{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:16:46Z","timestamp":1793128606034,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK007634"],"award-info":[{"award-number":["T32 DK007634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T35 DK007386"],"award-info":[{"award-number":["T35 DK007386"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.dld.2021.10.004","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T15:35:59Z","timestamp":1636904159000},"page":"477-482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Older patients with eosinophilic esophagitis have high treatment response to topical steroids"],"prefix":"10.1016","volume":"54","author":[{"given":"Corey J.","family":"Ketchem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisan P.","family":"Thakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumana","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney B.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Abichandani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talya L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole C.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swathi","family":"Eluri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig C.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-1101","authenticated-orcid":false,"given":"Evan S.","family":"Dellon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.dld.2021.10.004_bib0001","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2011.02.040","article-title":"Eosinophilic Esophagitis: updated consensus recommendations for children and adults","volume":"128","author":"Liacouras","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.dld.2021.10.004_bib0002","series-title":"Proceedings of the AGREE conference","article-title":"Updated international consensus diagnostic criteria for Eosinophilic Esophagitis","author":"Dellon","year":"2018"},{"issue":"5","key":"10.1016\/j.dld.2021.10.004_bib0003","doi-asserted-by":"crossref","DOI":"10.1038\/ajg.2013.71","article-title":"ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and Eosinophilic Esophagitis (EoE)","volume":"108","author":"Dellon","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"10.1016\/j.dld.2021.10.004_bib0004","doi-asserted-by":"crossref","DOI":"10.1038\/ajg.2014.316","article-title":"Health-care utilization, costs, and the burden of disease related to Eosinophilic Esophagitis in the United States","volume":"110","author":"Jensen","year":"2015","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"10.1016\/j.dld.2021.10.004_bib0005","doi-asserted-by":"crossref","DOI":"10.1093\/dote\/doy015","article-title":"Natural history of Eosinophilic Esophagitis: a systematic review of epidemiology and disease course","volume":"31","author":"Shaheen","year":"2018","journal-title":"Dis Esophagus"},{"issue":"2","key":"10.1016\/j.dld.2021.10.004_bib0006","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2017.06.067","article-title":"Epidemiology and natural history of Eosinophilic Esophagitis","volume":"154","author":"Dellon","year":"2018","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.dld.2021.10.004_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.gie.2013.10.027","article-title":"A phenotypic analysis shows that Eosinophilic Esophagitis is a progressive fibrostenotic disease","volume":"79","author":"Dellon","year":"2014","journal-title":"Gastrointest Endosc"},{"issue":"6","key":"10.1016\/j.dld.2021.10.004_bib0008","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2013.08.015","article-title":"Delay in diagnosis of Eosinophilic Esophagitis increases risk for stricture formation in a time-dependent manner","volume":"145","author":"Schoepfer","year":"2013","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.dld.2021.10.004_bib0009","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.02.038","article-title":"AGA institute and the joint task force on allergy-immunology practice parameters clinical guidelines for the management of Eosinophilic Esophagitis","volume":"158","author":"Hirano","year":"2020","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.dld.2021.10.004_bib0010","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.02.039","article-title":"Technical review on the management of Eosinophilic Esophagitis: a report from the AGA institute and the joint task force on allergy-immunology practice parameters","volume":"158","author":"Rank","year":"2020","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.dld.2021.10.004_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2019.10.027","article-title":"Emerging therapies for Eosinophilic Esophagitis","volume":"145","author":"Greuter","year":"2020","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"10.1016\/j.dld.2021.10.004_bib0012","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2018.10.051","article-title":"RPC4046, a monoclonal antibody against IL13, reduces histologic and endoscopic activity in patients with Eosinophilic Esophagitis","volume":"156","author":"Hirano","year":"2019","journal-title":"Gastroenterology"},{"issue":"17","key":"10.1016\/j.dld.2021.10.004_bib0013","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2012047","article-title":"Anti\u2013siglec-8 antibody for Eosinophilic gastritis and duodenitis","volume":"383","author":"Dellon","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.dld.2021.10.004_bib0014","article-title":"Budesonide oral suspension improves outcomes in patients with Eosinophilic Esophagitis: results from a phase 3 trial","author":"Hirano","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.dld.2021.10.004_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2018.05.051","article-title":"Safety and efficacy of budesonide oral suspension maintenance therapy in patients with Eosinophilic Esophagitis","volume":"17","author":"Dellon","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.dld.2021.10.004_bib0016","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.03.025","article-title":"Efficacy of budesonide orodispersible tablets as induction therapy for Eosinophilic Esophagitis in a randomized placebo-controlled trial","volume":"157","author":"Lucendo","year":"2019","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.dld.2021.10.004_bib0017","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.09.042","article-title":"Efficacy of dupilumab in a phase 2 randomized trial of adults with active Eosinophilic Esophagitis","volume":"158","author":"Hirano","year":"2020","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.dld.2021.10.004_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2013.09.008","article-title":"Prevalence of Eosinophilic Esophagitis in the United States","volume":"12","author":"Dellon","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"11","key":"10.1016\/j.dld.2021.10.004_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2019.01.030","article-title":"A conceptual approach to understanding treatment response in Eosinophilic Esophagitis","volume":"17","author":"Dellon","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.dld.2021.10.004_bib0020","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2016.11.021","article-title":"Budesonide oral suspension improves symptomatic, endoscopic, and histologic parameters compared with placebo in patients with Eosinophilic Esophagitis","volume":"152","author":"Dellon","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2021.10.004_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2020.03.060","article-title":"Long-term treatment of Eosinophilic Esophagitis with budesonide oral suspension","author":"Dellon","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.dld.2021.10.004_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2009.08.030","article-title":"Clinical, endoscopic, and histologic findings distinguish Eosinophilic Esophagitis from gastroesophageal reflux disease","volume":"7","author":"Dellon","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.dld.2021.10.004_bib0023","doi-asserted-by":"crossref","DOI":"10.1038\/ajg.2015.399","article-title":"Outcomes of esophageal dilation in Eosinophilic Esophagitis: safety, efficacy, and persistence of the fibrostenotic phenotype","volume":"111","author":"Runge","year":"2016","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.dld.2021.10.004_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2014.07.034","article-title":"Predictors of response to steroid therapy for Eosinophilic Esophagitis and treatment of steroid-refractory patients","volume":"13","author":"Wolf","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.dld.2021.10.004_bib0025","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2017.27","article-title":"Diminishing effectiveness of long-term maintenance topical steroid therapy in ppi non-responsive Eosinophilic Esophagitis","volume":"8","author":"Eluri","year":"2017","journal-title":"Clin Transl Gastroenterol"},{"issue":"6","key":"10.1016\/j.dld.2021.10.004_bib0026","doi-asserted-by":"crossref","DOI":"10.14309\/ajg.0000000000000597","article-title":"Psychiatric comorbidities and psychiatric medication use are highly prevalent in patients with Eosinophilic Esophagitis and associate with clinical presentation","volume":"115","author":"Reed","year":"2020","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"10.1016\/j.dld.2021.10.004_bib0027","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2014.07.055","article-title":"Advances in clinical management of Eosinophilic Esophagitis","volume":"147","author":"Dellon","year":"2014","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.dld.2021.10.004_bib0028","article-title":"Viscous budesonide is effective and provides a durable response in Eosinophilic Esophagitis","volume":"7","author":"C Reed","year":"2018","journal-title":"J Gastroenterol Hepatol Res"},{"key":"10.1016\/j.dld.2021.10.004_bib0029","article-title":"Treatment with compounded fluticasone suspension improves the clinical, endoscopic, and histologic features of Eosinophilic Esophagitis","author":"Ketchem","year":"2020","journal-title":"Dis Esophagus"},{"issue":"10","key":"10.1016\/j.dld.2021.10.004_bib0030","article-title":"Evaluation of histologic cutpoints for treatment response in Eosinophilic Esophagitis","volume":"4","author":"Wolf","year":"2015","journal-title":"J Gastroenterol Hepatol Res"},{"issue":"2","key":"10.1016\/j.dld.2021.10.004_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2017.09.046","article-title":"Optimal histologic cutpoints for treatment response in patients with Eosinophilic Esophagitis: analysis of data from a prospective cohort study","volume":"16","author":"Reed","year":"2018","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.dld.2021.10.004_bib0032","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2011-301817","article-title":"Endoscopic assessment of the oesophageal features of Eosinophilic Oesophagitis: validation of a novel classification and grading system","volume":"62","author":"Hirano","year":"2013","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.dld.2021.10.004_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2015.08.040","article-title":"Accuracy of the Eosinophilic Esophagitis endoscopic reference score in diagnosis and determining response to treatment","volume":"14","author":"Dellon","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"8","key":"10.1016\/j.dld.2021.10.004_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2013.12.034","article-title":"Dietary elimination therapy is an effective option for adults with Eosinophilic Esophagitis","volume":"12","author":"Wolf","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"9","key":"10.1016\/j.dld.2021.10.004_bib0035","doi-asserted-by":"crossref","DOI":"10.1111\/apt.14290","article-title":"Food elimination diets are effective for long-term treatment of adults with Eosinophilic Oesophagitis","volume":"46","author":"Reed","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"issue":"7","key":"10.1016\/j.dld.2021.10.004_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2012.03.018","article-title":"Swallowed fluticasone improves histologic but not symptomatic response of adults with Eosinophilic Esophagitis","volume":"10","author":"Alexander","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"3","key":"10.1016\/j.dld.2021.10.004_bib0037","doi-asserted-by":"crossref","DOI":"10.1038\/ajg.2012.443","article-title":"Randomized controlled trial comparing aerosolized swallowed fluticasone to esomeprazole for esophageal eosinophilia","volume":"108","author":"Moawad","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"10.1016\/j.dld.2021.10.004_bib0038","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2014-308815","article-title":"A randomised, double-blind trial comparing budesonide formulations and dosages for short-term treatment of Eosinophilic Oesophagitis","volume":"65","author":"Miehlke","year":"2016","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.dld.2021.10.004_bib0039","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2019.03.014","article-title":"Efficacy of budesonide vs fluticasone for initial treatment of Eosinophilic Esophagitis in a randomized controlled trial","volume":"157","author":"Dellon","year":"2019","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.dld.2021.10.004_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.gie.2015.11.019","article-title":"The extremely narrow-caliber esophagus is a treatment-resistant subphenotype of Eosinophilic Esophagitis","volume":"83","author":"Eluri","year":"2016","journal-title":"Gastrointest Endosc"},{"issue":"6","key":"10.1016\/j.dld.2021.10.004_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2018.09.005","article-title":"Clinical and molecular factors associated with histologic response to topical steroid treatment in patients with Eosinophilic Esophagitis","volume":"17","author":"Eluri","year":"2019","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.dld.2021.10.004_bib0042","doi-asserted-by":"crossref","DOI":"10.1111\/cea.13748","article-title":"Epigenetic methylation in Eosinophilic Esophagitis: molecular ageing and novel biomarkers for treatment response","volume":"50","author":"Jensen","year":"2020","journal-title":"Clin Exp Allergy"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865821008094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865821008094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:18:45Z","timestamp":1761625125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865821008094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1590865821008094"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2021.10.004","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Older patients with eosinophilic esophagitis have high treatment response to topical steroids","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2021.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}