{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T12:47:57Z","timestamp":1793969277954,"version":"4.8.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z171100001717008"],"award-info":[{"award-number":["Z171100001717008"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012173","name":"China-Japan Friendship Hospital","doi-asserted-by":"publisher","award":["2019-64-K44"],"award-info":[{"award-number":["2019-64-K44"]}],"id":[{"id":"10.13039\/501100012173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2014BAI08B00"],"award-info":[{"award-number":["2014BAI08B00"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.dld.2021.04.022","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T02:22:57Z","timestamp":1622168577000},"page":"1120-1127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Faecal bile acids and colonic bile acid membrane receptor correlate with symptom severity of diarrhoea-predominant irritable bowel syndrome: A pilot study"],"prefix":"10.1016","volume":"53","author":[{"given":"Wei","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shukun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.dld.2021.04.022_bib0001","first-page":"59","article-title":"Irritable bowel syndrome subtypes: clinical and psychological features, body mass index and comorbidities","volume":"108","author":"Kibune Nagasako","year":"2016","journal-title":"Rev Esp Enferm Dig"},{"issue":"5","key":"10.1016\/j.dld.2021.04.022_bib0002","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1111\/jgh.13642","article-title":"Comparison of the Rome IV and Rome III criteria for IBS diagnosis: a cross-sectional survey","volume":"32","author":"Bai","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.dld.2021.04.022_bib0003","doi-asserted-by":"crossref","first-page":"544","DOI":"10.5056\/jnm18082","article-title":"Sex-gender differences in irritable bowel syndrome","volume":"24","author":"Kim","year":"2018","journal-title":"J Neurogastroenterol Motil"},{"issue":"7","key":"10.1016\/j.dld.2021.04.022_bib0004","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ajg.2012.131","article-title":"Effect of gender on prevalence of irritable bowel syndrome in the community: systematic review and meta-analysis","volume":"107","author":"Lovell","year":"2012","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.dld.2021.04.022_bib0005","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/apt.15106","article-title":"Bile and fat excretion are biomarkers of clinically significant diarrhoea and constipation in irritable bowel syndrome","volume":"49","author":"Vijayvargiya","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2021.04.022_bib0006","doi-asserted-by":"crossref","first-page":"939","DOI":"10.3389\/fphar.2018.00939","article-title":"Bile acid synthesis: from Nature to the chemical modification and synthesis and their applications as drugs and nutrients","volume":"9","author":"\u0160arenac","year":"2018","journal-title":"Front Pharmacol"},{"issue":"2","key":"10.1016\/j.dld.2021.04.022_bib0007","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3727\/105221618X15156018385515","article-title":"Bile acid metabolism in liver pathobiology","volume":"18","author":"Chiang","year":"2018","journal-title":"Gene Expr"},{"issue":"11","key":"10.1016\/j.dld.2021.04.022_bib0008","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cgh.2009.07.026","article-title":"Chronic diarrhea due to excessive bile acid synthesis and not defective ileal transport: a new syndrome of defective fibroblast growth factor 19 release","volume":"7","author":"Hofmann","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"7","key":"10.1016\/j.dld.2021.04.022_bib0009","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nrgastro.2014.32","article-title":"Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy","volume":"11","author":"Walters","year":"2014","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2021.04.022_bib0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2017.01.006","article-title":"Bile acids and their receptors","volume":"56","author":"Martinot","year":"2017","journal-title":"Mol Asp Med"},{"issue":"5","key":"10.1016\/j.dld.2021.04.022_bib0011","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2013.03.013","article-title":"Pleiotropic roles of bile acids in metabolism","volume":"17","author":"de Aguiar Vallim","year":"2013","journal-title":"Cell Metab"},{"issue":"7","key":"10.1016\/j.dld.2021.04.022_bib0012","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.bbalip.2010.04.006","article-title":"Bile acids and their nuclear receptor FXR: relevance for hepatobiliary and gastrointestinal disease","volume":"1801","author":"Gadaleta","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"20","key":"10.1016\/j.dld.2021.04.022_bib0013","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1101\/gad.12.20.3195","article-title":"SXR, a novel steroid and xenobiotic-sensing nuclear receptor","volume":"12","author":"Blumberg","year":"1998","journal-title":"Genes Dev"},{"issue":"11","key":"10.1016\/j.dld.2021.04.022_bib0014","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1074\/jbc.M209706200","article-title":"A G protein-coupled receptor responsive to bile acids","volume":"278","author":"Kawamata","year":"2003","journal-title":"J Biol Chem"},{"issue":"6 Suppl","key":"10.1016\/j.dld.2021.04.022_bib0015","doi-asserted-by":"crossref","first-page":"1689s","DOI":"10.1093\/ajcn\/80.6.1689S","article-title":"Overview of general physiologic features and functions of vitamin D","volume":"80","author":"DeLuca","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1016\/j.dld.2021.04.022_bib0016","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.abb.2012.04.001","article-title":"Where is the vitamin D receptor?","volume":"523","author":"Wang","year":"2012","journal-title":"Arch Biochem Biophys"},{"issue":"8","key":"10.1016\/j.dld.2021.04.022_bib0017","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.dld.2018.05.016","article-title":"Bile acids and FXR in functional gastrointestinal disorders","volume":"50","author":"Mosinska","year":"2018","journal-title":"Dig Liver Dis"},{"issue":"5","key":"10.1016\/j.dld.2021.04.022_bib0018","doi-asserted-by":"crossref","first-page":"G508","DOI":"10.1152\/ajpgi.00178.2014","article-title":"Genetic variation in GPBAR1 predisposes to quantitative changes in colonic transit and bile acid excretion","volume":"307","author":"Camilleri","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"11","key":"10.1016\/j.dld.2021.04.022_bib0019","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1365-2982.2011.01772.x","article-title":"Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders","volume":"23","author":"Camilleri","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.dld.2021.04.022_bib0020","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.3389\/fimmu.2019.01070","article-title":"Nuclear receptors regulate intestinal inflammation in the context of IBD","volume":"10","author":"Klepsch","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.dld.2021.04.022_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2624941","article-title":"Nuclear receptors in the pathogenesis and management of inflammatory bowel disease","volume":"2019","author":"Ning","year":"2019","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.dld.2021.04.022_bib0022","doi-asserted-by":"crossref","DOI":"10.1177\/1756284818822566","article-title":"The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status","volume":"12","author":"Garg","year":"2019","journal-title":"Therap Adv Gastroenterol"},{"key":"10.1016\/j.dld.2021.04.022_bib0023","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/164_2019_238","article-title":"The pharmacology of bile acids and their receptors","volume":"256","author":"Fiorucci","year":"2019","journal-title":"Handb Exp Pharmacol"},{"issue":"5571","key":"10.1016\/j.dld.2021.04.022_bib0024","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1070477","article-title":"Vitamin D receptor as an intestinal bile acid sensor","volume":"296","author":"Makishima","year":"2002","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.dld.2021.04.022_bib0025","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/03602532.2012.740048","article-title":"Nuclear receptors in bile acid metabolism","volume":"45","author":"Li","year":"2013","journal-title":"Drug Metab Rev"},{"issue":"2","key":"10.1016\/j.dld.2021.04.022_bib0026","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1096\/fj.201800935RR","article-title":"Bile acids induce visceral hypersensitivity via mucosal mast cell-to-nociceptor signaling that involves the farnesoid X receptor\/nerve growth factor\/transient receptor potential vanilloid 1 axis","volume":"33","author":"Li","year":"2019","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.dld.2021.04.022_bib0027","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s10620-020-06208-3","article-title":"Deoxycholic acid-induced gut dysbiosis disrupts bile acid enterohepatic circulation and promotes intestinal inflammation","volume":"66","author":"Xu","year":"2021","journal-title":"Dig Dis Sci"},{"issue":"2","key":"10.1016\/j.dld.2021.04.022_bib0028","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2036.1997.142318000.x","article-title":"The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress","volume":"11","author":"Francis","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.dld.2021.04.022_bib0029","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1053\/j.gastro.2003.11.055","article-title":"Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome","volume":"126","author":"Barbara","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2021.04.022_bib0030","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.biopha.2018.09.168","article-title":"Suppression of TGP on myocardial remodeling by regulating the NF-kappaB pathway","volume":"108","author":"Naveed","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"10.1016\/j.dld.2021.04.022_bib0031","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/PAI.0b013e3181a13bf2","article-title":"Survivin expression quantified by image pro-plus compared with visual assessment","volume":"17","author":"Wang","year":"2009","journal-title":"Appl Immunohistochem Mol Morphol"},{"issue":"1","key":"10.1016\/j.dld.2021.04.022_bib0032","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI130976","article-title":"A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome","volume":"130","author":"Zhao","year":"2020","journal-title":"J Clin Investig"},{"issue":"12","key":"10.1016\/j.dld.2021.04.022_bib0033","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1111\/nmo.12421","article-title":"Validating biomarkers of treatable mechanisms in irritable bowel syndrome","volume":"26","author":"Camilleri","year":"2014","journal-title":"Neurogastroenterol Motil"},{"issue":"9","key":"10.1016\/j.dld.2021.04.022_bib0034","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.cgh.2012.05.006","article-title":"Increased bile acid biosynthesis is associated with irritable bowel syndrome with diarrhea","volume":"10","author":"Wong","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2021.04.022_bib0035","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/gutjnl-2013-305965","article-title":"Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS","volume":"64","author":"Bajor","year":"2015","journal-title":"Gut"},{"issue":"11","key":"10.1016\/j.dld.2021.04.022_bib0036","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cgh.2009.04.024","article-title":"A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis","volume":"7","author":"Walters","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"9","key":"10.1016\/j.dld.2021.04.022_bib0037","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/nmo.12829","article-title":"Interplay between bile acid metabolism and microbiota in irritable bowel syndrome","volume":"28","author":"Dior","year":"2016","journal-title":"Neurogastroenterol Motil"},{"issue":"10","key":"10.1016\/j.dld.2021.04.022_bib0038","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ajg.2014.215","article-title":"Effect of increased bile acid synthesis or fecal excretion in irritable bowel syndrome-diarrhea","volume":"109","author":"Camilleri","year":"2014","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.dld.2021.04.022_bib0039","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5009\/gnl14397","article-title":"Bile Acid diarrhea: prevalence, pathogenesis, and therapy","volume":"9","author":"Camilleri","year":"2015","journal-title":"Gut Liver"},{"issue":"1","key":"10.1016\/j.dld.2021.04.022_bib0040","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/apt.13227","article-title":"Systematic review with meta-analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea","volume":"42","author":"Slattery","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.dld.2021.04.022_bib0041","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00042737-200604000-00013","article-title":"Normal or increased bile acid uptake in isolated mucosa from patients with bile acid malabsorption","volume":"18","author":"Bajor","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2021.04.022_bib0042","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jgh.13471","article-title":"Alterations of gut microbiota in patients with irritable bowel syndrome: A systematic review and meta-analysis","volume":"32","author":"Zhuang","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.dld.2021.04.022_bib0043","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41424-018-0027-2","article-title":"Characteristics of the bacterial microbiome in association with common intestinal parasites in irritable bowel syndrome","volume":"9","author":"Krogsgaard","year":"2018","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.dld.2021.04.022_bib0044","article-title":"Compositional and functional changes in the gut microbiota in irritable bowel syndrome patients","author":"Lee","year":"2020","journal-title":"Gut Liver"},{"issue":"1","key":"10.1016\/j.dld.2021.04.022_bib0045","doi-asserted-by":"crossref","first-page":"20436","DOI":"10.1038\/s41598-020-77374-7","article-title":"The pathophysiology of bile acid diarrhoea: differences in the colonic microbiome, metabolome and bile acids","volume":"10","author":"Sagar","year":"2020","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.dld.2021.04.022_bib0046","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.cgh.2013.04.020","article-title":"Bowel functions, fecal unconjugated primary and secondary bile acids, and colonic transit in patients with irritable bowel syndrome","volume":"11","author":"Shin","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.dld.2021.04.022_bib0047","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2982.2012.01893.x","article-title":"Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome","volume":"24","author":"Duboc","year":"2012","journal-title":"Neurogastroenterol Motil"},{"issue":"5","key":"10.1016\/j.dld.2021.04.022_bib0048","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.cgh.2016.11.012","article-title":"Colonic transit and bile acid synthesis or excretion in patients with irritable bowel syndrome-diarrhea without bile acid malabsorption","volume":"15","author":"Peleman","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.dld.2021.04.022_bib0049","doi-asserted-by":"crossref","first-page":"C447","DOI":"10.1152\/ajpcell.00416.2012","article-title":"Chenodeoxycholic acid stimulates Cl- secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells","volume":"305","author":"Ao","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"issue":"8","key":"10.1016\/j.dld.2021.04.022_bib0050","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1172\/JCI106644","article-title":"Colonic secretion of water and electrolytes induced by bile acids: perfusion studies in man","volume":"50","author":"Mekjian","year":"1971","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.dld.2021.04.022_bib0051","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.cgh.2009.10.020","article-title":"Effects of chenodeoxycholate and a bile acid sequestrant, colesevelam, on intestinal transit and bowel function","volume":"8","author":"Odunsi-Shiyanbade","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2021.04.022_bib0052","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-2999(94)90630-0","article-title":"Nitric oxide involvement in sodium choleate-induced fluid secretion and diarrhoea in rats","volume":"264","author":"Mascolo","year":"1994","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"10.1016\/j.dld.2021.04.022_bib0053","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/j.1365-2982.2010.01487.x","article-title":"Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system","volume":"22","author":"Poole","year":"2010","journal-title":"Neurogastroenterol Motil"},{"issue":"8","key":"10.1016\/j.dld.2021.04.022_bib0054","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/nmo.12148","article-title":"The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon","volume":"25","author":"Ward","year":"2013","journal-title":"Neurogastroenterol Motil"},{"issue":"6","key":"10.1016\/j.dld.2021.04.022_bib0055","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"issue":"20","key":"10.1016\/j.dld.2021.04.022_bib0056","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131712","article-title":"Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity","volume":"4","author":"Castro","year":"2019","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.dld.2021.04.022_bib0057","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/gut.30.3.383","article-title":"Effect of bile acid on anorectal function in man","volume":"30","author":"Edwards","year":"1989","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.dld.2021.04.022_bib0058","doi-asserted-by":"crossref","first-page":"G443","DOI":"10.1152\/ajpgi.00194.2001","article-title":"The proximal colonic motor response to rectal mechanical and chemical stimulation","volume":"282","author":"Bampton","year":"2002","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"10.1016\/j.dld.2021.04.022_bib0059","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1053\/j.gastro.2012.09.055","article-title":"The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice","volume":"144","author":"Alemi","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2021.04.022_bib0060","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cmet.2016.05.005","article-title":"Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism","volume":"24","author":"Wahlstr\u00f6m","year":"2016","journal-title":"Cell Metab"},{"issue":"4","key":"10.1016\/j.dld.2021.04.022_bib0061","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/jgh.15225","article-title":"Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome","volume":"36","author":"Miura","year":"2021","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865821002073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865821002073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:15:58Z","timestamp":1761624958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865821002073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1590865821002073"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2021.04.022","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Faecal bile acids and colonic bile acid membrane receptor correlate with symptom severity of diarrhoea-predominant irritable bowel syndrome: A pilot study","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2021.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}