{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:37:35Z","timestamp":1780673855913,"version":"3.54.1"},"reference-count":120,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.dld.2009.07.005","type":"journal-article","created":{"date-parts":[[2009,8,9]],"date-time":"2009-08-09T04:30:57Z","timestamp":1249792257000},"page":"772-780","source":"Crossref","is-referenced-by-count":92,"title":["Irritable bowel syndrome: Novel views on the epidemiology and potential risk factors"],"prefix":"10.1016","volume":"41","author":[{"given":"E.","family":"Rey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.J.","family":"Talley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2009.07.005_bib1","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1053\/gast.2002.37095","article-title":"AGA technical review on irritable bowel syndrome","volume":"123","author":"Drossman","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib2","first-page":"106","article-title":"On certain painful afflictions of the intestinal canal","volume":"6","author":"Powell","year":"1818","journal-title":"Med Trans Roy Coll Phys"},{"key":"10.1016\/j.dld.2009.07.005_bib3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0140-6736(02)09712-X","article-title":"Irritable bowel syndrome: a little understood organic bowel disease?","volume":"360","author":"Talley","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2009.07.005_bib4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/bmj.2.6138.653","article-title":"Towards positive diagnosis of the irritable bowel","volume":"2","author":"Manning","year":"1978","journal-title":"Br Med J"},{"key":"10.1016\/j.dld.2009.07.005_bib5","first-page":"92","article-title":"Irritable bowel syndrome: guidelines for the diagnosis","volume":"2","author":"Thompson","year":"1989","journal-title":"Gastroenterol Int"},{"key":"10.1016\/j.dld.2009.07.005_bib6","first-page":"159","article-title":"Identification of subgroups of functional gastrointestinal disorders","volume":"3","author":"Drossman","year":"1990","journal-title":"Gastroenterol Int"},{"key":"10.1016\/j.dld.2009.07.005_bib7","first-page":"75","article-title":"Functional bowel disorders and functional abdominal pain","volume":"5","author":"Thompson","year":"1992","journal-title":"Gastroenterol Int"},{"issue":"Suppl. 2","key":"10.1016\/j.dld.2009.07.005_bib8","doi-asserted-by":"crossref","first-page":"II43","DOI":"10.1136\/gut.45.2008.ii43","article-title":"Functional bowel disorders and functional abdominal pain","volume":"45","author":"Thompson","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.07.005_bib9","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib10","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/00365520310008782","article-title":"Diagnosing irritable bowel syndrome: poor agreement between general practitioners and the Rome II criteria","volume":"39","author":"Vandvik","year":"2004","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1365-2982.2005.00750.x","article-title":"Physician knowledge of Rome symptom criteria for irritable bowel syndrome is poor among non-gastroenterologists","volume":"18","author":"Charapata","year":"2006","journal-title":"Neurogastroenterol Motil"},{"issue":"Suppl. 1","key":"10.1016\/j.dld.2009.07.005_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2982.2008.01097.x","article-title":"Functional gastrointestinal disorders as a public health problem","volume":"20","author":"Talley","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2009.07.005_bib13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2982.2005.00627.x","article-title":"Irritable bowel syndrome in developing countries\u2014a disorder of civilization or colonization?","volume":"17","author":"Gwee","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2009.07.005_bib14","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(91)90717-Y","article-title":"Epidemiology of colonic symptoms and the irritable bowel syndrome","volume":"101","author":"Talley","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib15","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1023\/A:1018889318063","article-title":"Differences between individuals with self-reported irritable bowel syndrome (IBS) and IBS-like symptoms","volume":"42","author":"Hahn","year":"1997","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib16","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1111\/j.1572-0241.2000.03192.x","article-title":"A comparison of the Rome and Manning criteria for case identification in epidemiological investigations of irritable bowel syndrome","volume":"95","author":"Saito","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib17","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/j.1365-2036.2005.02463.x","article-title":"Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact","volume":"21","author":"Hungin","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/bmj.304.6819.87","article-title":"Irritable bowel syndrome in the general population","volume":"304","author":"Jones","year":"1992","journal-title":"Br Med J"},{"key":"10.1016\/j.dld.2009.07.005_bib19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0016-5085(95)90373-9","article-title":"Irritable bowel syndrome and dyspepsia in the general population: overlap and lack of stability over time","volume":"109","author":"Agreus","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib20","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1136\/gut.43.6.770","article-title":"Irritable bowel syndrome, gastro-oesophageal reflux, and bronchial hyper-responsiveness in the general population","volume":"43","author":"Kennedy","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.07.005_bib21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0300-2977(01)00128-0","article-title":"Functional bowel symptoms in a general Dutch population and associations with common stimulants","volume":"59","author":"Boekema","year":"2001","journal-title":"Neth J Med"},{"key":"10.1016\/j.dld.2009.07.005_bib22","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1080\/00365520152584770","article-title":"Irritable bowel syndrome prevalence varies enormously depending on the employed diagnostic criteria: comparison of Rome II versus previous criteria in a general population","volume":"36","author":"Mearin","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2036.2003.01456.x","article-title":"The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects","volume":"17","author":"Hungin","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib24","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0399-8320(04)95011-7","article-title":"Prevalence of irritable bowel syndrome (IBS) and variability of diagnostic criteria","volume":"28","author":"Bommelaer","year":"2004","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.dld.2009.07.005_bib25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2036.2004.02034.x","article-title":"Prevalence of irritable bowel syndrome according to different diagnostic criteria in a non-selected adult population","volume":"20","author":"Hillila","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1080\/00365520510012271","article-title":"Prevalence and impact of upper and lower gastrointestinal symptoms in the Greek urban general population","volume":"40","author":"Papatheodoridis","year":"2005","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/gut.41.3.394","article-title":"Predictors of health care seeking for irritable bowel syndrome: a population based study","volume":"41","author":"Talley","year":"1997","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.07.005_bib28","first-page":"U220","article-title":"Prevalence and correlates of irritable bowel symptoms in a New Zealand birth cohort","volume":"115","author":"Barbezat","year":"2002","journal-title":"N Z Med J"},{"key":"10.1016\/j.dld.2009.07.005_bib29","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/BF01303162","article-title":"U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact","volume":"38","author":"Drossman","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1023\/A:1013208713670","article-title":"Functional gastrointestinal disorders in Canada: first population-based survey using Rome II criteria with suggestions for improving the questionnaire","volume":"47","author":"Thompson","year":"2002","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib31","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/0016-5085(92)90320-X","article-title":"Symptoms of irritable bowel syndrome in a British urban community: consulters and nonconsulters","volume":"102","author":"Heaton","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1445-5994.2006.01006.x","article-title":"Epidemiology of the functional gastrointestinal disorders diagnosed according to Rome II criteria: an Australian population-based study","volume":"36","author":"Boyce","year":"2006","journal-title":"Intern Med J"},{"key":"10.1016\/j.dld.2009.07.005_bib33","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1365-2036.2005.02671.x","article-title":"Prevalence and demographics of irritable bowel syndrome: results from a large web-based survey","volume":"22","author":"Andrews","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib34","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1053\/j.gastro.2007.06.010","article-title":"Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study","volume":"133","author":"Halder","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib35","first-page":"495","article-title":"Prevalence of irritable bowel syndrome: a community survey","volume":"54","author":"Wilson","year":"2004","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.dld.2009.07.005_bib36","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/00042737-200410000-00008","article-title":"Irritable bowel syndrome in France: a common, debilitating and costly disorder","volume":"16","author":"Dapoigny","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2009.07.005_bib37","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/00365520500442542","article-title":"Prevalence, comorbidity and impact of irritable bowel syndrome in Norway","volume":"41","author":"Vandvik","year":"2006","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib38","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1572-0241.1998.00526.x","article-title":"Prevalence of gastrointestinal symptoms in a multiracial Asian population, with particular reference to reflux-type symptoms","volume":"93","author":"Ho","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib39","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/j.1572-0241.2004.04161.x","article-title":"The prevalence, symptom characteristics, and impact of irritable bowel syndrome in an Asian urban community","volume":"99","author":"Gwee","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib40","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1111\/j.1365-2036.2004.01939.x","article-title":"A population-based epidemiologic study of irritable bowel syndrome in South China: stratified randomized study by cluster sampling","volume":"19","author":"Xiong","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib41","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1572-0241.2001.03760.x","article-title":"Irritable bowel syndrome in a rural community in Bangladesh: prevalence, symptoms pattern, and health care seeking behavior","volume":"96","author":"Masud","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib42","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1023\/A:1020549118299","article-title":"Epidemiology of irritable bowel syndrome in Chinese","volume":"47","author":"Lau","year":"2002","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib43","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1046\/j.1440-1746.2002.02871.x","article-title":"Prevalence of irritable bowel syndrome in Hong Kong","volume":"17","author":"Kwan","year":"2002","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2009.07.005_bib44","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.rmed.2005.03.036","article-title":"Correlation between asthma and irritable bowel syndrome in a general population in Iran in 2003","volume":"100","author":"Amra","year":"2006","journal-title":"Respir Med"},{"key":"10.1016\/j.dld.2009.07.005_bib45","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1440-1746.2004.03367.x","article-title":"Epidemiological features of irritable bowel syndrome in a Turkish urban society","volume":"19","author":"Celebi","year":"2004","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2009.07.005_bib46","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1742-1241.2004.00377.x","article-title":"The epidemiological aspects of irritable bowel syndrome in Southeastern Anatolia: a stratified randomised community-based study","volume":"59","author":"Yilmaz","year":"2005","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.dld.2009.07.005_bib47","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/MEG.0b013e32801140e2","article-title":"A comparative reappraisal of the Rome II and Rome III diagnostic criteria: are we getting closer to the \u2018true\u2019 prevalence of irritable bowel syndrome?","volume":"19","author":"Sperber","year":"2007","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2009.07.005_bib48","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/j.1440-1746.2006.04269.x","article-title":"Prevalence of irritable bowel syndrome in Korea: population-based survey using the Rome II criteria","volume":"21","author":"Han","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2009.07.005_bib49","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1542-3565(05)00157-6","article-title":"Irritable bowel syndrome: toward an understanding of severity","volume":"3","author":"Lembo","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2009.07.005_bib50","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/j.1365-2982.2008.01143.x","article-title":"A population-based study of irritable bowel syndrome in a non-Western population","volume":"20","author":"Husain","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2009.07.005_bib51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/oxfordjournals.aje.a116483","article-title":"Onset and disappearance of gastrointestinal symptoms and functional gastrointestinal disorders","volume":"136","author":"Talley","year":"1992","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.dld.2009.07.005_bib52","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.pain.2007.08.029","article-title":"Psychosocial risk markers for new onset irritable bowel syndrome\u2014results of a large prospective population-based study","volume":"137","author":"Nicholl","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.dld.2009.07.005_bib53","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/j.1572-0241.2007.01740.x","article-title":"Irritable bowel syndrome: a 10-yr natural history of symptoms and factors that influence consultation behavior","volume":"103","author":"Ford","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib54","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/j.1365-2036.2004.01938.x","article-title":"Incidence of a clinical diagnosis of the irritable bowel syndrome in a United States population","volume":"19","author":"Locke","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib55","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/003655200750024191","article-title":"Detection of colorectal tumor and inflammatory bowel disease during follow-up of patients with initial diagnosis of irritable bowel syndrome","volume":"35","author":"Garcia Rodriguez","year":"2000","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib56","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1159\/000121356","article-title":"Do gastrointestinal symptoms fluctuate in the short-term perspective? The Kalixanda study","volume":"26","author":"Bolling-Sternevald","year":"2008","journal-title":"Dig Dis"},{"key":"10.1016\/j.dld.2009.07.005_bib57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1365-2036.2006.03197.x","article-title":"Change over time of bowel habit in irritable bowel syndrome: a prospective, observational, 1-year follow-up study (RITMO study)","volume":"25","author":"Garrigues","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib58","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1053\/j.gastro.2004.12.006","article-title":"A prospective assessment of bowel habit in irritable bowel syndrome in women: defining an alternator","volume":"128","author":"Drossman","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib59","doi-asserted-by":"crossref","first-page":"107","DOI":"10.7326\/0003-4819-122-2-199501150-00005","article-title":"The irritable bowel syndrome: long-term prognosis and the physician\u2013patient interaction","volume":"122","author":"Owens","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.dld.2009.07.005_bib60","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1111\/j.1572-0241.2002.07027.x","article-title":"The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review","volume":"97","author":"Cash","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib61","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0016-5085(84)90706-6","article-title":"Symptom complaints and health care seeking behavior in subjects with bowel dysfunction","volume":"87","author":"Sandler","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib62","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0016-5085(80)90142-0","article-title":"Functional bowel disorders in apparently healthy people","volume":"79","author":"Thompson","year":"1980","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib63","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/oxfordjournals.aje.a117548","article-title":"Irritable bowel syndrome in a community: symptom subgroups, risk factors, and health care utilization","volume":"142","author":"Talley","year":"1995","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.dld.2009.07.005_bib64","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2165\/00019053-200220110-00004","article-title":"Burden of illness in irritable bowel syndrome comparing Rome I and Rome II criteria","volume":"20","author":"Badia","year":"2002","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.dld.2009.07.005_bib65","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/j.1572-0241.2001.03789.x","article-title":"Predictors of health care seeking for irritable bowel syndrome and nonulcer dyspepsia: a critical review of the literature on symptom and psychosocial factors","volume":"96","author":"Koloski","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib66","first-page":"459","article-title":"Reasons for consultation in irritable bowel syndrome: symptoms and patient characteristics","volume":"42","author":"Kettell","year":"1992","journal-title":"Br J Gen Pract"},{"key":"10.1016\/j.dld.2009.07.005_bib67","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0022-3476(96)70246-9","article-title":"Abdominal pain and irritable bowel syndrome in adolescents: a community-based study","volume":"129","author":"Hyams","year":"1996","journal-title":"J Pediatr"},{"key":"10.1016\/j.dld.2009.07.005_bib68","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0016-5085(88)80017-9","article-title":"Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome","volume":"95","author":"Drossman","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib69","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0016-5085(88)80018-0","article-title":"Symptoms of psychologic distress associated with irritable bowel syndrome. Comparison of community and medical clinic samples","volume":"95","author":"Whitehead","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib70","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0016-5085(90)90817-K","article-title":"Psychosocial factors are associated with health care seeking rather than diagnosis in irritable bowel syndrome","volume":"98","author":"Smith","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib71","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1080\/00365520701320455","article-title":"Why do subjects with irritable bowel syndrome seek health care for their symptoms?","volume":"42","author":"Ringstrom","year":"2007","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib72","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1572-0241.2004.04043.x","article-title":"Psychosocial factors are linked to functional gastrointestinal disorders: a population based nested case\u2013control study","volume":"99","author":"Locke","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib73","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0022-3999(97)00141-4","article-title":"Negative affect and the seeking of medical care in university students with irritable bowel syndrome: a preliminary study","volume":"43","author":"Gick","year":"1997","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.dld.2009.07.005_bib74","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10620-005-1294-9","article-title":"Is health care seeking for irritable bowel syndrome and functional dyspepsia a socially learned response to illness?","volume":"50","author":"Koloski","year":"2005","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib75","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1111\/j.1572-0241.2004.40478.x","article-title":"Increased somatic complaints and health-care utilization in children: effects of parent IBS status and parent response to gastrointestinal symptoms","volume":"99","author":"Levy","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib76","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1007\/BF01303163","article-title":"Irritable bowel-type symptoms in HMO examinees. Prevalence, demographics, and clinical correlates","volume":"38","author":"Longstreth","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib77","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/MCG.0b013e3181574d48","article-title":"Value of different diagnostic criteria for the irritable bowel syndrome among men and women","volume":"42","author":"Hammer","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib78","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0891-5245(96)90054-1","article-title":"Symptoms of irritable bowel in school children: prevalence and psychosocial effects","volume":"10","author":"Thomson","year":"1996","journal-title":"J Pediatr Health Care"},{"key":"10.1016\/j.dld.2009.07.005_bib79","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0016-5085(92)90175-X","article-title":"Prevalence of gastrointestinal symptoms in the elderly: a population-based study","volume":"102","author":"Talley","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib80","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF02208587","article-title":"Health-care-seeking behaviors related to bowel complaints. Hispanics versus non-hispanic whites","volume":"41","author":"Zuckerman","year":"1996","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib81","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1007\/BF02220455","article-title":"Irritable bowel syndrome defined by factor analysis. Gender and race comparisons","volume":"40","author":"Taub","year":"1995","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib82","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S1542-3565(05)00367-8","article-title":"Epidemiology of irritable bowel syndrome among African Americans as compared with whites: a population-based study","volume":"3","author":"Wigington","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2009.07.005_bib83","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jpsychores.2008.02.021","article-title":"Somatic comorbidities of irritable bowel syndrome: a systematic analysis","volume":"64","author":"Riedl","year":"2008","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.dld.2009.07.005_bib84","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00045391-200301000-00014","article-title":"Comorbidity of irritable bowel syndrome in psychiatric patients: a review","volume":"10","author":"Garakani","year":"2003","journal-title":"Am J Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib85","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1053\/gast.2002.32392","article-title":"Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?","volume":"122","author":"Whitehead","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib86","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1111\/j.1572-0241.2003.07699.x","article-title":"Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrhea","volume":"98","author":"Talley","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib87","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2982.2004.00581.x","article-title":"Overlap of gastrointestinal symptom complexes in a US community","volume":"17","author":"Locke","year":"2005","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2009.07.005_bib88","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1007\/s10620-006-9306-y","article-title":"Studying the overlap between IBS and GERD: a systematic review of the literature","volume":"51","author":"Nastaskin","year":"2006","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib89","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2036.2007.03366.x","article-title":"Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome: prevalence and risk factors in the general population","volume":"26","author":"Jung","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib90","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1136\/gut.52.11.1616","article-title":"Cluster analysis of symptoms and health seeking behaviour differentiates subgroups of patients with severe irritable bowel syndrome","volume":"52","author":"Guthrie","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.07.005_bib91","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1572-0241.2001.03741.x","article-title":"The irritable bowel syndrome and psychiatric disorders in the community: is there a link?","volume":"96","author":"Talley","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib92","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1017\/S1092852900024123","article-title":"Prevalence of irritable bowel syndrome in obsessive\u2013compulsive disorder","volume":"11","author":"Masand","year":"2006","journal-title":"CNS Spectr"},{"key":"10.1016\/j.dld.2009.07.005_bib93","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10620-006-9530-5","article-title":"Incidence of IBS in a cohort of people with asthma","volume":"52","author":"Cole","year":"2007","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2009.07.005_bib94","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1046\/j.1365-2036.2003.01499.x","article-title":"Systematic review: abdominal and pelvic surgery in patients with irritable bowel syndrome","volume":"17","author":"Hasler","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib95","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2036.2008.03715.x","article-title":"Biliary events and an increased risk of new onset irritable bowel syndrome: a population-based cohort study","author":"McNally","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2009.07.005_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.dld.2008.02.013","article-title":"Gallstones, cholecystectomy and irritable bowel syndrome (IBS) MICOL population-based study","author":"Corazziari","year":"2008","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2009.07.005_bib97","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1136\/gut.33.6.814","article-title":"Relation between hysterectomy and the irritable bowel: a prospective study","volume":"33","author":"Prior","year":"1992","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.07.005_bib98","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1136\/gut.34.8.1108","article-title":"Bowel function and irritable bowel symptoms after hysterectomy and cholecystectomy\u2014a population based study","volume":"34","author":"Heaton","year":"1993","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.07.005_bib99","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/j.1365-2982.2007.01077.x","article-title":"Irritable bowel syndrome aggregates strongly in families: a family-based case\u2013control study","volume":"20","author":"Saito","year":"2008","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2009.07.005_bib100","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1111\/j.1572-0241.2008.02048.x","article-title":"Genetics of irritable bowel syndrome","volume":"103","author":"Saito","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib101","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1572-0241.2007.01722.x","article-title":"Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review","volume":"103","author":"Chitkara","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib102","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1111\/j.1572-0241.2005.41753.x","article-title":"The natural history of childhood abdominal pain and its association with adult irritable bowel syndrome: birth-cohort study","volume":"100","author":"Howell","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib103","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00042737-199801000-00011","article-title":"Antibiotic use, childhood affluence and irritable bowel syndrome (IBS)","volume":"10","author":"Mendall","year":"1998","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2009.07.005_bib104","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1111\/j.1572-0241.2004.40188.x","article-title":"The irritable bowel syndrome has origins in the childhood socioeconomic environment","volume":"99","author":"Howell","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib105","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1136\/gut.52.8.1117","article-title":"Prevalence of gastrointestinal diseases in two British national birth cohorts","volume":"52","author":"Ehlin","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.07.005_bib106","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1136\/gut.2006.097287","article-title":"Irritable bowel syndrome in twins: genes and environment","volume":"55","author":"Bengtson","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.07.005_bib107","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jpeds.2004.06.057","article-title":"Gastric suction at birth: not an innocent bystander","volume":"145","author":"Anand","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.dld.2009.07.005_bib108","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.1572-0241.2000.01678.x","article-title":"Risk factors for irritable bowel syndrome: role of analgesics and food sensitivities","volume":"95","author":"Locke","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib109","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1111\/j.1572-0241.2005.00288.x","article-title":"Diet and functional gastrointestinal disorders: a population-based case\u2013control study","volume":"100","author":"Saito","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1136\/gut.42.1.47","article-title":"Is the association between irritable bowel syndrome and abuse explained by neuroticism? A population based study","volume":"42","author":"Talley","year":"1998","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.07.005_bib111","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/00006842-199903000-00005","article-title":"Psychological factors in functional gastrointestinal disorders: characteristics of the disorder or of the illness behavior?","volume":"61","author":"Herschbach","year":"1999","journal-title":"Psychosom Med"},{"key":"10.1016\/j.dld.2009.07.005_bib112","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1111\/j.1572-0241.2002.05783.x","article-title":"Epidemiology and health care seeking in the functional GI disorders: a population-based study","volume":"97","author":"Koloski","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib113","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1053\/j.gastro.2005.11.057","article-title":"Psychosocial aspects of the functional gastrointestinal disorders","volume":"130","author":"Levy","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib114","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jpsychores.2008.02.016","article-title":"The relationship between somatisation and outcome in patients with severe irritable bowel syndrome","volume":"64","author":"Creed","year":"2008","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.dld.2009.07.005_bib115","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.gastro.2005.11.033","article-title":"Hypothalamic\u2013pituitary\u2013gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?","volume":"130","author":"Dinan","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib116","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2007.01.046","article-title":"Immune activation in patients with irritable bowel syndrome","volume":"132","author":"Liebregts","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib117","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/0016-5085(94)90228-3","article-title":"Gastrointestinal tract symptoms and self-reported abuse: a population-based study","volume":"107","author":"Talley","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.07.005_bib118","first-page":"366","article-title":"Self-reported abuse and gastrointestinal disease in outpatients: association with irritable bowel-type symptoms","volume":"90","author":"Talley","year":"1995","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.07.005_bib119","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000087722","article-title":"A history of abuse in community subjects with irritable bowel syndrome and functional dyspepsia: the role of other psychosocial variables","volume":"72","author":"Koloski","year":"2005","journal-title":"Digestion"},{"key":"10.1016\/j.dld.2009.07.005_bib120","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S1542-3565(04)00776-1","article-title":"Prevalence of functional gastrointestinal disorders in women who report domestic violence to the police","volume":"3","author":"Perona","year":"2005","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865809002965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865809002965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T18:49:56Z","timestamp":1558464596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865809002965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":120,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S1590865809002965"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2009.07.005","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}