{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:43:05Z","timestamp":1778524985722,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.dld.2004.02.007","type":"journal-article","created":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T05:50:07Z","timestamp":1083390607000},"page":"471-477","source":"Crossref","is-referenced-by-count":6,"title":["C4BQ0: a genetic marker of familial HCV-related liver cirrhosis"],"prefix":"10.1016","volume":"36","author":[{"given":"L","family":"Pasta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Pietrosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Marrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"D\u2019Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Licata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Misiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Madonia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Mercadante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Pagliaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2004.02.007_BIB1","first-page":"90","article-title":"Chronic liver disease","volume":"14","author":"Pagliaro","year":"1986","journal-title":"Ital J Gastroenterol"},{"key":"10.1016\/j.dld.2004.02.007_BIB2","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1016\/0168-8278(89)90581-3","article-title":"Familiarity of cirrhosis. Familial predisposition or environmental factors?","volume":"9","author":"Pasta","year":"1989","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2004.02.007_BIB3","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1053\/gast.1997.v113.pm9352872","article-title":"Genes of the major histocompatibility complex class II influence the outcome of hepatitis C virus infection","volume":"113","author":"Alric","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2004.02.007_BIB4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-8278(98)80195-5","article-title":"Association between HLA class II alleles and protection from or susceptibility to chronic hepatitis, C","volume":"28","author":"Zavaglia","year":"1998","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2004.02.007_BIB5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0168-8278(97)80169-9","article-title":"MHC class II genes influence the susceptibility to chronic active hepatitis, C","volume":"27","author":"Hohler","year":"1997","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2004.02.007_BIB6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/hep.510270136","article-title":"Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus","volume":"27","author":"Kuzushita","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2004.02.007_BIB7","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/S0168-8278(99)80249-9","article-title":"Association of the HLA-DRB1*01 allele with spontaneous viral clearance in an Irish cohort infected with hepatitis C virus via contaminated anti-D immunoglobulin","volume":"30","author":"Barrett","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2004.02.007_BIB8","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/S0140-6736(99)91443-5","article-title":"Thomas HC for the HENCORE group. Influence of MHC class II genotype on outcome of infection with hepatitis C virus","volume":"354","author":"Thursz","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2004.02.007_BIB9","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/0016-5085(94)90427-8","article-title":"Immunogenetics of chronic liver diseases","volume":"106","author":"Manns","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2004.02.007_BIB10","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/hep.510290445","article-title":"Human leukocyte antigen class II and III alleles and severity of hepatitis C virus-related chronic liver disease","volume":"29","author":"Asti","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2004.02.007_BIB11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2337\/diabetes.36.1.93","article-title":"Age corrected empirical genetic risk estimates for first degree relatives of IDDM patients","volume":"36","author":"Tillil","year":"1987","journal-title":"Diabetes"},{"key":"10.1016\/j.dld.2004.02.007_BIB12","unstructured":"Pagliaro L, Pasta L, D\u2019Amico G, Puleo A, Politi F, Vizzini G, Natural history of cirrhosis: Predictors of death risk overview of published studies and validation in a new test. In: Dobrilla G, Felder M, De Pretis G (Eds.), Advances in hepatobiliary and pancreatic diseases: Special Clinical Topics, 1994. p. 82\u201393."},{"key":"10.1016\/j.dld.2004.02.007_BIB13","unstructured":"Distribuzione della popolazione Siciliana. In: Bollettino dell\u2019Osservatorio Epidemiologico Regionale dell\u2019Assessorato Sanit\u00e0 della Regione Sicilia. Publisicula ed. Palermo 1 (1998) 19\u201320."},{"key":"10.1016\/j.dld.2004.02.007_BIB14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000153559","article-title":"Association between C3 complement types and childhood cirrhosis","volume":"36","author":"Srivistava","year":"1985","journal-title":"Hum Hered"},{"key":"10.1016\/j.dld.2004.02.007_BIB15","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1099\/0022-1317-74-11-2385","article-title":"Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primers for specific detection","volume":"74","author":"Okamoto","year":"1993","journal-title":"J Gen Virol"},{"key":"10.1016\/j.dld.2004.02.007_BIB16","unstructured":"Armitage P, Comparison of different groups. In: Statistical Methods in Clinical Research. Blackwell Scientific Publication, 1971. p. 188\u2013214."},{"key":"10.1016\/j.dld.2004.02.007_BIB17","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/hep.1840200611","article-title":"Prevalence of chronic liver disease in the General population of Northern Italy: The Dionysos study","volume":"6","author":"Bellentani","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2004.02.007_BIB18","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/hep.1840200519","article-title":"Pathogenic factors in cirrhosis with and without hepatocellular carcinoma: a multicenter Italian study","volume":"20","author":"De Bac","year":"1994","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2004.02.007_BIB19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/BF01740815","article-title":"Hepatitis C virus infection in households of anti-HCV chronic carriers in Italy: a multicentre case-control study","volume":"25","author":"Sagnelli","year":"1997","journal-title":"Infection"},{"key":"10.1016\/j.dld.2004.02.007_BIB20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00144427","article-title":"HCV transmission in family members of subjects with HCV related chronic liver disease","volume":"12","author":"Demelia","year":"1996","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.dld.2004.02.007_BIB21","first-page":"5","article-title":"Prevalence of anti HCV among spouses and offspring of anti-HCV positive subjects: an Italian multicentre study","volume":"27","author":"Caporaso","year":"1995","journal-title":"Ital J Gastroenterol"},{"key":"10.1016\/j.dld.2004.02.007_BIB22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/BF01716699","article-title":"Prevalence of hepatitis C virus infection in the household contacts of patients with HCV-related chronic liver disease","volume":"22","author":"Coltorti","year":"1994","journal-title":"Infection"},{"key":"10.1016\/j.dld.2004.02.007_BIB23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1365-2893.2000.00203.x","article-title":"Intrafamilial transmission of hepatitis C virus: a systematic review","volume":"7","author":"Ackerman","year":"2000","journal-title":"J of Viral Hepatitis"},{"key":"10.1016\/j.dld.2004.02.007_BIB24","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1136\/bmj.296.6637.1627","article-title":"Influence of C4 null genes on infection with human immunodeficiency virus","volume":"296","author":"Cameron","year":"1988","journal-title":"Br Med J (Clin Res Ed)"},{"key":"10.1016\/j.dld.2004.02.007_BIB25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2249.1992.tb03067.x","article-title":"Prolonged clinically asymptomatic evolution after HIV infection is marked by the absence of complement C4 null alleles at the MHC","volume":"88","author":"Hentges","year":"1992","journal-title":"Clinic Exp Immunol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865804001252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865804001252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,9]],"date-time":"2019-02-09T16:29:01Z","timestamp":1549729741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865804001252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S1590865804001252"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2004.02.007","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}