{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:09:56Z","timestamp":1753520996129},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["dldjournalonline.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.dld.2015.11.016","type":"journal-article","created":{"date-parts":[[2015,11,29]],"date-time":"2015-11-29T11:23:22Z","timestamp":1448796202000},"page":"376-380","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["No increased mortality in 109,000 first-degree relatives of celiac individuals"],"prefix":"10.1016","volume":"48","author":[{"given":"Louise","family":"Emilsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyshah","family":"Abdul Sultan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2015.11.016_bib0190","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.dld.2015.11.016_bib0195","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/ajg.2014.55","article-title":"Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study","volume":"109","author":"West","year":"2014","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2015.11.016_bib0200","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/apt.12973","article-title":"Systematic review with meta-analysis: associations between coeliac disease and type 1 diabetes","volume":"40","author":"Elfstrom","year":"2014","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"10.1016\/j.dld.2015.11.016_bib0205","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1210\/jc.2008-0798","article-title":"Risk of thyroid disease in individuals with celiac disease","volume":"93","author":"Elfstrom","year":"2008","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.dld.2015.11.016_bib0210","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1089\/thy.2012.0306","article-title":"Risk of thyroid cancer in a nationwide cohort of patients with biopsy-verified celiac disease","volume":"23","author":"Ludvigsson","year":"2013","journal-title":"Thyroid"},{"key":"10.1016\/j.dld.2015.11.016_bib0215","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1365-2036.2012.04998.x","article-title":"The long-term risk of malignancy following a diagnosis of coeliac disease or dermatitis herpetiformis: a cohort study","volume":"35","author":"Grainge","year":"2012","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"10.1016\/j.dld.2015.11.016_bib0220","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cgh.2011.06.029","article-title":"Low risk of gastrointestinal cancer among patients with celiac disease, inflammation, or latent celiac disease","volume":"10","author":"Elfstrom","year":"2012","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.dld.2015.11.016_bib0225","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0002-9343(03)00302-4","article-title":"Risk of malignancy in patients with celiac disease","volume":"115","author":"Green","year":"2003","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.dld.2015.11.016_bib0230","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1001\/archinte.163.13.1566","article-title":"Causes of death in patients with celiac disease in a population-based Swedish cohort","volume":"163","author":"Peters","year":"2003","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.dld.2015.11.016_bib0235","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0016-5085(89)90060-7","article-title":"Mortality in celiac disease","volume":"97","author":"Logan","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2015.11.016_bib0240","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/j.1572-0241.2007.01111.x","article-title":"Long-term mortality in people with celiac disease diagnosed in childhood compared with adulthood: a population-based cohort study","volume":"102","author":"Solaymani-Dodaran","year":"2007","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2015.11.016_bib0245","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1136\/bmj.38169.486701.7C","article-title":"Malignancy and mortality in people with coeliac disease: population based cohort study","volume":"329","author":"West","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.dld.2015.11.016_bib0250","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1001\/jama.2009.1320","article-title":"Small-intestinal histopathology and mortality risk in celiac disease","volume":"302","author":"Ludvigsson","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.dld.2015.11.016_bib0255","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/ajg.2010.506","article-title":"Causes of death in people with celiac disease spanning the pre- and post-serology era: a population-based cohort study from Derby, UK","volume":"106","author":"Grainge","year":"2011","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2015.11.016_bib0260","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1136\/gutjnl-2014-308285","article-title":"Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis","volume":"64","author":"Abdul Sultan","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.dld.2015.11.016_bib0265","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12876-014-0194-x","article-title":"The changing clinical profile of celiac disease: a 15-year experience (1998\u20132012) in an Italian referral center","volume":"14","author":"Volta","year":"2014","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.dld.2015.11.016_bib0270","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1136\/archdischild-2014-307105","article-title":"Socioeconomic variation in the incidence of childhood coeliac disease in the UK","volume":"100","author":"Zingone","year":"2015","journal-title":"Archives of Disease in Childhood"},{"key":"10.1016\/j.dld.2015.11.016_bib0275","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1365-2036.2011.04972.x","article-title":"Meta-analysis: coeliac disease and the risk of all-cause mortality, any malignancy and lymphoid malignancy","volume":"35","author":"Tio","year":"2012","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"10.1016\/j.dld.2015.11.016_bib0280","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/aje\/kws397","article-title":"Mortality rate in children born to mothers and fathers with celiac disease: a nationwide cohort study","volume":"177","author":"Zugna","year":"2013","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.dld.2015.11.016_bib0285","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0140-6736(01)05554-4","article-title":"Mortality in patients with coeliac disease and their relatives: a cohort study","volume":"358","author":"Corrao","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2015.11.016_bib0290","first-page":"17","article-title":"Malignancy in relatives of patients with coeliac disease","volume":"30","author":"Stokes","year":"1976","journal-title":"British Journal of Preventive & Social Medicine"},{"key":"10.1016\/j.dld.2015.11.016_bib0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2015.01.026","article-title":"Autoimmune disease in first-degree relatives and spouses of individuals with celiac disease","volume":"13","author":"Emilsson","year":"2015","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.dld.2015.11.016_bib0300","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0016-5085(92)91819-P","article-title":"Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (\u2018celiac sprue\u2019)","volume":"102","author":"Marsh","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2015.11.016_bib0305","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-230X-9-19","article-title":"Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers","volume":"9","author":"Ludvigsson","year":"2009","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.dld.2015.11.016_bib0310","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.iac.2015.04.003","article-title":"Eosinophils in gastrointestinal disorders: eosinophilic gastrointestinal diseases, celiac disease, inflammatory bowel diseases, and parasitic infections","volume":"35","author":"Mehta","year":"2015","journal-title":"Immunology and Allergy Clinics of North America"},{"key":"10.1016\/j.dld.2015.11.016_bib0315","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1136\/jcp.2005.035345","article-title":"Coeliac disease: an update for pathologists","volume":"59","author":"Dickson","year":"2006","journal-title":"Journal of Clinical Pathology"},{"key":"10.1016\/j.dld.2015.11.016_bib0320","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.mayocp.2012.06.003","article-title":"Severe spruelike enteropathy associated with olmesartan","volume":"87","author":"Rubio-Tapia","year":"2012","journal-title":"Mayo Clinic Proceedings"},{"key":"10.1016\/j.dld.2015.11.016_bib0325","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.mayocp.2015.04.002","article-title":"Blockers of angiotensin other than olmesartan in patients with villous atrophy: a nationwide case\u2013control study","volume":"90","author":"Marild","year":"2015","journal-title":"Mayo Clinic Proceedings"},{"key":"10.1016\/j.dld.2015.11.016_bib0330","series-title":"The total population register of statistics Sweden, new possibilities and better quality","author":"Johannesson","year":"2002"},{"key":"10.1016\/j.dld.2015.11.016_bib0335","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/978-1-59745-423-0_10","article-title":"The Swedish Multi-generation Register","volume":"675","author":"Ekbom","year":"2011","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.dld.2015.11.016_bib0340","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.0954-6820.1976.tb08223.x","article-title":"A validation of cause-of-death certification in 1,156 deaths","volume":"200","author":"de Faire","year":"1976","journal-title":"Acta Medica Scandinavica"},{"key":"10.1016\/j.dld.2015.11.016_bib0345","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/ije\/29.3.495","article-title":"Comparing Swedish hospital discharge records with death certificates: implications for mortality statistics","volume":"29","author":"Johansson","year":"2000","journal-title":"International Journal of Epidemiology"},{"key":"10.1016\/j.dld.2015.11.016_bib0350","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.gastro.2008.09.031","article-title":"Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association","volume":"136","author":"Gao","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2015.11.016_bib0355","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1161\/CIRCULATIONAHA.110.965624","article-title":"Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease","volume":"123","author":"Ludvigsson","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.dld.2015.11.016_bib0360","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/eci.12242","article-title":"Ischaemic heart disease in first-degree relatives to coeliac patients","volume":"44","author":"Emilsson","year":"2014","journal-title":"European Journal of Clinical Investigation"},{"key":"10.1016\/j.dld.2015.11.016_bib0365","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/ajg.2014.194","article-title":"Incidence of malignancies in diagnosed celiac patients: a population-based estimate","volume":"109","author":"Ilus","year":"2014","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2015.11.016_bib0370","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/jnci\/djq564","article-title":"Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease","volume":"103","author":"Elfstrom","year":"2011","journal-title":"Journal of the National Cancer Institute"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865815300827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865815300827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T05:55:38Z","timestamp":1537163738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865815300827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1590865815300827"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2015.11.016","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"No increased mortality in 109,000 first-degree relatives of celiac individuals","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2015.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}