{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:26:48Z","timestamp":1778664408979,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Severi Sapienza","award":["000324_13"],"award-info":[{"award-number":["000324_13"]}]}],"content-domain":{"domain":["dldjournalonline.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.dld.2018.03.005","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T21:49:54Z","timestamp":1521409794000},"page":"820-827","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Myogenic oxidative imbalance interferes with antral motility in obese subjects"],"prefix":"10.1016","volume":"50","author":[{"given":"Annunziata","family":"Scirocco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Pallotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Rengo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia","family":"Ignazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia","family":"Carabotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Cicenia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Vona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Chirletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"Maselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Donghia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagrazia","family":"Coluzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Matarrese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Silecchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9249-1318","authenticated-orcid":false,"given":"Carola","family":"Severi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2018.03.005_bib0005","doi-asserted-by":"crossref","first-page":"10497","DOI":"10.3390\/ijms140510497","article-title":"Obesity-associated oxidative stress: strategies finalized to improve redox state","volume":"14","author":"Savini","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dld.2018.03.005_bib0010","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1549-8719.2011.00130.x","article-title":"Microvascular dysfunction: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension","volume":"19","author":"De Boer","year":"2012","journal-title":"Microcirculation"},{"key":"10.1016\/j.dld.2018.03.005_bib0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.dld.2018.03.005_bib0020","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s11357-012-9402-1","article-title":"The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad","volume":"35","author":"Wadley","year":"2013","journal-title":"Age (Dordr)"},{"key":"10.1016\/j.dld.2018.03.005_bib0025","doi-asserted-by":"crossref","first-page":"615312","DOI":"10.1155\/2014\/615312","article-title":"The role of oxidative stress and inflammation in cardiovascular aging","volume":"2014","author":"Wu","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.dld.2018.03.005_bib0030","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/CS20100355","article-title":"Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with type 2 diabetes","volume":"120","author":"Georgescu","year":"2011","journal-title":"Clin Sci"},{"key":"10.1016\/j.dld.2018.03.005_bib0035","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1152\/ajplung.2001.281.6.L1425","article-title":"Mechanisms of cytokine effects on G protein-coupled receptor-mediated signaling in airway smooth muscle","volume":"281","author":"Pascual","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.dld.2018.03.005_bib0040","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1365-2982.2006.00822.x","article-title":"Vasoactive intestinal peptide receptor subtypes and signalling pathways involved in relaxation of human stomach","volume":"8","author":"Severi","year":"2006","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2018.03.005_bib0045","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.physiol.68.040504.094707","article-title":"Signaling for contraction and relaxation in smooth muscle of the gut","volume":"68","author":"Murthy","year":"2006","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.dld.2018.03.005_bib0050","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1038\/oby.2010.83","article-title":"Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity","volume":"18","author":"Liu","year":"2010","journal-title":"Obesity"},{"key":"10.1016\/j.dld.2018.03.005_bib0055","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.dld.2004.06.016","article-title":"Optimisation of isolation of richly pure and homogeneous primary human colonic smooth muscle cells","volume":"36","author":"Tattoli","year":"2004","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2018.03.005_bib0060","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/jcp.22053","article-title":"Exposure of toll-like receptors 4 to bacterial lipopolysaccharide (LPS) impairs human colonic smooth muscle cell function","volume":"223","author":"Scirocco","year":"2010","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.dld.2018.03.005_bib0065","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/jmri.20738","article-title":"Quantification of distal antral contractile motility in healthy human stomach with magnetic resonance imaging","volume":"24","author":"Kwiatek","year":"2006","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.dld.2018.03.005_bib0070","series-title":"Rome II the functional gastrointestinal disorders","article-title":"The Rome II Modular Questionnaire: investigator and respondent forms","author":"Drossman","year":"2000"},{"key":"10.1016\/j.dld.2018.03.005_bib0075","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2018.03.005_bib0080","first-page":"47","article-title":"High-fat diet-induced oxidative stress and its impact on metabolic syndrome: a review","volume":"9","author":"Kesh","year":"2016","journal-title":"Asian J Pharm Clin Res"},{"key":"10.1016\/j.dld.2018.03.005_bib0085","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/jcp.22922","article-title":"NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells","volume":"227","author":"Muzaffar","year":"2012","journal-title":"Cell Physiol"},{"key":"10.1016\/j.dld.2018.03.005_bib0090","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/sj.bjp.0702193","article-title":"Role of cyclo-oxygenase-2 induction in interleukin-1\u03b2 induced attenuation of cultured human airway smooth muscle cell cyclic AMP generation in response to isoprenaline","volume":"125","author":"Pang","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.dld.2018.03.005_bib0095","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1172\/JCI28570.","article-title":"Tnf-alpha downregulates enos expression and mitochondrial biogenesis in fat and muscle of obese rodents","volume":"116","author":"Valerio","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.dld.2018.03.005_bib0100","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0008-6363(03)00296-7","article-title":"Downregulation of eNOS mRNA expression by TNFalpha: identification and functional characterization of RNA-protein interactions in the 3\u2019UTR","volume":"59","author":"Lai","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.dld.2018.03.005_bib0105","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/sj.ijo.0803134","article-title":"Relationship between body composition and skeletal muscle eNOS","volume":"30","author":"Hickner","year":"2006","journal-title":"Int J Obes"},{"key":"10.1016\/j.dld.2018.03.005_bib0110","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00424-010-0808-2","article-title":"Nitric oxide and oxidative stress in vascular disease","volume":"459","author":"F\u00f6rstermann","year":"2010","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.dld.2018.03.005_bib0115","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-5793(98)01723-2","article-title":"Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells","volume":"443","author":"Lapperre","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.dld.2018.03.005_bib0120","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/gut.39.3.470","article-title":"Inhibition of acetylcholine induced intestinal motility by interleukin 1 beta in the rat","volume":"39","author":"Aub\u00e9","year":"1996","journal-title":"Gut"},{"key":"10.1016\/j.dld.2018.03.005_bib0125","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jep.2005.04.017","article-title":"Barakol suppresses norepinephrine-induced inhibition of spontaneous longitudinal smooth muscle contractions in isolated rat small intestine","volume":"101","author":"Deachapunya","year":"2005","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.dld.2018.03.005_bib0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/10739680701282887","article-title":"Mechanisms of coronary dysfunction in obesity and insulin resistance","volume":"14","author":"Knudson","year":"2007","journal-title":"Microcirculation"},{"key":"10.1016\/j.dld.2018.03.005_bib0135","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1056\/NEJMra1501505","article-title":"Functional dyspepsia","volume":"373","author":"Talley","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.dld.2018.03.005_bib0140","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1365-2982.2006.00768.x","article-title":"Proximal stomach function in obesity with normal or abnormal oesophageal acid exposure","volume":"18","author":"Iovino","year":"2006","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2018.03.005_bib0145","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00464-006-9102-y","article-title":"Esophageal motility disorders in the morbidly obese population","volume":"21","author":"Koppman","year":"2007","journal-title":"Surg Endosc"},{"key":"10.1016\/j.dld.2018.03.005_bib0150","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s11695-015-1861-x","article-title":"Usefulness of upper gastrointestinal symptoms as a driver to prescribe gastroscopy in obese patients candidate to bariatric surgery. A prospective study","volume":"26","author":"Carabotti","year":"2016","journal-title":"Obes Surg"},{"key":"10.1016\/j.dld.2018.03.005_bib0155","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3945\/an.112.002063","article-title":"Global gender disparities in obesity: a review","volume":"3","author":"Kanter","year":"2012","journal-title":"Adv Nutr"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865818302238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865818302238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T03:17:19Z","timestamp":1719890239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865818302238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1590865818302238"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2018.03.005","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myogenic oxidative imbalance interferes with antral motility in obese subjects","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2018.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}