{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:21:13Z","timestamp":1770326473547,"version":"3.49.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:00:00Z","timestamp":1682208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008235","name":"Peking Union Medical College Hospital","doi-asserted-by":"publisher","award":["2022-PUMCH-B-063"],"award-info":[{"award-number":["2022-PUMCH-B-063"]}],"id":[{"id":"10.13039\/501100008235","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1309004"],"award-info":[{"award-number":["2017YFC1309004"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2017-I2M-1\u2013005"],"award-info":[{"award-number":["2017-I2M-1\u2013005"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.dld.2023.04.019","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T08:19:53Z","timestamp":1683015593000},"page":"1757-1764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Elaboration of NTRK-rearranged colorectal cancer: Integration of immunoreactivity pattern, cytogenetic identity, and rearrangement variant"],"prefix":"10.1016","volume":"55","author":[{"given":"Shafei","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8711-753X","authenticated-orcid":false,"given":"Xuan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2023.04.019_bib0001","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.dld.2023.04.019_bib0002","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1158\/2159-8290.CD-14-0765","article-title":"TRKing down an old oncogene in a new era of targeted therapy","volume":"5","author":"Vaishnavi","year":"2015","journal-title":"Canc Discov"},{"key":"10.1016\/j.dld.2023.04.019_bib0003","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s40265-018-1044-x","article-title":"Larotrectinib: first global approval","volume":"79","author":"Scott","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.dld.2023.04.019_bib0004","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s40265-019-01177-y","article-title":"Entrectinib: first global approval","volume":"79","author":"Al Salama","year":"2019","journal-title":"Drugs"},{"issue":"5","key":"10.1016\/j.dld.2023.04.019_bib0005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/pin.13082","article-title":"NTRK fusion positive colorectal cancer in Japanese population","volume":"71","author":"Yonemaru","year":"2021","journal-title":"Pathol Int"},{"issue":"2","key":"10.1016\/j.dld.2023.04.019_bib0006","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/PAS.0000000000001377","article-title":"Colonic adenocarcinomas harboring NTRK fusion genes: a clinicopathologic and molecular genetic study of 16 cases and review of the literature","volume":"44","author":"Lasota","year":"2020","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"10.1016\/j.dld.2023.04.019_bib0007","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/annonc\/mdz204","article-title":"ESMO recommendations on the standard methods to detect NTRK fusions in daily practice and clinical research","volume":"30","author":"Marchi\u00f2","year":"2019","journal-title":"Ann Oncol"},{"issue":"13","key":"10.1016\/j.dld.2023.04.019_bib0008","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1158\/0008-5472.CAN-19-0372","article-title":"Detection of NTRK fusions: merits and limitations of current diagnostic platforms","volume":"79","author":"Solomon","year":"2019","journal-title":"Cancer Res"},{"issue":"11","key":"10.1016\/j.dld.2023.04.019_bib0009","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1097\/PAS.0000000000000911","article-title":"Pan-Trk immunohistochemistry is an efficient and reliable screen for the detection of NTRK fusions","volume":"41","author":"Hechtman","year":"2017","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.dld.2023.04.019_bib0010","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/s41379-019-0417-3","article-title":"NTRK gene rearrangements are highly enriched in MLH1\/PMS2 deficient, BRAF wild-type colorectal carcinomas-a study of 4569 cases","volume":"33","author":"Chou","year":"2020","journal-title":"Mod Pathol"},{"issue":"3","key":"10.1016\/j.dld.2023.04.019_bib0011","doi-asserted-by":"crossref","first-page":"321","DOI":"10.5858\/arpa.2017-0388-CP","volume":"142","author":"Lindeman","year":"2018","journal-title":"Arch Pathol Lab Med"},{"issue":"7","key":"10.1016\/j.dld.2023.04.019_bib0012","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/s41379-019-0212-1","article-title":"Prevalence of recurrent oncogenic fusion in mismatch repair-deficient colorectal carcinoma with hypermethylated MLH1 and wild-type BRAF and KRAS","volume":"32","author":"Wang","year":"2019","journal-title":"Mod Pathol"},{"key":"10.1016\/j.dld.2023.04.019_bib0013","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.humpath.2021.05.006","article-title":"MSI-High RAS-BRAF wild-type colorectal adenocarcinomas with MLH1 loss have a high frequency of targetable oncogenic gene fusions whose diagnoses are feasible using methods easy-to-implement in pathology laboratories","volume":"114","author":"Bocciarelli","year":"2021","journal-title":"Hum Pathol"},{"key":"10.1016\/j.dld.2023.04.019_bib0014","first-page":"397","article-title":"Mismatch repair protein expression in colorectal cancer","volume":"4","author":"Kheirelseid","year":"2013","journal-title":"J Gastrointest Oncol"},{"issue":"1","key":"10.1016\/j.dld.2023.04.019_bib0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41379-018-0118-3","article-title":"Molecular characterization of cancers with NTRK gene fusions","volume":"32","author":"Gatalica","year":"2019","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.dld.2023.04.019_bib0016","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.1038\/s41598-021-85075-y","article-title":"NTRK fusion in Japanese colorectal adenocarcinomas","volume":"11","author":"Yamashiro","year":"2021","journal-title":"Sci Rep."},{"issue":"4","key":"10.1016\/j.dld.2023.04.019_bib0017","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/clinem\/dgaa913","article-title":"Pitfalls in RET fusion detection using break-apart FISH probes in papillary thyroid carcinoma","volume":"106","author":"Liu","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.dld.2023.04.019_bib0018","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/jmedgenet-2014-102552","article-title":"Tumour MLH1 promoter region methylation testing is an effective prescreen for Lynch Syndrome (HNPCC)","volume":"51","author":"Newton","year":"2014","journal-title":"J Med Genet"},{"issue":"1","key":"10.1016\/j.dld.2023.04.019_bib0019","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1186\/s12885-020-07516-7","article-title":"Role of circulating free DNA in evaluating clinical tumor burden and predicting survival in Chinese metastatic colorectal cancer patients","volume":"20","author":"Xu","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.dld.2023.04.019_bib0020","article-title":"Comparable performance of deep learning-based to manual-based tumor segmentation in KRAS\/NRAS\/BRAF mutation prediction with MR-based radiomics in rectal cancer","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Oncol"},{"issue":"7","key":"10.1016\/j.dld.2023.04.019_bib0021","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/s41416-021-01501-y","article-title":"Depiction of the genomic and genetic landscape identifies CCL5 as a protective factor in colorectal neuroendocrine carcinoma","volume":"125","author":"Chen","year":"2021","journal-title":"Br J Cancer"},{"issue":"4","key":"10.1016\/j.dld.2023.04.019_bib0022","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s12022-020-09648-9","article-title":"Detection of NTRK1\/3 rearrangements in papillary thyroid carcinoma using immunohistochemistry, fluorescent in situ hybridization, and next-generation sequencing","volume":"31","author":"Lee","year":"2020","journal-title":"Endocr Pathol"},{"issue":"6","key":"10.1016\/j.dld.2023.04.019_bib0023","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/PAS.0000000000001055","article-title":"NTRK fusions define a novel uterine sarcoma subtype with features of fibrosarcoma","volume":"42","author":"Chiang","year":"2018","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1016\/j.dld.2023.04.019_bib0024","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/path.4701","article-title":"Paediatric and adult soft tissue sarcomas with NTRK1 gene fusions: a subset of spindle cell sarcomas unified by a prominent myopericytic\/haemangiopericytic pattern","volume":"238","author":"Haller","year":"2016","journal-title":"J Pathol"},{"key":"10.1016\/j.dld.2023.04.019_bib0025","article-title":"Recommended testing algorithms for NTRK gene fusions in pediatric and selected adult cancers: consensus of a Singapore Task Force","author":"Lim","year":"2021","journal-title":"Asia Pac J Clin Oncol"},{"issue":"1","key":"10.1016\/j.dld.2023.04.019_bib0026","doi-asserted-by":"crossref","DOI":"10.1101\/mcs.a003376","article-title":"Refractory and metastatic infantile fibrosarcoma harboring LMNA-NTRK1 fusion shows complete and durable response to crizotinib","volume":"5","author":"Bender","year":"2019","journal-title":"Cold Spring Harb Mol Case Stud"},{"key":"10.1016\/j.dld.2023.04.019_bib0027","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.lungcan.2020.03.007","article-title":"Attenuated isolated 3\u2032 signal: a highly challenging therapy relevant ALK FISH pattern in NSCLC","volume":"143","author":"Smuk","year":"2020","journal-title":"Lung Cancer"},{"issue":"5","key":"10.1016\/j.dld.2023.04.019_bib0028","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00432-020-03166-1","article-title":"ALK detection in lung cancer: identification of atypical and cryptic ALK rearrangements using an optimal algorithm","volume":"146","author":"Liu","year":"2020","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"10.1016\/j.dld.2023.04.019_bib0029","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1097\/JTO.0000000000000013","article-title":"Atypical negative ALK break-apart FISH harboring a crizotinib-responsive ALK rearrangement in non-small-cell lung cancer","volume":"9","author":"Ren","year":"2014","journal-title":"J Thorac Oncol"},{"issue":"11","key":"10.1016\/j.dld.2023.04.019_bib0030","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/nm.3352","article-title":"Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer","volume":"19","author":"Vaishnavi","year":"2013","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.dld.2023.04.019_bib0031","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1073\/pnas.1819788116","article-title":"Genome-wide colocalization of RNA-DNA interactions and fusion RNA pairs","volume":"116","author":"Yan","year":"2019","journal-title":"Proc Natl Acad Sci USA."},{"issue":"4","key":"10.1016\/j.dld.2023.04.019_bib0032","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.gendis.2019.08.002","article-title":"Gene fusions and chimeric RNAs, and their implications in cancer","volume":"6","author":"Wu","year":"2019","journal-title":"Genes Dis"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823005789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823005789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:23:15Z","timestamp":1761625395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865823005789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1590865823005789"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2023.04.019","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elaboration of NTRK-rearranged colorectal cancer: Integration of immunoreactivity pattern, cytogenetic identity, and rearrangement variant","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2023.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}