{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:11:00Z","timestamp":1767841860820,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.dld.2022.01.130","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T15:48:51Z","timestamp":1644076131000},"page":"1038-1043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8229-3331","authenticated-orcid":false,"given":"Martijn C.G.J.","family":"Brouwers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nynke","family":"Simons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne Eline","family":"Kooi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rianneke","family":"de Ritter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martien C.J.M.","family":"van Dongen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone J.P.M.","family":"Eussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Bekers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"Kooman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marleen M.J.","family":"van Greevenbroek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla J.H.","family":"van der Kallen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda T.","family":"Schram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas C.","family":"Schaper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper G.","family":"Schalkwijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coen D.A.","family":"Stehouwer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2022.01.130_bib0001","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.jhep.2019.02.012","article-title":"Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease","volume":"70","author":"Hammoutene","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2022.01.130_bib0002","doi-asserted-by":"crossref","first-page":"e32785","DOI":"10.1371\/journal.pone.0032785","article-title":"Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD","volume":"7","author":"Pasarin","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.dld.2022.01.130_bib0003","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/liv.14384","article-title":"The endothelial function biomarker soluble E-selectin is associated with nonalcoholic fatty liver disease","volume":"40","author":"Simons","year":"2020","journal-title":"Liver Int"},{"key":"10.1016\/j.dld.2022.01.130_bib0004","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10654-014-9889-0","article-title":"The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities","volume":"29","author":"Schram","year":"2014","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.dld.2022.01.130_bib0005","doi-asserted-by":"crossref","first-page":"E462","DOI":"10.1152\/ajpendo.00064.2004","article-title":"Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population","volume":"288","author":"Szczepaniak","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.dld.2022.01.130_bib0006","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.nut.2018.10.015","article-title":"The Maastricht FFQ: development and validation of a comprehensive food frequency questionnaire for the Maastricht study","volume":"62","author":"van Dongen","year":"2019","journal-title":"Nutrition"},{"key":"10.1016\/j.dld.2022.01.130_bib0007","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1017\/S136898001700091X","article-title":"Development and evaluation of the Dutch healthy diet index 2015","volume":"20","author":"Looman","year":"2017","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.dld.2022.01.130_bib0008","series-title":"Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: report of a WHO\/IDF consultation","year":"2006"},{"key":"10.1016\/j.dld.2022.01.130_bib0009","doi-asserted-by":"crossref","DOI":"10.1007\/s10654-014-9889-0","article-title":"The Maastricht study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities","author":"Schram","year":"2014","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.dld.2022.01.130_bib0010","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jad.2015.09.028","article-title":"Association of Type D personality with increased vulnerability to depression: is there a role for inflammation or endothelial dysfunction? - the Maastricht study","volume":"189","author":"van Dooren","year":"2016","journal-title":"J Affect Disord"},{"key":"10.1016\/j.dld.2022.01.130_bib0011","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dld.2022.01.130_bib0012","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00394-019-02026-0","article-title":"Association of artificially sweetened and sugar-sweetened soft drinks with beta-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study","volume":"59","author":"den Biggelaar","year":"2020","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.dld.2022.01.130_bib0013","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.thromres.2007.12.009","article-title":"Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein E","volume":"122","author":"Brouwers","year":"2008","journal-title":"Thromb Res"},{"key":"10.1016\/j.dld.2022.01.130_bib0014","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2337\/dc07-1526","article-title":"Should nonalcoholic fatty liver disease be included in the definition of metabolic syndrome? A cross-sectional comparison with Adult Treatment Panel III criteria in nonobese nondiabetic subjects","volume":"31","author":"Musso","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.dld.2022.01.130_bib0015","first-page":"533","article-title":"Expression of E-selectin and E-selectin ligands in human liver inflammation","volume":"24","author":"Adams","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2022.01.130_bib0016","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/hep.26419","article-title":"Chronic plus binge ethanol feeding synergistically induces neutrophil infiltration and liver injury in mice: a critical role for E-selectin","volume":"58","author":"Bertola","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2022.01.130_bib0017","first-page":"131","article-title":"Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis","author":"Furuta","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.dld.2022.01.130_bib0018","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1161\/01.ATV.0000198392.05307.aa","article-title":"Elevated markers of endothelial dysfunction predict type 2 diabetes mellitus in middle-aged men and women from the general population","volume":"26","author":"Thorand","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.dld.2022.01.130_bib0019","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.2337\/db07-0250","article-title":"Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women","volume":"56","author":"Song","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.dld.2022.01.130_bib0020","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1001\/jama.291.16.1978","article-title":"Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus","volume":"291","author":"Meigs","year":"2004","journal-title":"JAMA"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865822001414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865822001414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:20:33Z","timestamp":1761625233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865822001414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S1590865822001414"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2022.01.130","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2022.01.130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}