{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:59:06Z","timestamp":1791831546017,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.dld.2023.05.001","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T08:07:31Z","timestamp":1685434051000},"page":"1673-1678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The significant IgG4 infiltrate in autoimmune hepatitis is associated with a greater ductular reaction and more advanced liver disease"],"prefix":"10.1016","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4368-8939","authenticated-orcid":false,"given":"Ana","family":"Barreira-D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Salcedo-Allende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Mart\u00ednez-Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olimpia","family":"Orozco-G\u00e1lvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Buti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9309-2052","authenticated-orcid":false,"given":"Mar","family":"Riveiro-Barciela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2023.05.001_bib0001","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.jhep.2015.06.030","article-title":"EASL clinical practice guidelines: autoimmune hepatitis","volume":"63","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2023.05.001_bib0002","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.jhep.2020.07.023","article-title":"Second-line and third-line therapy for autoimmune hepatitis: a position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group","volume":"73","author":"Lohse","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2023.05.001_bib0003","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/hep.22322","article-title":"Simplified criteria for the diagnosis of autoimmune hepatitis","volume":"48","author":"Hennes","year":"2008","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.dld.2023.05.001_bib0004","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-pathol-020117-043534","article-title":"Cellular and molecular mechanisms of autoimmune hepatitis","volume":"13","author":"Webb","year":"2018","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.dld.2023.05.001_bib0005","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2222.2009.03207.x","article-title":"Immunoglobulin G4: an odd antibody","volume":"39","author":"Aalberse","year":"2009","journal-title":"Clin Exp Allergy: J Br Soc Allergy Clin Immunol"},{"key":"10.1016\/j.dld.2023.05.001_bib0006","article-title":"IgG4-related disease: changing epidemiology and new thoughts on a multisystem disease","volume":"4","author":"Floreani","year":"2021","journal-title":"J Transl Autoimmun"},{"key":"10.1016\/j.dld.2023.05.001_bib0007","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s00535-003-1175-y","article-title":"A new clinicopathological entity of IgG4-related autoimmune disease","volume":"38","author":"Kamisawa","year":"2003","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.dld.2023.05.001_bib0008","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/08916934.2017.1280029","article-title":"Clonally expanded cytotoxic CD4(+) T cells and the pathogenesis of IgG4-related disease","volume":"50","author":"Mattoo","year":"2017","journal-title":"Autoimmunity"},{"key":"10.1016\/j.dld.2023.05.001_bib0009","first-page":"1181","article-title":"Consensus statement on the pathology of IgG4-related disease. Modern pathology: an official journal of the United States and Canadian Academy of Pathology","volume":"25","author":"Deshpande","year":"2012","journal-title":"Inc"},{"key":"10.1016\/j.dld.2023.05.001_bib0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.medcli.2017.10.034","article-title":"Update in ethiopathogeny, diagnosis and treatment of the IgG4 related disease","volume":"151","author":"Mart\u00ednez-Valle","year":"2018","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.dld.2023.05.001_bib0011","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/annrheumdis-2019-216561","article-title":"The 2019 American College of Rheumatology\/European league against rheumatism classification criteria for IgG4-related disease","volume":"79","author":"Wallace","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.dld.2023.05.001_bib0012","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0140-6736(14)60720-0","article-title":"IgG4-related disease","volume":"385","author":"Kamisawa","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.dld.2023.05.001_bib0013","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.3748\/wjg.v25.i19.2308","article-title":"Autoimmune hepatitis and IgG4-related disease","volume":"25","author":"Minaga","year":"2019","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.dld.2023.05.001_bib0014","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s00535-010-0323-4","article-title":"Clinical significance of immunoglobulin G4-associated autoimmune hepatitis","volume":"46","author":"Umemura","year":"2011","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.dld.2023.05.001_bib0015","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1159\/000355238","article-title":"Autoimmune hepatitis and immunoglobulin G4-associated autoimmune hepatitis","volume":"31","author":"Yada","year":"2013","journal-title":"Dig Dis"},{"key":"10.1016\/j.dld.2023.05.001_bib0016","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/hep.510260305","article-title":"Serum autoantibodies in chronic hepatitis C: comparison with autoimmune hepatitis and impact on the disease profile","volume":"26","author":"Cassani","year":"1997","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.dld.2023.05.001_bib0017","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jhep.2016.12.003","article-title":"EASL clinical practical guidelines on the management of acute (fulminant) liver failure","volume":"66","author":"Wendon","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2023.05.001_bib0018","doi-asserted-by":"crossref","first-page":"15s","DOI":"10.1002\/hep.510260703","article-title":"Hepatitis C: the clinical spectrum of disease","volume":"26","author":"Hoofnagle","year":"1997","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.dld.2023.05.001_bib0019","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/hepr.13252","article-title":"Prompt initiation of high-dose i.v. corticosteroids seems to prevent progression to liver failure in patients with original acute severe autoimmune hepatitis","volume":"49","author":"Zachou","year":"2019","journal-title":"Hepatol Res: Off J Japan Soc Hepatol"},{"key":"10.1016\/j.dld.2023.05.001_bib0020","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0168-8278(99)80297-9","article-title":"International autoimmune hepatitis group report: review of criteria for diagnosis of autoimmune hepatitis","volume":"31","author":"Alvarez","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2023.05.001_bib0021","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","article-title":"Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis","volume":"1","author":"Knodell","year":"1981","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.dld.2023.05.001_bib0022","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/hep.26937","article-title":"The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease","volume":"59","author":"Gadd","year":"2014","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.dld.2023.05.001_bib0023","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/lt.21447","article-title":"Posttransplant plasma cell hepatitis (de novo autoimmune hepatitis) is a variant of rejection and may lead to a negative outcome in patients with hepatitis C virus","volume":"14","author":"Fiel","year":"2008","journal-title":"Liver Transpl: Off Publ Am Assoc Study Liver Dis Int Liver Transpl Soc"},{"key":"10.1016\/j.dld.2023.05.001_bib0024","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nrgastro.2016.132","article-title":"IgG4-related hepatobiliary disease: an overview","volume":"13","author":"Culver","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2023.05.001_bib0025","first-page":"21","article-title":"The role of IgG4 in the fine tuning of tolerance in IgE-mediated allergy and cancer","author":"Bianchini","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.dld.2023.05.001_bib0026","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/hep.20650","article-title":"Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis","volume":"41","author":"Clouston","year":"2005","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.dld.2023.05.001_bib0027","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-2004-823101","article-title":"The histopathology of regeneration in massive hepatic necrosis","volume":"24","author":"Craig","year":"2004","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.dld.2023.05.001_bib0028","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0168-8278(03)00309-X","article-title":"Regeneration of hepatocyte 'buds' in cirrhosis from intrabiliary stem cells","volume":"39","author":"Falkowski","year":"2003","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2023.05.001_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102618","article-title":"2020 international consensus on ANCA testing beyond systemic vasculitis","volume":"19","author":"Moiseev","year":"2020","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.dld.2023.05.001_bib0030","first-page":"439","article-title":"Diagnostic accuracy of atypical p-ANCA in autoimmune hepatitis using ROC- and multivariate regression analysis","volume":"9","author":"Terjung","year":"2004","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.dld.2023.05.001_bib0031","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1055\/s-0036-1584320","article-title":"Histopathology of IgG4-related autoimmune hepatitis and IgG4-related hepatopathy in IgG4-related disease","volume":"36","author":"Nakanuma","year":"2016","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.dld.2023.05.001_bib0032","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1478-3231.2009.02092.x","article-title":"Identification and characterization of IgG4-associated autoimmune hepatitis","volume":"30","author":"Chung","year":"2010","journal-title":"Liver Int: Off J Int Assoc Study Liver"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823006096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823006096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:24:27Z","timestamp":1761625467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865823006096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S1590865823006096"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2023.05.001","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The significant IgG4 infiltrate in autoimmune hepatitis is associated with a greater ductular reaction and more advanced liver disease","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2023.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}