{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:31:05Z","timestamp":1787729465717,"version":"build-2784847793"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010600","name":"Tays","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010600","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005744","name":"Lastentautien Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.dld.2019.11.011","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T08:11:08Z","timestamp":1577693468000},"page":"289-295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Prevalence and diagnostic outcomes of children with duodenal lesions and negative celiac serology"],"prefix":"10.1016","volume":"52","author":[{"given":"Ida","family":"Gustafsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleena","family":"Repo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Popp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katri","family":"Kaukinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauliina","family":"Hiltunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"Arvola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Taavela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Vornanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kivel\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-2164","authenticated-orcid":false,"given":"Kalle","family":"Kurppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2019.11.011_bib0005","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/MPG.0b013e31818c52cc","article-title":"Celiac disease revealed in 3% of Swedish 12-year-olds born during an epidemic","volume":"49","author":"Myl\u00e9us","year":"2009","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2019.11.011_bib0010","article-title":"European Society for Pediatric Gastroenterology, Hepatology and Nutrition guidelines for diagnosing coeliac disease 2019","author":"Husby","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2019.11.011_bib0015","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1053\/j.gastro.2017.06.002","article-title":"Accuracy of diagnosis of celiac disease without biopsies in clinical practice","volume":"153","author":"Werkstetter","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2019.11.011_bib0020","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1053\/j.gastro.2017.04.023","article-title":"Validation of antibody-based strategies for diagnosis of pediatric celiac disease without biopsy","volume":"153","author":"Wolf","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2019.11.011_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.1536-4801.2005.tb00917.x","article-title":"Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition","volume":"40","author":"Hill","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2019.11.011_bib0030","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1136\/gut.2005.071514","article-title":"Endomysial antibody-negative coeliac disease: clinical characteristics and intestinal autoantibody deposits","volume":"55","author":"Salmi","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.dld.2019.11.011_bib0035","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1136\/gutjnl-2016-312271","article-title":"The clinical and phenotypical assessment of seronegative villous atrophy; a prospective UK centre experience evaluating 200 adult cases over a 15-year period (2000\u20132015)","volume":"66","author":"Aziz","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.dld.2019.11.011_bib0040","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1038\/ctg.2017.41","article-title":"Clinical and histologic mimickers of celiac disease","volume":"8","author":"Kamboj","year":"2017","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.dld.2019.11.011_bib0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.5858\/arpa.2016-0608-RA","article-title":"Celiac disease and other causes of duodenitis","volume":"142","author":"Owen","year":"2018","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.dld.2019.11.011_bib0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/01.MPG.0000161972.60610.0E","article-title":"Celiac disease: from inflammation to atrophy: a long-term follow-up study","volume":"41","author":"L\u00e4hdeaho","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2019.11.011_bib0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/MPG.0b013e318267c353","article-title":"Duodenal intraepithelial lymphocytosis with normal villous architecture in pediatric patients: mayo Clinic experience, 2000\u20132009","volume":"56","author":"Shmidt","year":"2013","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2019.11.011_bib0060","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1111\/j.1572-0241.2007.01360.x","article-title":"Fate of five celiac disease-associated antibodies during normal diet in genetically risk children observed from birth in a natural history study","volume":"102","author":"Simell","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2019.11.011_bib0065","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ajg.2014.77","article-title":"Potential celiac children: 9-year follow-up on a gluten-containing diet","volume":"109","author":"Auricchio","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2019.11.011_bib0070","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/ajg.2015.387","article-title":"A prospective study on the usefulness of duodenal bulb biopsies in celiac disease diagnosis in children: urging caution","volume":"111","author":"Taavela","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2019.11.011_bib0075","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.jpeds.2015.07.057","article-title":"Presentation of celiac disease in Finnish children is no longer changing: a 50-year perspective","volume":"167","author":"Kivel\u00e4","year":"2015","journal-title":"J Pediatr"},{"key":"10.1016\/j.dld.2019.11.011_bib0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076163","article-title":"Validation of morphometric analyses of small-intestinal biopsy readouts in celiac disease","volume":"8","author":"Taavela","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.dld.2019.11.011_bib0085","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1136\/gut.35.6.776","article-title":"Endomysium antibodies in coeliac disease: an improved method","volume":"35","author":"Ladinser","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.dld.2019.11.011_bib0090","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/jcp.49.9.704","article-title":"Serological diagnosis of gluten sensitive enteropathy","volume":"49","author":"Unsworth","year":"1996","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.dld.2019.11.011_bib0095","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1572-0241.2002.05471.x","article-title":"HLA-DQ typing in the diagnosis of celiac disease","volume":"97","author":"Kaukinen","year":"2002","journal-title":"Am J Gastro"},{"key":"10.1016\/j.dld.2019.11.011_bib0100","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1136\/gutjnl-2017-314297","article-title":"ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation","volume":"66","author":"Rostami","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.dld.2019.11.011_bib0105","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1572-0241.2003.07456.x","article-title":"Intraepithelial lymphocytes in celiac disease","volume":"98","author":"J\u00e4rvinen","year":"2003","journal-title":"Am J Gastro"},{"key":"10.1016\/j.dld.2019.11.011_bib0110","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1542\/peds.2014-3675","article-title":"Clinical features of celiac disease: a prospective birth cohort","volume":"135","author":"Agardh","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.dld.2019.11.011_bib0115","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1023\/B:DDAS.0000026296.02308.00","article-title":"Seronegative celiac disease: increased prevalence with lesser degrees of villous atrophy","volume":"49","author":"Abrams","year":"2004","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.dld.2019.11.011_bib0120","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.dld.2016.05.024","article-title":"Seronegative celiac disease: shedding light on an obscure clinical entity","volume":"48","author":"Volta","year":"2016","journal-title":"Dig Liv Dis"},{"key":"10.1016\/j.dld.2019.11.011_bib0125","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.3748\/wjg.15.4775","article-title":"Duodenal biopsy may be avoided when high transglutaminase antibody titers are present","volume":"15","author":"Vivas","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.dld.2019.11.011_bib0130","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1136\/gut.52.11.1567","article-title":"Elevation of IgG antibodies against tissue transglutaminase as a diagnostic tool for coeliac disease in selective IgA deficiency","volume":"52","author":"Korponay-Szabo","year":"2003","journal-title":"Gut"},{"key":"10.1016\/j.dld.2019.11.011_bib0135","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s10875-011-9514-x","article-title":"Serodiagnostic assays for celiac disease based on the open or closed conformation of the autoantigen, transglutaminase 2","volume":"31","author":"Lindfors","year":"2011","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.dld.2019.11.011_bib0140","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/MCG.0b013e3181fbdfa6","article-title":"Antibodies against deamidated gliadin peptides in early-stage celiac disease","volume":"45","author":"Kurppa","year":"2011","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.dld.2019.11.011_bib0145","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/MCG.0b013e3181b64557","article-title":"Usefulness of small-bowel mucosal transglutaminase-2 specific autoantibody deposits in the diagnosis and follow-up of celiac disease","volume":"44","author":"Koskinen","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.dld.2019.11.011_bib0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0198-8859(03)00027-2","article-title":"HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease","volume":"64","author":"Karell","year":"2013","journal-title":"Hum Immunol"},{"key":"10.1016\/j.dld.2019.11.011_bib0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/nu9101050","article-title":"Intestinal production of anti-tissue transglutaminase 2 antibodies in patients with diagnosis other than celiac disease","volume":"9","author":"Maglio","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.dld.2019.11.011_bib0160","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.crohns.2014.06.004","article-title":"Incidence and initial disease course of inflammatory bowel diseases in 2011 in Europe and Australia: results of the 2011 ECCO-EpiCom inception cohort","volume":"8","author":"Vegh","year":"2014","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.dld.2019.11.011_bib0165","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.mayocp.2017.10.025","article-title":"Not all that flattens villi is celiac disease: a review of enteropathies","volume":"93","author":"Jansson-Knodell","year":"2018","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.dld.2019.11.011_bib0170","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2350\/14-07-1529-OA.1","article-title":"Histopathology of duodenal mucosal lesions in pediatric patients with inflammatory bowel disease: statistical analysis to identify distinctive features","volume":"17","author":"Hardee","year":"2014","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.dld.2019.11.011_bib0175","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/MOG.0000000000000436","article-title":"Seronegative coeliac disease: clearing the diagnostic dilemma","volume":"34","author":"Schiepatti","year":"2018","journal-title":"Curr Opin Gastroenterol"},{"key":"10.1016\/j.dld.2019.11.011_bib0180","first-page":"443","article-title":"Upper gastrointestinal mucosal disease in pediatric Crohn disease and ulcerative colitis: a blinded, controlled study","volume":"32","author":"Tobin","year":"2001","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2019.11.011_bib0185","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1080\/00365520310008773","article-title":"Villous tip intraepithelial lymphocytes as markers of early-stage coeliac disease","volume":"39","author":"J\u00e4rvinen","year":"2004","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2019.11.011_bib0190","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-1305","article-title":"Co-occurrence of type 1 diabetes and celiac disease autoimmunity","volume":"140","author":"Hagopian","year":"2017","journal-title":"Pediatrics"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S159086581930920X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S159086581930920X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:11:40Z","timestamp":1761624700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S159086581930920X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S159086581930920X"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2019.11.011","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence and diagnostic outcomes of children with duodenal lesions and negative celiac serology","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2019.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}