{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:51:00Z","timestamp":1790553060912,"version":"4.1.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic and Interventional Imaging"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.diii.2019.02.011","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T18:53:04Z","timestamp":1553885584000},"page":"391-400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Interventional radiology techniques for pain reduction and mobility improvement in patients with knee osteoarthritis"],"prefix":"10.1016","volume":"100","author":[{"given":"D.","family":"Filippiadis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Charalampopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mazioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Alexopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vrachliotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Brountzos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kelekis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kelekis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.diii.2019.02.011_bib0495","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/01.phm.0000245568.69434.1a","article-title":"Osteoarthritis: epidemiology, risk factors, and pathophysiology","volume":"85","author":"Garstang","year":"2006","journal-title":"Am J Phys Med Rehabil"},{"key":"10.1016\/j.diii.2019.02.011_bib0500","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/j.pmrj.2012.02.004","article-title":"Imaging techniques in osteoarthritis","volume":"4","author":"Hunter","year":"2012","journal-title":"PM R"},{"key":"10.1016\/j.diii.2019.02.011_bib0505","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.joca.2016.12.009","article-title":"Osteoarthritis year in review 2016: Imaging","volume":"25","author":"Boesen","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0510","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.diii.2016.08.008","article-title":"Assessment of anterior subcutaneous hypersignal on proton-density-weighted MR imaging of the knee and relationship with anterior knee pain","volume":"98","author":"Unlu","year":"2017","journal-title":"Diagn Interv Imaging"},{"key":"10.1016\/j.diii.2019.02.011_bib0515","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.diii.2018.01.011","article-title":"Fused micro-computed tomography (\u03bcCT) and histological images of bone specimens","volume":"99","author":"Mourad","year":"2018","journal-title":"Diagn Interv Imaging"},{"key":"10.1016\/j.diii.2019.02.011_bib0520","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.arthro.2016.09.024","article-title":"Efficacy of platelet-rich plasma in the treatment of knee osteoarthritis: a meta-analysis of randomized controlled trials","volume":"33","author":"Dai","year":"2017","journal-title":"Arthroscopy"},{"key":"10.1016\/j.diii.2019.02.011_bib0525","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/acr.23013","article-title":"Efficacy of tailored exercise therapy on physical functioning in patients with knee osteoarthritis and comorbidity: a randomized controlled trial","volume":"69","author":"de Rooij","year":"2017","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.diii.2019.02.011_bib0530","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1080\/02656736.2017.1409910","article-title":"Intra-articular application of pulsed radiofrequency combined with viscosupplementation for improvement of knee osteoarthritis symptoms: a single centre prospective study","volume":"34","author":"Filippiadis","year":"2018","journal-title":"Int J Hyperthermia"},{"key":"10.1016\/j.diii.2019.02.011_bib0535","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.joca.2015.07.013","article-title":"The efficacy of non-surgical treatment on pain and sensitization in patients with knee osteoarthritis: a pre-defined ancillary analysis from a randomized controlled trial","volume":"24","author":"Skou","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0540","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1302\/0301-620X.100B1.BJJ-2017-0918.R1","article-title":"A pilot randomized trial of meniscal allograft transplantation versus personalized physiotherapy for patients with a symptomatic meniscal deficient knee compartment","volume":"100","author":"Smith","year":"2018","journal-title":"Bone Joint J"},{"key":"10.1016\/j.diii.2019.02.011_bib0545","article-title":"EUROVISCO Recommendations for optimizing the clinical results of viscosupplementation in osteoarthritis","author":"Conrozier","year":"2018","journal-title":"CART"},{"key":"10.1016\/j.diii.2019.02.011_bib0550","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11926-018-0765-x","article-title":"Current concepts and future directions of minimally invasive treatment for knee pain","volume":"20","author":"Goldman","year":"2018","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.diii.2019.02.011_bib0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.csm.2013.08.002","article-title":"Nonoperative treatment of unicompartmental arthritis: from bracing to injection","volume":"33","author":"Bert","year":"2014","journal-title":"Clin Sports Med"},{"key":"10.1016\/j.diii.2019.02.011_bib0560","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41536-018-0041-8","article-title":"Effectiveness of mesenchymal stem cells for treating patients with knee osteoarthritis: a meta-analysis toward the establishment of effective regenerative rehabilitation","volume":"3","author":"Iijima","year":"2018","journal-title":"NPJ Regen Med"},{"key":"10.1016\/j.diii.2019.02.011_bib0565","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","article-title":"OARSI guidelines for the non-surgical management of knee osteoarthritis","volume":"22","author":"McAlindon","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0570","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1302\/0301-620X.40B4.636","article-title":"The value of intra-articular injections in osteoarthritis of the knee","volume":"40","author":"Miller","year":"1958","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.diii.2019.02.011_bib0575","doi-asserted-by":"crossref","first-page":"182","DOI":"10.11138\/ccmbm\/2017.14.1.182","article-title":"Hyaluronic acid vs corticosteroids in symptomatic knee osteoarthritis: a mini-review of the literature","volume":"14","author":"Bisicchia","year":"2017","journal-title":"Clin Cases Miner Bone Metab"},{"key":"10.1016\/j.diii.2019.02.011_bib0580","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2165\/00003495-199652040-00004","article-title":"Intra-articular corticosteroids: guide to selection and indications for use","volume":"52","author":"Caldwell","year":"1996","journal-title":"Drugs"},{"key":"10.1016\/j.diii.2019.02.011_bib0585","first-page":"95","article-title":"Intra-articular corticosteroids in arthritic disease: a guide to treatment","volume":"9","author":"Ostergaard","year":"1998","journal-title":"Bio Drugs"},{"key":"10.1016\/j.diii.2019.02.011_bib0590","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/00002281-199909000-00016","article-title":"Intra-articular corticosteroid treatment in osteoarthritis","volume":"11","author":"Creamer","year":"1999","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.diii.2019.02.011_bib0595","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1742-1241.2012.02963.x","article-title":"Corticosteroid injection into the osteoarthritic knee: drug selection, dose, and injection frequency","volume":"66","author":"Douglas","year":"2012","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.diii.2019.02.011_bib0600","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jcot.2016.09.008","article-title":"Intra-articular hyaluronic acid is superior to steroids in knee osteoarthritis: A comparative, randomized study","volume":"8","author":"Vaishya","year":"2017","journal-title":"J Clin Orthop Trauma"},{"key":"10.1016\/j.diii.2019.02.011_bib0605","first-page":"Cd005328","article-title":"Intraarticular corticosteroid for treatment of osteoarthritis of the knee","author":"Bellamy","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.diii.2019.02.011_bib0610","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1001\/jama.2016.17565","article-title":"Intra-articular corticosteroids for osteoarthritis of the knee","volume":"316","author":"da Costa","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.diii.2019.02.011_bib0615","first-page":"204","article-title":"Brief report: a phase IIb trial of a novel extended-release microsphere formulation of triamcinolone acetonide for intraarticular injection in knee osteoarthritis","volume":"70","author":"Conaghan","year":"2018","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.diii.2019.02.011_bib0620","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.joca.2007.10.011","article-title":"A randomised controlled trial of tidal irrigation vs corticosteroid injection in knee osteoarthritis: the KIVIS Study","volume":"16","author":"Arden","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0625","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/ard.54.5.379","article-title":"Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response","volume":"54","author":"Gaffney","year":"1995","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.diii.2019.02.011_bib0630","doi-asserted-by":"crossref","first-page":"e0191342","DOI":"10.1371\/journal.pone.0191342","article-title":"Clinical and ultrasonographic features associated to response to intraarticular corticosteroid injection: a one year follow up prospective cohort study in knee osteoarthritis patient with joint effusion","volume":"13","author":"Calvet","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.diii.2019.02.011_bib0635","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.3899\/jrheum.171385","article-title":"Longterm effectiveness of intraarticular injections on patient-reported symptoms in knee osteoarthritis","volume":"45","author":"Liu","year":"2018","journal-title":"J Rheumatol"},{"key":"10.1016\/j.diii.2019.02.011_bib0640","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1001\/jama.2017.5283","article-title":"Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial","volume":"317","author":"McAlindon","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.diii.2019.02.011_bib0645","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/14740338.2017.1344211","article-title":"The safety of intra-articular injections for the treatment of knee osteoarthritis: a critical narrative review","volume":"16","author":"Nguyen","year":"2017","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.diii.2019.02.011_bib0650","first-page":"Cd005328","article-title":"Intra-articular corticosteroid for knee osteoarthritis","author":"Uni","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.diii.2019.02.011_bib0655","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.clinthera.2016.11.023","article-title":"Efficacy of methylprednisolone acetate versus triamcinolone acetonide intra-articular knee injection in patients with chronicinflammatory aathritis: a 24-week randomized controlled trial","volume":"39","author":"Kumar","year":"2017","journal-title":"Clin Ther"},{"key":"10.1016\/j.diii.2019.02.011_bib0660","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/art.1780100407","article-title":"Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritis human fluids","volume":"10","author":"Balazs","year":"1967","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.diii.2019.02.011_bib0665","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/bip.1968.360060603","article-title":"Rheology of hyaluronic acid","volume":"6","author":"Gibbs","year":"1968","journal-title":"Biopolymers"},{"key":"10.1016\/j.diii.2019.02.011_bib0670","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1365-2796.1997.00170.x","article-title":"its nature, distribution, functions and turnover","volume":"242","author":"Fraser","year":"1997","journal-title":"J Intern Med"},{"key":"10.1016\/j.diii.2019.02.011_bib0675","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/ard.44.12.817","article-title":"Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies","volume":"44","author":"Dahl","year":"1985","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.diii.2019.02.011_bib0680","first-page":"19","article-title":"The pathophysiology of osteoarthritis and the implication of the use of hyaluronan and hylan as therapeutic agents in viscosupplementation","volume":"39","author":"Pelletier","year":"1993","journal-title":"J Rheumatol Suppl"},{"key":"10.1016\/j.diii.2019.02.011_bib0685","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.joca.2014.09.017","article-title":"Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression","volume":"23","author":"Band","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0690","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/00913847.2016.1168272","article-title":"Intra-articular treatment of knee osteoarthritis: from anti-inflammatories to products of regenerative medicine","volume":"44","author":"Richards","year":"2016","journal-title":"Phys Sportsmed"},{"key":"10.1016\/j.diii.2019.02.011_bib0695","doi-asserted-by":"crossref","first-page":"e0187227","DOI":"10.1371\/journal.pone.0187227","article-title":"Do intra-articular hyaluronic acid injections delay total knee replacement in patients with osteoarthritis: a Cox model analysis","volume":"12","author":"Delbarre","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.diii.2019.02.011_bib0700","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.1016\/j.actbio.2013.03.005","article-title":"Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment","volume":"9","author":"Fakhari","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.diii.2019.02.011_bib0705","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/ar623","article-title":"Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action","volume":"5","author":"Moreland","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.diii.2019.02.011_bib0710","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1016\/j.otsr.2014.07.027","article-title":"techniques, indications, results","volume":"101","author":"Legr\u00e9-Boyer","year":"2015","journal-title":"Orthop Traumatol Surg Res"},{"key":"10.1016\/j.diii.2019.02.011_bib0715","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1177\/1759720X17729641","article-title":"Intra-articular hyaluronic acid in the treatment of knee osteoarthritis: a Canadian evidence-based perspective","volume":"9","author":"Bhandari","year":"2017","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.diii.2019.02.011_bib0720","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/acr.23204","article-title":"Use of intraarticular hyaluronic acid in the management of knee osteoarthritis in clinical practice","volume":"69","author":"Cooper","year":"2017","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.diii.2019.02.011_bib0725","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1177\/1947603516662503","article-title":"Appropriate use criteria for hyaluronic acid in the treatment of knee osteoarthritis in the United States","volume":"8","author":"Bhadra","year":"2017","journal-title":"Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0730","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1093\/ageing\/afs199","article-title":"Guidance on the management of pain in older people","volume":"42","author":"Abdulla","year":"2013","journal-title":"Age Ageing"},{"key":"10.1016\/j.diii.2019.02.011_bib0735","article-title":"Why we should definitely include intra-articular hyaluronic acid as a therapeutic option in the management of knee osteoarthritis: results of an extensive critical literature review","author":"Maheu","year":"2018","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.diii.2019.02.011_bib0740","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00256-009-0839-y","article-title":"Adverse events from diagnostic and therapeutic joint injections: a literature review","volume":"40","author":"Peterson","year":"2011","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.diii.2019.02.011_bib0745","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1056\/NEJMct1215534","article-title":"Viscosupplementation for osteoarthritis of the knee","volume":"372","author":"Hunter","year":"2015","journal-title":"NEJM"},{"key":"10.1016\/j.diii.2019.02.011_bib0750","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s100670050034","article-title":"Induction of an acute attack of calcium pyrophosphate dihydrate arthritis by intra-articular injection of hylan G-F 20 (Synvisc)","volume":"19","author":"Kroesen","year":"2000","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.diii.2019.02.011_bib0755","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/1947603516642271","article-title":"Safety of repeated injections of sodium hyaluronate (SUPARTZ) for knee osteoarthritis: a systematic review and meta-analysis","volume":"7","author":"Bannuru","year":"2016","journal-title":"Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0760","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/1947603517693043","article-title":"Decision algorithms for the retreatment with viscosupplementation in patients suffering from knee osteoarthritis: recommendations from the EUROpean VIScosupplementation COnsensus Group (EUROVISCO)","volume":"9","author":"Raman","year":"2018","journal-title":"Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0765","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijsu.2017.01.087","article-title":"Efficacy and safety of intraarticular hyaluronic acid and corticosteroid for knee osteoarthritis: a meta-analysis","volume":"39","author":"He","year":"2017","journal-title":"Int J Surg"},{"key":"10.1016\/j.diii.2019.02.011_bib0770","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1136\/ard.2011.152017","article-title":"A 40-month multicentre, randomised placebo-controlled study to assess the efficacy and carry-over effect of repeated intra-articular injections of hyaluronic acid in knee osteoarthritis: the AMELIA project","volume":"70","author":"Navarro-Sarabia","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.diii.2019.02.011_bib0775","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1055\/s-0035-1568992","article-title":"Association between hyaluronic acid anjections and time-to-total knee replacement surgery","volume":"29","author":"Altman","year":"2016","journal-title":"J Knee Surg"},{"key":"10.1016\/j.diii.2019.02.011_bib0780","article-title":"Combined intra-articular injection of corticosteroid and hyaluronic acid reduces pain compared to hyaluronic acid alone in the treatment of knee osteoarthritis","author":"Smith","year":"2018","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.diii.2019.02.011_bib0785","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13018-017-0521-3","article-title":"The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials","volume":"12","author":"Shen","year":"2017","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.diii.2019.02.011_bib0790","first-page":"5405","article-title":"Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial","volume":"6","author":"Rayegani","year":"2014","journal-title":"Orthop Rev"},{"key":"10.1016\/j.diii.2019.02.011_bib0795","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/2277-9175.135156","article-title":"Platelet-rich plasma application in chondrogenesis","volume":"3","author":"Kabiri","year":"2014","journal-title":"Adv Biomed Res"},{"key":"10.1016\/j.diii.2019.02.011_bib0800","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s00167-013-2743-1","article-title":"Platelet-rich plasma: why intra-articular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration","volume":"23","author":"Filardo","year":"2015","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.diii.2019.02.011_bib0805","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1177\/0363546515624678","article-title":"Intra-articular autologusconditioned plasma injections provide safe and efficacious treatment for knee osteoarthritis: an FDA-sanctioned, randomized, double-blind, placebo-controlled clinical trial","volume":"44","author":"Smith","year":"2016","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.diii.2019.02.011_bib0810","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.arthro.2015.08.005","article-title":"Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: a systematic review","volume":"32","author":"Meheux","year":"2016","journal-title":"Arthroscopy"},{"key":"10.1016\/j.diii.2019.02.011_bib0815","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/j.arthro.2013.09.006","article-title":"The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis","volume":"29","author":"Khoshbin","year":"2013","journal-title":"Arthroscopy"},{"key":"10.1016\/j.diii.2019.02.011_bib0820","article-title":"Injective mesenchymal stem cell-based treatments for knee osteoarthritis: from mechanisms of action to current clinical evidences","author":"Lopa","year":"2018","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.diii.2019.02.011_bib0825","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/jcp.24223","article-title":"Human mesenchymal stem cells: a bank perspective on the isolation, characterization and potential of alternative sources for the regeneration of musculoskeletal tissues","volume":"228","author":"Moroni","year":"2013","journal-title":"J Cell Physio"},{"key":"10.1016\/j.diii.2019.02.011_bib0830","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/stem.1681","article-title":"Concise review: the surface markers and identity of human mesenchymal stem cells","volume":"32","author":"Lv","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.diii.2019.02.011_bib0835","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s00167-015-3763-9","article-title":"Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential","volume":"25","author":"Atesok","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.diii.2019.02.011_bib0840","doi-asserted-by":"crossref","first-page":"e115963","DOI":"10.1371\/journal.pone.0115963","article-title":"Impact of aging on the regenerative properties of bone marrow-, muscle-, and adipose-derived mesenchymal stem\/stromal cells","volume":"9","author":"Beane","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.diii.2019.02.011_bib0845","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/wrr.12051","article-title":"Diabetes impairs adipose tissue-derived stem cell function and efficiency in promoting wound healing","volume":"21","author":"Cianfarani","year":"2013","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.diii.2019.02.011_bib0850","doi-asserted-by":"crossref","first-page":"284215","DOI":"10.1155\/2015\/284215","article-title":"Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells","volume":"2015","author":"Sun","year":"2015","journal-title":"J Immunol Res"},{"key":"10.1016\/j.diii.2019.02.011_bib0855","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11926-018-0776-7","article-title":"Evaluating the current literature on treatments containing adipose-derived stem cells for osteoarthritis: a progress update","volume":"20","author":"Ranmuthu","year":"2018","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.diii.2019.02.011_bib0860","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13018-017-0689-6","article-title":"Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I\/II study","volume":"12","author":"Al-Najar","year":"2017","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.diii.2019.02.011_bib0865","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.joca.2018.05.001","article-title":"Efficacy and safety of single-dose onabotulinumtoxinA in the treatment of symptoms of osteoarthritis of the knee: results of a placebo-controlled, double-blind study","volume":"26","author":"McAlindon","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0870","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/03009742.2016.1203988","article-title":"Intra-articular onabotulinumtoxinA in osteoarthritis knee pain: effect on human mechanistic pain biomarkers and clinical pain","volume":"46","author":"Arendt-Nielsen","year":"2017","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.diii.2019.02.011_bib0875","doi-asserted-by":"crossref","first-page":"e0179185","DOI":"10.1371\/journal.pone.0179185","article-title":"Comparison between intra-articular ozone and placebo in the treatment of knee osteoarthritis: a randomized, double-blinded, placebo-controlled study","volume":"12","author":"Lopes de Jesus","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.diii.2019.02.011_bib0880","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00167-016-4110-5","article-title":"Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options","volume":"25","author":"Duymus","year":"2017","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.diii.2019.02.011_bib0885","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1186\/s12891-017-1830-8","article-title":"Structural effects of intra-articular TGF-beta1 in moderate to advanced knee osteoarthritis: MRI-based assessment in a randomized controlled trial","volume":"18","author":"Guermazi","year":"2017","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.diii.2019.02.011_bib0890","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.joca.2015.06.019","article-title":"Preliminary results of a phase II randomized study to determine the efficacy and safety of genetically engineered allogeneic human chondrocytes expressing TGF-beta1 in patients with grade 3 chronic degenerative joint disease of the knee","volume":"23","author":"Cherian","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0895","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/humc.2014.145","article-title":"A multicenter, single-blind, phase IIa clinical trial to evaluate the efficacy and safety of a cell-mediated gene therapy in degenerative knee arthritis patients","volume":"26","author":"Ha","year":"2015","journal-title":"Hum Gene Ther Clin Dev"},{"key":"10.1016\/j.diii.2019.02.011_bib0900","doi-asserted-by":"crossref","first-page":"E437","DOI":"10.36076\/ppj.2017.E444","article-title":"A review of long-term pain relief after genicular nerve radiofrequency ablation in chronic knee osteoarthritis","volume":"20","author":"Iannaccone","year":"2017","journal-title":"Pain Physician"},{"key":"10.1016\/j.diii.2019.02.011_bib0905","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002640050001","article-title":"Nerve distribution to the human knee joint: anatomical and immunohistochemical study","volume":"24","author":"Hirasawa","year":"2000","journal-title":"Int Orthop"},{"key":"10.1016\/j.diii.2019.02.011_bib0910","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/036354658201000601","article-title":"Nerve supply of the human knee and its functional importance","volume":"10","author":"Kennedy","year":"1982","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.diii.2019.02.011_bib0915","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.pain.2010.09.029","article-title":"Radiofrequency treatment relieves chronic knee osteoarthritis pain: a double-blind randomized controlled trial","volume":"152","author":"Choi","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.diii.2019.02.011_bib0920","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1093\/pm\/pnx069","article-title":"Cooled radiofrequency ablation of the genicular nerves for chronic pain due to knee osteoarthritis: six-month outcomes","volume":"1","author":"McCormick","year":"2017","journal-title":"Pain Med"},{"key":"10.1016\/j.diii.2019.02.011_bib0925","doi-asserted-by":"crossref","first-page":"155","DOI":"10.36076\/ppj.2017.171","article-title":"Comparative effectiveness review of cooled versus pulsed radiofrequency ablation for the treatment of knee osteoarthritis: a systematic review","volume":"20","author":"Gupta","year":"2017","journal-title":"Pain Physician"},{"key":"10.1016\/j.diii.2019.02.011_bib0930","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.2147\/JPR.S144633","article-title":"Radiofrequency techniques to treat chronic knee pain: a comprehensive review of anatomy, effectiveness, treatment parameters, and patient selection","volume":"11","author":"Jamison","year":"2018","journal-title":"J Pain Res"},{"key":"10.1016\/j.diii.2019.02.011_bib0935","first-page":"E697","article-title":"Is genicularnNerve radiofrequency ablation safe? a literature review and anatomical study","volume":"19","author":"Kim","year":"2016","journal-title":"Pain Physician"},{"key":"10.1016\/j.diii.2019.02.011_bib0940","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00776-012-0209-9","article-title":"Neural mechanisms underlying deafferentation pain: a hypothesis from a neuroimaging perspective","volume":"17","author":"Hanakawa","year":"2012","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.diii.2019.02.011_bib0945","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2214\/AJR.17.18452","article-title":"Percutaneous image-guided cryoneurolysis","volume":"210","author":"Bittman","year":"2018","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.diii.2019.02.011_bib0950","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/mus.24306","article-title":"Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies","volume":"51","author":"Hsu","year":"2015","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.diii.2019.02.011_bib0955","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jbspin.2016.09.004","article-title":"Cryotherapy decreases synovial Doppler activity and pain in knee arthritis: a randomized-controlled trial","volume":"84","author":"Guillot","year":"2017","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.diii.2019.02.011_bib0960","doi-asserted-by":"crossref","first-page":"e0178668","DOI":"10.1371\/journal.pone.0178668","article-title":"Local cryotherapy improves adjuvant-induced arthritis through down-regulation of IL-6\/IL-17 pathway but independently of TNFalpha","volume":"12","author":"Guillot","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.diii.2019.02.011_bib0965","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.joca.2017.03.006","article-title":"Cryoneurolysis to treat the pain and symptoms of knee osteoarthritis: a multicenter, randomized, double-blind, sham-controlled trial","volume":"25","author":"Radnovich","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.diii.2019.02.011_bib0970","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1007\/s00270-014-0944-8","article-title":"Transcatheter arterial embolization as a treatment for medial knee pain in patients with mild to moderate osteoarthritis","volume":"38","author":"Okuno","year":"2015","journal-title":"Cardiovasc Intervent Radiol"},{"key":"10.1016\/j.diii.2019.02.011_bib0975","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jvir.2017.02.033","article-title":"Midterm clinical outcomes and MR imaging changes after transcatheter arterial embolization as a treatment for mild to moderate radiographic knee osteoarthritis resistant to conservative treatment","volume":"28","author":"Okuno","year":"2017","journal-title":"J Vasc Interv Radiol"},{"key":"10.1016\/j.diii.2019.02.011_bib0980","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.rehab.2016.02.008","article-title":"Evidence and recommendations for use of intra-articular injections for knee osteoarthritis","volume":"59","author":"Nguyen","year":"2016","journal-title":"Ann Phys Rehabil Med"}],"container-title":["Diagnostic and Interventional Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211568419300695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211568419300695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:33:35Z","timestamp":1761932015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211568419300695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":98,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S2211568419300695"],"URL":"https:\/\/doi.org\/10.1016\/j.diii.2019.02.011","relation":{},"ISSN":["2211-5684"],"issn-type":[{"value":"2211-5684","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interventional radiology techniques for pain reduction and mobility improvement in patients with knee osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Diagnostic and Interventional Imaging","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.diii.2019.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Soci\u00e9t\u00e9 fran\u00e7aise de radiologie. Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}