{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:12:22Z","timestamp":1782252742968,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.dld.2010.01.002","type":"journal-article","created":{"date-parts":[[2010,2,17]],"date-time":"2010-02-17T09:39:21Z","timestamp":1266399561000},"page":"724-728","source":"Crossref","is-referenced-by-count":58,"title":["Autoimmune hepatitis in children\u2014Impact of cirrhosis at presentation on natural history and long-term outcome"],"prefix":"10.1016","volume":"42","author":[{"given":"Kadakkal R.","family":"Radhakrishnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naim","family":"Alkhouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Worley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Arrigain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Hupertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Yerian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wyllie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel E.","family":"Feldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2010.01.002_bib0005","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra050408","article-title":"Autoimmune hepatitis","volume":"354","author":"Krawitt","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.dld.2010.01.002_bib0010","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1053\/jhep.2002.34944","article-title":"Diagnosis and treatment of autoimmune hepatitis","volume":"36","author":"Czaja","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2010.01.002_bib0015","first-page":"371","article-title":"Autoimmune hepatitis, physiopathologic, clinical, histological, and therapeutic features","volume":"152","author":"Duclos-Vallee","year":"2001","journal-title":"Ann Med Intern (Paris)"},{"key":"10.1016\/j.dld.2010.01.002_bib0020","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0022-3476(86)80880-0","article-title":"Liver disease associated with anti-liver-kidney microsome antibody in children","volume":"108","author":"Maggiore","year":"1986","journal-title":"J Pediatr"},{"key":"10.1016\/j.dld.2010.01.002_bib0025","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1002\/hep.21059","article-title":"Autoimmune hepatitis, from mechanisms to therapy","volume":"43","author":"Manns","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2010.01.002_bib0030","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/j.1572-0241.2005.41841.x","article-title":"Clinical course and outcome of autoimmune hepatitis\/primary sclerosing cholangitis overlap syndrome","volume":"100","author":"Floreani","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2010.01.002_bib0035","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1365-2036.2006.03104.x","article-title":"Type I autoimmune hepatitis: clinical course and outcome in an Italian multicentre study","volume":"24","author":"Floreani","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2010.01.002_bib0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/jhep.2002.30991","article-title":"Current and novel immunosuppressive therapy for autoimmune hepatitis","volume":"35","author":"Heneghan","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2010.01.002_bib0045","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0168-8278(00)00095-7","article-title":"Duration of immunosuppressive therapy in autoimmune hepatitis","volume":"34","author":"Kanzler","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2010.01.002_bib0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/hep.20732","article-title":"Autoimmune hepatitis: effect of symptoms and cirrhosis on natural history and outcome","volume":"42","author":"Feld","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2010.01.002_bib0055","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/hep.510250308","article-title":"Autoimmune hepatitis in childhood: a 20-year experience","volume":"25","author":"Gregorio","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2010.01.002_bib0060","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/00005176-199311000-00007","article-title":"Autoimmune hepatitis associated with anti-actin antibodies in children and adolescents","volume":"17","author":"Maggiore","year":"1993","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2010.01.002_bib0065","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1046\/j.1440-1746.2001.02615.x","article-title":"Long-term outcome of autoimmune hepatitis in children","volume":"16","author":"Saadah","year":"2001","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2010.01.002_bib0070","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0022-3476(05)81078-9","article-title":"Incidence of cirrhosis in children with chronic hepatitis","volume":"117","author":"Vajro","year":"1990","journal-title":"J Pediatr"},{"key":"10.1016\/j.dld.2010.01.002_bib0075","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2010.01.002_bib0080","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jaut.2004.11.009","article-title":"Clinical features and biochemical data of Caucasian children at diagnosis of autoimmune hepatitis","volume":"24","author":"Oettinger","year":"2005","journal-title":"J Autoimmun"},{"key":"10.1016\/j.dld.2010.01.002_bib0085","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0022-3476(05)82892-6","article-title":"Autoimmune hepatitis with initial presentation as acute hepatic failure in young children","volume":"116","author":"Maggiore","year":"1990","journal-title":"J Pediatr"},{"key":"10.1016\/j.dld.2010.01.002_bib0090","first-page":"19","article-title":"Autoimmune hepatitis in children","volume":"127","author":"Olbjorn","year":"2007","journal-title":"Tidsskr Nor Laegeforen"},{"key":"10.1016\/j.dld.2010.01.002_bib0095","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1053\/jhep.2001.22131","article-title":"Autoimmune hepatitis\/sclerosing cholangitis overlap syndrome in childhood: a 16-year prospective study","volume":"33","author":"Gregorio","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2010.01.002_bib0100","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1053\/gast.1996.v110.pm8608895","article-title":"Prognosis of histological cirrhosis in type 1 autoimmune hepatitis","volume":"110","author":"Roberts","year":"1996","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2010.01.002_bib0105","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1111\/j.1572-0241.2004.30457.x","article-title":"Factors predicting relapse and poor outcome in type I autoimmune hepatitis: role of cirrhosis development, patterns of transaminases during remission and plasma cell activity in the liver biopsy","volume":"99","author":"Verma","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2010.01.002_bib0110","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1053\/jlts.2001.21449","article-title":"Recurrent autoimmune hepatitis after orthotopic liver transplantation","volume":"7","author":"Gonzalez-Koch","year":"2001","journal-title":"Liver Transpl"},{"key":"10.1016\/j.dld.2010.01.002_bib0115","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1097\/00007890-199812270-00013","article-title":"Outcome of autoimmune hepatitis after liver transplantation","volume":"66","author":"Prados","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.dld.2010.01.002_bib0120","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/MPG.0b013e3181a1c265","article-title":"Autoimmune hepatitis","volume":"49","author":"Mieli-Vergani","year":"2009","journal-title":"J Pediatr Gastr Nutr"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S159086581000006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S159086581000006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T05:54:22Z","timestamp":1544680462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S159086581000006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S159086581000006X"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2010.01.002","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}