{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:06:45Z","timestamp":1763644005207,"version":"build-2065373602"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100016045","name":"University of Central Punjab","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DST\/INSPIRE-Fellowship\/2019\/IF190501"],"award-info":[{"award-number":["DST\/INSPIRE-Fellowship\/2019\/IF190501"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["GP.25"],"award-info":[{"award-number":["GP.25"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ECR\/2016\/001660"],"award-info":[{"award-number":["ECR\/2016\/001660"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","dldjournalonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Digestive and Liver Disease"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.dld.2023.09.014","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T06:56:29Z","timestamp":1696834589000},"page":"258-264","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A duodenal mucosa transcriptome study identified reduced expression of a novel gene CDH18 in celiac disease"],"prefix":"10.1016","volume":"56","author":[{"given":"Pratibha","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajit","family":"Sood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Midha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikram","family":"Narang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0742-9171","authenticated-orcid":false,"given":"Jasmine","family":"Grover","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-7432","authenticated-orcid":false,"given":"Sabyasachi","family":"Senapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.dld.2023.09.014_bib0001","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1136\/gut.50.5.624","article-title":"The first large population based twin study of coeliac disease","volume":"50","author":"Greco","year":"2002","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.dld.2023.09.014_bib0002","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1136\/gut.2005.083964","article-title":"Concordance, disease progression, and heritability of coeliac disease in Italian twins","volume":"55","author":"Nistic\u00f2","year":"2006","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.dld.2023.09.014_bib0003","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.dld.2015.11.007","article-title":"Prevalence of celiac disease among first-degree relatives of Indian celiac disease patients","volume":"48","author":"Mishra","year":"2016","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.dld.2023.09.014_bib0004","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/2050640619844125","article-title":"European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders","volume":"7","author":"Al-Toma","year":"2019","journal-title":"United Eur Gastroenterol J"},{"issue":"4","key":"10.1016\/j.dld.2023.09.014_bib0005","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ng.543","article-title":"Multiple common variants for celiac disease influencing immune gene expression","volume":"42","author":"Dubois","year":"2010","journal-title":"Nat Genet"},{"issue":"12","key":"10.1016\/j.dld.2023.09.014_bib0006","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"Trynka","year":"2011","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.dld.2023.09.014_bib0007","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bpg.2015.04.004","article-title":"Genetics of celiac disease","volume":"29","author":"Rica\u00f1o-Ponce","year":"2015","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"1","key":"10.1016\/j.dld.2023.09.014_bib0008","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bpsgos.2021.03.002","article-title":"Investigating pleiotropy between depression and autoimmune diseases using the UK Biobank","volume":"1","author":"Glanville","year":"2021","journal-title":"Biol Psychiatry Glob Open Sci"},{"issue":"10","key":"10.1016\/j.dld.2023.09.014_bib0009","first-page":"1190","article-title":"Human Leukocyte Antigen DQ (HLA-DQ) genotypes and haplotypes and their association with phenotype in patients with celiac disease in India","volume":"5","author":"Ramakrishna","year":"2021","journal-title":"J Gastroenterol Andhepatol"},{"issue":"10","key":"10.1016\/j.dld.2023.09.014_bib0010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41424-018-0059-7","article-title":"First degree relatives of patients with celiac disease harbour an intestinal transcriptomic signature that might protect them from enterocyte damage","volume":"9","author":"Acharya","year":"2018","journal-title":"Clin Transl Gastroenterol"},{"key":"10.1016\/j.dld.2023.09.014_bib0011","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1007\/s00018-018-2898-5","article-title":"Celiac disease biomarkers identified by transcriptome analysis of small intestinal biopsies","volume":"75","author":"Bragde","year":"2018","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"10.1016\/j.dld.2023.09.014_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215132","article-title":"RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis","volume":"14","author":"Leonard","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.dld.2023.09.014_bib0013","doi-asserted-by":"crossref","first-page":"16163","DOI":"10.1038\/s41598-019-52733-1","article-title":"Defining the celiac disease transcriptome using clinical pathology specimens reveals biologic pathways and supports diagnosis","volume":"9","author":"Loberman-Nachum","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.dld.2023.09.014_bib0014","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1053\/j.gastro.2021.01.221","article-title":"Mucosal genomics implicate lymphocyte activation and lipid metabolism in refractory environmental enteric dysfunction","volume":"160","author":"Haberman","year":"2021","journal-title":"Gastroenterol"},{"key":"10.1016\/j.dld.2023.09.014_bib0015","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3390\/cells12060823","article-title":"Interaction between gut microbiota and celiac disease: from pathogenesis to treatment","volume":"12","author":"Rossi","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.dld.2023.09.014_bib0016","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/ajg.2015.398","article-title":"Prevalence of adult celiac disease in India: regional variations and associations","volume":"111","author":"Ramakrishna","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.dld.2023.09.014_bib0017","unstructured":"Andrews S. FastQC: a quality control tool for high throughput sequence data (2010). http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/."},{"issue":"19","key":"10.1016\/j.dld.2023.09.014_bib0018","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"issue":"17","key":"10.1016\/j.dld.2023.09.014_bib0019","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.dld.2023.09.014_bib0020","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.dld.2023.09.014_bib0021","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.dld.2023.09.014_bib0022","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.23297.1","article-title":"GFF utilities: GffRead and GffCompare","volume":"9","author":"Pertea","year":"2020","journal-title":"F1000Res"},{"issue":"7","key":"10.1016\/j.dld.2023.09.014_bib0023","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.dld.2023.09.014_bib0024","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.dld.2023.09.014_bib0025","doi-asserted-by":"crossref","first-page":"D419","DOI":"10.1093\/nar\/gky1038","article-title":"PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools","volume":"47","author":"Mi","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.dld.2023.09.014_bib0026","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"Kyoto Encyclopedia of Genes and Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"11","key":"10.1016\/j.dld.2023.09.014_bib0027","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.dld.2023.09.014_bib0028","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"10.1016\/j.dld.2023.09.014_bib0029","doi-asserted-by":"crossref","first-page":"W234","DOI":"10.1093\/nar\/gkz240","article-title":"NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis","volume":"47","author":"Zhou","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.dld.2023.09.014_bib0030","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.dld.2023.09.014_bib0031","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nmeth.2811","article-title":"BoxPlotR: a web tool for generation of box plots","volume":"11","author":"Spitzer","year":"2014","journal-title":"Nat Methods"},{"issue":"15","key":"10.1016\/j.dld.2023.09.014_bib0032","article-title":"Distinct populations of antigen-specific tissue-resident CD8+ T cells in human cervix mucosa","volume":"6","author":"Peng","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.dld.2023.09.014_bib0033","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ctrv.2017.11.007","article-title":"CXCL9, CXCL10, CXCL11\/CXCR3 axis for immune activation - a target for novel cancer therapy","volume":"63","author":"Tokunaga","year":"2018","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.dld.2023.09.014_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106633","article-title":"Untangling determinants of gut microbiota and tumor immunologic status through a multi-omics approach in colorectal cancer","volume":"188","author":"Zhang","year":"2023","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.dld.2023.09.014_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-020-00811-2","article-title":"Predictable modulation of cancer treatment outcomes by the gut microbiota","volume":"8","author":"Heshiki","year":"2020","journal-title":"Microbiome"},{"key":"10.1016\/j.dld.2023.09.014_bib0036","doi-asserted-by":"crossref","unstructured":"Sharma, N., Narang, V., Sood, A., Midha, V., & Senapati, S. (2023, September 13). Reduced expression of ankyrin-G and E-cadherin in duodenal mucosal biopsy of subjects with celiac disease suggest its functional association with the disease pathology. Retrieved from osf.io\/ydw23.","DOI":"10.31219\/osf.io\/ydw23"},{"issue":"6","key":"10.1016\/j.dld.2023.09.014_bib0037","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1083\/jcb.201009141","article-title":"Dynamics of adherens junctions in epithelial establishment, maintenance, and remodeling","volume":"192","author":"Baum","year":"2011","journal-title":"J Cell Biol"},{"issue":"3","key":"10.1016\/j.dld.2023.09.014_bib0038","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.bbamem.2007.07.012","article-title":"Adherens and tight junctions: structure, function and connections to the actin cytoskeleton","volume":"1778","author":"Hartsock","year":"2008","journal-title":"Biochim Biophys Acta-Biomembranes"},{"issue":"3","key":"10.1016\/j.dld.2023.09.014_bib0039","article-title":"Adherens junctions on the move\u2014membrane trafficking of E-cadherin","volume":"9","author":"Br\u00fcser","year":"2017","journal-title":"Cold Spring Harb Perspectbiol"},{"issue":"1","key":"10.1016\/j.dld.2023.09.014_bib0040","first-page":"14","article-title":"CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells","volume":"7","author":"Junghof","year":"2022","journal-title":"NPJ RegenMed"},{"key":"10.1016\/j.dld.2023.09.014_bib0041","doi-asserted-by":"crossref","unstructured":"Hullar M., et\u00a0al. Genome-wide association study (GWAS) of host germline variation and the gut microbiome: the Multiethnic Cohort Study. 2023.","DOI":"10.21203\/rs.3.rs-2298426\/v1"},{"key":"10.1016\/j.dld.2023.09.014_bib0042","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.2147\/IJGM.S324483","article-title":"Integrated bioinformatics analysis to identify abnormal methylated differentially expressed genes for predicting prognosis of human colon cancer","author":"Luo","year":"2021","journal-title":"Int J Gen Med"},{"issue":"39","key":"10.1016\/j.dld.2023.09.014_bib0043","doi-asserted-by":"crossref","first-page":"15418","DOI":"10.1073\/pnas.0707210104","article-title":"Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors","volume":"104","author":"Kosinski","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"10.1016\/j.dld.2023.09.014_bib0044","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1002\/ijc.25821","article-title":"Identification of candidate predisposing copy number variants in familial and early-onset colorectal cancer patients","volume":"129","author":"Venkatachalam","year":"2011","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.dld.2023.09.014_bib0045","doi-asserted-by":"crossref","first-page":"323","DOI":"10.32471\/exp-oncology.2312-8852.vol-41-no-4.13841","article-title":"Deletions in metastatic colorectal cancer with chromothripsis","volume":"41","author":"Skuja","year":"2019","journal-title":"Exp Oncol"},{"key":"10.1016\/j.dld.2023.09.014_bib0046","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainres.2012.06.020","article-title":"Cadherins and neuropsychiatric disorders","volume":"1470","author":"Redies","year":"2012","journal-title":"Brain Res"},{"issue":"5","key":"10.1016\/j.dld.2023.09.014_bib0047","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.3390\/biomedicines11051254","article-title":"Identification of novel biomarkers of spinal muscular atrophy and therapeutic response by proteomic and metabolomic profiling of human biological fluid samples","volume":"11","author":"Meneri","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.dld.2023.09.014_bib0048","doi-asserted-by":"crossref","first-page":"18287","DOI":"10.1038\/s41598-019-54675-0","article-title":"Transcriptome changes in undifferentiated Caco-2 cells exposed to food-grade titanium dioxide (E171): contribution of the nano-and micro-sized particles","volume":"9","author":"Proquin","year":"2019","journal-title":"Sci Rep"}],"container-title":["Digestive and Liver Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823009581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1590865823009581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:24:20Z","timestamp":1761625460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1590865823009581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S1590865823009581"],"URL":"https:\/\/doi.org\/10.1016\/j.dld.2023.09.014","relation":{},"ISSN":["1590-8658"],"issn-type":[{"type":"print","value":"1590-8658"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A duodenal mucosa transcriptome study identified reduced expression of a novel gene CDH18 in celiac disease","name":"articletitle","label":"Article Title"},{"value":"Digestive and Liver Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.dld.2023.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}