{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:46:35Z","timestamp":1761896795821,"version":"3.40.5"},"reference-count":10,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["dldjournalonline.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.dld.2018.04.018","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T22:49:02Z","timestamp":1524782942000},"page":"859-862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["A severe hemojuvelin mutation leading to late onset of  HFE2 -hemochromatosis"],"prefix":"10.1016","volume":"50","author":[{"given":"Giulia","family":"Ravasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Pelucchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Camaschella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0343-0204","authenticated-orcid":false,"given":"Alberto","family":"Piperno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2018.04.018_bib0005","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ng1777","article-title":"Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression","volume":"38","author":"Babitt","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.dld.2018.04.018_bib0010","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.1074\/jbc.M008923200","article-title":"A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload","volume":"276","author":"Pigeon","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.dld.2018.04.018_bib0015","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1046\/j.1365-2141.2002.03509.x","article-title":"Natural history of juvenile haemochromatosis","volume":"117","author":"De Gobbi","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.dld.2018.04.018_bib0020","first-page":"1269","article-title":"Efficacy of recombinant human erythropoietin therapy started one month after autologous peripheral blood stem cell transplantation","volume":"90","author":"Vanstraelen","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.dld.2018.04.018_bib0025","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3324\/haematol.10842","article-title":"Liver iron concentrations and urinary hepcidin in beta-thalassemia","volume":"92","author":"Origa","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.dld.2018.04.018_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002706","article-title":"Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry","volume":"3","author":"Swinkels","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.dld.2018.04.018_bib0035","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3324\/haematol.12508","article-title":"Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response","volume":"93","author":"Pagani","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.dld.2018.04.018_bib0040","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1182\/blood-2006-08-041004","article-title":"Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis","volume":"109","author":"Silvestri","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.dld.2018.04.018_bib0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.clinre.2013.11.003","article-title":"Non-HFE hemochromatosis: pathophysiological and diagnostic aspects","volume":"38","author":"Bardou-Jacquet","year":"2014","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.dld.2018.04.018_bib0050","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jhep.2005.06.024","article-title":"Three patients with middle-age-onset hemochromatosis caused by novel mutations in the hemojuvelin gene","volume":"43","author":"Koyama","year":"2005","journal-title":"J Hepatol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865818307151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865818307151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:49:05Z","timestamp":1532306945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865818307151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1590865818307151"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2018.04.018","relation":{},"ISSN":["1590-8658"],"issn-type":[{"type":"print","value":"1590-8658"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A severe hemojuvelin mutation leading to late onset of HFE2-hemochromatosis","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2018.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}