{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:47:45Z","timestamp":1791384465468,"version":"4.3.3"},"reference-count":33,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["dldjournalonline.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.dld.2017.02.008","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T19:30:34Z","timestamp":1488396634000},"page":"757-763","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The effects of paroxetine and amitriptyline on the upper esophageal sphincter (UES) pressure and its natural history in globus pharyngeus"],"prefix":"10.1016","volume":"49","author":[{"given":"Wen-cong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-yun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-man","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2017.02.008_bib0005","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/1751-2980.12354","article-title":"Epidemiology of globus symptoms and associated psychological factors in China","volume":"17","author":"Tang","year":"2016","journal-title":"Journal of Digestive Diseases"},{"key":"10.1016\/j.dld.2017.02.008_bib0010","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/00005537-199710000-00015","article-title":"Gastroesophageal reflux, motility disorders, and psychological profiles in the etiology of globus pharyngis","volume":"107","author":"Hill","year":"1997","journal-title":"Laryngoscope"},{"key":"10.1016\/j.dld.2017.02.008_bib0015","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1002\/lary.21147","article-title":"Globus pharyngeus and extraesophageal reflux: simultaneous pH<4.0 and pH<5.0 analysis","volume":"120","author":"Zelenik","year":"2010","journal-title":"Laryngoscope"},{"key":"10.1016\/j.dld.2017.02.008_bib0020","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/j.1365-2982.2009.01316.x","article-title":"Evidence for oesophageal visceral hypersensitivity and aberrant symptom referral in patients with globus","volume":"21","author":"Chen","year":"2009","journal-title":"Neurogastroenterology & Motility"},{"key":"10.1016\/j.dld.2017.02.008_bib0025","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/014556130508400206","article-title":"Treatment of globus by upper esophageal sphincter injection with botulinum A toxin","volume":"84","author":"Halum","year":"2005","journal-title":"Ear, Nose & Throat Journal"},{"key":"10.1016\/j.dld.2017.02.008_bib0030","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1023\/A:1018862814873","article-title":"Globus sensation is associated with hypertensive upper esophageal sphincter but not with gastroesophageal reflux","volume":"43","author":"Corso","year":"1998","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.dld.2017.02.008_bib0035","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(74)90074-9","article-title":"Hypertonicity of the cricopharyngeal sphincter: a cause of globus sensation","volume":"2","author":"Watson","year":"1974","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2017.02.008_bib0040","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/MCG.0000000000000078","article-title":"Assessment of upper esophageal sphincter function on high-resolution manometry: identification of predictors of globus symptoms","volume":"49","author":"Peng","year":"2015","journal-title":"Journal of Clinical Gastroenterology"},{"key":"10.1016\/j.dld.2017.02.008_bib0045","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00405-009-1134-1","article-title":"Globus sensation and increased upper esophageal sphincter pressure with distal esophageal acid perfusion","volume":"267","author":"Tokashiki","year":"2010","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"key":"10.1016\/j.dld.2017.02.008_bib0050","doi-asserted-by":"crossref","first-page":"952","DOI":"10.3748\/wjg.v8.i5.952","article-title":"Study on the function of pharynx upper esophageal sphincter in globus hystericus","volume":"8","author":"Sun","year":"2002","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2017.02.008_bib0055","first-page":"657","article-title":"Lansoprazole in globus pharyngeus: double-blind, randomized, placebo-controlled trial","volume":"37","author":"Dumper","year":"2008","journal-title":"Journal of Otolaryngology: Head & Neck Surgery"},{"key":"10.1016\/j.dld.2017.02.008_bib0060","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.dld.2016.05.025","article-title":"Comparison of paroxetine and amitriptyline in the treatment of refractory globus pharyngeus","volume":"48","author":"Chen","year":"2016","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.dld.2017.02.008_bib0065","doi-asserted-by":"crossref","first-page":"7455","DOI":"10.3748\/wjg.v19.i42.7455","article-title":"Effect of low-dose amitriptyline on globus pharyngeus and its side effects","volume":"19","author":"You","year":"2013","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2017.02.008_bib0070","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2036.2008.03918.x","article-title":"Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome","volume":"29","author":"Thoua","year":"2009","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"10.1016\/j.dld.2017.02.008_bib0075","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/MPG.0b013e318217df7c","article-title":"Long-term efficacy of low-dose tricyclic antidepressants for children with functional gastrointestinal disorders","volume":"53","author":"Teitelbaum","year":"2011","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"10.1016\/j.dld.2017.02.008_bib0080","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/gast.2003.50055","article-title":"The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome","volume":"124","author":"Creed","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2017.02.008_bib0085","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1053\/j.gastro.2005.08.060","article-title":"Functional esophageal disorders","volume":"130","author":"Galmiche","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2017.02.008_bib0090","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0022-3999(94)00104-D","article-title":"Globus pharyngis: development of a symptom assessment scale","volume":"39","author":"Deary","year":"1995","journal-title":"Journal of Psychosomatic Research"},{"key":"10.1016\/j.dld.2017.02.008_bib0095","first-page":"46","article-title":"Heartburn and globus in apparently healthy people","volume":"126","author":"Thompson","year":"1982","journal-title":"Canadian Medical Association Journal"},{"key":"10.1016\/j.dld.2017.02.008_bib0100","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1001\/archotol.1982.00790590062017","article-title":"The globus symptom. Incidence, therapeutic response, and age and sex relationships","volume":"108","author":"Moloy","year":"1982","journal-title":"Archives of Otolaryngology"},{"key":"10.1016\/j.dld.2017.02.008_bib0105","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1001\/archinte.158.12.1365","article-title":"Globus sensation: pharyngoesophageal function, psychometric and psychiatric findings, and follow-up in 88 patients","volume":"158","author":"Moser","year":"1998","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.dld.2017.02.008_bib0110","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-2982.2004.00539.x","article-title":"High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry","volume":"16","author":"Fox","year":"2004","journal-title":"Neurogastroenterology & Motility"},{"key":"10.1016\/j.dld.2017.02.008_bib0115","first-page":"G568","article-title":"Physiology of the esophageal pressure transition zone: separate contraction waves above and below","volume":"290","author":"Ghosh","year":"2006","journal-title":"American Journal of Physiology: Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.dld.2017.02.008_bib0120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1148\/radiology.191.1.8134604","article-title":"Globus pharyngeus: radiographic evaluation and 24-hour pH monitoring of the pharynx and esophagus in 22 patients","volume":"191","author":"Ott","year":"1994","journal-title":"Radiology"},{"key":"10.1016\/j.dld.2017.02.008_bib0125","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1136\/gut.2004.047423","article-title":"Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome","volume":"54","author":"Morgan","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.dld.2017.02.008_bib0130","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.3748\/wjg.v19.i26.4214","article-title":"Effect of amitriptyline on gastrointestinal function and brain-gut peptides: a double-blind trial","volume":"19","author":"Huang","year":"2013","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2017.02.008_bib0135","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1369\/jhc.6A7084.2006","article-title":"Adult human upper esophageal sphincter contains specialized muscle fibers expressing unusual myosin heavy chain isoforms","volume":"55","author":"Mu","year":"2007","journal-title":"Journal of Histochemistry & Cytochemistry"},{"key":"10.1016\/j.dld.2017.02.008_bib0140","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/BF01540336","article-title":"Upper esophageal sphincter tone and reactivity to stress in patients with a history of globus sensation","volume":"34","author":"Cook","year":"1989","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.dld.2017.02.008_bib0145","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.dld.2015.11.015","article-title":"Clinical-psychological characteristics of refractory globus patients in China","volume":"48","author":"Tang","year":"2016","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.dld.2017.02.008_bib0150","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ajg.2008.150","article-title":"Hyperdynamic upper esophageal sphincter pressure: a manometric observation in patients reporting globus sensation","volume":"104","author":"Kwiatek","year":"2009","journal-title":"The American Journal of Gastroenterology"},{"key":"10.1016\/j.dld.2017.02.008_bib0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2273.1987.tb00201.x","article-title":"Globus sensation is not due to gastro-oesophageal reflux","volume":"12","author":"Wilson","year":"1987","journal-title":"Clinical Otolaryngology & Allied Sciences"},{"key":"10.1016\/j.dld.2017.02.008_bib0160","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1288\/00005537-199510000-00019","article-title":"The natural history of globus pharyngeus","volume":"105","author":"Rowley","year":"1995","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.dld.2017.02.008_bib0165","doi-asserted-by":"crossref","first-page":"159630","DOI":"10.1155\/2010\/159630","article-title":"The natural history of globus pharyngeus","volume":"2010","author":"Cashman","year":"2010","journal-title":"International Journal of Otolaryngology"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865817302293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865817302293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T06:31:33Z","timestamp":1568874693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865817302293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1590865817302293"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2017.02.008","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of paroxetine and amitriptyline on the upper esophageal sphincter (UES) pressure and its natural history in globus pharyngeus","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2017.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}