{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:56:50Z","timestamp":1790287010897,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020027","name":"Dr Rolf M Schwiete Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.dld.2023.05.016","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T08:46:48Z","timestamp":1686646008000},"page":"1362-1367","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Presence of NOD2 mutations is not associated with hepatic or systemic hemodynamic abnormalities of cirrhosis"],"prefix":"10.1016","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7561-6294","authenticated-orcid":false,"given":"Robin","family":"Greinert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zipprich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Casper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias Christian","family":"Reichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9704-4741","authenticated-orcid":false,"given":"Cristina","family":"Ripoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.dld.2023.05.016_bib0001","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.jhep.2015.01.003","article-title":"Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments","volume":"62","author":"Bosch","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2023.05.016_bib0002","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jhep.2015.07.004","article-title":"Mechanisms of decompensation and organ failure in cirrhosis: from peripheral arterial vasodilation to systemic inflammation hypothesis","volume":"63","author":"Bernardi","year":"2015","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2023.05.016_bib0003","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1053\/jhep.2003.50038","article-title":"Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement","volume":"37","author":"Albillos","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2023.05.016_bib0004","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cgh.2012.02.025","article-title":"Rifaximin improves systemic hemodynamics and renal function in patients with alcohol-related cirrhosis and ascites","volume":"10","author":"Kalambokis","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.dld.2023.05.016_bib0005","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/j.1365-2036.2009.03958.x","article-title":"Intestinal decontamination improves liver haemodynamics in patients with alcohol-related decompensated cirrhosis","volume":"29","author":"Vlachogiannakos","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.dld.2023.05.016_bib0006","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.dld.2023.05.016_bib0007","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.dld.2023.05.016_bib0008","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00330.2016","article-title":"From sensing to shaping microbiota: insights into the role of NOD2 in intestinal homeostasis and progression of Crohn's disease","volume":"313","author":"Balasubramanian","year":"2017","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.dld.2023.05.016_bib0009","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/imr.12193","article-title":"Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohn's disease","volume":"260","author":"Strober","year":"2014","journal-title":"Immunol Rev"},{"key":"10.1016\/j.dld.2023.05.016_bib0010","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/hep.23440","article-title":"Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis","volume":"51","author":"Appenrodt","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2023.05.016_bib0011","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1478-3231.2011.02561.x","article-title":"NOD2 gene variants are a risk factor for culture-positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis","volume":"32","author":"Bruns","year":"2012","journal-title":"Liver Int"},{"key":"10.1016\/j.dld.2023.05.016_bib0012","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13063-015-0594-4","article-title":"The INCA trial (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites): study protocol for a randomized controlled trial","volume":"16","author":"Casper","year":"2015","journal-title":"Trials"},{"key":"10.1016\/j.dld.2023.05.016_bib0013","doi-asserted-by":"crossref","DOI":"10.1002\/hep4.2102","article-title":"Evaluation of the definition of hyperdynamic circulation in patients with cirrhosis and ascites","author":"Ripoll","year":"2022","journal-title":"Hepatol Comm"},{"key":"10.1016\/j.dld.2023.05.016_bib0014","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-230X-14-4","article-title":"A non-interventional study of the genetic polymorphisms of NOD2 associated with increased mortality in non-alcoholic liver transplant patients","volume":"14","author":"Saner","year":"2014","journal-title":"BMC Gastroenterol"},{"key":"10.1016\/j.dld.2023.05.016_bib0015","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/liv.14392","article-title":"Genetic variants of innate immunity receptors are associated with mortality in cirrhotic patients with bacterial infection","volume":"40","author":"Schaapman","year":"2020","journal-title":"Liver Int"},{"key":"10.1016\/j.dld.2023.05.016_bib0016","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/liv.13664","article-title":"Functional polymorphisms of innate immunity receptors are not risk factors for the non-SBP type bacterial infections in cirrhosis","volume":"38","author":"Dinya","year":"2018","journal-title":"Liver Int"},{"key":"10.1016\/j.dld.2023.05.016_bib0017","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1111\/liv.14842","article-title":"Isolated bacterial infection without decompensation has no impact on survival of compensated patients with cirrhosis","volume":"41","author":"Reichert","year":"2021","journal-title":"Liver Int"},{"key":"10.1016\/j.dld.2023.05.016_bib0018","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/hep.510300124","article-title":"Carvedilol, a new nonselective beta-blocker with intrinsic anti- Alpha1-adrenergic activity, has a greater portal hypotensive effect than propranolol in patients with cirrhosis","volume":"30","author":"Banares","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.dld.2023.05.016_bib0019","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1053\/j.gastro.2003.12.007","article-title":"Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis","volume":"126","author":"Zafra","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2023.05.016_bib0020","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jhep.2012.12.011","article-title":"Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis","volume":"58","author":"Reiberger","year":"2013","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2023.05.016_bib0021","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1365-2362.2011.02609.x","article-title":"Altered intestinal tight junctions' expression in patients with liver cirrhosis: a pathogenetic mechanism of intestinal hyperpermeability","volume":"42","author":"Assimakopoulos","year":"2012","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.dld.2023.05.016_bib0022","doi-asserted-by":"crossref","first-page":"G147","DOI":"10.1152\/ajpgi.00330.2013","article-title":"Large intestine permeability is increased in patients with compensated liver cirrhosis","volume":"306","author":"Pijls","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.dld.2023.05.016_bib0023","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.3748\/wjg.14.3884","article-title":"Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites","volume":"14","author":"Lee","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.dld.2023.05.016_bib0024","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/0016-5085(92)91124-M","article-title":"Hemodynamic effects of endotoxin and platelet activating factor in cirrhotic rats","volume":"103","author":"Kleber","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.dld.2023.05.016_bib0025","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/j.jhep.2014.07.014","article-title":"Liver sinusoidal endothelial dysfunction after LPS administration: a role for inducible-nitric oxide synthase","volume":"61","author":"La Mura","year":"2014","journal-title":"J Hepatol"},{"key":"10.1016\/j.dld.2023.05.016_bib0026","doi-asserted-by":"crossref","first-page":"702","DOI":"10.5009\/gnl16478","article-title":"Rifaximin and propranolol combination therapy is more effective than propranolol monotherapy for the reduction of portal pressure: an open randomized controlled pilot study","volume":"11","author":"Lim","year":"2017","journal-title":"Gut Liver"},{"key":"10.1016\/j.dld.2023.05.016_bib0027","doi-asserted-by":"crossref","first-page":"186","DOI":"10.7326\/0003-4819-139-3-200308050-00008","article-title":"The effect of selective intestinal decontamination on the hyperdynamic circulatory state in cirrhosis. A randomized trial","volume":"139","author":"Rasaratnam","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.dld.2023.05.016_bib0028","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/liv.13589","article-title":"The pathophysiology of arterial vasodilatation and hyperdynamic circulation in cirrhosis","volume":"38","author":"Moller","year":"2018","journal-title":"Liver Int"},{"key":"10.1016\/j.dld.2023.05.016_bib0029","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jhep.2021.09.010","article-title":"Rifaximin-alpha reduces gut-derived inflammation and mucin degradation in cirrhosis and encephalopathy: RIFSYS randomised controlled trial","volume":"76","author":"Patel","year":"2022","journal-title":"J Hepatol"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823006254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823006254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:24:06Z","timestamp":1761625446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865823006254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1590865823006254"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2023.05.016","relation":{},"ISSN":["1590-8658"],"issn-type":[{"value":"1590-8658","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presence of NOD2 mutations is not associated with hepatic or systemic hemodynamic abnormalities of cirrhosis","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2023.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l.","name":"copyright","label":"Copyright"}]}}