":"https:\/\/doi.org\/10.1016\/j.diff.2022.06.001","relation":{},"ISSN":["0301-4681"],"issn-type":[{"value":"0301-4681","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Piezo channels for skeletal development and homeostasis: Insights from mouse genetic models","name":"articletitle","label":"Article Title"},{"value":"Differentiation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diff.2022.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}