{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:36:26Z","timestamp":1770140186993,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.dld.2020.04.035","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T17:35:32Z","timestamp":1591637732000},"page":"889-894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Secondary hepatic dysfunction in pediatric intensive care unit: Risk factors and outcome"],"prefix":"10.1016","volume":"52","author":[{"given":"Engy A.","family":"Mogahed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haytham","family":"Ghita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona S.","family":"El-Raziky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seham A.","family":"El-Sherbini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa","family":"Meshref","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanaa","family":"El-Karaksy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2020.04.035_bib0001","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1186\/cc14616","article-title":"Liver dysfunction is associated with long-term mortality in septic shock","volume":"19","author":"Nesseler","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.dld.2020.04.035_bib0002","series-title":"Diet nutr crit care","first-page":"1","article-title":"Liver dysfunction in critically ill patients","author":"Newton","year":"2015"},{"key":"10.1016\/j.dld.2020.04.035_bib0003","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1521-6918(03)00025-8","article-title":"Gastrointestinal disorders of the critically ill.","volume":"17","author":"Strassburg","year":"2003","journal-title":"Shock Liver. Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.dld.2020.04.035_bib0004","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/SHK.0b013e31819d8204","article-title":"Prospective assessment of hepatic function and mechanisms of dysfunction in the critically ill","volume":"32","author":"Kortgen","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.dld.2020.04.035_bib0005","first-page":"35","article-title":"Liver dysfunction in the intensive care unit","volume":"18","author":"Soultati","year":"2005","journal-title":"Ann Gastroenterol"},{"key":"10.1016\/j.dld.2020.04.035_bib0006","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mayocp.2013.09.016","article-title":"Drug-induced liver injury","volume":"89","author":"Leise","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.dld.2020.04.035_bib0007","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/MPG.0b013e31821d6cfd","article-title":"Characteristics of idiosyncratic drug-induced liver injury in children: results from the DILIN prospective study","volume":"53","author":"Molleston","year":"2011","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2020.04.035_bib0008","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/CCM.0b013e3181de0db2","article-title":"Drug-induced acute liver failure and gastrointestinal complications","volume":"38","author":"Lat","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.dld.2020.04.035_bib0009","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/01.CCM.0000259462.97164.A0","article-title":"Incidence and prognosis of early hepatic dysfunction in critically ill patients-a prospective multicenter study","volume":"35","author":"Kramer","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.dld.2020.04.035_bib0010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.11613\/BM.2011.015","article-title":"Effects of hemolysis interferences on routine biochemistry parameters","volume":"21","author":"Koseoglu","year":"2011","journal-title":"Biochem Med (Zagreb)"},{"key":"10.1016\/j.dld.2020.04.035_bib0011","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/hep.20548","article-title":"Serum alanine aminotransferase in skeletal muscle diseases","volume":"41","author":"Nathwani","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2020.04.035_bib0012","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cld.2012.03.012","article-title":"Approach to a patient with elevated serum alkaline phosphatase","volume":"16","author":"Siddique","year":"2012","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.dld.2020.04.035_bib0013","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2052-0492-2-15","article-title":"Diagnosis and treatment of disseminated intravascular coagulation (DIC) according to four DIC guidelines","volume":"2","author":"Wada","year":"2014","journal-title":"J Intensive Care"},{"key":"10.1016\/j.dld.2020.04.035_bib0014","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.0894-0959.2004.17603.x","article-title":"Serum albumin: relationship to inflammation and nutrition","volume":"17","author":"Don","year":"2004","journal-title":"Semin Dial"},{"key":"10.1016\/j.dld.2020.04.035_bib0015","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4103\/0975-7406.76489","article-title":"Acute-phase proteins: as diagnostic tool","volume":"3","author":"Jain","year":"2011","journal-title":"J Pharm Bioallied Sci"},{"key":"10.1016\/j.dld.2020.04.035_bib0016","series-title":"Nelson textbook of pediatrics","first-page":"3467","article-title":"Reference intervals for laboratory tests and procedures","author":"Lo","year":"2016"},{"key":"10.1016\/j.dld.2020.04.035_bib0017","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","article-title":"International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics","volume":"6","author":"Goldstein","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.dld.2020.04.035_bib0018","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s13312-013-0189-7","article-title":"Etiology and prognostic factors of acute liver failure in children","volume":"50","author":"Kaur","year":"2013","journal-title":"Indian Pediatr"},{"key":"10.1016\/j.dld.2020.04.035_bib0019","first-page":"128","article-title":"Hypoxic liver injury and cholestasis in critically ill patients","volume":"19","author":"Horvatits","year":"2013","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.dld.2020.04.035_bib0020","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/BF01959078","article-title":"Liver dysfunction and acute cardiocirculatory failure in children","volume":"151","author":"Jacquemin","year":"1992","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.dld.2020.04.035_bib0021","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1007\/s00134-009-1511-7","article-title":"Liver function tests on the intensive care unit: a prospective, observational study","volume":"35","author":"Thomson","year":"2009","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.dld.2020.04.035_bib0022","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.injury.2016.08.017","article-title":"Hepatic dysfunction: a common occurrence in severely injured patients","volume":"48","author":"Saloojee","year":"2017","journal-title":"Injury"},{"key":"10.1016\/j.dld.2020.04.035_bib0023","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1590\/S0037-86822012005000003","article-title":"Nosocomial infections in a pediatric intensive care unit of a developing country: NHSN surveillance","volume":"45","author":"Porto","year":"2012","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.dld.2020.04.035_bib0024","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3109\/08830185.2014.889129","article-title":"The role of the liver in sepsis","volume":"33","author":"Yan","year":"2014","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.dld.2020.04.035_bib0025","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2169\/internalmedicine.46.0059","article-title":"Hypoxic hepatopathy: pathophysiology and prognosis","volume":"46","author":"Birrer","year":"2007","journal-title":"Intern Med"},{"key":"10.1016\/j.dld.2020.04.035_bib0026","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1007\/s00134-011-2248-7","article-title":"Impact of hypoxic hepatitis on mortality in the intensive care unit","volume":"37","author":"Fuhrmann","year":"2011","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.dld.2020.04.035_bib0027","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1097\/CCM.0B013E31816532BE","article-title":"Catecholamines induce an inflammatory response in human hepatocytes","volume":"36","author":"Aninat","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.dld.2020.04.035_bib0028","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4103\/0972-5229.182197","article-title":"Evaluation of antibiotic use in pediatric intensive care unit of a developing country","volume":"20","author":"Abbas","year":"2016","journal-title":"Indian J Crit Care Med"},{"key":"10.1016\/j.dld.2020.04.035_bib0029","first-page":"391","article-title":"Prescribing pattern of antimicrobial agents in the pediatric intensive care unit of a tertiary care teaching hospital in puducherry union territory","volume":"8","author":"Pandiamunian","year":"2017","journal-title":"Int J Pharma Bio Sci"},{"key":"10.1016\/j.dld.2020.04.035_bib0030","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1053\/j.gastro.2015.03.006","article-title":"Features and outcomes of 899 patients with drug-induced liver injury: the DILIN prospective study","volume":"148","author":"Chalasani","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2020.04.035_bib0031","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2036.2011.04674.x","article-title":"Review article: drug-induced liver injury\u2013its pathophysiology and evolving diagnostic tools","volume":"34","author":"Au","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2020.04.035_bib0032","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jhep.2007.03.009","article-title":"Genetics in liver diseases","volume":"46","author":"Pietrangelo","year":"2007","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2020.04.035_bib0033","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jhep.2015.02.025","article-title":"Genetics of liver disease: from pathophysiology to clinical practice","volume":"62","author":"Karlsen","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2020.04.035_bib0034","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00134-015-4054-0","article-title":"Cholestatic liver dysfunction during sepsis and other critical illnesses","volume":"42","author":"Jenniskens","year":"2016","journal-title":"Intensive Care Med"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865820301924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865820301924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:12:43Z","timestamp":1761624763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865820301924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S1590865820301924"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2020.04.035","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Secondary hepatic dysfunction in pediatric intensive care unit: Risk factors and outcome","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2020.04.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}