{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:14:24Z","timestamp":1764688464278},"reference-count":31,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1016\/j.dld.2005.05.005","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T18:12:11Z","timestamp":1120673531000},"page":"768-772","source":"Crossref","is-referenced-by-count":14,"title":["CARD15\/NOD2 polymorphisms do not explain concordance of Crohn's disease in Swedish monozygotic twins"],"prefix":"10.1016","volume":"37","author":[{"given":"J.","family":"Halfvarson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Bresso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"D\u2019Amato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"J\u00e4rnerot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Pettersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tysk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2005.05.005_bib1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S1590-8658(02)80153-0","article-title":"Inflammatory bowel disease: dogmas and heresies","volume":"34","author":"Fiocchi","year":"2002","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2005.05.005_bib2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.dld.2005.05.005_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.dld.2005.05.005_bib4","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1053\/gast.2002.32413","article-title":"The molecular classification of the clinical manifestations of Crohn's disease","volume":"122","author":"Ahmad","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2005.05.005_bib5","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1053\/gast.2002.32415","article-title":"The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease","volume":"122","author":"Cuthbert","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2005.05.005_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1590-8658(02)80249-3","article-title":"3020insC mutation within the NOD2 gene in Crohn's disease: frequency and association with clinical pattern in an Italian population","volume":"34","author":"Vavassori","year":"2002","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2005.05.005_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00054725-200309000-00001","article-title":"Defining complex contributions of NOD2\/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes","volume":"9","author":"Brant","year":"2003","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.dld.2005.05.005_bib8","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1080\/00365520310006612","article-title":"Prevalence of mutations of the NOD2\/CARD15 gene and relation to phenotype in Spanish patients with Crohn's disease","volume":"38","author":"Mendoza","year":"2003","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2005.05.005_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.dld.2003.10.001","article-title":"Genetic and serological markers to identify phenotypic subgroups in a Dutch Crohn's disease population","volume":"36","author":"Linskens","year":"2004","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2005.05.005_bib10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1086\/339432","article-title":"CARD15\/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease","volume":"70","author":"Lesage","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.dld.2005.05.005_bib11","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1086\/341124","article-title":"CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure","volume":"71","author":"Vermeire","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.dld.2005.05.005_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1572-0241.2004.04040.x","article-title":"Transmission of CARD15 (NOD2) variants within families of patients with inflammatory bowel disease","volume":"99","author":"Esters","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2005.05.005_bib13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1053\/gast.2002.35393","article-title":"Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease","volume":"123","author":"Abreu","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2005.05.005_bib14","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0140-6736(02)08590-2","article-title":"Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study","volume":"359","author":"Hampe","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2005.05.005_bib15","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S1590-8658(03)00461-4","article-title":"CARD 15 and toll-like receptors: the link with Crohn's disease","volume":"35","author":"Caprilli","year":"2003","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2005.05.005_bib16","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1053\/j.gastro.2004.01.061","article-title":"Clinical relevance of advances in genetics and pharmacogenetics of IBD","volume":"126","author":"Ahmad","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2005.05.005_bib17","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1136\/gut.29.7.990","article-title":"Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking","volume":"29","author":"Tysk","year":"1988","journal-title":"Gut"},{"key":"10.1016\/j.dld.2005.05.005_bib18","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0016-5085(03)00385-8","article-title":"Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics","volume":"124","author":"Halfvarson","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2005.05.005_bib19","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1080\/003655200451207","article-title":"Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study","volume":"35","author":"Orholm","year":"2000","journal-title":"Scand J Gastroenterol"},{"issue":"Suppl. I","key":"10.1016\/j.dld.2005.05.005_bib20","first-page":"A40","article-title":"Concordance rates of twins and siblings in inflammatory bowel disease (IBD) [abstract]","volume":"42","author":"Subhani","year":"1998","journal-title":"Gut"},{"issue":"Suppl. 2","key":"10.1016\/j.dld.2005.05.005_bib21","first-page":"359","article-title":"Genetic Crohn's disease. A different entity than sporadic. A study in monozygotic twins [abstract]","volume":"126","author":"Halfvarson","year":"2004","journal-title":"Gastroenterology"},{"issue":"Suppl. II","key":"10.1016\/j.dld.2005.05.005_bib22","first-page":"A45","article-title":"Decreasing pair concordance in monozygotic twins with Crohn's disease [abstract]","volume":"126","author":"Halfvarson","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2005.05.005_bib23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ibd.3780060103","article-title":"A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna, 1998","volume":"6","author":"Gasche","year":"2000","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.dld.2005.05.005_bib24","first-page":"338","article-title":"Studies on similarity diagnosis in twins with the aid of mailed questionnaires","volume":"11","author":"Cederl\u00f6f","year":"1961","journal-title":"Acta Genet"},{"key":"10.1016\/j.dld.2005.05.005_bib25","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1046\/j.1365-2796.2002.01032.x","article-title":"The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies","volume":"252","author":"Lichtenstein","year":"2002","journal-title":"J Intern Med"},{"key":"10.1016\/j.dld.2005.05.005_bib26","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.0006-341X.2001.00963.x","article-title":"On small-sample confidence intervals for parameters in discrete distributions","volume":"57","author":"Agresti","year":"2001","journal-title":"Biometrics"},{"issue":"Suppl. 1","key":"10.1016\/j.dld.2005.05.005_bib27","first-page":"A298","article-title":"NOD2\/CARD15 mutations in a Scottish Crohn's disease population [abstract]","volume":"122","author":"Crichton","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2005.05.005_bib28","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/sj.ejhg.5200954","article-title":"Association of NOD2 with Crohn's disease in a homogenous Irish population","volume":"11","author":"Bairead","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.dld.2005.05.005_bib29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1136\/gut.52.4.558","article-title":"CARD15\/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease","volume":"52","author":"Helio","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.dld.2005.05.005_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.dld.2003.10.010","article-title":"Frequency of NOD2\/CARD15 variants in both sporadic and familial cases of Crohn's disease across Italy. An Italian Group for Inflammatory Bowel Disease Study","volume":"36","author":"Annese","year":"2004","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2005.05.005_bib31","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S1590-8658(03)00213-5","article-title":"Genetics of inflammatory bowel disease: the beginning of the end or the end of the beginning?","volume":"35","author":"Annese","year":"2003","journal-title":"Dig Liver Dis"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865805002367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865805002367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T14:55:16Z","timestamp":1548341716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865805002367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S1590865805002367"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2005.05.005","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}