{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:27:15Z","timestamp":1791260835558,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.dld.2009.10.009","type":"journal-article","created":{"date-parts":[[2009,12,23]],"date-time":"2009-12-23T10:42:14Z","timestamp":1261564934000},"page":"490-495","source":"Crossref","is-referenced-by-count":67,"title":["Descriptive epidemiology of cholangiocarcinoma in Italy"],"prefix":"10.1016","volume":"42","author":[{"given":"Domenico","family":"Alvaro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Crocetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Consiglia","family":"Bragazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Capocaccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2009.10.009_bib1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/hep.22310","article-title":"Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment","volume":"48","author":"Blechacz","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2009.10.009_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cld.2007.11.003","article-title":"Cholangiocarcinoma","volume":"12","author":"Blechacz","year":"2008","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.dld.2009.10.009_bib3","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1136\/gut.2007.138859","article-title":"Cholangiocarcinoma and its management","volume":"56","author":"Khan","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.dld.2009.10.009_bib4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/MOG.0b013e3280495451","article-title":"Cholangiocarcinoma: emerging approaches to a challenging cancer","volume":"23","author":"Patel","year":"2007","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.dld.2009.10.009_bib5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/MCG.0b013e31806daf89","article-title":"Cholangiocarcinoma: natural history, treatment, and strategies for surveillance in high-risk patients","volume":"42","author":"Yachimski","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.dld.2009.10.009_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mam.2007.09.007","article-title":"New insights on the molecular and cell biology of human cholangiopathies","volume":"29","author":"Alvaro","year":"2008","journal-title":"Mol Aspects Med"},{"key":"10.1016\/j.dld.2009.10.009_bib7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/j.gastro.2006.07.023","article-title":"Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver","volume":"132","author":"Alvaro","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.10.009_bib8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1080\/003655202760373434","article-title":"Cholangiocarcinoma in primary sclerosing cholangitis: risk factors and clinical presentation","volume":"37","author":"Boberg","year":"2002","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2009.10.009_bib9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1572-0241.2004.04067.x","article-title":"Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis","volume":"99","author":"Burak","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.10.009_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/028418698423212","article-title":"Incidence, etiologic aspects and clinicopathologic features in intrahepatic cholangiocellular carcinoma\u2014a study of 51 cases from a low-endemicity area","volume":"37","author":"Kaczynski","year":"1998","journal-title":"Acta Oncol"},{"key":"10.1016\/j.dld.2009.10.009_bib11","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1053\/gast.2003.50156","article-title":"Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis","volume":"124","author":"Pardi","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.10.009_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0168-8278(01)00251-3","article-title":"Development of dominant bile duct stenoses in patient with primary sclerosing cholangitis treated with ursodeoxycholic acid: outcome after endoscopic treatment","volume":"36","author":"Stiehl","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2009.10.009_bib13","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1053\/j.gastro.2005.08.017","article-title":"High-dose ursodeoxycholic acid in primary sclerosing cholangitis: a 5-year multicenter, randomized controlled study","volume":"129","author":"Olsson","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2009.10.009_bib14","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jhep.2004.01.002","article-title":"Liver transplantation for primary slerosing cholangitis; predictors and consequences of hepatobiliary malignancy","volume":"40","author":"Brandsaeter","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2009.10.009_bib15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/ijc.2910480302","article-title":"Liver cancer in Thailand. I. A case control study of cholangicarcinoma","volume":"48","author":"Parkin","year":"1991","journal-title":"Int J Cancer"},{"key":"10.1016\/j.dld.2009.10.009_bib16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0002-9440(10)63645-0","article-title":"Identification of novel cellular targets in biliary tract cancers using global gene expression technology","volume":"163","author":"Hansel","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.dld.2009.10.009_bib17","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hep.20718","article-title":"Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinoma","volume":"41","author":"Obama","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2009.10.009_bib18","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/hep.21330","article-title":"Comparison of gene expression profiles between Opisthorchis viverrini and non-Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma","volume":"44","author":"Jinawath","year":"2006","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2009.10.009_bib19","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1053\/jhep.2001.25087","article-title":"Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States","volume":"33","author":"Patel","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2009.10.009_bib20","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1158\/1055-9965.EPI-05-0811","article-title":"A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States","volume":"15","author":"McGlynn","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.dld.2009.10.009_bib21","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/jnci\/djj234","article-title":"Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States","volume":"98","author":"Welzel","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.dld.2009.10.009_bib22","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jhep.2003.11.030","article-title":"Rising incidence of intrahepatic cholangiocarcinoma in the United States: a true increase?","volume":"40","author":"Shaib","year":"2004","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2009.10.009_bib23","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0959-8049(03)00544-6","article-title":"Do increases in mortality from intrahepatic cholangiocarcinoma reflect a genuine increase in risk? Insights from cancer registry data in Scotland","volume":"39","author":"Wood","year":"2003","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.dld.2009.10.009_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2407-2-10","article-title":"Worldwide trends in mortality from biliary tract malignancies","volume":"3","author":"Patel","year":"2002","journal-title":"BMC Cancer"},{"key":"10.1016\/j.dld.2009.10.009_bib25","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1038\/sj.bjc.6603127","article-title":"Trends in the incidence of primary liver and biliary tract cancers in England and Wales 1971-2001","volume":"94","author":"West","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.dld.2009.10.009_bib27","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/jnci\/djk201","article-title":"Incidence rates of intra- and extrahepatic cholangiocarcinomas in Denmark from 1978 through 2002","volume":"99","author":"Jepsen","year":"2007","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.dld.2009.10.009_bib28","doi-asserted-by":"crossref","first-page":"451","DOI":"10.7326\/0003-4819-147-7-200710020-00003","article-title":"Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis","volume":"147","author":"Alvaro","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.dld.2009.10.009_bib29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/MOG.0b013e328325a894","article-title":"Serum and bile biomarkers for cholangiocarcinoma","volume":"25","author":"Alvaro","year":"2009","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.dld.2009.10.009_bib30","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/hep.22606","article-title":"Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: a population-based study of U.S. veterans","volume":"49","author":"El-Serag","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2009.10.009_bib31","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1111\/j.1572-0241.2008.01796.x","article-title":"Hepatitis B virus infection and intrahepatic cholangiocarcinoma in Korea: a case-control study","volume":"103","author":"Lee","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2009.10.009_bib32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/MOG.0b013e3282f79b32","article-title":"Genetics of biliary tract diseases: new insights into gallstone disease and biliary tract cancers","volume":"24","author":"H\u00f6blinger","year":"2008","journal-title":"Curr Opin Gastroenterol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865809004332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865809004332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T09:23:37Z","timestamp":1544779417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865809004332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1590865809004332"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2009.10.009","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}