{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:50:10Z","timestamp":1768517410438,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Swiss Government Excellence Scholarship"},{"name":"Stiftung f\u00fcr Leberkrankheiten"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.dld.2020.06.048","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T10:38:12Z","timestamp":1595932692000},"page":"958-965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effect of poorly absorbable antibiotics on hepatic venous pressure gradient in cirrhosis: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"52","author":[{"given":"Yuly P.","family":"Mendoza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana G.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Berzigotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1 Suppl","key":"10.1016\/j.dld.2020.06.048_bib0001","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.jhep.2015.01.003","article-title":"Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments","volume":"62","author":"Bosch","year":"2015","journal-title":"J Hepatol"},{"issue":"6","key":"10.1016\/j.dld.2020.06.048_bib0002","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/cld.604","article-title":"Mechanisms of portal hypertension: bench to bedside","volume":"8","author":"Gracia-Sancho","year":"2016","journal-title":"Clin Liver Dis (Hoboken)"},{"issue":"4","key":"10.1016\/j.dld.2020.06.048_bib0003","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/hep.510280405","article-title":"Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats","volume":"28","author":"Gupta","year":"1998","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.dld.2020.06.048_bib0004","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1053\/gast.2002.31040","article-title":"5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes","volume":"122","author":"Graupera","year":"2002","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.dld.2020.06.048_bib0005","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/hep.28264","article-title":"Development of hyperdynamic circulation and response to \u03b2-blockers in compensated cirrhosis with portal hypertension","volume":"63","author":"Villanueva","year":"2016","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.dld.2020.06.048_bib0006","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1128\/iai.23.2.403-411.1979","article-title":"Translocation of certain indigenous bacteria from the gastrointestinal tract to the mesenteric lymph nodes and other organs in a gnotobiotic mouse model","volume":"23","author":"Berg","year":"1979","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.dld.2020.06.048_bib0007","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1053\/jhep.2003.50038","article-title":"Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement","volume":"37","author":"Albillos","year":"2003","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.dld.2020.06.048_bib0008","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jhep.2013.07.044","article-title":"Pathological bacterial translocation in liver cirrhosis","volume":"60","author":"Wiest","year":"2014","journal-title":"J Hepatol"},{"issue":"5","key":"10.1016\/j.dld.2020.06.048_bib0009","first-page":"828","article-title":"Abnormalities in proximal small bowel motility in patients with cirrhosis","volume":"17","author":"Chesta","year":"1993","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.dld.2020.06.048_bib0010","doi-asserted-by":"crossref","first-page":"186","DOI":"10.7326\/0003-4819-139-3-200308050-00008","article-title":"The effect of selective intestinal decontamination on the hyperdynamic circulatory state in cirrhosis","volume":"139","author":"Rasaratnam","year":"2003","journal-title":"A randomized trial. Ann Intern Med."},{"issue":"5","key":"10.1016\/j.dld.2020.06.048_bib0011","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jhep.2015.07.004","article-title":"Mechanisms of decompensation and organ failure in cirrhosis: from peripheral arterial vasodilation to systemic inflammation hypothesis","volume":"63","author":"Bernardi","year":"2015","journal-title":"J Hepatol"},{"issue":"11","key":"10.1016\/j.dld.2020.06.048_bib0012","doi-asserted-by":"crossref","first-page":"985","DOI":"10.7326\/0003-4819-127-11-199712010-00007","article-title":"Effect of fluoroquinolone on the enhanced nitric oxide-induced peripheral vasodilation seen in cirrhosis","volume":"127","author":"Chin-Dusting","year":"1997","journal-title":"Ann Intern Med"},{"issue":"7","key":"10.1016\/j.dld.2020.06.048_bib0013","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cgh.2012.02.025","article-title":"Rifaximin improves systemic hemodynamics and renal function in patients with alcohol-related cirrhosis and ascites","volume":"10","author":"Kalambokis","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"9","key":"10.1016\/j.dld.2020.06.048_bib0014","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/j.1365-2036.2009.03958.x","article-title":"Intestinal decontamination improves liver haemodynamics in patients with alcohol-related decompensated cirrhosis","volume":"29","author":"Vlachogiannakos","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.dld.2020.06.048_bib0015","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/jgh.12070","article-title":"Long-term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosis","volume":"28","author":"Vlachogiannakos","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"issue":"10","key":"10.1016\/j.dld.2020.06.048_bib0016","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2009.149","article-title":"The clinical use of HVPG measurements in chronic liver disease","volume":"6","author":"Bosch","year":"2009","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.dld.2020.06.048_bib0017","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/hep.28898","article-title":"Rifaximin has no effect on hemodynamics in decompensated cirrhosis: a randomized, double-blind, placebo-controlled trial","volume":"65","author":"Kimer","year":"2017","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.dld.2020.06.048_bib0018","doi-asserted-by":"crossref","first-page":"702","DOI":"10.5009\/gnl16478","article-title":"Rifaximin and propranolol combination therapy is more effective than propranolol monotherapy for the reduction of portal pressure: an open randomized controlled pilot study","volume":"11","author":"Lim","year":"2017","journal-title":"Gut Liver"},{"key":"10.1016\/j.dld.2020.06.048_bib0019","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.dld.2020.06.048_bib0020","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The cochrane collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.dld.2020.06.048_bib0021","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.dld.2020.06.048_bib0022","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Methodol"},{"issue":"2","key":"10.1016\/j.dld.2020.06.048_bib0023","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cct.2006.04.004","article-title":"Random-effects model for meta-analysis of clinical trials: an update","volume":"28","author":"DerSimonian","year":"2007","journal-title":"Contemp Clin Trials"},{"issue":"7414","key":"10.1016\/j.dld.2020.06.048_bib0024","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.dld.2020.06.048_bib0025","series-title":"Comprehensive meta analysis version 3.0.","first-page":"1","author":"Borenstein","year":"2004"},{"issue":"8","key":"10.1016\/j.dld.2020.06.048_bib0026","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/liv.12172","article-title":"Effects of the adjunctive probiotic VSL#3 on portal haemodynamics in patients with cirrhosis and large varices: a randomized trial","volume":"33","author":"Gupta","year":"2013","journal-title":"Liver Int"},{"issue":"3","key":"10.1016\/j.dld.2020.06.048_bib0027","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1478-3231.2008.01850.x","article-title":"Norfloxacin treatment for clinically significant portal hypertension: results of a randomised double-blind placebo-controlled crossover trial","volume":"29","author":"Kemp","year":"2009","journal-title":"Liver Int"},{"issue":"suppl 1","key":"10.1016\/j.dld.2020.06.048_bib0028","article-title":"Dynamic prediction of the risk of decompensation\/ death in patients with compensated cirrhosis based on serial hepatic venous pressure gradient (HVPG) measurements","volume":"68","author":"Abraldes JG","year":"2018","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.dld.2020.06.048_bib0029","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/j.1478-3231.2009.02038.x","article-title":"beta-Blockers protect against spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis","volume":"29","author":"Senzolo","year":"2009","journal-title":"Liver Int: Off J Int Assoc Study Liver"},{"issue":"8","key":"10.1016\/j.dld.2020.06.048_bib0030","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1136\/gut.2009.185413","article-title":"Splanchnic sympathectomy prevents translocation and spreading of E coli but not S aureus in liver cirrhosis","volume":"59","author":"Worlicek","year":"2010","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.dld.2020.06.048_bib0031","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/hep.510310109","article-title":"Effect of propranolol on the factors promoting bacterial translocation in cirrhotic rats with ascites","volume":"31","author":"P\u00e9rez-Paramo","year":"2000","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.dld.2020.06.048_bib0032","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jhep.2012.12.011","article-title":"Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis","volume":"58","author":"Reiberger","year":"2013","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2020.06.048_bib0033","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/apt.14366","article-title":"Beta-blockers in hospitalised patients with cirrhosis and ascites: mortality and factors determining discontinuation and reinitiation","volume":"47","author":"Bhutta","year":"2018","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.dld.2020.06.048_bib0034","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jhep.2015.10.018","article-title":"Treatment with non-selective beta blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failure","volume":"64","author":"Mookerjee","year":"2016","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2020.06.048_bib0035","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jhep.2016.08.007","article-title":"The anti-inflammatory role of propranolol in cirrhosis: preventing the inflammatory exhaustion?","volume":"66","author":"Brito-Azevedo","year":"2017","journal-title":"J Hepatol"},{"issue":"8","key":"10.1016\/j.dld.2020.06.048_bib0036","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1136\/gutjnl-2016-311696","article-title":"Propranolol improves endothelial dysfunction in advanced cirrhosis: the 'endothelial exhaustion' hypothesis","volume":"65","author":"Brito-Azevedo","year":"2016","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.dld.2020.06.048_bib0037","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.cgh.2013.12.021","article-title":"Rifaximin is safe and well tolerated for long-term maintenance of remission from overt hepatic encephalopathy","volume":"12","author":"Mullen","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2020.06.048_bib0038","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/jhep.2002.30082","article-title":"Bacterial infections in cirrhosis: epidemiological changes with invasive procedures and norfloxacin prophylaxis","volume":"35","author":"Fern\u00e1ndez","year":"2002","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.dld.2020.06.048_bib0039","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.cgh.2012.08.017","article-title":"High prevalence of antibiotic-resistant bacterial infections among patients with cirrhosis at a US liver center","volume":"10","author":"Tandon","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2020.06.048_bib0040","unstructured":"FDADrug Safety Communication 07-26-2016. 2016."},{"key":"10.1016\/j.dld.2020.06.048_bib0041","unstructured":"European Medicines Agency. 2018;44. Available from:EMA Press Releasehttps:\/\/www.ema.europa.eu\/en\/news\/disabling-potentially-permanent-side-effects-leadsuspension-restrictions-quinolone-fluoroquinolone."}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865820303406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865820303406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:12:48Z","timestamp":1761624768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865820303406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S1590865820303406"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2020.06.048","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of poorly absorbable antibiotics on hepatic venous pressure gradient in cirrhosis: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2020.06.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}