{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:44:41Z","timestamp":1784036681292,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.dld.2022.11.021","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T15:27:42Z","timestamp":1671809262000},"page":"743-750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Diagnostic delay in adult coeliac disease: An Italian multicentre study"],"prefix":"10.1016","volume":"55","author":[{"given":"Marco Vincenzo","family":"Lenti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Aronico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Ilaria","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela Cinzia","family":"D'Agate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Volta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gloria","family":"Mumolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Astegiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino Salvatore","family":"Calabr\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Zingone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Latella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Sario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Carroccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ciacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Luzza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Bagnato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo Claudio","family":"Fantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Elli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Cammarota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Andrea","family":"Latorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Petrucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Quatraccioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Iannelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Vecchione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Maria","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Broglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Ianiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Marsilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bibb\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Marinoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Tomaselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Abenavoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Pilia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Santacroce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Carrieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Mansueto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Gabba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Alunno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Onnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Efthymakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Cesaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vernero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Baiano Svizzero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Paolo","family":"Semeraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Silano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Vanoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Klersy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino Roberto","family":"Corazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0302-8645","authenticated-orcid":false,"given":"Antonio","family":"Di Sabatino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2022.11.021_bib0001","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0140-6736(09)60254-3","article-title":"Coeliac disease","volume":"373","author":"Di Sabatino","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2022.11.021_bib0002","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.amjmed.2017.05.027","article-title":"Delay in diagnosis of celiac disease in patients without gastrointestinal complaints","volume":"130","author":"Paez","year":"2017","journal-title":"Am J Med"},{"key":"10.1016\/j.dld.2022.11.021_bib0003","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12876-019-0980-6","article-title":"The impact of diagnosis on health-related quality of life in people with coeliac disease: a UK population-based longitudinal perspective","volume":"19","author":"Violato","year":"2019","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.dld.2022.11.021_bib0004","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.dld.2016.06.016","article-title":"Celiac disease diagnosis still significantly delayed - Doctor's but not patients' delay responsive for the increased total delay in women","volume":"48","author":"Vavricka","year":"2016","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2022.11.021_bib0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejim.2020.09.020","article-title":"Non-classical clinical presentation at diagnosis by male celiac disease patients of older age","volume":"83","author":"Tan","year":"2021","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.dld.2022.11.021_bib0006","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0140-6736(01)05554-4","article-title":"Club del tenue study group. Mortality in patients with coeliac disease and their relatives: a cohort study","volume":"358","author":"Corrao","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2022.11.021_bib0007","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000198987","article-title":"Delay in diagnosis of adult coeliac disease","volume":"28","author":"Gregory","year":"1983","journal-title":"Digestion"},{"key":"10.1016\/j.dld.2022.11.021_bib0008","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/00004836-199606000-00019","article-title":"Previous misdiagnosis and diagnostic delay in adult celiac sprue","volume":"22","author":"Corazza","year":"1996","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.dld.2022.11.021_bib0009","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000052819","article-title":"Club del tenue study group. Coeliac disease in the elderly. A multicentre Italian study","volume":"47","author":"Gasbarrini","year":"2001","journal-title":"Gerontology"},{"key":"10.1016\/j.dld.2022.11.021_bib0010","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-230X-11-118","article-title":"Delay to celiac disease diagnosis and its implications for health-related quality of life","volume":"11","author":"Norstr\u00f6m","year":"2011","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.dld.2022.11.021_bib0011","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1155\/2013\/741740","article-title":"Clinical features and symptom recovery on a gluten-free diet in Canadian adults with celiac disease","volume":"27","author":"Pulido","year":"2013","journal-title":"Can J Gastroenterol"},{"key":"10.1016\/j.dld.2022.11.021_bib0012","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/2050640617751253","article-title":"Delayed celiac disease diagnosis predisposes to reduced quality of life and incremental use of health care services and medicines: a prospective nationwide study","volume":"6","author":"Fuchs","year":"2018","journal-title":"United Eur Gastroenterol J"},{"key":"10.1016\/j.dld.2022.11.021_bib0013","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.dld.2021.11.016","article-title":"Improving the diagnostic approach to celiac disease: experience from a regional network","volume":"54","author":"Mansueto","year":"2022","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2022.11.021_bib0014","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.dld.2021.05.016","article-title":"Clinical features and psychological impact of celiac disease at diagnosis","volume":"53","author":"Zingone","year":"2021","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2022.11.021_bib0015","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3109\/00365521.2014.923502","article-title":"Factors associated with long diagnostic delay in celiac disease","volume":"49","author":"Fuchs","year":"2014","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2022.11.021_bib0016","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bpg.2005.02.004","article-title":"Coeliac disease: is it time for mass screening?","volume":"19","author":"Mearin","year":"2005","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.dld.2022.11.021_bib0017","first-page":"1","article-title":"The Delphi technique: making sense of consensus","volume":"12","author":"Hsu","year":"2007","journal-title":"PARE"},{"key":"10.1016\/j.dld.2022.11.021_bib0018","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"BSG coeliac disease guidelines development group; British society of gastroenterology. Diagnosis and management of adult coeliac disease: guidelines from the British society of gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.dld.2022.11.021_bib0019","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ajg.2016.551","article-title":"CVID and celiac disease","volume":"112","author":"J\u00f8rgensen","year":"2017","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2022.11.021_bib0020","doi-asserted-by":"crossref","first-page":"7486","DOI":"10.3390\/nu7095350","article-title":"Seronegative celiac disease and Immunoglobulin deficiency: where to look in the submerged iceberg?","volume":"7","author":"Giorgio","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.dld.2022.11.021_bib0021","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"147","author":"von Elm","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.dld.2022.11.021_bib0022","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12876-014-0194-x","article-title":"The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center","volume":"14","author":"Volta","year":"2014","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.dld.2022.11.021_bib0023","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","volume":"54","author":"Husby","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2022.11.021_bib0024","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/MPG.0000000000002424","article-title":"Diagnostic delays in children with coeliac disease in the central European region","volume":"69","author":"Riznik","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.dld.2022.11.021_bib0025","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11739-020-02580-0","article-title":"Diagnostic reasoning in internal medicine: a practical reappraisal","volume":"16","author":"Corazza","year":"2021","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.dld.2022.11.021_bib0026","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/ecco-jcc\/jjx041","article-title":"The time course of diagnostic delay in inflammatory bowel disease over the last sixty years: an Italian multicentre study","volume":"11","author":"Cantoro","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.dld.2022.11.021_bib0027","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/apt.15317","article-title":"Determinants of diagnostic delay in autoimmune atrophic gastritis","volume":"50","author":"Lenti","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2022.11.021_bib0028","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1016\/j.dld.2021.05.017","article-title":"Diagnostic delay and misdiagnosis in eosinophilic oesophagitis","volume":"53","author":"Lenti","year":"2021","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2022.11.021_bib0029","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/s41395-018-0103-y","article-title":"The global phenomenon of self-reported wheat sensitivity","volume":"113","author":"Aziz","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2022.11.021_bib0030","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/2050640615578388","article-title":"Non-coeliac gluten sensitivity: piecing the puzzle together","volume":"3","author":"Biesiekierski","year":"2015","journal-title":"United Eur Gastroenterol J"},{"key":"10.1016\/j.dld.2022.11.021_bib0031","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1053\/j.gastro.2005.02.023","article-title":"Should all children be screened for celiac disease?","volume":"128","author":"Hoffenberg","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2022.11.021_bib0032","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1053\/j.gastro.2005.02.021","article-title":"Should adults be screened for celiac disease? What are the benefits and harms of screening?","volume":"128","author":"Collin","year":"2005","journal-title":"Gastroenterology"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865822008192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865822008192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:22:00Z","timestamp":1761625320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865822008192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S1590865822008192"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2022.11.021","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic delay in adult coeliac disease: An Italian multicentre study","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2022.11.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}