{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:48:59Z","timestamp":1792435739212,"version":"4.5.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.dld.2008.07.318","type":"journal-article","created":{"date-parts":[[2008,10,15]],"date-time":"2008-10-15T15:49:53Z","timestamp":1224085793000},"page":"9-14","source":"Crossref","is-referenced-by-count":28,"title":["Intercellular space diameters of the oesophageal epithelium in NERD patients: Head to head comparison between light and electron microscopy analysis"],"prefix":"10.1016","volume":"41","author":[{"given":"M.","family":"Ribolsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Perrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Caviglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Emerenziani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.P.","family":"Luca Guarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Petitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cicala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2008.07.318_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1136\/gut.44.2008.S1","article-title":"An evidence-based appraisal of reflux disease management: The Genval Workshop Report","volume":"44","author":"Dent","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.dld.2008.07.318_bib2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1572-0241.2001.03511.x","article-title":"Nonerosive reflux disease: current concepts and dilemmas","volume":"96","author":"Fass","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2008.07.318_bib3","first-page":"1","article-title":"Functional gastrointestinal disorders","volume":"25","author":"Clouse","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.dld.2008.07.318_bib4","first-page":"1997","article-title":"Omeprazole as a diagnostic tool in gastroesophageal reflux disease","volume":"92","author":"Schenk","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2008.07.318_bib5","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1001\/archinte.155.16.1808","article-title":"Empiric therapy for gastroesophageal reflux disease","volume":"155","author":"Schindlbeck","year":"1995","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.dld.2008.07.318_bib6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1590-8658(01)80100-6","article-title":"Non-erosive reflux disease: the real problem in gastro-esophageal reflux disease","volume":"33","author":"Quigley","year":"2001","journal-title":"Digest Liver Dis"},{"key":"10.1016\/j.dld.2008.07.318_bib7","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s004280050032","article-title":"Altered intercellular glycoconjugates and dilated intercellular spaces of esophageal epithelium in reflux disease","volume":"436","author":"Solcia","year":"2000","journal-title":"Virchows Arch"},{"key":"10.1016\/j.dld.2008.07.318_bib8","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1111\/j.1572-0241.2005.50209.x","article-title":"Reassessment of the diagnostic value of histology in patients with GERD, using multiple biopsy sites and an appropriate control group","volume":"100","author":"Zentilin","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2008.07.318_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.gie.2006.03.635","article-title":"Microscopic changes in non erosive reflux disease (NERD) can be diagnosed during ongoing endoscopy by confocal laser endomicroscopy (CLE) [abstract]","volume":"63","author":"Kiesslich","year":"2006","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2008.07.318_bib10","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000080319","article-title":"What parameters are relevant for the histological diagnosis of gastroesophageal reflux disease without Barrett\u2019s mucosa?","volume":"22","author":"Vieth","year":"2004","journal-title":"Dig Dis"},{"key":"10.1016\/j.dld.2008.07.318_bib11","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1053\/gast.1996.v111.pm8898633","article-title":"Dilated intercellular spaces: a morphological feature of acid reflux damaged human esophageal epithelium","volume":"111","author":"Tobey","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2008.07.318_bib12","first-page":"G718","article-title":"Mechanisms of H+ injury in rabbit esophageal epithelium","volume":"246","author":"Orlando","year":"1984","journal-title":"Am J Physiol"},{"key":"10.1016\/j.dld.2008.07.318_bib13","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1111\/j.1572-0241.2001.05260.x","article-title":"The role of pepsin in acid injury to esophageal epithelium","volume":"96","author":"Tobey","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2008.07.318_bib14","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1136\/gut.2006.113688","article-title":"Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces","volume":"56","author":"Farre","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.dld.2008.07.318_bib15","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1572-0241.2005.40978.x","article-title":"Dilated intercellular spaces of esophageal epithelium in nonerosive reflux disease patients with physiological esophageal acid exposure","volume":"100","author":"Caviglia","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2008.07.318_bib16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1365-2036.2006.03237.x","article-title":"Dilated intercellular spaces and acid reflux at the distal and proximal oesophagus in patients with non-erosive gastro-oesophageal reflux disease","volume":"25","author":"Caviglia","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2008.07.318_bib17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1572-0241.2005.40476.x","article-title":"Reversibility of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment","volume":"100","author":"Calabrese","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2008.07.318_bib18","doi-asserted-by":"crossref","first-page":"A416","DOI":"10.1016\/S0016-5085(03)82103-0","article-title":"Are endoscopy negative GERD and reflux esophagitis different diseases? Baseline histology in GERD patients off-therapy\u2014The CHEER Study","volume":"124","author":"Armstrong","year":"2003","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.dld.2008.07.318_bib19","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/j.1572-0241.2007.01688.x","article-title":"Esophageal dilated intercellular spaces (DIS) and nonerosive reflux disease","volume":"103","author":"van Malenstein","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2008.07.318_bib20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.cgh.2006.08.006","article-title":"Microscopic esophageal mucosal injury in nonerosive reflux disease","volume":"5","author":"Dent","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2008.07.318_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000048833","article-title":"Dilated intercellular spaces as markers of reflux disease: histology, semiquantitative score and morphometry upon light microscopy","volume":"64","author":"Villanacci","year":"2001","journal-title":"Digestion"},{"key":"10.1016\/j.dld.2008.07.318_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1572-0241.2001.03451.x","article-title":"Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease","volume":"96","author":"Shaw","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2008.07.318_bib23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/BF01536258","article-title":"Physiological gastroesophageal reflux and esophageal motor activity studied with a new system for 24-hour recording and automated analysis","volume":"34","author":"Smout","year":"1989","journal-title":"Dig Dis Sci"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865808006026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865808006026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T20:43:56Z","timestamp":1631997836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865808006026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S1590865808006026"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2008.07.318","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}