{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:43:14Z","timestamp":1784648594387,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["dldjournalonline.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.dld.2015.05.020","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T20:51:35Z","timestamp":1433451095000},"page":"757-762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Proton pump inhibitors are associated with lower gastrointestinal tract bleeding in low-dose aspirin users with ischaemic heart disease"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6457-4036","authenticated-orcid":false,"given":"Kazumasa","family":"Miyake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Akimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nagoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kodaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobue","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Kusunoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Kawagoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Futagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choitsu","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2015.05.020_bib0280","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.amjmed.2005.11.013","article-title":"Aspirin to prevent heart attack and stroke: what's the right dose","volume":"119","author":"Dalen","year":"2006","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.dld.2015.05.020_bib0285","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1185\/030079907X162656","article-title":"Low-dose aspirin and upper gastrointestinal damage: epidemiology, prevention and treatment","volume":"23","author":"Lanas","year":"2007","journal-title":"Current Medical Research and Opinion"},{"key":"10.1016\/j.dld.2015.05.020_bib0290","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrgastro.2011.97","article-title":"Gastrointestinal effects of aspirin","volume":"8","author":"Sostres","year":"2011","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"10.1016\/j.dld.2015.05.020_bib0295","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1001\/archinte.162.19.2197","article-title":"Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events","volume":"162","author":"Weisman","year":"2002","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.dld.2015.05.020_bib0300","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.amjcard.2005.06.056","article-title":"Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes","volume":"96","author":"Rao","year":"2005","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.dld.2015.05.020_bib0305","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.jacc.2009.07.019","article-title":"Gastrointestinal bleeding in patients with acute coronary syndromes: incidence, predictors, and clinical implications: analysis from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trial","volume":"54","author":"Nikolsky","year":"2009","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.dld.2015.05.020_bib0310","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/0016-5085(93)90667-2","article-title":"Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans","volume":"104","author":"Bjarnason","year":"1993","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2015.05.020_bib0315","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/bmj.290.6465.347","article-title":"Use of anti-inflammatory drugs by patients admitted with small or large bowel perforations and hemorrhage","volume":"290","author":"Langman","year":"1985","journal-title":"British Medical Journal"},{"key":"10.1016\/j.dld.2015.05.020_bib0320","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1056\/NEJM199209103271101","article-title":"Gastrointestinal damage associated with the use of nonsteroidal anti-inflammatory drugs","volume":"327","author":"Allison","year":"1992","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.dld.2015.05.020_bib0325","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/0016-5085(92)90018-T","article-title":"Objective evidence of aspirin use in both ulcer and nonulcer upper and lower gastrointestinal bleeding","volume":"103","author":"Lanas","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2015.05.020_bib0330","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1053\/gast.1997.v112.pm9041228","article-title":"Evidence of aspirin use in both upper and lower gastrointestinal perforation","volume":"112","author":"Lanas","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2015.05.020_bib0335","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.3748\/wjg.v19.i12.1861","article-title":"Mechanisms, prevention and clinical implications of nonsteroidal anti-inflammatory drug-enteropathy","volume":"19","author":"Wallace","year":"2013","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2015.05.020_bib0340","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/ajg.2009.164","article-title":"Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice","volume":"104","author":"Lanas","year":"2009","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2015.05.020_bib0345","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1053\/j.gastro.2011.06.075","article-title":"Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis","volume":"141","author":"Wallace","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2015.05.020_bib0350","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/01.mog.0000153314.51198.58","article-title":"Nonsteroidal antiinflammatory drugs and the small intestine","volume":"21","author":"Fortun","year":"2005","journal-title":"Current Opinion in Gastroenterology"},{"key":"10.1016\/j.dld.2015.05.020_bib0355","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1046\/j.1365-2036.2002.01355.x","article-title":"Risk of upper gastrointestinal bleeding in patients taking low-dose aspirin for the prevention of cardiovascular diseases","volume":"16","author":"Serrano","year":"2002","journal-title":"Alimentary Pharmacology and Therapeutics"},{"key":"10.1016\/j.dld.2015.05.020_bib0360","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1572-0241.2006.01062.x","article-title":"Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants","volume":"102","author":"Lanas","year":"2007","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2015.05.020_bib0365","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1136\/heartjnl-2012-301632","article-title":"Lower GI bleeding is more common than upper among patients on dual antiplatelet therapy: long-term follow-up of a cohort of patients commonly using PPI co-therapy","volume":"98","author":"Casado Arroyo","year":"2012","journal-title":"Heart"},{"key":"10.1016\/j.dld.2015.05.020_bib0370","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/gut.39.1.54","article-title":"Bacterial overgrowthduring treatment with omeprazole compared with cimetidine: a prospective randomised double blind study","volume":"39","author":"Thorens","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.dld.2015.05.020_bib0375","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.cgh.2014.11.007","article-title":"Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants","volume":"13","author":"Lanas","year":"2015","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.dld.2015.05.020_bib0380","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1038\/ajg.2010.445","volume":"105","author":"Abraham","year":"2010","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2015.05.020_bib0385","first-page":"CD002296","article-title":"Prevention of NSAID-induced gastroduodenal ulcers","volume":"4","author":"Rostom","year":"2002","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.dld.2015.05.020_bib0390","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1001\/jama.281.18.1714","article-title":"The definition of anemia in older persons","volume":"281","author":"Izaks","year":"1999","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.dld.2015.05.020_bib0395","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1001\/archinte.165.19.2214","article-title":"A prospective study of anemia status, hemoglobin concentration, and mortality in an elderly cohort: The Cardiovascular Health Study","volume":"165","author":"Zakai","year":"2005","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.dld.2015.05.020_bib0400","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1182\/blood-2005-10-4308","article-title":"Impact of anemia on hospitalization and mortality in older adults","volume":"107","author":"Culleton","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.dld.2015.05.020_bib0405","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1182\/blood-2006-10-055384","article-title":"Racial variation in the relationship of anemia with mortality and mobility disability among older adults","volume":"109","author":"Patel","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.dld.2015.05.020_bib0410","first-page":"357","article-title":"Iron status and anemia in a populationbased study of women with and without disability living in the community: The Women's Health and Aging Studies","volume":"89","author":"Semba","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.dld.2015.05.020_bib0415","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1532-5415.2004.52208.x","article-title":"Anemia is associated with disability and decreased physical performance and muscle strength in the elderly","volume":"52","author":"Penninx","year":"2004","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/j.dld.2015.05.020_bib0420","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/j.1532-5415.2004.52502.x","article-title":"What constitutes normal hemoglobin concentration in community-dwelling disabled older women","volume":"52","author":"Chaves","year":"2004","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/j.dld.2015.05.020_bib0425","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4065\/84.2.149","article-title":"Expanding the recognition and assessment of bleeding events associated with antiplatelet therapy in primary care","volume":"84","author":"Cohen","year":"2009","journal-title":"Mayo Clinic Proceedings"},{"key":"10.1016\/j.dld.2015.05.020_bib0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0735-1097(88)90158-1","article-title":"Thrombolysis in Myocardial Infarction (TIMI) Trial \u2013 phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase","volume":"11","author":"Rao","year":"1988","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.dld.2015.05.020_bib0435","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1056\/NEJM199309023291001","article-title":"An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. The GUSTO investigators","volume":"329","year":"1993","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.dld.2015.05.020_bib0440","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.amjcard.2006.07.091","article-title":"Assessment of bleeding events in clinical trials \u2013 proposal of a new classification","volume":"99","author":"Serebruany","year":"2007","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.dld.2015.05.020_bib0445","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1038\/srep05227","article-title":"Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors","volume":"4","author":"Nakayama","year":"2014","journal-title":"Scientific Reports"},{"key":"10.1016\/j.dld.2015.05.020_bib0450","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1080\/15257770.2013.866679","article-title":"ABCG2 dysfunction increases the risk of renal overload hyperuricemia","volume":"33","author":"Matsuo","year":"2014","journal-title":"Nucleosides, Nucleotides and Nucleic Acids"},{"key":"10.1016\/j.dld.2015.05.020_bib0455","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1038\/srep03755","article-title":"ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload","volume":"4","author":"Matsuo","year":"2014","journal-title":"Scientific Reports"},{"key":"10.1016\/j.dld.2015.05.020_bib0460","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/15257770.2013.854902","article-title":"ABCG2 dysfunction increases serum uric acid by decreased intestinal urate excretion","volume":"33","author":"Takada","year":"2014","journal-title":"Nucleosides, Nucleotides and Nucleic Acids"},{"key":"10.1016\/j.dld.2015.05.020_bib0465","doi-asserted-by":"crossref","first-page":"976.e1","DOI":"10.1016\/j.ahj.2006.02.013","article-title":"Statins are associated with lower risk of gastrointestinal bleeding in patients with unstable coronary syndromes: analysis of the Orbofiban in Patients with Unstable coronary Syndromes-Thrombolysis In Myocardial Infarction 16 (OPUS-TIMI 16) trial","volume":"151","author":"Atar","year":"2006","journal-title":"American Heart Journal"},{"key":"10.1016\/j.dld.2015.05.020_bib0470","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1161\/hq0801.094222","article-title":"In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products","volume":"21","author":"Diomede","year":"2001","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.dld.2015.05.020_bib0475","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.yexcr.2004.05.039","article-title":"HMG-CoA reductase inhibitors induce COX-2 gene expression in murine macrophages: role of MAPK cascades and promoter elements for CREB and C\/EBPbeta","volume":"301","author":"Chen","year":"2004","journal-title":"Experimental Cell Research"},{"key":"10.1016\/j.dld.2015.05.020_bib0480","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s003950200000","article-title":"Pleiotropic effects of HMG-CoA reductase inhibitors","volume":"97","author":"Werner","year":"2002","journal-title":"Basic Research in Cardiology"},{"key":"10.1016\/j.dld.2015.05.020_bib0485","doi-asserted-by":"crossref","first-page":"24F","DOI":"10.1016\/j.amjcard.2005.06.009","article-title":"Effects of statins on 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition beyond low-density lipoprotein cholesterol","volume":"96","author":"Liao","year":"2005","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.dld.2015.05.020_bib0490","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ejphar.2009.02.008","article-title":"Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins","volume":"607","author":"Heeba","year":"2009","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.dld.2015.05.020_bib0495","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1007\/s10620-006-9638-7","article-title":"Anti-inflammatory effects of pravastatin on Helicobacter pylori-induced gastritis in mice","volume":"52","author":"Yamato","year":"2007","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.dld.2015.05.020_bib0500","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000139008","article-title":"Comparative inhibitory effects of dihydropyridines on platelet aggregation, calcium uptake and cyclic AMP concentration","volume":"45","author":"Blache","year":"1992","journal-title":"Pharmacology"},{"key":"10.1016\/j.dld.2015.05.020_bib0505","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0049-3848(94)90060-4","article-title":"Inhibitory effect of clentiazem (TA-3090) on platelet aggregation \u2013 alone and in combination with aspirin or ticlopidine","volume":"75","author":"Odawara","year":"1994","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.dld.2015.05.020_bib0510","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0002-9149(99)80516-5","article-title":"Platelet aggregability in vivo is attenuated by verapamil but not by metoprolol in patients with stable angina pectoris","volume":"75","author":"Wall\u00e9n","year":"1995","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.dld.2015.05.020_bib0515","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1055\/s-0038-1648858","article-title":"The calcium modulator nifedipine exerts its antiaggregatory property via a nitric oxide mediated process","volume":"72","author":"Berkels","year":"1994","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.dld.2015.05.020_bib0520","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0140-6736(96)90276-7","article-title":"Risk of gastrointestinal hemorrhage with calcium antagonists in hypertensive persons over 67 years old","volume":"347","author":"Pahor","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2015.05.020_bib0525","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1001\/archinte.160.12.1849","article-title":"Use of calcium channel blockers and risk of hospitalized gastrointestinal tract bleeding","volume":"160","author":"Kaplan","year":"2000","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.dld.2015.05.020_bib0530","first-page":"315","article-title":"Protective effect of verapamil on gastric hemorrhagic ulcers in severe atherosclerotic rats","volume":"50","author":"Hung","year":"2007","journal-title":"Chinese Journal of Physiology"},{"key":"10.1016\/j.dld.2015.05.020_bib0535","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1254\/jjp.78.435","article-title":"Anti-ulcer effects of antioxidants, quercetin, alpha-tocopherol, nifedipine and tetracycline in rats","volume":"78","author":"Suzuki","year":"1998","journal-title":"Japanese Journal of Pharmacology"},{"key":"10.1016\/j.dld.2015.05.020_bib0540","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000139384","article-title":"Influence of gallopamil on the gastric effects of stress in conscious rats","volume":"52","author":"Co\u015fkun","year":"1996","journal-title":"Pharmacology"},{"key":"10.1016\/j.dld.2015.05.020_bib0545","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.dld.2012.05.016","article-title":"Differences in the severity of small bowel mucosal injury based on the type of aspirin as evaluated by capsule endoscopy","volume":"44","author":"Endo","year":"2012","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.dld.2015.05.020_bib0550","first-page":"5","article-title":"Sustained release and enteric coated NSAIDs: are they really GI safe","volume":"2","author":"Davies","year":"1999","journal-title":"Journal of Pharmacy and Pharmaceutical Sciences"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865815003497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865815003497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T01:23:35Z","timestamp":1566782615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865815003497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1590865815003497"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2015.05.020","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proton pump inhibitors are associated with lower gastrointestinal tract bleeding in low-dose aspirin users with ischaemic heart disease","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2015.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}