{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T01:51:11Z","timestamp":1780969871718,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsingin ja Uudenmaan Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.dld.2021.05.009","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T08:48:41Z","timestamp":1623142121000},"page":"1020-1027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Use of thiopurines is not a risk factor for post-ERC pancreatitis in patients with primary sclerosing cholangitis"],"prefix":"10.1016","volume":"53","author":[{"given":"Vilja","family":"Koskensalo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasi","family":"Aronen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martti","family":"F\u00e4rkkil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Kyl\u00e4np\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Rainio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Udd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalle","family":"Jokelainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Tenca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2021.05.009_bib0001","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1016\/S0140-6736(18)30300-3","article-title":"Primary sclerosing cholangitis","volume":"391","author":"Dyson","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2021.05.009_bib0002","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1148\/radiol.10091953","article-title":"Primary sclerosing cholangitis: meta-analysis of diagnostic performance of MR cholangiopancreatography","volume":"256","author":"Dave","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.dld.2021.05.009_bib0003","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1111\/liv.13899","article-title":"The role of magnetic resonance imaging and endoscopic retrograde cholangiography in the evaluation of disease activity and severity in primary sclerosing cholangitis","volume":"38","author":"Tenca","year":"2018","journal-title":"Liver Int"},{"key":"10.1016\/j.dld.2021.05.009_bib0004","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1055\/s-0043-107029","article-title":"Role of endoscopy in primary sclerosing cholangitis: european Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) clinical guideline","volume":"49","author":"Aabakken","year":"2017","journal-title":"Endoscopy"},{"key":"10.1016\/j.dld.2021.05.009_bib0005","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1055\/s-0041-110792","article-title":"Screening primary sclerosing cholangitis and biliary dysplasia with endoscopic retrograde cholangiography and brush cytology: risk factors for biliary neoplasia","volume":"48","author":"Boyd","year":"2016","journal-title":"Endoscopy"},{"key":"10.1016\/j.dld.2021.05.009_bib0006","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/a-1075-4080","article-title":"ERCP-related adverse events: European Society of Gastrointestinal Endoscopy (ESGE) guideline","volume":"52","author":"Dumonceau","year":"2020","journal-title":"Endoscopy"},{"key":"10.1016\/j.dld.2021.05.009_bib0007","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ajg.2008.161","article-title":"Complications of endoscopic retrograde cholangiopancreatography in primary sclerosing cholangitis","volume":"104","author":"Bangarulingam","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2021.05.009_bib0008","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jhep.2017.02.013","volume":"66","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2021.05.009_bib0009","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1055\/s-0032-1325677","article-title":"Risk factors for complications of ERCP in primary sclerosing cholangitis","volume":"44","author":"Ismail","year":"2012","journal-title":"Endoscopy"},{"key":"10.1016\/j.dld.2021.05.009_bib0010","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.gie.2014.06.030","article-title":"ERCP-related adverse events in patients with primary sclerosing cholangitis","volume":"81","author":"Navaneethan","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2021.05.009_bib0011","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/liv.12640","article-title":"Primary sclerosing cholangitis increases the risk for pancreatitis after endoscopic retrograde cholangiopancreatography","volume":"35","author":"von Seth","year":"2015","journal-title":"Liver Int"},{"key":"10.1016\/j.dld.2021.05.009_bib0012","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1177\/2050640620912608","article-title":"Diclofenac does not reduce the risk of acute pancreatitis in patients with primary sclerosing cholangitis after endoscopic retrograde cholangiography","volume":"8","author":"Koskensalo","year":"2020","journal-title":"United Eur. Gastroenterol J"},{"key":"10.1016\/j.dld.2021.05.009_bib0013","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ecco-jcc\/jjw168","article-title":"3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn\u2019s Disease 2016: part 1: diagnosis and medical management","volume":"11","author":"Gomollon","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.dld.2021.05.009_bib0014","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/ecco-jcc\/jjx009","article-title":"Third european evidence-based consensus on diagnosis and management of ulcerative colitis. Part 2: current management","volume":"11","author":"Harbord","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.dld.2021.05.009_bib0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s002280100346","article-title":"Spontaneous reports on drug-induced pancreatitis in Denmark from 1968 to 1999","volume":"57","author":"Andersen","year":"2001","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.dld.2021.05.009_bib0016","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/j.1572-0241.2003.07459.x","article-title":"Risk of acute pancreatitis in users of azathioprine: a population-based case-control study","volume":"98","author":"Floyd","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2021.05.009_bib0017","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bpg.2010.02.002","article-title":"Drug induced pancreatitis","volume":"24","author":"Nitsche","year":"2010","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.dld.2021.05.009_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0231883","article-title":"Drug induced pancreatitis: a systematic review of case reports to determine potential drug associations","volume":"15","author":"Wolfe","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dld.2021.05.009_bib0019","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/01.mcg.0000173929.60115.b4","article-title":"Drug-induced pancreatitis: an update","volume":"39","author":"Trivedi","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.dld.2021.05.009_bib0020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2009.04.009","article-title":"European association for the study of the L. EASL clinical practice guidelines: management of cholestatic liver diseases","volume":"51","year":"2009","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2021.05.009_bib0021","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.gie.2010.12.036","article-title":"Grading the complexity of endoscopic procedures: results of an ASGE working party","volume":"73","author":"Cotton","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2021.05.009_bib0022","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.gie.2008.10.039","article-title":"Risk factors for complications after ERCP: a multivariate analysis of 11,497 procedures over 12 years","volume":"70","author":"Cotton","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2021.05.009_bib0023","series-title":"Statistical Thinking for Non-Statisticians in Drug Regulation","author":"Kay","year":"2014"},{"key":"10.1016\/j.dld.2021.05.009_bib0024","series-title":"Regression Modeling Strategies","author":"Harrell","year":"2015"},{"key":"10.1016\/j.dld.2021.05.009_bib0025","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.mayocp.2016.10.028","article-title":"The \"Scope\" of post-ERCP pancreatitis","volume":"92","author":"Parekh","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.dld.2021.05.009_bib0026","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/S0016-5107(03)02019-4","article-title":"Are drugs a risk factor of post-ERCP pancreatitis?","volume":"58","author":"Perney","year":"2003","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2021.05.009_bib0027","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/MPA.0b013e31827309fd","article-title":"Pancreatitis potentially associated drugs as a risk factor for post-endoscopic retrograde cholangiopancreatography pancreatitis: a prospective cohort study","volume":"42","author":"Sigounas","year":"2013","journal-title":"Pancreas"},{"key":"10.1016\/j.dld.2021.05.009_bib0028","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.gie.2016.06.051","article-title":"Adverse events associated with ERCP","volume":"85","author":"Chandrasekhara","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.dld.2021.05.009_bib0030","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S1542-3565(04)00344-1","article-title":"Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety","volume":"2","author":"Dubinsky","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2021.05.009_bib0031","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/liv.13458","article-title":"Autoimmune hepatitis: from current knowledge and clinical practice to future research agenda","volume":"38","author":"Sebode","year":"2018","journal-title":"Liver Int"},{"key":"10.1016\/j.dld.2021.05.009_bib0032","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1046\/j.1365-2036.2003.01485.x","article-title":"Discrepancies between population-based data and adverse reaction reports in assessing drugs as causes of acute pancreatitis","volume":"17","author":"Lancashire","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2021.05.009_bib0033","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1097\/MIB.0b013e318281f28f","article-title":"Safety of thiopurine therapy in inflammatory bowel disease: long-term follow-up study of 3931 patients","volume":"19","author":"Chaparro","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.dld.2021.05.009_bib0034","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2036.2004.02197.x","article-title":"Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases","volume":"20","author":"Weersma","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2021.05.009_bib0035","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/apt.12461","article-title":"Drug-induced acute pancreatitis: results from the hospital-based Berlin case-control surveillance study of 102 cases","volume":"38","author":"Douros","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2021.05.009_bib0036","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3389\/fmed.2019.00279","article-title":"Can we predict the toxicity and response to thiopurines in inflammatory bowel diseases?","volume":"6","author":"Luber","year":"2019","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.dld.2021.05.009_bib0037","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2036.2008.03746.x","article-title":"Acute pancreatitis in inflammatory bowel disease, with special reference to azathioprine-induced pancreatitis","volume":"28","author":"Bermejo","year":"2008","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2021.05.009_bib0038","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1572-0241.2004.04123.x","article-title":"Inflammatory bowel diseases, 5-aminosalicylic acid and sulfasalazine treatment and risk of acute pancreatitis: a population-based case-control study","volume":"99","author":"Munk","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2021.05.009_bib0039","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/hep.20457","article-title":"Metronidazole and ursodeoxycholic acid for primary sclerosing cholangitis: a randomized placebo-controlled trial","volume":"40","author":"Farkkila","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2021.05.009_bib0040","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2036.2005.02344.x","article-title":"Metronidazole and risk of acute pancreatitis: a population-based case-control study","volume":"21","author":"Norgaard","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2021.05.009_bib0041","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.surge.2014.11.005","article-title":"Risk factors for post-ERCP pancreatitis: a systematic review and meta-analysis","volume":"13","author":"Ding","year":"2015","journal-title":"Surgeon"},{"key":"10.1016\/j.dld.2021.05.009_bib0042","article-title":"Periampullary diverticula and ERCP outcomes: a systematic review and meta-analysis","author":"Jayaraj","year":"2018","journal-title":"Dig Dis Sci"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865821002607?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865821002607?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:16:01Z","timestamp":1761624961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865821002607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1590865821002607"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2021.05.009","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of thiopurines is not a risk factor for post-ERC pancreatitis in patients with primary sclerosing cholangitis","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2021.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}