{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:48:00Z","timestamp":1791823680294,"version":"4.3.4"},"reference-count":182,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["dldjournalonline.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.dld.2014.10.005","type":"journal-article","created":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T02:58:20Z","timestamp":1415415500000},"page":"S165-S173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":211,"special_numbering":"S5","title":["Extrahepatic manifestations of chronic hepatitis C virus infection"],"prefix":"10.1016","volume":"46","author":[{"given":"Patrice","family":"Cacoub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Gragnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cloe","family":"Comarmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Linda","family":"Zignego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2014.10.005_bib0005","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1002\/1529-0131(199910)42:10<2204::AID-ANR24>3.0.CO;2-D","article-title":"Extrahepatic manifestations of chronic hepatitis C MULTIVIRC Group. Multidepartment Virus C","volume":"42","author":"Cacoub","year":"1999","journal-title":"Arthritis & Rheumatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00005792-200001000-00005","article-title":"Extrahepatic manifestations associated with hepatitis C virus infection. A prospective multicenter study of 321 patients. The GERMIVIC. Groupe d\u2019Etude et de Recherche en Medecine Interne et Maladies Infectieuses sur le Virus de l\u2019Hepatite C","volume":"79","author":"Cacoub","year":"2000","journal-title":"Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0168-8278(99)80239-6","article-title":"Extrahepatic manifestations of HCV infection: facts and controversies","volume":"31","author":"Zignego","year":"1999","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.dld.2006.06.008","article-title":"Italian Association of the Study of Liver Commission on extrahepatic manifestations of HCV infection extrahepatic manifestations of hepatitis C virus infection: a general overview and guidelines for a clinical approach","volume":"39","author":"Zignego","year":"2007","journal-title":"Digestive and Liver Disease"},{"issue":"Suppl. 1","key":"10.1016\/j.dld.2014.10.005_bib0025","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S1590-8658(07)80009-0","article-title":"Hepatitis C virus lymphotropism: lessons from a decade of studies","volume":"39","author":"Zignego","year":"2007","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.dld.2014.10.005_bib0030","first-page":"2199","article-title":"Longterm course of mixed cryoglobulinemia in patients infected with hepatitis C virus","volume":"31","author":"Sene","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0035","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1002\/art.30319","article-title":"Prognostic factors in patients with hepatitis C virus infection and systemic vasculitis","volume":"63","author":"Terrier","year":"2011","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0040","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.semarthrit.2003.10.001","article-title":"Mixed cryoglobulinemia: demographic, clinical, and serologic features and survival in 231 patients","volume":"33","author":"Ferri","year":"2004","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0045","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.semarthrit.2006.08.005","article-title":"Life-threatening cryoglobulinemia: clinical and immunological characterization of 29 cases","volume":"36","author":"Ramos-Casals","year":"2006","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0050","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0b013e3182a5cf71","article-title":"Life-threatening cryoglobulinemic patients with hepatitis C: clinical description and outcome of 279 patients","author":"Retamozo","year":"2013","journal-title":"Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0055","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.amjcard.2012.09.028","article-title":"Presentation and prognosis of cardiac involvement in hepatitis C virus-related vasculitis","volume":"111","author":"Terrier","year":"2013","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.dld.2014.10.005_bib0065","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1002\/art.21270","article-title":"Involvement of chemokines and type 1 cytokines in the pathogenesis of hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy","volume":"52","author":"Saadoun","year":"2005","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0070","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1182\/blood-2003-07-2598","article-title":"CD4+ CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis","volume":"103","author":"Boyer","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0075","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMoa1105143","article-title":"Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis","volume":"365","author":"Saadoun","year":"2011","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0080","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/1529-0131(200109)44:9<2118::AID-ART364>3.0.CO;2-X","article-title":"Influence of HLA-DR phenotype on the risk of hepatitis C virus-associated mixed cryoglobulinemia","volume":"44","author":"Cacoub","year":"2001","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0085","doi-asserted-by":"crossref","DOI":"10.1038\/gene.2014.41","article-title":"Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis","author":"Zignego","year":"2014","journal-title":"Genes and Immunity"},{"key":"10.1016\/j.dld.2014.10.005_bib0090","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/art.30274","article-title":"Genetic determinants in hepatitis C virus-associated mixed cryoglobulinemia: role of polymorphic variants of BAFF promoter and Fc\u03b3 receptors","volume":"63","author":"Gragnani","year":"2011","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0095","doi-asserted-by":"crossref","first-page":"e62965","DOI":"10.1371\/journal.pone.0062965","article-title":"Role of microRNA profile modifications in hepatitis C virus-related mixed cryoglobulinemia","volume":"8","author":"Fognani","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.dld.2014.10.005_bib0100","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1182\/blood.V81.5.1132.1132","article-title":"Interferon-alpha in mixed cryoglobulinemia patients: a randomized, crossover-controlled trial","volume":"81","author":"Ferri","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0105","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1056\/NEJM199403173301104","article-title":"Interferon alfa-2a therapy in cryoglobulinemia associated with hepatitis C virus","volume":"330","author":"Misiani","year":"1994","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0110","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1002\/art.22168","article-title":"Antiviral therapy for hepatitis C virus \u2013 associated mixed cryoglobulinemia vasculitis: a long-term follow-up study","volume":"54","author":"Saadoun","year":"2006","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0115","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/art.23305","article-title":"Relapse of hepatitis C virus-associated mixed cryoglobulinemia vasculitis in patients with sustained viral response","volume":"58","author":"Landau","year":"2008","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0120","article-title":"Peg-IFN\u03b1 ribavirin\/protease inhibitor combination in severe hepatitis C virus associated mixed cryoglobulinemia vasculitis","author":"Saadoun","year":"2014","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0125","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.dld.2014.05.017","article-title":"Triple antiviral therapy in hepatitis C virus infection with or without mixed cryoglobulinaemia: a prospective, controlled pilot study","volume":"46","author":"Gragnani","year":"2014","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.dld.2014.10.005_bib0130","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jhep.2013.11.003","article-title":"EASL clinical practice guidelines: management of hepatitis C virus infection","volume":"60","author":"European Association for Study of Liver","year":"2014","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0135","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1093\/ndt\/gfh469","article-title":"Long-term effects of anti-CD20 monoclonal antibody treatment of cryoglobulinaemic glomerulonephritis","volume":"19","author":"Roccatello","year":"2004","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"10.1016\/j.dld.2014.10.005_bib0140","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1136\/ard.2007.081653","article-title":"Rituximab combined with Peg-interferon-ribavirin in refractory hepatitis C virus-associated cryoglobulinaemia vasculitis","volume":"67","author":"Saadoun","year":"2008","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0145","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1182\/blood-2002-10-3162","article-title":"Monoclonal antibody treatment of mixed cryoglobulinemia resistant to interferon alpha with an anti-CD20","volume":"101","author":"Sansonno","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0150","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1182\/blood-2002-09-2856","article-title":"Efficacy and safety of rituximab in type II mixed cryoglobulinemia","volume":"101","author":"Zaja","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0155","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/ard.2006.065565","article-title":"Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemic vasculitis: where do we stand?","volume":"67","author":"Cacoub","year":"2008","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0160","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/art.34331","article-title":"A randomized controlled trial of rituximab for the treatment of severe cryoglobulinemic vasculitis","volume":"64","author":"De Vita","year":"2012","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0165","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/art.34322","article-title":"A randomized controlled trial of rituximab following failure of antiviral therapy for hepatitis C virus-associated cryoglobulinemic vasculitis","volume":"64","author":"Sneller","year":"2012","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0170","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/acr.21990","article-title":"Kinetic profiles and management of hepatitis B virus reactivation in patients with immune-mediated inflammatory diseases","volume":"65","author":"Droz","year":"2013","journal-title":"Arthritis Care and Research"},{"key":"10.1016\/j.dld.2014.10.005_bib0175","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1182\/blood-2009-11-253948","article-title":"Safety and efficacy of rituximab in patients with hepatitis C virus-related mixed cryoglobulinemia and severe liver disease","volume":"116","author":"Petrarca","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0180","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1182\/blood-2009-10-245878","article-title":"Pegylated interferon-alpha, ribavirin, and rituximab combined therapy of hepatitis C virus-related mixed cryoglobulinemia: a long-term study","volume":"116","author":"Dammacco","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0185","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1182\/blood-2009-10-248518","article-title":"Rituximab plus Peg-interferon-alpha\/ribavirin compared with Peg-interferon-alpha\/ribavirin in hepatitis C-related mixed cryoglobulinemia","volume":"116","author":"Saadoun","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/BOR.0b013e3282f1330c","article-title":"Treatment of hepatitis C-associated mixed cryoglobulinemia vasculitis","volume":"20","author":"Saadoun","year":"2008","journal-title":"Current Opinion in Rheumatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0195","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/acr.21856","article-title":"Using rituximab plus fludarabine and cyclophosphamide as a treatment for refractory mixed cryoglobulinemia associated with lymphoma","volume":"65","author":"Saadoun","year":"2013","journal-title":"Arthritis Care and Research"},{"key":"10.1016\/j.dld.2014.10.005_bib0200","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/jama.1994.03520050033023","article-title":"Non-Hodgkin's lymphoma: possible role of hepatitis C virus","volume":"272","author":"Ferri","year":"1994","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.dld.2014.10.005_bib0205","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/0959-8049(94)90066-3","article-title":"Hepatitis C virus infection and B-cell lymphomas","volume":"30A","author":"Ferri","year":"1994","journal-title":"European Journal of Cancer"},{"key":"10.1016\/j.dld.2014.10.005_bib0210","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cgh.2008.02.011","article-title":"Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology Consortium","volume":"6","author":"De Sanjose","year":"2008","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0215","doi-asserted-by":"crossref","first-page":"423","DOI":"10.7326\/0003-4819-127-6-199709150-00002","article-title":"Hepatitis C virus infection in patients with B-cell non-Hodgkin lymphoma","volume":"127","author":"Zuckerman","year":"1997","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0220","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1053\/j.gastro.2003.09.025","article-title":"Prevalence of hepatitis C virus infection in B-cell non-Hodgkin's lymphoma: systematic review and meta-analysis","volume":"125","author":"Gisbert","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2014.10.005_bib0225","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1158\/1055-9965.EPI-06-0308","article-title":"Hepatitis C virus and risk of lymphoma and other lymphoid neoplasms: a meta-analysis of epidemiologic studies","volume":"15","author":"Dal Maso","year":"2006","journal-title":"Cancer Epidemiology, Biomarkers and Prevention"},{"key":"10.1016\/j.dld.2014.10.005_bib0230","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/j.1349-7006.2004.tb03256.x","article-title":"Effect of hepatitis C virus infection on the risk of non-Hodgkin's lymphoma: a meta-analysis of epidemiological studies","volume":"95","author":"Matsuo","year":"2004","journal-title":"Cancer Science"},{"key":"10.1016\/j.dld.2014.10.005_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.20205","article-title":"B-cell non-Hodgkin's lymphoma and hepatitis C virus infection: a systematic review","volume":"111","author":"Negri","year":"2004","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.dld.2014.10.005_bib0240","doi-asserted-by":"crossref","first-page":"294","DOI":"10.7326\/0003-4819-129-4-199808150-00005","article-title":"Prevalence of monoclonal gammopathies in patients with hepatitis C virus infection","volume":"129","author":"Andreone","year":"1998","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0245","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.amjmed.2007.06.022","article-title":"Viral elimination reduces incidence of malignant lymphoma in patients with hepatitis C","volume":"120","author":"Kawamura","year":"2007","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0250","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1182\/blood.V99.6.2259","article-title":"Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3 Bcl-2 overexpression, and type II cryoglobulinemia","volume":"99","author":"Casato","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0255","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1182\/blood-2004-05-1711","article-title":"Splenic lymphoma with villous lymphocytes, associated with type II cryoglobulinemia and HCV infection: a new entity?","volume":"105","author":"Saadoun","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0260","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1056\/NEJMoa013376","article-title":"Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection","volume":"347","author":"Hermine","year":"2002","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0265","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1182\/blood-2002-05-1537","article-title":"Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation","volume":"102","author":"Giannelli","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0270","doi-asserted-by":"crossref","first-page":"571","DOI":"10.7326\/0003-4819-137-7-200210010-00008","article-title":"Prevalence of bcl-2 rearrangement in patients with hepatitis C virus-related mixed cryoglobulinemia with or without B-cell lymphomas","volume":"137","author":"Zignego","year":"2002","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0275","first-page":"980942","article-title":"HCV and lymphoproliferation","author":"Zignego","year":"2012","journal-title":"Clinical and Developmental Immunology"},{"key":"10.1016\/j.dld.2014.10.005_bib0280","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1136\/ard.2007.085910","article-title":"The B lymphocyte stimulator receptor\u2013ligand system in hepatitis C virus-induced B cell clonal disorders","volume":"68","author":"Landau","year":"2009","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0285","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/ajcp\/109.5.508","article-title":"Hepatitis C virus and non-Hodgkin's lymphoma","volume":"109","author":"Lai","year":"1998","journal-title":"American Journal of Clinical Pathology"},{"key":"10.1016\/j.dld.2014.10.005_bib0290","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.4049\/jimmunol.160.7.3594","article-title":"Clonal analysis of intrahepatic B cells from HCV-infected patients with and without mixed cryoglobulinemia","volume":"160","author":"Sansonno","year":"1998","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.dld.2014.10.005_bib0295","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1002\/art.20594","article-title":"Clonal B cell populations in the blood and liver of patients with chronic hepatitis C virus infection","volume":"50","author":"Vallat","year":"2004","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0300","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1126\/science.282.5390.938","article-title":"Binding of hepatitis C virus to CD81","volume":"282","author":"Pileri","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.dld.2014.10.005_bib0305","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1182\/blood-2013-10-532895","article-title":"B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins","volume":"123","author":"Ng","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0310","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1182\/blood.V96.10.3578","article-title":"Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia","volume":"96","author":"De Re","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0315","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/infdis\/171.3.672","article-title":"Hepatitis C virus RNA in the bone marrow of patients with mixed cryoglobulinemia and in subjects with noncryoglobulinemic chronic hepatitis type C","volume":"171","author":"Galli","year":"1995","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0320","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0168-8278(92)90073-X","article-title":"Infection of peripheral mononuclear blood cells by hepatitis C virus","volume":"15","author":"Zignego","year":"1992","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0325","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/hep.510280127","article-title":"Hepatitis C virus persistence in human hematopoietic cells injected into SCID mice","volume":"28","author":"Bronowicki","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0330","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1128\/JVI.77.3.2134-2146.2003","article-title":"Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection","volume":"77","author":"Sung","year":"2003","journal-title":"Journal of Virology"},{"key":"10.1016\/j.dld.2014.10.005_bib0335","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1073\/pnas.0303971101","article-title":"Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes","volume":"101","author":"Machida","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.dld.2014.10.005_bib0340","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.1182\/blood-2010-05-283358","article-title":"Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo","volume":"116","author":"Kasama","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0345","doi-asserted-by":"crossref","first-page":"167501","DOI":"10.5402\/2011\/167501","article-title":"Hepatitis C virus-related lymphomagenesis in a mouse model","volume":"2011","author":"Tsukiyama-Kohara","year":"2011","journal-title":"ISRN Hematology"},{"key":"10.1016\/j.dld.2014.10.005_bib0350","first-page":"711","article-title":"Frequency of bcl-2 rearrangement in patients with mixed cryoglobulinemia and HCV-positive liver diseases","volume":"15","author":"Zignego","year":"1997","journal-title":"Clinical and Experimental Rheumatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0355","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/hep.510310230","article-title":"T(14;18) translocation in chronic hepatitis C virus infection","volume":"31","author":"Zignego","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0360","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/hep.21132","article-title":"Association between mixed cryoglobulinemia, translocation (14;18), and persistence of occult HCV lymphoid infection after treatment","volume":"43","author":"Giannini","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0365","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1182\/blood-2007-09-112490","article-title":"Association between persistent lymphatic infection by hepatitis C virus after antiviral treatment and mixed cryoglobulinemia","volume":"111","author":"Giannini","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0370","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.4161\/cbt.4.11.2087","article-title":"Elevated serum levels of osteopontin in HCV-associated lymphoproliferative disorders","volume":"4","author":"Libra","year":"2005","journal-title":"Cancer Biology and Therapy"},{"key":"10.1016\/j.dld.2014.10.005_bib0375","first-page":"1305","article-title":"Analysis of interleukin (IL)-1beta IL-1 receptor antagonist, soluble IL-1 receptor type II and IL-1 accessory protein in HCV-associated lymphoproliferative disorders","volume":"15","author":"Libra","year":"2006","journal-title":"Oncology Reports"},{"key":"10.1016\/j.dld.2014.10.005_bib0380","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/art.22456","article-title":"Role of matrix metalloproteinases, proinflammatory cytokines, and oxidative stress-derived molecules in hepatitis C virus-associated mixed cryoglobulinemia vasculitis neuropathy","volume":"56","author":"Saadoun","year":"2007","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.dld.2014.10.005_bib0385","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.4049\/jimmunol.0902038","article-title":"Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage","volume":"183","author":"Sansonno","year":"2009","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.dld.2014.10.005_bib0390","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/rheumatology\/kel177","article-title":"Hepatitis C virus-associated B-cell proliferation \u2013 the role of serum B lymphocyte stimulator (BLyS\/BAFF)","volume":"46","author":"S\u00e8ne","year":"2007","journal-title":"Rheumatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0395","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.autrev.2008.05.005","article-title":"Hepatitis C virus infection, mixed cryoglobulinemia and BLyS upregulation: targeting the infectious trigger, the autoimmune response, or both?","volume":"8","author":"De Vita","year":"2008","journal-title":"Autoimmunity Reviews"},{"key":"10.1016\/j.dld.2014.10.005_bib0400","doi-asserted-by":"crossref","first-page":"4353","DOI":"10.1182\/blood-2008-07-170613","article-title":"Can BAFF promoter polymorphism be a predisposing condition for HCV-related mixed cryoglobulinemia?","volume":"112","author":"Giannini","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0405","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1038\/leu.2012.29","article-title":"Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection","volume":"26","author":"Peveling-Oberhag","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.dld.2014.10.005_bib0410","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/sj.leu.2403443","article-title":"Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas","volume":"18","author":"Kelaidi","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.dld.2014.10.005_bib0415","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1200\/JCO.2005.06.008","article-title":"Role of anti-hepatitis C virus (HCV) treatment in HCV-related, low-grade, B-cell, non-Hodgkin's lymphoma: a multicenter Italian experience","volume":"23","author":"Vallisa","year":"2005","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/j.dld.2014.10.005_bib0420","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2141.2008.07565.x","article-title":"Pegylated-interferon plus ribavirin for HCV-positive indolent non-Hodgkin lymphomas","volume":"145","author":"Mazzaro","year":"2009","journal-title":"British Journal of Haematology"},{"key":"10.1016\/j.dld.2014.10.005_bib0425","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/annonc\/mdu166","article-title":"Antiviral treatment in patients with indolent B-cell lymphomas associated with HCV infection: a study of the Fondazione Italiana Linfomi","volume":"25","author":"Arcaini","year":"2014","journal-title":"Annals of Oncology"},{"key":"10.1016\/j.dld.2014.10.005_bib0430","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1182\/blood.V88.2.752.bloodjournal882752","article-title":"Hepatitis C virus infection: a new bridge between hematologists and gastroenterologists?","volume":"88","author":"Musto","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.dld.2014.10.005_bib0435","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jhep.2008.06.025","article-title":"Antiviral therapy after complete response to chemotherapy could be efficacious in HCV-positive non-Hodgkin's lymphoma","volume":"49","author":"La Mura","year":"2008","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0440","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1200\/JCO.2002.08.674","article-title":"Rituximab as first-line and maintenance therapy for patients with indolent non-Hodgkin's lymphoma","volume":"20","author":"Hainsworth","year":"2002","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/j.dld.2014.10.005_bib0450","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1136\/ard.57.12.728","article-title":"Cryoglobulinaemia and rheumatic manifestations in patients with hepatitis C virus infection","volume":"57","author":"Lee","year":"1998","journal-title":"Annals of the Rheumatic Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-200101000-00001","article-title":"Hepatitis C virus infection mimicking primary Sj\u00f6gren syndrome. A clinical and immunologic description of 35 cases","volume":"80","author":"Ramos-Casals","year":"2001","journal-title":"Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0460","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2796.1999.00414.x","article-title":"Extrahepatic manifestations of chronic hepatitis C infection and the interrelationship between primary Sj\u00f6gren's syndrome and hepatitis C in Swedish patients","volume":"245","author":"Verbaan","year":"1999","journal-title":"Journal of Internal Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0465","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1073\/pnas.94.1.233","article-title":"Sialadenitis histologically resembling Sjogren syndrome in mice transgenic for hepatitis C virus envelope genes","volume":"94","author":"Koike","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.dld.2014.10.005_bib0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2011.03.004","article-title":"A sustained virologic response reduces risk of all-cause mortality in patients with hepatitis C","volume":"9","author":"Backus","year":"2011","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0475","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/cid\/cir306","article-title":"All-cause, liver-related, and non-liver-related mortality among HCV-infected individuals in the general US population","volume":"53","author":"El-Kamary","year":"2011","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0480","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1017\/S0950268805005340","article-title":"HCV National Register Steering Group Survival of a national cohort of hepatitis C virus infected patients, 16 years after exposure","volume":"134","author":"Harris","year":"2006","journal-title":"Epidemiology and Infection"},{"key":"10.1016\/j.dld.2014.10.005_bib0485","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/hep.26892","article-title":"Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients","volume":"59","author":"Hsu","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0490","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/infdis\/jis385","article-title":"Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study","volume":"206","author":"Lee","year":"2012","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0495","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/hep.23002","article-title":"Increased rate of death related to presence of viremia among hepatitis C virus antibody-positive subjects in a community-based cohort study","volume":"50","author":"Uto","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0500","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/apt.12485","article-title":"The impact of chronic hepatitis C on resource utilisation and in-patient mortality for Medicare beneficiaries between 2005 and 2010","volume":"38","author":"Younossi","year":"2013","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1016\/j.dld.2014.10.005_bib0505","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bpg.2012.09.009","article-title":"Natural history of acute and chronic hepatitis C","volume":"26","author":"Maasoumy","year":"2012","journal-title":"Best Practice and Research. Clinical Gastroenterology"},{"key":"10.1016\/j.dld.2014.10.005_bib0510","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cgh.2010.09.014","article-title":"Increased mortality among persons infected with hepatitis C virus","volume":"9","author":"Omland","year":"2011","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0515","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1053\/jhep.2001.21905","article-title":"Long-term mortality and morbidity of transfusion-associated non-A, non-B, and type C hepatitis: a National Heart, Lung, and Blood Institute collaborative study","volume":"33","author":"Seeff","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0520","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.3748\/wjg.v20.i13.3410","article-title":"Chronic hepatitis C virus infection and atherosclerosis: clinical impact and mechanisms","volume":"20","author":"Adinolfi","year":"2014","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2014.10.005_bib0525","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/hc0902.105718","article-title":"Increased prevalence of carotid atherosclerosis in hepatitis B virus carriers","volume":"105","author":"Ishizaka","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.dld.2014.10.005_bib0530","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/01.STR.0000089015.51603.CC","article-title":"Inflammation and infections as risk factors for ischemic stroke","volume":"34","author":"Lindsberg","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.dld.2014.10.005_bib0535","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/157016109787455707","article-title":"Infection, its treatment and the risk for stroke","volume":"7","author":"Palm","year":"2009","journal-title":"Current Vascular Pharmacology"},{"key":"10.1016\/j.dld.2014.10.005_bib0540","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1001\/jama.289.10.1245-b","article-title":"Hepatitis C virus and atherosclerosis in patients with type 2 diabetes","volume":"289","author":"Fukui","year":"2003","journal-title":"Journal of the American Medical Association"},{"issue":"Suppl. 1","key":"10.1016\/j.dld.2014.10.005_bib0545","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/S1590-8658(07)80012-0","article-title":"HCV infection facilitates asymptomatic carotid atherosclerosis: preliminary report of HCV RNA localization in human carotid plaques","volume":"39","author":"Boddi","year":"2007","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.dld.2014.10.005_bib0550","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jcv.2009.10.005","article-title":"Hepatitis C virus RNA localization in human carotid plaques","volume":"47","author":"Boddi","year":"2010","journal-title":"Journal of Clinical Virology"},{"key":"10.1016\/j.dld.2014.10.005_bib0555","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/hep.25508","article-title":"Carotid atherosclerosis and chronic hepatitis C: a prospective study of risk associations","volume":"55","author":"Petta","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0560","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.atherosclerosis.2009.10.006","article-title":"Hepatitis C and carotid atherosclerosis: a retrospective analysis","volume":"209","author":"Aslam","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.dld.2014.10.005_bib0565","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nm1102-1257","article-title":"Stabilization of atherosclerotic plaques: new mechanisms and clinical targets","volume":"8","author":"Libby","year":"2002","journal-title":"Nature Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0570","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.atherosclerosis.2012.01.051","article-title":"Chronic HCV infection is a risk of atherosclerosis Role of HCV and HCV-related steatosis","volume":"221","author":"Adinolfi","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.dld.2014.10.005_bib0575","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.atherosclerosis.2012.02.027","article-title":"Atherosclerosis risk in HIV-infected patients: the influence of hepatitis C virus co-infection","volume":"222","author":"Sosner","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.dld.2014.10.005_bib0580","first-page":"e58130","article-title":"Hepatitis C virus infection and risk of stroke: a systematic review and meta-analysis","volume":"8","author":"He","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.dld.2014.10.005_bib0585","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/apt.12391","article-title":"Interferon-based therapy reduces risk of stroke in chronic hepatitis C patients: a population-based cohort study in Taiwan","volume":"38","author":"Hsu","year":"2013","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1016\/j.dld.2014.10.005_bib0590","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1086\/599371","article-title":"Hepatitis C virus infection and the risk of coronary disease","volume":"49","author":"Butt","year":"2009","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0595","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jhep.2012.07.045","article-title":"Myocardial injury in patients with chronic hepatitis C infection","volume":"58","author":"Maruyama","year":"2013","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0600","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.clinre.2013.02.002","article-title":"Renal involvement in HCV-related vasculitis","volume":"37","author":"Terrier","year":"2013","journal-title":"Clinics and Research in Hepatology and Gastroenterology"},{"key":"10.1016\/j.dld.2014.10.005_bib0605","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/jhep.2002.34613","article-title":"Hepatitis C infection and the patient with end-stage renal disease","volume":"36","author":"Fabrizi","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0610","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1097\/00007890-199506270-00006","article-title":"De novo membranoproliferative glomerulonephritis in hepatitis C virus-infected renal allograft recipients","volume":"59","author":"Roth","year":"1995","journal-title":"Transplantation"},{"key":"10.1016\/j.dld.2014.10.005_bib0615","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/hep.1840360621","article-title":"Extrahepatic manifestations of hepatitis C among United States male veterans","volume":"36","author":"El-Serag","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0620","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2215\/CJN.00470107","article-title":"Hepatitis C virus infection and the prevalence of renal insufficiency","volume":"2","author":"Dalrymple","year":"2007","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"10.1016\/j.dld.2014.10.005_bib0625","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cgh.2009.08.031","article-title":"Lack of association between hepatitis C infection and chronic kidney disease","volume":"8","author":"Asrani","year":"2010","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0630","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.ajkd.2010.09.023","article-title":"HCV infection and the incidence of CKD","volume":"57","author":"Butt","year":"2011","journal-title":"American Journal of Kidney Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0635","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1053\/j.ajkd.2010.01.015","article-title":"Association of hepatitis C and B virus infection with CKD in an endemic area in Taiwan: a cross-sectional study","volume":"56","author":"Lee","year":"2010","journal-title":"American Journal of Kidney Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0640","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1681\/ASN.2005091006","article-title":"Relationship between hepatitis C and chronic kidney disease: results from the Third National Health and Nutrition Examination Survey","volume":"17","author":"Tsui","year":"2006","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.dld.2014.10.005_bib0645","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1097\/QAD.0b013e32832ac36a","article-title":"Kidney diseases in HIV\/HCV-co-infected patients","volume":"23","author":"Izzedine","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.dld.2014.10.005_bib0650","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1097\/QAD.0b013e32830e0152","article-title":"The impact of hepatitis C virus coinfection on HIV-related kidney disease: a systematic review and meta-analysis","volume":"22","author":"Wyatt","year":"2008","journal-title":"AIDS"},{"key":"10.1016\/j.dld.2014.10.005_bib0655","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1053\/j.ajkd.2012.08.040","article-title":"Hepatitis C virus infection, mixed cryoglobulinemia, and kidney disease","volume":"61","author":"Fabrizi","year":"2013","journal-title":"American Journal of Kidney Diseases"},{"key":"10.1016\/j.dld.2014.10.005_bib0660","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2796.2006.01686.x","article-title":"Viral hepatitis and proteinuria in an area endemic for hepatitis B and C infections: another chain of link?","volume":"260","author":"Huang","year":"2006","journal-title":"Journal of Internal Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0665","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1523-1755.2005.00080.x","article-title":"Relationship between hepatitis C and microalbuminuria: results from the NHANES III","volume":"67","author":"Liangpunsakul","year":"2005","journal-title":"Kidney International"},{"key":"10.1016\/j.dld.2014.10.005_bib0670","first-page":"S1","article-title":"KDIGO clinical practice guidelines for the prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease","author":"Kidney Disease: Improving Global Outcomes (KDIGO)","year":"2008","journal-title":"Kidney International. Supplement"},{"key":"10.1016\/j.dld.2014.10.005_bib0675","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/lt.500010306","article-title":"Hepatitis C \u2013 associated glomerular disease in liver transplant recipients","volume":"1","author":"Davis","year":"1995","journal-title":"Liver Transplantation and Surgery"},{"key":"10.1016\/j.dld.2014.10.005_bib0680","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1097\/00007890-200212270-00021","article-title":"Remission of hepatitis C virus-associated cryoglobulinemic glomerulonephritis with interferon alfa-2b and ribavirin combination therapy after liver transplantation","volume":"74","author":"Sikaneta","year":"2002","journal-title":"Transplantation"},{"key":"10.1016\/j.dld.2014.10.005_bib0685","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/01.mcg.0000225569.04773.8b","article-title":"Treatment with pegylated interferon and ribavirin for hepatitis C virus-associated severe cryoglobulinemia in a liver\/kidney transplant recipient","volume":"41","author":"Montalbano","year":"2007","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1016\/j.dld.2014.10.005_bib0690","first-page":"875","article-title":"Early effect of peginterferon alpha-2b plus ribavirin treatment on blood pressure and insulin resistance in patients with chronic hepatitis C","volume":"58","author":"Taskoparan","year":"2011","journal-title":"Hepato-Gastroenterology"},{"key":"10.1016\/j.dld.2014.10.005_bib0695","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/hep.25867","article-title":"Sustained virological response prevents the development of insulin resistance in patients with chronic hepatitis C","volume":"56","author":"Aghemo","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0700","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3851\/IMP1298","article-title":"Insulin resistance impairs sustained virological response rate to pegylated interferon plus ribavirin in HIV-hepatitis C virus-coinfected patients: HOMAVIC-ANRS HC02 Study","volume":"14","author":"Cacoub","year":"2009","journal-title":"Antiviral Therapy"},{"issue":"Suppl. 2","key":"10.1016\/j.dld.2014.10.005_bib0705","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1478-3231.2008.01952.x","article-title":"Hepatitis C insulin resistance and diabetes: clinical and pathogenic data","volume":"29","author":"Serfaty","year":"2009","journal-title":"Liver International"},{"key":"10.1016\/j.dld.2014.10.005_bib0710","first-page":"1480","article-title":"Increased prevalence of diabetes mellitus in patients with chronic hepatitis C virus infection","volume":"91","author":"Ozyilkan","year":"1996","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2014.10.005_bib0715","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2796.1994.tb01075.x","article-title":"Increased prevalence of hepatitis C virus antibodies in patients with diabetes mellitus","volume":"235","author":"Ozyilkan","year":"1994","journal-title":"Journal of Internal Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0720","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0168-8278(05)80631-2","article-title":"Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population","volume":"21","author":"Allison","year":"1994","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0725","doi-asserted-by":"crossref","first-page":"998","DOI":"10.2337\/diacare.19.9.998","article-title":"High prevalence of hepatitis C virus infection in diabetic patients","volume":"19","author":"Sim\u00f3","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dld.2014.10.005_bib0730","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1464-5491.1995.tb00466.x","article-title":"High prevalence of hepatitis C infection in Afro-Caribbean patients with type 2 diabetes and abnormal liver function tests","volume":"12","author":"Gray","year":"1995","journal-title":"Diabetic Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0735","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/hep.510300416","article-title":"Further evidence for an association between non-insulin-dependent diabetes mellitus and chronic hepatitis C virus infection","volume":"30","author":"Caronia","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0740","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.510290235","article-title":"Association of diabetes mellitus and chronic hepatitis C virus infection","volume":"29","author":"Mason","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0745","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/j.gastro.2003.11.056","article-title":"Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance","volume":"126","author":"Shintani","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2014.10.005_bib0750","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0002-9440(10)63408-6","article-title":"Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3","volume":"165","author":"Kawaguchi","year":"2004","journal-title":"American Journal of Pathology"},{"key":"10.1016\/j.dld.2014.10.005_bib0755","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/(SICI)1096-9136(199809)15:9<797::AID-DIA675>3.0.CO;2-M","article-title":"Antibodies to GAD in diabetic patients with chronic hepatitis C","volume":"15","author":"Ando","year":"1998","journal-title":"Diabetic Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0760","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1067\/mlc.2001.111515","article-title":"Islet cell and thyroid antibody prevalence in patients with hepatitis C virus infection: effect of treatment with interferon","volume":"137","author":"Piquer","year":"2001","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0765","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S1590-8658(00)80266-2","article-title":"Virus, liver and autoimmunity","volume":"32","author":"Bogdanos","year":"2000","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.dld.2014.10.005_bib0770","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1034\/j.1600-0676.2001.021004225.x","article-title":"Molecular mimicry and autoimmune liver disease: virtuous intentions, malign consequences","volume":"21","author":"Bogdanos","year":"2001","journal-title":"Liver"},{"key":"10.1016\/j.dld.2014.10.005_bib0775","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/BOR.0b013e3283533719","article-title":"Infection as a cause of type 1 diabetes?","volume":"24","author":"Christen","year":"2012","journal-title":"Current Opinion in Rheumatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0780","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.autrev.2009.02.017","article-title":"Infection and type 1 diabetes mellitus \u2013 a two edged sword?","volume":"8","author":"Goldberg","year":"2009","journal-title":"Autoimmunity Reviews"},{"key":"10.1016\/j.dld.2014.10.005_bib0785","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4103\/2230-8210.129111","article-title":"Hepatitis C virus infection in Egyptian children with type 1 diabetes mellitus: a single center study","volume":"18","author":"Farghaly","year":"2014","journal-title":"Indian Journal of Endocrinology and Metabolism"},{"key":"10.1016\/j.dld.2014.10.005_bib0790","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1053\/jhep.2002.30688","article-title":"Hepatitis C and cognitive impairment in a cohort of patients with mild liver disease","volume":"35","author":"Forton","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0795","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/hep.20635","article-title":"Prevalence and significance of neurocognitive dysfunction in hepatitis C in the absence of correlated risk factors","volume":"41","author":"McAndrews","year":"2005","journal-title":"Hepatology"},{"issue":"Suppl. 3","key":"10.1016\/j.dld.2014.10.005_bib0800","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1097\/01.aids.0000192083.41561.00","article-title":"Emerging evidence of hepatitis C virus neuroinvasion","volume":"19","author":"Laskus","year":"2005","journal-title":"AIDS"},{"key":"10.1016\/j.dld.2014.10.005_bib0805","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/hep.510290124","article-title":"Reduction of health-related quality of life in chronic hepatitis C and improvement with interferon therapy. The Consensus Interferon Study Group","volume":"29","author":"Bonkovsky","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0810","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jhep.2006.10.009","article-title":"Health-related quality of life in patients with chronic hepatitis C and advanced fibrosis","volume":"46","author":"Bonkovsky","year":"2007","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0815","doi-asserted-by":"crossref","first-page":"7494","DOI":"10.3748\/wjg.v11.i47.7494","article-title":"Health-related quality of life and impact of antiviral treatment in Chinese patients with chronic hepatitis C in Taiwan","volume":"11","author":"Kang","year":"2005","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2014.10.005_bib0820","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/hep.21565","article-title":"The effects of HCV infection and management on health-related quality of life","volume":"45","author":"Younossi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0825","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1478-3231.2011.02461.x","article-title":"Adherence to treatment and quality of life during hepatitis C therapy: a prospective, real-life, observational study","volume":"31","author":"Marcellin","year":"2011","journal-title":"Liver International"},{"key":"10.1016\/j.dld.2014.10.005_bib0830","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2036.2010.04235.x","article-title":"Changes in quality of life and sexual health are associated with low-dose peginterferon therapy and disease progression in patients with chronic hepatitis C","volume":"31","author":"Snow","year":"2010","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1016\/j.dld.2014.10.005_bib0835","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0168-8278(02)00067-3","article-title":"Impact of treatment on extra hepatic manifestations in patients with chronic hepatitis C","volume":"36","author":"Cacoub","year":"2002","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0840","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0168-8278(00)00026-X","article-title":"The effects of interferon alpha-2b in combination with ribavirin on health related quality of life and work productivity","volume":"34","author":"McHutchison","year":"2001","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0845","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/hep.20659","article-title":"Impact of hepatitis C on health related quality of life: a systematic review and quantitative assessment","volume":"41","author":"Spiegel","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0850","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.genhosppsych.2005.06.006","article-title":"Depression and anxiety in patients with hepatitis C: prevalence, detection rates and risk factors","volume":"27","author":"Golden","year":"2005","journal-title":"General Hospital Psychiatry"},{"key":"10.1016\/j.dld.2014.10.005_bib0855","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jhep.2005.11.046","article-title":"Depression, anemia and health-related quality of life in chronic hepatitis C","volume":"44","author":"Dan","year":"2006","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0860","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1365-2893.2005.00706.x","article-title":"Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients","volume":"13","author":"Cozzi","year":"2006","journal-title":"Journal of Viral Hepatitis"},{"key":"10.1016\/j.dld.2014.10.005_bib0865","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jhep.2011.09.015","article-title":"Effects of anti-viral therapy and HCV clearance on cerebral metabolism and cognition","volume":"56","author":"Byrnes","year":"2012","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0870","first-page":"484","article-title":"Central nervous system involvement in hepatitis C virus cryoglobulinemia vasculitis: a multicenter case\u2013control study using magnetic resonance imaging and neuropsychological tests","volume":"32","author":"Casato","year":"2005","journal-title":"Journal of Rheumatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0875","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1136\/gut.2006.100081","article-title":"Altered monoaminergic transporter binding in hepatitis C related cerebral dysfunction: a neuroimmunologial condition?","volume":"55","author":"Forton","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.dld.2014.10.005_bib0880","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1136\/gut.2005.080267","article-title":"Monoaminergic neurotransmission is altered in hepatitis C virus infected patients with chronic fatigue and cognitive impairment","volume":"55","author":"Weissenborn","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.dld.2014.10.005_bib0885","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4088\/JCP.v66n0106","article-title":"Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction","volume":"66","author":"Raison","year":"2005","journal-title":"Journal of Clinical Psychiatry"},{"key":"10.1016\/j.dld.2014.10.005_bib0890","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10620-007-9896-z","article-title":"Cognitive dysfunction in chronic hepatitis C: a review","volume":"53","author":"Perry","year":"2008","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.dld.2014.10.005_bib0895","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jhep.2005.04.006","article-title":"Cognitive function in hepatitis C patients with advanced fibrosis enrolled in the HALT-C trial","volume":"43","author":"Fontana","year":"2005","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2014.10.005_bib0900","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-2893.2009.01188.x","article-title":"Investigating health-related quality of life, mood and neuropsychological test performance in a homogeneous cohort of Irish female hepatitis C patients","volume":"17","author":"Lowry","year":"2010","journal-title":"Journal of Viral Hepatitis"},{"key":"10.1016\/j.dld.2014.10.005_bib0905","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1111\/j.1468-1293.2007.00505.x","article-title":"Improved cognitive function as a consequence of hepatitis C virus treatment","volume":"8","author":"Thein","year":"2007","journal-title":"HIV Medicine"},{"key":"10.1016\/j.dld.2014.10.005_bib0910","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1007\/s10620-006-9708-x","article-title":"Fatigue and health-related quality of life (HRQL) in chronic hepatitis C virus infection","volume":"52","author":"Kallman","year":"2007","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.dld.2014.10.005_bib0915","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1365-2893.2002.00364.x","article-title":"Fatigue in patients with chronic hepatitis C","volume":"9","author":"Poynard","year":"2002","journal-title":"Journal of Viral Hepatitis"},{"key":"10.1016\/j.dld.2014.10.005_bib0920","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jhep.2013.11.030","article-title":"Active at night, sleepy all day \u2013 sleep disturbances in patients with hepatitis C virus infection","volume":"60","author":"Heeren","year":"2014","journal-title":"Journal of Hepatology"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865814007294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865814007294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T20:24:41Z","timestamp":1689625481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865814007294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":182,"alternative-id":["S1590865814007294"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2014.10.005","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extrahepatic manifestations of chronic hepatitis C virus infection","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2014.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}