{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:37:10Z","timestamp":1768693030491,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["dldjournalonline.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.dld.2016.03.022","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T17:30:03Z","timestamp":1460395803000},"page":"771-779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Glucocorticoid treatment alters systemic bile acid homeostasis by regulating the biosynthesis and transport of bile salts"],"prefix":"10.1016","volume":"48","author":[{"given":"Yongtao","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kejun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2016.03.022_bib0195","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.dld.2016.03.022_bib0200","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1665-2681(19)32126-X","article-title":"Cholestasis: human disease and experimental animal models","volume":"2","author":"Rodriguez-Garay","year":"2003","journal-title":"Annals of Hepatology"},{"key":"10.1016\/j.dld.2016.03.022_bib0205","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.tips.2007.03.002","article-title":"FXR: a promising target for the metabolic syndrome?","volume":"28","author":"Cariou","year":"2007","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.dld.2016.03.022_bib0210","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cmet.2008.08.001","article-title":"The glucocorticoid receptor controls hepatic dyslipidemia through Hes1","volume":"8","author":"Lemke","year":"2008","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.dld.2016.03.022_bib0215","first-page":"695","article-title":"Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells","volume":"118","author":"Arenas","year":"2008","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.dld.2016.03.022_bib0220","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/hep.20646","article-title":"Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: a three-year randomized trial","volume":"41","author":"Rautiainen","year":"2005","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.dld.2016.03.022_bib0225","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1177\/000313481408000908","article-title":"Differentiating biliary atresia from other causes of cholestatic jaundice","volume":"80","author":"Robie","year":"2014","journal-title":"American Surgeon"},{"key":"10.1016\/j.dld.2016.03.022_bib0230","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1002\/hep.21873","article-title":"Randomized, double-blind, placebo-controlled trial of corticosteroids after Kasai portoenterostomy for biliary atresia","volume":"46","author":"Davenport","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2016.03.022_bib0235","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/hep.22001","article-title":"Corticosteroid treatment in biliary atresia: tonic or toast?","volume":"46","author":"Sokol","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2016.03.022_bib0240","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1001\/jama.2014.2623","article-title":"Use of corticosteroids after hepatoportoenterostomy for bile drainage in infants with biliary atresia: the START randomized clinical trial","volume":"311","author":"Bezerra","year":"2014","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.dld.2016.03.022_bib0245","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1371\/journal.pgen.0010016","article-title":"Glucocorticoid receptor-dependent gene regulatory networks","volume":"1","author":"Phuc Le","year":"2005","journal-title":"PLoS Genetics"},{"key":"10.1016\/j.dld.2016.03.022_bib0250","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.bcp.2013.01.001","article-title":"FXR-dependent and -independent interaction of glucocorticoids with the regulatory pathways involved in the control of bile acid handling by the liver","volume":"85","author":"Rosales","year":"2013","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.dld.2016.03.022_bib0255","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.08.029","article-title":"Glucocorticoids promote hepatic cholestasis in mice by inhibiting the transcriptional activity of the farnesoid X receptor","volume":"143","author":"Lu","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2016.03.022_bib0260","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cmet.2011.04.010","article-title":"Molecular control of systemic bile acid homeostasis by the liver glucocorticoid receptor","volume":"14","author":"Rose","year":"2011","journal-title":"Cell Metabolism"},{"key":"10.1016\/j.dld.2016.03.022_bib0265","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF02774711","article-title":"Sterol and bile acid metabolism after short-term prednisolone treatment in patients with chronic active hepatitis","volume":"20","author":"Yamanishi","year":"1985","journal-title":"Gastroenterologia Japonica."},{"key":"10.1016\/j.dld.2016.03.022_bib0270","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1210\/me.2005-0159","article-title":"The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism","volume":"20","author":"Eloranta","year":"2006","journal-title":"Molecular Endocrinology"},{"key":"10.1016\/j.dld.2016.03.022_bib0275","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jhep.2014.03.025","article-title":"Prednisolone increases enterohepatic cycling of bile acids by induction of Asbt and promotes reverse cholesterol transport","volume":"61","author":"Out","year":"2014","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2016.03.022_bib0280","doi-asserted-by":"crossref","first-page":"15816","DOI":"10.1074\/jbc.M010878200","article-title":"Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway","volume":"276","author":"Gupta","year":"2001","journal-title":"The Journal of biological chemistry"},{"key":"10.1016\/j.dld.2016.03.022_bib0285","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/hep.20919","article-title":"Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis","volume":"43","author":"Song","year":"2006","journal-title":"Hepatology."},{"key":"10.1016\/j.dld.2016.03.022_bib0290","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/bj1600049","article-title":"The role of glucocorticoids in the regulation of the diurnal rhythm of hepatic beta-hydroxy-beta-methylglutaryl-coenzyme A reductase and cholesterol 7 alpha-hydroxylase","volume":"160","author":"Mitropoulos","year":"1976","journal-title":"The Biochemical journal."},{"key":"10.1016\/j.dld.2016.03.022_bib0295","doi-asserted-by":"crossref","first-page":"e6843","DOI":"10.1371\/journal.pone.0006843","article-title":"Circadian dysregulation disrupts bile acid homeostasis","volume":"4","author":"Ma","year":"2009","journal-title":"PloS one."},{"key":"10.1016\/j.dld.2016.03.022_bib0300","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jhep.2014.10.033","article-title":"Dysregulated miR-124 and miR-200 expression contribute to cholangiocyte proliferation in the cholestatic liver by targetingIL-6\/STAT3 signalling","volume":"62","author":"Xiao","year":"2015","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2016.03.022_bib0305","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1096\/fj.13-231860","article-title":"Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption","volume":"27","author":"Xie","year":"2013","journal-title":"FASEB Journal"},{"key":"10.1016\/j.dld.2016.03.022_bib0310","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1194\/jlr.D028803","article-title":"Targeted profiling of circulating and hepatic bile acids in human, mouse, and rat using a UPLC-MRM-MS-validated method","volume":"53","author":"Garcia-Canaveras","year":"2012","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.dld.2016.03.022_bib0315","doi-asserted-by":"crossref","first-page":"G182","DOI":"10.1152\/ajpgi.00205.2011","article-title":"Suppression of the HPA axis during extrahepatic biliary obstruction induces cholangiocyte proliferation in the rat","volume":"302","author":"Quinn","year":"2012","journal-title":"American Journal of Physiology Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.dld.2016.03.022_bib0320","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jhep.2009.10.037","article-title":"Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice","volume":"52","author":"McNeilly","year":"2010","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.dld.2016.03.022_bib0325","first-page":"G197","article-title":"Glucocorticoids upregulate taurocholate transport by ileal brush-border membrane","volume":"273","author":"Nowicki","year":"1997","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.dld.2016.03.022_bib0330","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1073\/pnas.88.9.3807","article-title":"The different tissue transcription patterns of genes for HNF-1, C\/EBP, HNF-3, and HNF-4, protein factors that govern liver-specific transcription","volume":"88","author":"Xanthopoulos","year":"1991","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.dld.2016.03.022_bib0335","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nm.1853","article-title":"Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress","volume":"14","author":"Bochkis","year":"2008","journal-title":"Nature Medicine"},{"key":"10.1016\/j.dld.2016.03.022_bib0340","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1203\/PDR.0b013e318165b8af","article-title":"Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics","volume":"63","author":"Liu","year":"2008","journal-title":"Pediatric research."},{"key":"10.1016\/j.dld.2016.03.022_bib0345","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/gut.53.1.78","article-title":"Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor","volume":"53","author":"Jung","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.dld.2016.03.022_bib0350","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/bj2620341","article-title":"Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7 alpha-hydroxylase","volume":"262","author":"Princen","year":"1989","journal-title":"Biochemical Journal"},{"key":"10.1016\/j.dld.2016.03.022_bib0355","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1194\/jlr.M500449-JLR200","article-title":"The stimulatory effect of LXRalpha is blocked by SHP despite the presence of a LXRalpha binding site in the rabbit CYP7A1 promoter","volume":"47","author":"Shang","year":"2006","journal-title":"Journal of lipid research"},{"key":"10.1016\/j.dld.2016.03.022_bib0360","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1101\/gr.118042.110","article-title":"Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes","volume":"21","author":"Rao","year":"2011","journal-title":"Genome Research"},{"key":"10.1016\/j.dld.2016.03.022_bib0365","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0022-2275(20)37548-9","article-title":"Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells","volume":"37","author":"Wang","year":"1996","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.dld.2016.03.022_bib0370","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1021\/bi00124a014","article-title":"Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene","volume":"31","author":"Molowa","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/j.dld.2016.03.022_bib0375","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/nature03649","article-title":"The initiation of liver development is dependent on Foxa transcription factors","volume":"435","author":"Lee","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.dld.2016.03.022_bib0380","doi-asserted-by":"crossref","first-page":"39885","DOI":"10.1074\/jbc.M105370200","article-title":"Accessory factors facilitate the binding of glucocorticoid receptor to the phosphoenolpyruvate carboxykinase gene promoter","volume":"276","author":"Stafford","year":"2001","journal-title":"Journal of Biological Chemistry"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865816303796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865816303796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T16:43:55Z","timestamp":1655484235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865816303796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S1590865816303796"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2016.03.022","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glucocorticoid treatment alters systemic bile acid homeostasis by regulating the biosynthesis and transport of bile salts","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2016.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}