{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:45:44Z","timestamp":1770288344572,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.dld.2011.07.017","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T22:16:23Z","timestamp":1314828983000},"page":"996-1000","source":"Crossref","is-referenced-by-count":8,"title":["Hepatitis E virus infection as a cause of acute hepatitis in Southern Italy"],"prefix":"10.1016","volume":"43","author":[{"given":"Irene","family":"Cacciola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Messineo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Cacopardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Di Marco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Galli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Squadrito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Musolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Saitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Pollicino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Raimondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2011.07.017_bib0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000149370","article-title":"Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route","volume":"20","author":"Balayan","year":"1983","journal-title":"Intervirology"},{"key":"10.1016\/j.dld.2011.07.017_bib0010","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jhep.2007.12.008","article-title":"Hepatitis E: an emerging awareness of an old disease","volume":"48","author":"Purcell","year":"2008","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2011.07.017_bib0015","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/jmv.21116","article-title":"Hepatitis E virus: molecular virology, clinical features, diagnosis, transmission, epidemiology, and prevention","volume":"80","author":"Mushahwar","year":"2008","journal-title":"J Med Virol"},{"key":"10.1016\/j.dld.2011.07.017_bib0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/rmv.522","article-title":"Hepatitis E virus","volume":"17","author":"Panda","year":"2007","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.dld.2011.07.017_bib0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s12038-008-0064-1","article-title":"Molecular biology and pathogenesis of hepatitis E virus","volume":"33","author":"Chandra","year":"2008","journal-title":"J Biosci"},{"key":"10.1016\/j.dld.2011.07.017_bib0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/rmv.482","article-title":"Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis","volume":"16","author":"Lu","year":"2006","journal-title":"Rev Med Virol"},{"key":"10.1016\/j.dld.2011.07.017_bib0035","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2893.2009.01257.x","article-title":"Recent advances in hepatitis E virus","volume":"17","author":"Meng","year":"2010","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.dld.2011.07.017_bib0040","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.virusres.2007.02.002","article-title":"Genetic variability and evolution of hepatitis E virus","volume":"127","author":"Okamoto","year":"2007","journal-title":"Virus Res"},{"key":"10.1016\/j.dld.2011.07.017_bib0045","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/jac\/dkq085","article-title":"Hepatitis E virus: a zoonosis adapting to humans","volume":"65","author":"Bihl","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.dld.2011.07.017_bib0050","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/j.1440-1746.2009.05933.x","article-title":"Epidemiology of hepatitis E: current status","volume":"24","author":"Aggarwal","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2011.07.017_bib0055","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.vaccine.2009.10.136","article-title":"Hepatitis A and E: update on prevention and epidemiology","volume":"28","author":"FitzSimons","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.dld.2011.07.017_bib0060","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S1473-3099(08)70255-X","article-title":"Hepatitis E: an emerging infection in developed countries","volume":"8","author":"Dalton","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.dld.2011.07.017_bib0065","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0923-2516(99)89005-0","article-title":"Epidemiology and prevention of enterically transmitted hepatitis in Italy","volume":"149","author":"Coppola","year":"1998","journal-title":"Res Virol"},{"key":"10.1016\/j.dld.2011.07.017_bib0070","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1365-2893.2006.00800.x","article-title":"Autochthonous hepatitis E in southwest England","volume":"14","author":"Dalton","year":"2007","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.dld.2011.07.017_bib0075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcv.2010.09.016","article-title":"Diagnosis of acute hepatitis E by antibody and molecular testing; a study on 277 suspected cases","volume":"50","author":"Echevarria","year":"2011","journal-title":"J Clin Virol"},{"key":"10.1016\/j.dld.2011.07.017_bib0080","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1086\/599319","article-title":"Epidemiology of hepatitis E virus in the United States: results from the Third National Health and Nutrition Examination Survey, 1988\u20131994","volume":"200","author":"Kuniholm","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.dld.2011.07.017_bib0085","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/jmv.1890420321","article-title":"Hepatitis type E in Italy: a seroepidemiological survey. Study Group of Hepatitis E","volume":"42","author":"Zanetti","year":"1994","journal-title":"J Med Virol"},{"key":"10.1016\/j.dld.2011.07.017_bib0090","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1086\/653943","article-title":"The two faces of hepatitis E virus","volume":"51","author":"Teshale","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.dld.2011.07.017_bib0095","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(07)60595-9","article-title":"Locally acquired hepatitis E in chronic liver disease","volume":"369","author":"Dalton","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2011.07.017_bib0100","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1097\/MEG.0b013e3282f5195a","article-title":"Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease","volume":"20","author":"Dalton","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2011.07.017_bib0105","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0255-0857(21)03069-3","article-title":"Prevalence and severity of acute viral hepatitis and fulminant hepatitis during pregnancy: a prospective study from north India","volume":"21","author":"Beniwal","year":"2003","journal-title":"Indian J Med Microbiol"},{"key":"10.1016\/j.dld.2011.07.017_bib0110","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1440-1746.2007.04913.x","article-title":"Hepatitis E virus infection and fulminant hepatic failure during pregnancy","volume":"22","author":"Jilani","year":"2007","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2011.07.017_bib0115","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/j.1600-6143.2010.03068.x","article-title":"Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis","volume":"10","author":"Kamar","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.dld.2011.07.017_bib0120","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jhep.2006.09.016","article-title":"Hepatitis E virus (HEV) infection in patients with cirrhosis is associated with rapid decompensation and death","volume":"46","author":"Kumar","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2011.07.017_bib0125","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1440-1746.2007.05243.x","article-title":"Hepatitis E virus as an etiology of acute exacerbation of previously unrecognized asymptomatic patients with hepatitis B virus-related chronic liver disease","volume":"23","author":"Kumar","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2011.07.017_bib0130","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1097\/MEG.0b013e3282f1cbff","article-title":"Hepatitis E autochthonous infection in chronic liver disease","volume":"20","author":"Lockwood","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2011.07.017_bib0135","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/hep.22548","article-title":"Hepatitis E: does it cause chronic hepatitis?","volume":"48","author":"Aggarwal","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2011.07.017_bib0140","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1469-0691.2008.02102.x","article-title":"Hepatitis E virus as a newly identified cause of acute viral hepatitis during human immunodeficiency virus infection","volume":"14","author":"Colson","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.dld.2011.07.017_bib0145","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1056\/NEJMc0708687","article-title":"Chronic hepatitis E with cirrhosis in a kidney-transplant recipient","volume":"358","author":"Gerolami","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.dld.2011.07.017_bib0150","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1056\/NEJMoa0706992","article-title":"Hepatitis E virus and chronic hepatitis in organ-transplant recipients","volume":"358","author":"Kamar","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.dld.2011.07.017_bib0155","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1111\/j.1600-6143.2008.02286.x","article-title":"Hepatitis E virus-related cirrhosis in kidney- and kidney\u2013pancreas-transplant recipients","volume":"8","author":"Kamar","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1016\/j.dld.2011.07.017_bib0160","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1093\/ndt\/gfq282","article-title":"Three-month pegylated interferon-alpha-2a therapy for chronic hepatitis E virus infection in a haemodialysis patient","volume":"25","author":"Kamar","year":"2010","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/j.dld.2011.07.017_bib0165","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/lt.21958","article-title":"Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients","volume":"16","author":"Pischke","year":"2010","journal-title":"Liver Transpl"},{"key":"10.1016\/j.dld.2011.07.017_bib0170","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1056\/NEJMc0903778","article-title":"Persistent carriage of hepatitis E virus in patients with HIV infection","volume":"361","author":"Dalton","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.dld.2011.07.017_bib0175","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/jmv.2031","article-title":"Genetic heterogeneity of hepatitis E virus","volume":"65","author":"Schlauder","year":"2001","journal-title":"J Med Virol"},{"key":"10.1016\/j.dld.2011.07.017_bib0180","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/(SICI)1096-9071(199903)57:3<243::AID-JMV6>3.0.CO;2-R","article-title":"Novel hepatitis E virus (HEV) isolates from Europe: evidence for additional genotypes of HEV","volume":"57","author":"Schlauder","year":"1999","journal-title":"J Med Virol"},{"key":"10.1016\/j.dld.2011.07.017_bib0185","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/jmv.10276","article-title":"Molecular investigation of hepatitis E virus infection in patients with acute hepatitis in Kathmandu, Nepal","volume":"69","author":"Shrestha","year":"2003","journal-title":"J Med Virol"},{"key":"10.1016\/j.dld.2011.07.017_bib0190","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10096-008-0480-z","article-title":"Autochthonous hepatitis E in Southwest England: a comparison with hepatitis A","volume":"27","author":"Dalton","year":"2008","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.dld.2011.07.017_bib0195","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jhep.2010.06.017","article-title":"Hepatitis E in Italy: a long-term prospective study","volume":"54","author":"Roman\u00f2","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2011.07.017_bib0200","doi-asserted-by":"crossref","unstructured":"Aggarwal R. Clinical presentation of Hepatitis E. Virus Res 2011; in press.","DOI":"10.1016\/j.virusres.2011.03.017"},{"key":"10.1016\/j.dld.2011.07.017_bib0205","doi-asserted-by":"crossref","unstructured":"Khuroo MS. Discovery of hepatitis E: the epidemic non-A, non-B, hepatitis 30 years down the memory lane. Virus Res 2011; in press.","DOI":"10.1016\/j.virusres.2011.02.007"},{"key":"10.1016\/j.dld.2011.07.017_bib0210","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.vaccine.2008.12.061","article-title":"Randomized-controlled phase II clinical trial of a bacterically expressed recombinant hepatitis E vaccine","volume":"27","author":"Zhang","year":"2009","journal-title":"Vaccine"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865811002878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865811002878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T15:09:19Z","timestamp":1638457759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865811002878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1590865811002878"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2011.07.017","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}