{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T13:17:48Z","timestamp":1781875068623,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Differentiation"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.diff.2023.10.005","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T18:58:51Z","timestamp":1699383531000},"page":"100737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["FGF20"],"prefix":"10.1016","volume":"139","author":[{"given":"Justine D.","family":"Van Greenen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2613-6216","authenticated-orcid":false,"given":"Dorit","family":"Hockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diff.2023.10.005_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/oxfordjournals.jhered.a106685","article-title":"Scaleless, an inherited ectodermal defect in the domestic fowl","volume":"48","author":"Abbott","year":"1957","journal-title":"J. Hered."},{"key":"10.1016\/j.diff.2023.10.005_bib2","first-page":"3454","article-title":"Preclinical characterization of CG53135 (FGF-20) in radiation and concomitant chemotherapy\/radiation-induced oral mucositis","volume":"9","author":"Alvarez","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.diff.2023.10.005_bib3","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.devcel.2012.04.018","article-title":"FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man","volume":"22","author":"Barak","year":"2012","journal-title":"Dev. Cell"},{"key":"10.1016\/j.diff.2023.10.005_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrd2792","article-title":"The FGF family: biology, pathophysiology and therapy","volume":"8","author":"Beenken","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.diff.2023.10.005_bib5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neuropharm.2018.04.017","article-title":"Fibroblast growth factor 20 is protective towards dopaminergic neurons in vivo in a paracrine manner","volume":"137","author":"Boshoff","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.diff.2023.10.005_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004951","article-title":"Characterisation of the fibroblast growth factor dependent transcriptome in early development","volume":"4","author":"Branney","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.diff.2023.10.005_bib7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.emboj.7600460","article-title":"FGF-20 and DKK1 are transcriptional targets of \u03b2-catenin and FGF-20 is implicated in cancer and development","volume":"24","author":"Chamorro","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.diff.2023.10.005_bib8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41419-022-04724-w","article-title":"Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.diff.2023.10.005_bib9","article-title":"Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients","volume":"5","author":"Clarimon","year":"2005","journal-title":"BMC Neurol."},{"key":"10.1016\/j.diff.2023.10.005_bib10","first-page":"3389","article-title":"Fibroblast growth factor-20 increases the yield of midbrain dopaminergic neurons derived from human embryonic stem cells","volume":"110","author":"Correia","year":"2007","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.diff.2023.10.005_bib11","doi-asserted-by":"crossref","first-page":"D988","DOI":"10.1093\/nar\/gkab1049","article-title":"Ensembl 2022","volume":"50","author":"Cunningham","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.diff.2023.10.005_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.neulet.2010.05.019","article-title":"FGF20 rs12720208 SNP and microRNA-433 variation: No association with Parkinson's disease in Spanish patients","volume":"479","author":"de Mena","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.diff.2023.10.005_bib13","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1038\/s41598-017-04637-1","article-title":"Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty","volume":"7","author":"Elo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.diff.2023.10.005_bib14","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/mp060097h","article-title":"Effects of pH and polyanions on the thermal stability of fibroblast growth factor 20","volume":"4","author":"Fan","year":"2007","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.diff.2023.10.005_bib15","first-page":"bax028","article-title":"GeneHancer: genome-wide integration of enhancers and target genes in GeneCards","author":"Fishilevich","year":"2017","journal-title":"Database"},{"key":"10.1016\/j.diff.2023.10.005_bib16","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.diff.2023.10.005_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.nbd.2004.07.007","article-title":"Fibroblast growth factor-20 promotes the differentiation of Nurr1-overexpressing neural stem cells into tyrosine hydroxylase-positive neurons","volume":"17","author":"Grothe","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.diff.2023.10.005_bib18","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1242\/dev.079558","article-title":"Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling","volume":"139","author":"H\u00e4\u00e4r\u00e4","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.diff.2023.10.005_bib19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jns.2015.05.020","article-title":"Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population","volume":"355","author":"Haghnejad","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.diff.2023.10.005_bib20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0925-4773(01)00656-6","article-title":"Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development","volume":"113","author":"Hajihosseini","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.diff.2023.10.005_bib21","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1523\/JNEUROSCI.1690-08.2008","article-title":"Fgf20 is required for sensory epithelial specification in the developing cochlea","volume":"28","author":"Hayashi","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.diff.2023.10.005_bib22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/hmg\/ddac258","article-title":"FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies","volume":"32","author":"Hecker","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.diff.2023.10.005_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001231","article-title":"Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal","volume":"10","author":"Huh","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.diff.2023.10.005_bib24","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05921","article-title":"Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling","volume":"4","author":"Huh","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.diff.2023.10.005_bib25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1101\/gad.198945.112","article-title":"Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles","volume":"27","author":"Huh","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.diff.2023.10.005_bib26","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1053\/gast.2002.36041","article-title":"A novel human fibroblast growth factor treats experimental intestinal inflammation","volume":"123","author":"Jeffers","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.diff.2023.10.005_bib27","first-page":"3131","article-title":"Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis","volume":"61","author":"Jeffers","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.diff.2023.10.005_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh2169","article-title":"A single\u2013cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.diff.2023.10.005_bib29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/bbrc.2000.3142","article-title":"Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22","volume":"274","author":"Kirikoshi","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.diff.2023.10.005_bib30","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1006\/bbrc.1999.1039","article-title":"Characterization of a novel member of the FGF family, XFGF-20, in Xenopus laevis","volume":"261","author":"Koga","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.diff.2023.10.005_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082148","article-title":"Functional roles of fgf signaling in early development of vertebrate embryos","author":"Kumar","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.diff.2023.10.005_bib32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.devcel.2004.12.002","article-title":"Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo","volume":"8","author":"Lavine","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.diff.2023.10.005_bib33","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/dvdy.21913","article-title":"Temporal and spatial expression of FGF ligands and receptors during Xenopus development","volume":"238","author":"Lea","year":"2009","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.diff.2023.10.005_bib34","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1038\/onc.2009.139","article-title":"Anchorage-independent cell growth signature identifies tumors with metastatic potential","volume":"28","author":"Mori","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.diff.2023.10.005_bib35","doi-asserted-by":"crossref","first-page":"9750","DOI":"10.1523\/JNEUROSCI.2745-06.2006","article-title":"A specific survival response in dopamine neurons at most risk in Parkinson's disease","volume":"26","author":"Murase","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.diff.2023.10.005_bib36","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jnr.10592","article-title":"Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c","volume":"72","author":"Ohmachi","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.diff.2023.10.005_bib37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/bbrc.2000.3675","article-title":"FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain","volume":"277","author":"Ohmachi","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.diff.2023.10.005_bib38","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.parkreldis.2012.01.017","article-title":"Fibroblast growth factor 20 (FGF20) polymorphism is a risk factor for Parkinson's disease in Chinese population","volume":"18","author":"Pan","year":"2012","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.diff.2023.10.005_bib39","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1469-7580.2011.01352.x","article-title":"Expression of fibroblast growth factors (Fgfs) in murine tooth development","volume":"218","author":"Porntaveetus","year":"2011","journal-title":"J. Anat."},{"key":"10.1016\/j.diff.2023.10.005_bib40","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1074\/jbc.275.11.8083","article-title":"Fibroblast growth factor 9 secretion is mediated by a non-cleaved amino-terminal signal sequence","volume":"275","author":"Revest","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.diff.2023.10.005_bib41","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neulet.2018.03.059","article-title":"Evaluation of FGF 20 variants for susceptibility to Parkinson's disease in Eastern Indians","volume":"675","author":"Sadhukhan","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.diff.2023.10.005_bib42","doi-asserted-by":"crossref","DOI":"10.1097\/WNR.0b013e328133265b","article-title":"Fibroblast growth factor 20 gene and Parkinson's disease in the Japanese population","volume":"18","author":"Satake","year":"2007","journal-title":"Neuroreport"},{"key":"10.1016\/j.diff.2023.10.005_bib43","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jbiosc.2008.12.013","article-title":"Differentiation of dopaminergic neurons from human embryonic stem cells: modulation of differentiation by FGF-20","volume":"107","author":"Shimada","year":"2009","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.diff.2023.10.005_bib44","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1073\/pnas.0509567103","article-title":"Lewy bodies","volume":"103","author":"Shults","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.diff.2023.10.005_bib45","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.neuropharm.2012.07.029","article-title":"Fibroblast growth factor-20 protects against dopamine neuron loss in vitro and provides functional protection in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease","volume":"63","author":"Sleeman","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.diff.2023.10.005_bib46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1172\/JCI21137","article-title":"Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model","volume":"115","author":"Takagi","year":"2005","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.diff.2023.10.005_bib47","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1134\/S1022795412090086","article-title":"Analysis of the rs12720208 single-nucleotide polymorphism of the FGF20 gene in Russian patients with sporadic Parkinson's disease","volume":"48","author":"Ustinova","year":"2012","journal-title":"Russ. J. Genet."},{"key":"10.1016\/j.diff.2023.10.005_bib48","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1086\/421052","article-title":"Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease","volume":"74","author":"van der Walt","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.diff.2023.10.005_bib49","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ajhg.2007.09.021","article-title":"Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of \u03b1-synuclein","volume":"82","author":"Wang","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.diff.2023.10.005_bib50","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1080\/01616412.2017.1286542","article-title":"Quantitative assessment of the effect of FGF20 rs12720208 variant on the risk of Parkinson's disease: a meta-analysis","volume":"39","author":"Wang","year":"2017","journal-title":"Neurol. Res."},{"key":"10.1016\/j.diff.2023.10.005_bib51","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/1471-2164-13-257","article-title":"Genome-wide SNP scan of pooled DNA reveals nonsense mutation in FGF20 in the scaleless line of featherless chickens","volume":"13","author":"Wells","year":"2012","journal-title":"BMC Genom."},{"key":"10.1016\/j.diff.2023.10.005_bib52","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/mds.22442","article-title":"FGF20 and Parkinson's disease: No evidence of association or pathogenicity via \u03b1-synuclein expression","volume":"24","author":"Wider","year":"2009","journal-title":"Mov. Disord."},{"key":"10.1016\/j.diff.2023.10.005_bib53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41392-020-00222-7","article-title":"FGF\/FGFR signaling in health and disease","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.diff.2023.10.005_bib54","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.jocn.2013.02.023","article-title":"Fibroblast growth factor 20 polymorphism in sporadic Parkinson's disease in Northern Han Chinese","volume":"20","author":"Xu","year":"2013","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.diff.2023.10.005_bib55","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.devcel.2018.07.010","article-title":"FGF20-Expressing, Wnt-responsive olfactory epithelial progenitors regulate underlying turbinate growth to optimize surface area","volume":"46","author":"Yang","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.diff.2023.10.005_bib56","doi-asserted-by":"crossref","first-page":"15694","DOI":"10.1074\/jbc.M601252200","article-title":"Receptor specificity of the fibroblast growth factor family: the complete mammalian FGF family","volume":"281","author":"Zhang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.diff.2023.10.005_bib57","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1101\/gad.1929210","article-title":"Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms","volume":"24","author":"Zhang","year":"2010","journal-title":"Genes Dev."}],"container-title":["Differentiation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468123000762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301468123000762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T05:24:28Z","timestamp":1726032268000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301468123000762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":57,"alternative-id":["S0301468123000762"],"URL":"https:\/\/doi.org\/10.1016\/j.diff.2023.10.005","relation":{},"ISSN":["0301-4681"],"issn-type":[{"value":"0301-4681","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FGF20","name":"articletitle","label":"Article Title"},{"value":"Differentiation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diff.2023.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V. on behalf of International Society of Differentiation.","name":"copyright","label":"Copyright"}],"article-number":"100737"}}