{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:16:31Z","timestamp":1791684991701,"version":"4.3.4"},"reference-count":101,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Disease-a-Month"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.disamonth.2019.100887","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T16:44:15Z","timestamp":1569861855000},"page":"100887","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Update and review of adult polycystic kidney disease"],"prefix":"10.1016","volume":"66","author":[{"given":"Gates B.","family":"Colbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed E.","family":"Elrggal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovy","family":"Gaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar V.","family":"Lerma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.disamonth.2019.100887_bib0001","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1056\/NEJMoa054341","article-title":"Volume progression in polycystic kidney disease","volume":"354","author":"Grantham","year":"2006","journal-title":"N Engl J Med"},{"issue":"13","key":"10.1016\/j.disamonth.2019.100887_bib0002","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nrneph.2017.127","article-title":"New treatment paradigms for ADPKD: moving towards precision medicine","author":"Lanktree","year":"2017","journal-title":"Nat Rev Nephrol"},{"issue":"8","key":"10.1016\/j.disamonth.2019.100887_bib0003","first-page":"1356","article-title":"Prevalence of autosomal dominant polycystic kidney disease in the European Union","volume":"32","author":"Willey","year":"2017","journal-title":"Nephrol Dial Transpl"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0004","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3949\/ccjm.76a.gr001","article-title":"Autosomal dominant polycystic kidney disease: emerging concepts of pathogenesis and new treatments","volume":"76","author":"Braun","year":"2009","journal-title":"Cleve Clin J Med"},{"key":"10.1016\/j.disamonth.2019.100887_bib0005","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/317542a0","article-title":"A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16","volume":"317","author":"Reeders","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.disamonth.2019.100887_bib0006","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/0092-8674(94)90137-6","article-title":"The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16","volume":"77","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.disamonth.2019.100887_bib0007","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1006\/geno.2001.6568","article-title":"Homologues to the first gene for autosomal dominant polycystic kidney disease are pseudogenes","volume":"74","author":"Bogdanova","year":"2001","journal-title":"Genomics"},{"key":"10.1016\/j.disamonth.2019.100887_bib0008","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1172\/JCI119090","article-title":"Identification and localization of polycystin, the PKD1 gene product","volume":"98","author":"Geng","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.disamonth.2019.100887_bib0009","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/01.ASN.0000013300.11876.37","article-title":"The position of the polycystic kidney disease 1 (PKD1) gene mutation correlates with the severity of renal disease","volume":"13","author":"Rossetti","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0010","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.272.5266.1339","article-title":"PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein","volume":"272","author":"Mochizuki","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.disamonth.2019.100887_bib0011","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1053\/ajkd.2000.17619","article-title":"Increased prevalence of polycystic kidney disease type 2 among elderly polycystic patients","volume":"36","author":"Torra","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.disamonth.2019.100887_bib0012","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1086\/318188","article-title":"Bilineal disease and trans-heterozygotes in autosomal dominant polycystic kidney disease","volume":"68","author":"Pei","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.disamonth.2019.100887_bib0013","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.ajhg.2016.05.004","article-title":"Mutations in GANAB, encoding the glucosidase II-alpha subunit, cause autosomal-dominant polycystic kidney and liver disease","volume":"98","author":"Porath","year":"2016","journal-title":"Am. J. Hum. Genet"},{"issue":"5","key":"10.1016\/j.disamonth.2019.100887_bib0014","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ajhg.2018.03.013","article-title":"Monoallelic mutations to DNAJB11 cause atypical autosomal-dominant polycystic kidney disease","volume":"102","author":"Cornec-Le Gall","year":"2018","journal-title":"Am. J. Hum. Genet"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12873-018-0192-3","article-title":"Autosomal dominant polycystic kidney disease and minimal trauma: medical review and case report","volume":"18","author":"Hajjar","year":"2018","journal-title":"BMC Emerg Med"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0016","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0272-6386(12)80541-5","article-title":"Clinical profiles of gross hematuria in autosomal dominant polycystic kidney disease","volume":"20","author":"Gabow","year":"1992","journal-title":"Am J Kidney Dis"},{"issue":"10","key":"10.1016\/j.disamonth.2019.100887_bib0017","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1681\/ASN.2013101122","article-title":"Polycystic kidney disease and cancer after renal transplantation","volume":"25","author":"Wetmore","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0018","first-page":"193","article-title":"A case of bilateral renal cell carcinoma in polycystic kidneys","volume":"24","author":"Sogbein","year":"1981","journal-title":"Can J Surg"},{"issue":"1\u20132","key":"10.1016\/j.disamonth.2019.100887_bib0019","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000351049","article-title":"Autosomal dominant polycystic kidney disease: prevalence of renal neoplasias in surgical kidney specimens","volume":"123","author":"Jilg","year":"2013","journal-title":"Nephron Clin. Pract"},{"issue":"7309","key":"10.1016\/j.disamonth.2019.100887_bib0020","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1136\/bmj.323.7309.386","article-title":"Lesson of the week: causes of haematuria in adult polycystic kidney disease","volume":"323","author":"Dedi","year":"2001","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0021","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/ki.1989.38","article-title":"The clinical utility of renal concentrating capacity in polycystic kidney disease","volume":"35","author":"Gabow","year":"1989","journal-title":"Kidney Int"},{"issue":"5","key":"10.1016\/j.disamonth.2019.100887_bib0022","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ki.1988.233","article-title":"Hypertension in autosomal dominant polycystic kidney disease","volume":"34","author":"Bell","year":"1988","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0023","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1681\/ASN.V121194","article-title":"Hypertension in autosomal-dominant polycystic kidney disease: early occurrence and unique aspects","volume":"12","author":"Ecder","year":"2001","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"10.1016\/j.disamonth.2019.100887_bib0024","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1681\/ASN.V381451","article-title":"Elevated blood pressure profile and left ventricular mass in children and young adults with autosomal dominant polycystic kidney disease","volume":"3","author":"Zeier","year":"1993","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.disamonth.2019.100887_bib0025","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1111\/j.1523-1755.2005.00682.x","article-title":"Biventricular diastolic dysfunction in patients with autosomal-dominant polycystic kidney disease","volume":"68","author":"Oflaz","year":"2005","journal-title":"Kidney Int"},{"issue":"16","key":"10.1016\/j.disamonth.2019.100887_bib0026","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1056\/NEJM199010183231602","article-title":"The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease","volume":"323","author":"Chapman","year":"1990","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.disamonth.2019.100887_bib0027","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1681\/ASN.V561349","article-title":"Overt proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease","volume":"5","author":"Chapman","year":"1994","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.disamonth.2019.100887_bib0028","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0272-6386(12)80922-X","article-title":"Renal stone disease in autosomal dominant polycystic kidney disease","volume":"22","author":"Torres","year":"1993","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1016\/j.disamonth.2019.100887_bib0029","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2215\/CJN.03100608","article-title":"Evaluation of nephrolithiasis in autosomal dominant polycystic kidney disease patients","volume":"4","author":"Nishiura","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1053\/ajkd.2000.8266","article-title":"Anatomic and metabolic risk factors for nephrolithiasis in patients with autosomal dominant polycystic kidney disease","volume":"36","author":"Grampsas","year":"2000","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0031","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cgh.2014.07.051","article-title":"Liver involvement in early autosomal-dominant polycystic kidney disease","volume":"13","author":"Hogan","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0032","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.clinimag.2017.07.014","article-title":"Complex liver cysts in autosomal dominant polycystic kidney disease","volume":"46","author":"Farooq","year":"2017","journal-title":"Clin Imaging"},{"issue":"3","key":"10.1016\/j.disamonth.2019.100887_bib0033","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1148\/radiol.2016151650","article-title":"Pancreatic cysts in autosomal dominant polycystic kidney disease: prevalence and association with PKD2 gene mutations","volume":"280","author":"Kim","year":"2016","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0034","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1148\/radiology.180.1.2052727","article-title":"Seminal vesicle cysts: association with adult polycystic kidney disease","volume":"180","author":"Alpern","year":"1991","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0035","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/ndt\/18.1.190","article-title":"Infertility in adults with polycystic kidney disease","volume":"18","author":"Li Vecchi","year":"2003","journal-title":"Nephrol Dial Transpl"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0036","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1053\/j.ajkd.2007.09.010","article-title":"Reproductive issues for adults with autosomal dominant polycystic kidney disease","volume":"51","author":"Vora","year":"2008","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0037","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.ackd.2010.01.003","article-title":"Extrarenal manifestations of autosomal dominant polycystic kidney disease","volume":"17","author":"Pirson","year":"2010","journal-title":"Adv Chronic Kidney Dis."},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0038","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/ndt\/gft437","article-title":"Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management","volume":"29","author":"Luciano","year":"2014","journal-title":"Nephrol Dial Transpl"},{"issue":"5","key":"10.1016\/j.disamonth.2019.100887_bib0039","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00701-017-3142-z","article-title":"Intracranial aneurysms in patients with autosomal dominant polycystic kidney disease: prevalence, risk of rupture, and management. a systematic review","volume":"159","author":"Cagnazzo","year":"2017","journal-title":"Acta Neurochir (Wien)"},{"issue":"1\u20132","key":"10.1016\/j.disamonth.2019.100887_bib0040","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000476073","article-title":"Is regular screening for intracranial aneurysm necessary in patients with autosomal dominant polycystic kidney disease? A systematic review and meta-analysis","volume":"44","author":"Zhou","year":"2017","journal-title":"Cerebrovasc Dis"},{"issue":"6","key":"10.1016\/j.disamonth.2019.100887_bib0041","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1432-2277.2011.01237.x","article-title":"Outcomes of renal transplantation in patients with autosomal dominant polycystic kidney disease: a nationwide longitudinal study","volume":"24","author":"Jacquet","year":"2011","journal-title":"Transpl Int"},{"issue":"11","key":"10.1016\/j.disamonth.2019.100887_bib0042","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.2215\/CJN.01460210","article-title":"Improved prognosis in patients with autosomal dominant polycystic kidney disease in denmark","volume":"5","author":"Orskov","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.disamonth.2019.100887_bib0043","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1053\/ajkd.2001.27720","article-title":"Survival after end-stage renal disease in autosomal dominant polycystic kidney disease: contribution of extrarenal complications to mortality","volume":"38","author":"Perrone","year":"2001","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1016\/j.disamonth.2019.100887_bib0044","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1016\/j.juro.2007.01.146","article-title":"Selective, concurrent bilateral nephrectomies at renal transplantation for autosomal dominant polycystic kidney disease","volume":"177","author":"Wagner","year":"2007","journal-title":"J Urol"},{"issue":"8","key":"10.1016\/j.disamonth.2019.100887_bib0045","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.2215\/CJN.14691218","article-title":"Presymptomatic screening for intracranial aneurysms in patients with autosomal dominant polycystic kidney disease","volume":"14","author":"Sanchis","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0046","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neurad.2007.11.004","article-title":"Natural history, epidemiology and screening of unruptured intracranial aneurysms","volume":"35","author":"Rinkel","year":"2008","journal-title":"J Neuroradiol"},{"issue":"3","key":"10.1016\/j.disamonth.2019.100887_bib0047","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.kint.2017.08.016","article-title":"Screening for intracranial aneurysms in autosomal dominant polycystic kidney disease is cost-effective","volume":"93","author":"Flahault","year":"2017","journal-title":"Kidney Int"},{"issue":"10","key":"10.1016\/j.disamonth.2019.100887_bib0048","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrneph.2015.128","article-title":"Vascular complications in autosomal dominant polycystic kidney disease","volume":"11","author":"Perrone","year":"2015","journal-title":"Nat Rev Nephrol"},{"issue":"14","key":"10.1016\/j.disamonth.2019.100887_bib0049","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM198810063191404","article-title":"Echocardiographic findings in autosomal dominant polycystic kidney disease","volume":"319","author":"Hossack","year":"1988","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.disamonth.2019.100887_bib0050","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1681\/ASN.V5122032","article-title":"Cardiovascular abnormalities in children with autosomal dominant polycystic kidney disease","volume":"5","author":"Ivy","year":"1995","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.disamonth.2019.100887_bib0051","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/ajkd.2001.29216","article-title":"Mitral valve prolapse and mitral regurgitation are common in patients with polycystic kidney disease type 1","volume":"38","author":"Lumiaho","year":"2001","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"10.1016\/j.disamonth.2019.100887_bib0052","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nrneph.2009.13","article-title":"Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease","volume":"5","author":"Ecder","year":"2009","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"10.1016\/j.disamonth.2019.100887_bib0053","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1093\/ndt\/gfw008","article-title":"Effect of genotype on the severity and volume progression of polycystic liver disease in autosomal dominant polycystic kidney disease","volume":"31","author":"Chebib","year":"2016","journal-title":"Nephrol Dial Transpl"},{"issue":"3","key":"10.1016\/j.disamonth.2019.100887_bib0054","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/liv.13965","article-title":"Severity in polycystic liver disease is associated with aetiology and female gender: results of the international pld registry","volume":"39","author":"van Aerts","year":"2019","journal-title":"Liver Int"},{"key":"10.1016\/j.disamonth.2019.100887_bib0055","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMoa1402685","article-title":"Blood pressure in early autosomal dominant polycystic kidney disease","volume":"371","author":"Schrier","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.disamonth.2019.100887_bib0056","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1056\/NEJMoa1402686","article-title":"Angiotensin blockade in late autosomal dominant polycystic kidney disease","volume":"317","author":"Torres","year":"2014","journal-title":"N Eng J Med"},{"key":"10.1016\/j.disamonth.2019.100887_bib0057","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.0509694103","article-title":"The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease","volume":"103","author":"Shillingford","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.disamonth.2019.100887_bib0058","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1681\/ASN.2004080660","article-title":"Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease","volume":"16","author":"Tao","year":"2005","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"10.1016\/j.disamonth.2019.100887_bib0059","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1056\/NEJMoa0907419","article-title":"Sirolimus and kidney growth in autosomal dominant polycystic kidney disease","volume":"363","author":"Serra","year":"2010","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.disamonth.2019.100887_bib0060","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1056\/NEJMoa1003491","article-title":"Everolimus in patients with autosomal dominant polycystic kidney disease","volume":"363","author":"Walz","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.disamonth.2019.100887_bib0061","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1096\/fasebj.3.14.2480260","article-title":"Renal epithelial fluid secretion and cyst growth: the role of cyclic amp","volume":"3","author":"Mangoo-Karim","year":"1989","journal-title":"FASEB J"},{"key":"10.1016\/j.disamonth.2019.100887_bib0062","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/S0140-6736(13)61407-5","article-title":"Effect of longacting somatostatin analogue on kidney and cyst growth in autosomal dominant polycystic kidney disease (ALADIN): a randomised, placebo-controlled, multicentre trial","volume":"382","author":"Caroli","year":"2013","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.disamonth.2019.100887_bib0063","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002777","article-title":"Octreotide-LAR in later-stage autosomal dominant polycystic kidney disease (ALADIN 2): a randomised, double-blind, placebo-controlled, multicentre trial","volume":"16","author":"Perico","year":"2019","journal-title":"PLoS Med"},{"issue":"19","key":"10.1016\/j.disamonth.2019.100887_bib0064","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1001\/jama.2018.15870","article-title":"DIPAK-1 investigators. effect of lanreotide on kidney function in patients with autosomal dominant polycystic kidney disease: the DIPAK-1 randomised clinical trial","volume":"320","author":"Meijer","year":"2018","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0065","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1053\/j.gastro.2019.04.018","article-title":"DIPAK-1 investigators. lanreotide reduces liver growth in patients with autosomal dominant polycystic liver and kidney disease","volume":"157","author":"van Aerts","year":"2019","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.disamonth.2019.100887_bib0066","first-page":"329","article-title":"The effect of hypervolemia on electrolyte level and level of volume regulating hormones in patients with autosomal dominant kidney disease","volume":"96","author":"Michalski","year":"1996","journal-title":"Pol Arch Med Wewn"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0067","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2215\/CJN.04560510","article-title":"Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease","volume":"6","author":"Meijer","year":"2011","journal-title":"CJASN"},{"issue":"6","key":"10.1016\/j.disamonth.2019.100887_bib0068","first-page":"457","article-title":"Histogenesis of the renal cysts in adult (autosomal dominant) polycystic kidney diease: a histochemical study","volume":"1","author":"Verani","year":"1988","journal-title":"Mod Pathol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0069","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1056\/NEJMoa1205511","article-title":"Tolvaptan in patients with autosomal dominant polycystic kidney disease","volume":"367","author":"Torres","year":"2012","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.disamonth.2019.100887_bib0070","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2215\/CJN.09500911","article-title":"Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease","volume":"7","author":"Chapman","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0071","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1056\/NEJMoa1710030","article-title":"Tolvaptan in later-stage autosomal dominant polycystic kidney disease","volume":"377","author":"Torres","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0072","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-018794","article-title":"Randomised controlled trial to determine the efficacy and safety of prescribed water intake to prevent kidney failure due to autosomal dominant polycystic kidney disease (PREVENT-ADPKD)","volume":"8","author":"Wong","year":"2018","journal-title":"BMJ Open"},{"issue":"5","key":"10.1016\/j.disamonth.2019.100887_bib0073","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1159\/000488807","article-title":"A randomised clinical trial of metformin to treat autosomal dominant polycystic kidney disease","volume":"47","author":"Seliger","year":"2018","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0074","doi-asserted-by":"crossref","unstructured":"Yanda M, Liu Q, Cebotaru L. A potential strategy for reducing cysts in autosomal dominant polycystic kidney disease with a cftr corrector. J. Biol. Chem. 293, 11513\u201311526.","DOI":"10.1074\/jbc.RA118.001846"},{"issue":"5","key":"10.1016\/j.disamonth.2019.100887_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216220","article-title":"Dopamine receptor antagonists as potential therapeutic agents for ADPKD","volume":"14","author":"Paul","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0076","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2015.59","article-title":"Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a kidney disease: improving global outcomes (KDIGO) controversies conference","volume":"88","author":"Chapman","year":"2015","journal-title":"Kidney Int."},{"issue":"8901","key":"10.1016\/j.disamonth.2019.100887_bib0077","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0140-6736(94)92026-5","article-title":"Evaluation of ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease 1","volume":"343","author":"Ravine","year":"1994","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0078","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1681\/ASN.2008050507","article-title":"Unified criteria for ultrasonographic diagnosis of adpkd","volume":"20","author":"Pei","year":"2009","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.disamonth.2019.100887_bib0079","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1681\/ASN.2014030297","article-title":"Imaging-based diagnosis of autosomal dominant polycystic kidney disease","volume":"26","author":"Pei","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.disamonth.2019.100887_bib0080","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1053\/ajkd.2001.22089","article-title":"Screening a living kidney donor for polycystic kidney disease using heavily T2-weighted MRI","volume":"37","author":"Zand","year":"2001","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0081","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1053\/j.ackd.2009.12.006","article-title":"Management of ESRD in patients with autosomal dominant polycystic kidney disease","volume":"17","author":"Alam","year":"2010","journal-title":"Adv Chronic Kidney Dis"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0082","doi-asserted-by":"crossref","first-page":"c42","DOI":"10.1159\/000334429","article-title":"Survival after starting renal replacement treatment in patients with autosomal dominant polycystic kidney disease: a single-centre 40-Year study","volume":"120","author":"Haynes","year":"2012","journal-title":"Nephron Clin Pract"},{"issue":"7","key":"10.1016\/j.disamonth.2019.100887_bib0083","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1016\/j.transproceed.2013.07.016","article-title":"Renal transplant in patients with polycystic disease: the Italian experience","volume":"45","author":"Mosconi","year":"2013","journal-title":"Transplant Proc"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0084","first-page":"15","article-title":"The effect of nephrectomy on the outcome of renal transplantation in patients with polycystic kidney disease","volume":"1","author":"Brazda","year":"1996","journal-title":"Ann Transpl"},{"issue":"2","key":"10.1016\/j.disamonth.2019.100887_bib0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000282815","article-title":"Transplantation in autosomal dominant polycystic kidney disease without nephrectomy","volume":"56","author":"Knispel","year":"1996","journal-title":"Urol Int"},{"issue":"1","key":"10.1016\/j.disamonth.2019.100887_bib0086","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/ndt\/gfv227","article-title":"Volume regression of native polycystic kidneys after renal transplantation","volume":"31","author":"Jung","year":"2016","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.disamonth.2019.100887_bib0087","doi-asserted-by":"crossref","first-page":"iv15","DOI":"10.1093\/ndt\/gfu017","article-title":"Renal replacement therapy for autosomal dominant polycystic kidney disease (ADPKD) in Europe: prevalence and survival \u2014 an analysis of data from the ERA-EDTA registry","volume":"29","author":"Spithoven","year":"2014","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.disamonth.2019.100887_bib0088","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/ndt\/gft437","article-title":"Extra-renal manifestations of autosomal dominant polycystic kidney disease (ADPKD): considerations for routine screening and management","volume":"29","author":"Luciano","year":"2014","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.disamonth.2019.100887_bib0089","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0272-6386(95)90096-9","article-title":"A century of mortality in five large families with polycystic kidney disease","volume":"25","author":"Florijn","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.disamonth.2019.100887_bib0090","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/ki.1990.330","article-title":"Renal structure and hypertension in autosomal dominant polycystic kidney disease","volume":"38","author":"Gabow","year":"1990","journal-title":"Kidney Int"},{"key":"10.1016\/j.disamonth.2019.100887_bib0091","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1681\/ASN.2008080882","article-title":"Renal volume, renin-angiotensin-aldosterone system, hypertension, and left ventricular hypertrophy in patients with autosomal dominant polycystic kidney disease","volume":"20","author":"Schrier","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0092","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1053\/j.ajkd.2011.01.023","article-title":"Use of antihypertensive medications and mortality of patients with autosomal dominant polycystic kidney disease: a population-based study","volume":"57","author":"Patch","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.disamonth.2019.100887_bib0093","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1111\/j.1523-1755.2004.00921.x","article-title":"Pain patterns in patients with polycystic kidney disease","volume":"66","author":"Bajwa","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.disamonth.2019.100887_bib0094","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1089\/end.2007.0359","article-title":"Followup for laparoscopic renal denervation and nephropexy for autosomal dominant polycystic kidney disease-related pain in pediatrics","volume":"22","author":"Casale","year":"2008","journal-title":"J Endourol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0095","first-page":"120","article-title":"Anxiety, depression, and quality of life in patients with familial glomerulonephritis or autosomal dominant polycystic kidney disease","volume":"33","author":"de Barros","year":"2011","journal-title":"J Bras Nefrol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0096","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1681\/ASN.2017050483","article-title":"Genetic complexity of autosomal dominant polycystic kidney and liver diseases","volume":"29","author":"Cornec-Le Gall","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0097","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.ajhg.2018.03.013","article-title":"HALT progression of polycystic kidney disease group; consortium for radiologic imaging studies of polycystic kidney disease: monoallelic mutations to DNAJB11 cause atypical autosomal dominant polycystic kidney disease","volume":"102","author":"Cornec-Le Gall","year":"2018","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.disamonth.2019.100887_bib0098","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-018794","article-title":"Randomised controlled trial to determine the efficacy and safety of prescribed water intake to prevent kidney failure due to autosomal dominant polycystic kidney disease (PREVENT-ADPKD)","volume":"8","author":"Wong","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.disamonth.2019.100887_bib0099","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000445959","article-title":"Hydration and chronic kidney disease progression: a critical review of the evidence","volume":"43","author":"Clark","year":"2016","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0100","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000382081","article-title":"Urine and plasma osmolality in patients with autosomal dominant polycystic kidney disease: reliable indicators of vasopressin activity and disease prognosis?","volume":"41","author":"Casteleijn","year":"2015","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.disamonth.2019.100887_bib0101","first-page":"1","article-title":"Molecular diagnosis of autosomal dominant polycystic kidney disease","volume":"13","author":"Song","year":"2017","journal-title":"Expert Rev Mol Diagn"}],"container-title":["Disease-a-Month"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011502919301282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011502919301282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T01:00:59Z","timestamp":1757898059000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011502919301282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":101,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0011502919301282"],"URL":"https:\/\/doi.org\/10.1016\/j.disamonth.2019.100887","relation":{},"ISSN":["0011-5029"],"issn-type":[{"value":"0011-5029","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Update and review of adult polycystic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Disease-a-Month","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.disamonth.2019.100887","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100887"}}