{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:40:40Z","timestamp":1759160440406},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.dld.2008.06.011","type":"journal-article","created":{"date-parts":[[2008,7,27]],"date-time":"2008-07-27T04:19:25Z","timestamp":1217132365000},"page":"253-262","source":"Crossref","is-referenced-by-count":6,"title":["Endothelial nitric oxide synthase (eNOS) is not upregulated in gastric mucosa of Helicobacter pylori (H. pylori)-positive patients with type 2 diabetes mellitus"],"prefix":"10.1016","volume":"41","author":[{"given":"G.","family":"Lazaraki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kountouras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Metallidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Vrettou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Alevizos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Tzioufa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dokas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Germanidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zavos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Nikolaidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2008.06.011_bib1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/jemt.1100","article-title":"Nitric oxide: relation to integrity, injury, and healing of the gastric mucosa","volume":"53","author":"Calatayud","year":"2001","journal-title":"Microsc Res Technol"},{"key":"10.1016\/j.dld.2008.06.011_bib2","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/gast.2000.9304","article-title":"Nitric oxide in mucosal defense: a little goes a long way","volume":"119","author":"Wallace","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2008.06.011_bib3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1476-5381.1990.tb12977.x","article-title":"Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat","volume":"99","author":"Whittle","year":"1990","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.dld.2008.06.011_bib4","doi-asserted-by":"crossref","first-page":"G341","DOI":"10.1152\/ajpgi.2000.279.2.G341","article-title":"Endothelial nitric oxide synthase modulates gastric ulcer healing in rats","volume":"279","author":"Ma","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.dld.2008.06.011_bib5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/sj.bjp.0703393","article-title":"Endothelial dysfunction in diabetes","volume":"130","author":"De Vriese","year":"2000","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.dld.2008.06.011_bib6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/01.HYP.31.5.1047","article-title":"Review of alterations in endothelial nitric oxide production in diabetes: protective role of arginine on endothelial dysfunction","volume":"31","author":"Pieper","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.dld.2008.06.011_bib7","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/sj.bjp.0701974","article-title":"Increased susceptibility of gastric mucosa to ulcerogenic stimulation in diabetic rats\u2014role of capsaicin-sensitive sensory neurons","volume":"124","author":"Tashima","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.dld.2008.06.011_bib8","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/BF02936947","article-title":"Gastric mucosal blood flow response to stress in streptozotocin diabetic rats: regulatory role of nitric oxide","volume":"32","author":"Suzuki","year":"1997","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.dld.2008.06.011_bib9","first-page":"E749","article-title":"Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats","volume":"254","author":"Pillion","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.dld.2008.06.011_bib10","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s005350050239","article-title":"Epalrestat prevents the decrease in gastric mucosal blood flow and protects the gastric mucosa in streptozotocin diabetic rats","volume":"34","author":"Suzuki","year":"1999","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.dld.2008.06.011_bib11","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/0016-5085(90)91075-H","article-title":"Protective role of intracellular glutathione against ethanol-induced damage in cultured rat gastric mucosal cells","volume":"98","author":"Mutoh","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2008.06.011_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000201019","article-title":"Endogenous sulfhydryls in healing gastric mucosal injury induced by HCl in the rat","volume":"54","author":"Takeuchi","year":"1993","journal-title":"Digestion"},{"key":"10.1016\/j.dld.2008.06.011_bib13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0928-4257(97)89491-0","article-title":"Impaired duodenal bicarbonate secretion in diabetic rats. Salutary effect of nitric oxide synthase inhibitor","volume":"91","author":"Takeuchi","year":"1997","journal-title":"J Physiol Paris"},{"key":"10.1016\/j.dld.2008.06.011_bib14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/oxfordjournals.bmb.a072637","article-title":"Diabetes mellitus and free radicals: free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications","volume":"49","author":"Wolff","year":"1993","journal-title":"Br Med Bull"},{"key":"10.1016\/j.dld.2008.06.011_bib15","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1053\/gast.1997.v112.pm9041247","article-title":"Gastric mucosal damage in experimental diabetes in rats: role of endogenous glutathione","volume":"112","author":"Goldin","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2008.06.011_bib16","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1464-5491.1987.tb00861.x","article-title":"The microcirculation in diabetes","volume":"4","author":"Tooke","year":"1987","journal-title":"Diabetic Med"},{"key":"10.1016\/j.dld.2008.06.011_bib17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1053\/j.gastro.2005.11.005","article-title":"GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow","volume":"130","author":"Guan","year":"2006","journal-title":"Gastroenterology"},{"issue":"Pt 3","key":"10.1016\/j.dld.2008.06.011_bib18","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1113\/jphysiol.1997.sp021902","article-title":"Diabetes and insulin-induced stimulation of l-arginine transport and nitric oxide synthesis in rabbit isolated gastric glands","volume":"498","author":"Contreras","year":"1997","journal-title":"J Physiol"},{"key":"10.1016\/j.dld.2008.06.011_bib19","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/MEG.0b013e3282f4c35a","article-title":"Helicobacter pylori infection upregulates endothelial nitric oxide synthase expression and induces angiogenesis in gastric mucosa of dyspeptic patients","volume":"20","author":"Lazaraki","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2008.06.011_bib20","first-page":"1095","article-title":"Proceedings of a consensus development conference on standardized measures in diabetic neuropathy. Autonomic nervous system testing","volume":"15","author":"Kahn","year":"1992","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dld.2008.06.011_bib21","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-199610000-00001","article-title":"Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994","volume":"20","author":"Dixon","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.dld.2008.06.011_bib22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/path.1512","article-title":"Expression of COPX-2, mPGE-synthase 1, MDR-1(P-gp), and Bcl-xL: a molecular pathway of H. pylori-related gastric carcinogenesis","volume":"202","author":"Nardone","year":"2004","journal-title":"Pathology"},{"key":"10.1016\/j.dld.2008.06.011_bib23","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1080\/003655201750422594","article-title":"Morphological support for paracrine inhibition of gastric acid secretion by nitric oxide in humans","volume":"36","author":"Berg","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2008.06.011_bib24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0165-6147(02)00049-4","article-title":"Endothelial nitric oxide synthase: the Cinderella of inflammation?","volume":"24","author":"Cirino","year":"2003","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.dld.2008.06.011_bib25","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/CIRCULATIONAHA.106.621854","article-title":"Advanced glycation end products. Sparking the development of diabetic vascular injury","volume":"114","author":"Goldin","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.dld.2008.06.011_bib26","doi-asserted-by":"crossref","first-page":"E50","DOI":"10.1161\/01.RES.86.3.e50","article-title":"Regulation of endothelial nitric oxide synthase expression by albumin derived advanced glycosylation end products","volume":"86","author":"Rojas","year":"2000","journal-title":"Circ Res"},{"key":"10.1016\/j.dld.2008.06.011_bib27","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2337\/diabetes.47.6.945","article-title":"Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products","volume":"47","author":"Chakravarthy","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.dld.2008.06.011_bib28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbrc.2005.11.017","article-title":"eNOS, COX-2, and prostacyclin production are impaired in endothelial cells from diabetics","volume":"339","author":"Bolego","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.dld.2008.06.011_bib29","first-page":"307","article-title":"Profile of neurohumoral agents on mesenteric and intestinal blood flow in health and disease","volume":"47","author":"Hansen","year":"1998","journal-title":"Physiol Res"},{"key":"10.1016\/j.dld.2008.06.011_bib30","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.3748\/wjg.v10.i15.2232","article-title":"Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor kappaB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma","volume":"10","author":"Chang","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.dld.2008.06.011_bib31","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/0264-6021:3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.dld.2008.06.011_bib32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1046\/j.1365-2036.1999.00489.x","article-title":"Expression of endothelial cell-derived nitric oxide synthase (eNOS) is increased during gastric adaptation to chronic aspirin intake in humans","volume":"13","author":"Fischer","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"issue":"Suppl. 1","key":"10.1016\/j.dld.2008.06.011_bib33","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1007\/s10620-005-2803-6","article-title":"Cellular and molecular mechanisms of gastrointestinal ulcer healing","volume":"50","author":"Tarnawski","year":"2005","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2008.06.011_bib34","series-title":"Cecil textbook of medicine","first-page":"1258","article-title":"Diabetes mellitus","author":"Sherwin","year":"1996"},{"key":"10.1016\/j.dld.2008.06.011_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2337\/diacare.20.3.413","article-title":"Prevalence and determinants of solid and liquid gastric emptying in unstable type I diabetes. Relationship to postprandial blood glucose concentrations","volume":"20","author":"Lyrenas","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dld.2008.06.011_bib36","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1007\/s00535-006-1909-8","article-title":"A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus","volume":"41","author":"Iwasaki","year":"2006","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.dld.2008.06.011_bib37","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1053\/gast.2002.34212","article-title":"Distribution of the novel eNOS-interacting protein NOSIP in the liver, pancreas, and gastrointestinal tract of the rat","volume":"123","author":"Konig","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2008.06.011_bib38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/mcne.2002.1111","article-title":"Sensory neurons respond to hypoxia with NO production associated with mitochondria","volume":"20","author":"Henrich","year":"2002","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.dld.2008.06.011_bib39","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1053\/gast.1997.v113.pm9352855","article-title":"Impaired expression of nitric oxide synthase in the gastric myenteric plexus of spontaneously diabetic rats","volume":"113","author":"Takahashi","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2008.06.011_bib40","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1007\/s00535-006-1962-3","article-title":"Diabetic gastropathy and interstitial cells of Cajal: a clue for bringing understanding out of chaos?","volume":"41","author":"Iwakiri","year":"2006","journal-title":"J Gastroenterol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865808002557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865808002557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T19:37:03Z","timestamp":1557689823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865808002557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S1590865808002557"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2008.06.011","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}