{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:28:57Z","timestamp":1789388937742,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.dld.2022.12.021","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T08:27:09Z","timestamp":1673944029000},"page":"1611-1620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Positive margins and plexitis increase the risk of recurrence after ileocecal resection: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-3919","authenticated-orcid":false,"given":"Clara","family":"Yzet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mentine","family":"Riault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Brazier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Grados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Nguyen-Khac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Chatelain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Sabbagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Buisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momar","family":"Diouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathurin","family":"Fumery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2022.12.021_bib0001","doi-asserted-by":"crossref","unstructured":"Cosnes J., Cattan S., Blain A., Beaugerie L., Carbonnel F., Parc R., et\u00a0al. Long-term evolution of disease behavior of Crohn's disease: inflammatory bowel diseases. 2002;8:244\u201350.","DOI":"10.1097\/00054725-200207000-00002"},{"key":"10.1016\/j.dld.2022.12.021_bib0002","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1136\/gut.2010.227884","article-title":"Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn's disease","volume":"60","author":"Peyrin-Biroulet","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.dld.2022.12.021_bib0003","doi-asserted-by":"crossref","unstructured":"Buisson A., Chevaux J.B., Allen P.B., Bommelaer G., Peyrin-Biroulet L. Review article: the natural history of postoperative Crohn's disease recurrence. Letters to the Editors. 2012;35:625\u201333.","DOI":"10.1111\/j.1365-2036.2012.05002.x"},{"key":"10.1016\/j.dld.2022.12.021_bib0004","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00384-008-0542-9","article-title":"The effect of smoking after surgery for Crohn's disease: a meta-analysis of observational studies","volume":"23","author":"Reese","year":"2008","journal-title":"Int J Colorectal Dis"},{"key":"10.1016\/j.dld.2022.12.021_bib0005","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ecco-jcc\/jjw169","article-title":"3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: part 2: surgical management and special situations","volume":"11","author":"Gionchetti","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.dld.2022.12.021_bib0006","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1046\/j.1365-2168.2000.01589.x","article-title":"Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn's disease","volume":"87","author":"Bernell","year":"2002","journal-title":"Br J Surg"},{"key":"10.1016\/j.dld.2022.12.021_bib0007","first-page":"152","article-title":"The impact of clinical types of disease manifestation on the risk of early postoperative recurrence in Crohn's disease","volume":"48","author":"Hofer","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.dld.2022.12.021_bib0008","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1365-2036.2004.02245.x","article-title":"Behaviour of the bowel wall during the first year after surgery is a strong predictor of symptomatic recurrence of Crohn's disease: a prospective study","volume":"20","author":"Parente","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2022.12.021_bib0009","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1463-1318.2006.01202.x","article-title":"Early symptomatic recurrence after intestinal resection in Crohn's disease is unpredictable","volume":"9","author":"Kurer","year":"2007","journal-title":"Colorect Dis"},{"key":"10.1016\/j.dld.2022.12.021_bib0010","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.3109\/00365528309181837","article-title":"Recurrence rate after surgical treatment of Crohn's disease","volume":"18","author":"Lindhagen","year":"1983","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2022.12.021_bib0011","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/BF02049707","article-title":"Do microscopic abnormalities at resection margins correlate with increased anastomotic recurrence in Crohn's disease?: retrospective analysis of 100 cases","volume":"34","author":"Kotanagi","year":"1991","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.dld.2022.12.021_bib0012","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/bjs.1800700904","article-title":"The influence of disease at the margin of resection on the outcome of Crohn's disease","volume":"70","author":"Heuman","year":"2005","journal-title":"Br J Surg"},{"key":"10.1016\/j.dld.2022.12.021_bib0013","first-page":"23","article-title":"The influence of microscopic disease at the margin of resection on recurrence rates in Crohn's disease","volume":"68","author":"Cooper","year":"1986","journal-title":"Ann R Coll Surg Engl"},{"key":"10.1016\/j.dld.2022.12.021_bib0014","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s10350-004-7292-8","article-title":"Comparison of conventional and laparoscopic ileocolic resection for Crohn's disease","volume":"46","author":"Bergamaschi","year":"2003","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.dld.2022.12.021_bib0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000171766","article-title":"Surgical management of Crohn's disease: how much to resect?","volume":"4","author":"Jaeck","year":"1987","journal-title":"Dig Surg"},{"key":"10.1016\/j.dld.2022.12.021_bib0016","first-page":"543","article-title":"Does the histologic appearance at the margin of resection affect the postoperative recurrence rate in Crohn's disease?","volume":"53","author":"Adloff","year":"1987","journal-title":"Am Surg"},{"key":"10.1016\/j.dld.2022.12.021_bib0017","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.cgh.2020.08.014","article-title":"Active margins, plexitis, and granulomas increase postoperative Crohn's recurrence: systematic review and meta-analysis","volume":"19","author":"Tandon","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2022.12.021_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2019.04.045","article-title":"Association between microscopic lesions at ileal resection margin and recurrence after surgery in patients with Crohn's disease","volume":"18","author":"Hammoudi","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2022.12.021_bib0019","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjx002.436","article-title":"P311 Microscopic inflammation and myenteric plexitis at the margin of resection do not predict endoscopic recurrence in patients with Crohn's disease after ileocolic resection","volume":"11","author":"Boland","year":"2017","journal-title":"J Crohn's Colitis"},{"key":"10.1016\/j.dld.2022.12.021_bib0020","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/ibd\/izz290","article-title":"The predictive value of inflammation at ileocecal resection margins for postoperative Crohn's recurrence: a cohort study","volume":"26","author":"Wasmann","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.dld.2022.12.021_bib0021","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/00000658-199610000-00014","article-title":"Effect of resection margins on the recurrence of Crohn's disease in the small bowel: a randomized controlled trial","volume":"224","author":"Fazio","year":"1996","journal-title":"Ann Surg"},{"key":"10.1016\/j.dld.2022.12.021_bib0022","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/ecco-jcc\/jjw135","article-title":"Submucosal plexitis as a predictive factor for postoperative endoscopic recurrence in patients with Crohn's disease undergoing a resection with ileocolonic anastomosis: results from a prospective single-centre study","volume":"11","author":"Lemmens","year":"2017","journal-title":"ECCOJC"},{"key":"10.1016\/j.dld.2022.12.021_bib0023","first-page":"179","article-title":"Recurrence after resection for Crohn's disease","volume":"18","author":"Speranza","year":"1988","journal-title":"Ital J Surg Sci"},{"key":"10.1016\/j.dld.2022.12.021_bib0024","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/ecco-jcc\/jjz153","article-title":"The influence of microscopic inflammation at resection margins on early postoperative endoscopic recurrence after ileocaecal resection for Crohn's disease","volume":"14","author":"Poredska","year":"2020","journal-title":"J Crohn's Colitis"},{"key":"10.1016\/j.dld.2022.12.021_bib0025","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1136\/gut.2009.177782","article-title":"Plexitis as a predictive factor of early postoperative clinical recurrence in Crohn's disease","volume":"58","author":"Sokol","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.dld.2022.12.021_bib0026","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1053\/j.gastro.2006.02.025","article-title":"The value of myenteric plexitis to predict early postoperative Crohn's disease recurrence","volume":"130","author":"Ferrante","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2022.12.021_bib0027","doi-asserted-by":"crossref","first-page":"56","DOI":"10.23922\/jarc.2016-006","article-title":"Predictive value of myenteric and submucosal plexitis for postoperative Crohn's disease recurrence","volume":"1","author":"Nakao","year":"2017","journal-title":"J Anus Rectum Colon"},{"key":"10.1016\/j.dld.2022.12.021_bib0028","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/MEG.0b013e328326a01e","article-title":"Clinical and surgical recurrence of Crohn\u02bcs disease after ileocolonic resection in a specialist unit","volume":"21","author":"Ng","year":"2009","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2022.12.021_bib0029","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1097\/MIB.0b013e3182971cec","article-title":"Decreased lymphatic vessel density is associated with postoperative endoscopic recurrence in Crohn's disease","volume":"19","author":"Rahier","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.dld.2022.12.021_bib0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00000658-198009000-00006","article-title":"Surgical management of Crohn\u02bcs disease: influence of disease at margin of resection","volume":"192","author":"Pennington","year":"1980","journal-title":"Ann Surg"},{"key":"10.1016\/j.dld.2022.12.021_bib0031","first-page":"57","article-title":"Crohn's disease: long-term results of surgical treatment","volume":"16","author":"Karesen","year":"1981","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2022.12.021_bib0032","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3109\/00365527709181336","article-title":"Crohn's disease: recurrence after surgical treatment","volume":"12","author":"Nygaard","year":"1977","journal-title":"Scand J Gastroenterol"},{"issue":"4","key":"10.1016\/j.dld.2022.12.021_bib0033","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3109\/00365528509089690","article-title":"A long-term study of the clinical course in 186 patients","volume":"20","author":"Krause","year":"1985","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.dld.2022.12.021_bib0034","doi-asserted-by":"crossref","first-page":"505","DOI":"10.5858\/arpa.2018-0011-OA","article-title":"The clinical significance of Crohn disease activity at resection margins","volume":"143","author":"Setoodeh","year":"2019","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.dld.2022.12.021_bib0035","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/bjs.10595","article-title":"Short- and medium-term outcomes following primary ileocaecal resection for Crohn's disease in two specialist centres","volume":"104","author":"de Buck van Overstraeten","year":"2017","journal-title":"Br J Surg"},{"key":"10.1016\/j.dld.2022.12.021_bib0036","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000089960","article-title":"Risk factors regarding the need for a second operation in patients with Crohn's disease","volume":"72","author":"Avidan","year":"2005","journal-title":"Digestion"},{"key":"10.1016\/j.dld.2022.12.021_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinre.2020.10.013","article-title":"Positive histologic margins is a risk factor of recurrence after ileocaecal resection in Crohn's disease","volume":"45","author":"Riault","year":"2021","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.dld.2022.12.021_bib0038","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1097\/MIB.0b013e318281f336","article-title":"Submucosal plexitis as a predictor of postoperative surgical recurrence in Crohn\u02bcs disease","volume":"19","author":"Bressenot","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.dld.2022.12.021_bib0039","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.dld.2016.02.023","article-title":"Myenteric plexitis is a risk factor for endoscopic and clinical postoperative recurrence after ileocolonic resection in Crohn's disease","volume":"48","author":"Decousus","year":"2016","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2022.12.021_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ibd\/izab044","article-title":"Natural history and risk stratification of recurrent Crohn's disease after ileocolonic resection: a multicenter retrospective cohort study","volume":"28","author":"Joustra","year":"2022","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.dld.2022.12.021_bib0041","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: an update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2022.12.021_bib0042","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ajg.2009.579","article-title":"The natural history of adult Crohn's disease in population-based cohorts","volume":"105","author":"Peyrin-Biroulet","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2022.12.021_bib0043","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1572-0241.2007.01548.x","article-title":"A meta-analysis comparing incidence of recurrence and indication for reoperation after surgery for perforating versus nonperforating Crohn's disease","volume":"103","author":"Simillis","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2022.12.021_bib0044","first-page":"651","article-title":"Risk stratification for prevention of recurrence of postoperative Crohn's disease","volume":"13","author":"Cohen-Mekelburg","year":"2017","journal-title":"Gastroenterol Hepatol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865822008702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865822008702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:22:53Z","timestamp":1761625373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865822008702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1590865822008702"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2022.12.021","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Positive margins and plexitis increase the risk of recurrence after ileocecal resection: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2022.12.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}